{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:18:08Z","timestamp":1764793088019,"version":"build-2065373602"},"reference-count":164,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["CA252590","RO1 AG076575"],"award-info":[{"award-number":["CA252590","RO1 AG076575"]}]},{"name":"National Institute of Aging","award":["CA252590","RO1 AG076575"],"award-info":[{"award-number":["CA252590","RO1 AG076575"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which uncomplicated cystitis triggers &gt; 25% of outpatient prescriptions of oral antimicrobial treatment (OAT). OAT aids immune cells infiltrating the urothelium in eliminating uropathogens capable of invading the urothelium and surviving hyperosmotic urine. This self-evident adaptability of uropathogens and the short interval between the introduction of Penicillin and the first report of antimicrobial resistance (AMR) implicate AMR as an evolutionary conserved heritable trait of mutant strains selected by the Darwinian principle to survive environmental threats through exponential proliferation. Therefore, AMR can only be countered by antimicrobial stewardship (AMS) following the principle of the five Ds\u2014drug, dose, duration, drug route, and de-escalation. While convenient to administer, the onset of the minimum inhibitory concentration (MIC) for OAT in urine leaves a window of opportunity for uropathogens to survive the first contact with an antimicrobial and arm their descendant colonies with AMR for surviving subsequent higher urine antimicrobial levels. Meanwhile, the initial dose of intravesical antimicrobial treatment (IAT) may be well above the MIC. Therefore, the widespread clinical use of OAT for cystitis warrants an analysis of the strengths, weaknesses, opportunity, and threats (SWOTs) and a root cause analysis of the AMR associated with OAT and IAT.<\/jats:p>","DOI":"10.3390\/antibiotics13040328","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T06:57:34Z","timestamp":1712213854000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SWOT and Root Cause Analyses of Antimicrobial Resistance to Oral Antimicrobial Treatment of Cystitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-4545","authenticated-orcid":false,"given":"Pradeep","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-3456","authenticated-orcid":false,"given":"Shachi","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Stewart","sequence":"additional","affiliation":[{"name":"Spire Murrayfield Hospital, Edinburgh EH12 6UD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Glickman","sequence":"additional","affiliation":[{"name":"Uropharma Ltd., Norwich NR1 1PY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/106351501750435040","article-title":"Environmental diversity of bacteria and archaea","volume":"50","author":"DeLong","year":"2001","journal-title":"Syst. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1072483","article-title":"Merging genomes with geochemistry in hydrothermal ecosystems","volume":"296","author":"Reysenbach","year":"2002","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41559-023-02269-5","article-title":"Horizontal gene transfer facilitates the molecular reverse-evolution of antibiotic sensitivity in experimental populations of H. pylori","volume":"8","author":"Nguyen","year":"2024","journal-title":"Nat. Ecol. Evol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wong, C. (2024). Antibiotic resistance is a growing threat\u2014Is climate change making it worse?. Nature, Online ahead of print.","DOI":"10.1038\/d41586-023-04077-0"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mib.2018.07.004","article-title":"Microbial communities as dynamical systems","volume":"44","author":"Gonze","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wright, E.S., Gupta, R., and Vetsigian, K.H. (2021). Multi-stable bacterial communities exhibit extreme sensitivity to initial conditions. FEMS Microbiol. Ecol., 97.","DOI":"10.1093\/femsec\/fiab073"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1111\/mec.15200","article-title":"Stochastic exits from dormancy give rise to heavy-tailed distributions of descendants in bacterial populations","volume":"28","author":"Wright","year":"2019","journal-title":"Mol. Ecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e0069723","DOI":"10.1128\/msystems.00697-23","article-title":"Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus","volume":"8","author":"Zhang","year":"2023","journal-title":"mSystems"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/01.ju.0000052404.42651.55","article-title":"Variation in urine composition in the human urinary tract: Evidence of urothelial function in situ?","volume":"169","author":"Cahill","year":"2003","journal-title":"J. Urol."},{"key":"ref_10","unstructured":"Sabih, A., and Leslie, S.W. (2024). StatPearls, StatPearls Publishing."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/bju.15756","article-title":"Guideline of guidelines: Management of recurrent urinary tract infections in women","volume":"130","author":"Kwok","year":"2022","journal-title":"BJU Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101041","DOI":"10.1016\/j.cont.2023.101041","article-title":"Unraveling the Complexity of bladder-centric chronic pain by intravesical contrast enhanced MRI","volume":"7","author":"Tyagi","year":"2023","journal-title":"Continence"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.46292\/sci23-00004","article-title":"Intravesical Lactobacillus rhamnosus GG Alters Urobiome Composition and Diversity Among People With Neurogenic Lower Urinary Tract Dysfunction","volume":"29","author":"Groah","year":"2023","journal-title":"Top. Spinal Cord Inj. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0022-5347(05)67823-8","article-title":"Urinary tract infection prophylaxis using Escherichia coli 83972 in spinal cord injured patients","volume":"163","author":"Hull","year":"2000","journal-title":"J. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"ofad561","DOI":"10.1093\/ofid\/ofad561","article-title":"Risk Factors for Recurrence of Community-Onset Urinary Tract Infections Caused by Extended-Spectrum Cephalosporin-Resistant Enterobacterales","volume":"10","author":"Zhang","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zhou, Z., Zheng, L., Gong, Z., Li, Y., Jin, Y., Huang, Y., and Chi, M. (2023). Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310537"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Koley, S., Ghosh, A., and Mukherjee, M. (2024). Occurrence of Imipenem-Resistant Uropathogenic Escherichia coli in Pregnant Women: An Insight into Their Virulence Profile and Clonal Structure. Curr. Microbiol., 81.","DOI":"10.1007\/s00284-023-03576-7"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e16401","DOI":"10.7717\/peerj.16401","article-title":"Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand","volume":"11","author":"Boueroy","year":"2023","journal-title":"PeerJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/cid\/ciad335","article-title":"A Retrospective, Observational Study of 12 Cases of Expanded-Access Customized Phage Therapy: Production, Characteristics, and Clinical Outcomes","volume":"77","author":"Green","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","first-page":"581","article-title":"The global burden of antimicrobial resistance\u2014Urinary tract infections","volume":"39","author":"Shevchuk","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_21","first-page":"e39458","article-title":"Association of Virulence Markers with Resistance to Oral Antibiotics in Escherichia coli Isolates Causing Uncomplicated Community-Acquired Cystitis","volume":"15","author":"Radera","year":"2023","journal-title":"Cureus"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eadg0188","DOI":"10.1126\/sciadv.adg0188","article-title":"Drugging evolution of antibiotic resistance at a regulatory network hub","volume":"9","author":"Zhai","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/jac\/dkz095","article-title":"The pharmacokinetics of nitrofurantoin in healthy female volunteers: A randomized crossover study","volume":"74","author":"Huttner","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00228-023-03477-5","article-title":"Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers","volume":"79","author":"Edwina","year":"2023","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sharma, R.P., Burgers, E.J., and Beltman, J.B. (2023). Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092199"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmi.2017.08.023","article-title":"High interindividual variability in urinary fosfomycin concentrations in healthy female volunteers","volume":"24","author":"Wijma","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000222043","article-title":"Pharmacokinetic study of fosfomycin and its bioavailability","volume":"23","author":"Cadorniga","year":"1977","journal-title":"Chemotherapy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000222042","article-title":"Fosfomycin: Absorption and excretion","volume":"23","author":"Shimizu","year":"1977","journal-title":"Chemotherapy"},{"key":"ref_29","first-page":"505","article-title":"Sequential intravenous\/oral ciprofloxacin as an empiric antimicrobial therapy: Results of a Canadian multicenter study. The Canadian Collaborative Investigational Group","volume":"16","author":"Davis","year":"1994","journal-title":"Clin. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/cid\/ciad009","article-title":"Defining the Optimal Duration of Therapy for Hospitalized Patients with Complicated Urinary Tract Infections and Associated Bacteremia","volume":"76","author":"McAteer","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: Epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/cpdd.1192","article-title":"Pharmacokinetic, Safety, and Tolerability Evaluations of Gepotidacin (GSK2140944) in Healthy Japanese Participants","volume":"12","author":"Barth","year":"2023","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0140-6736(23)02196-7","article-title":"Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): Two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials","volume":"403","author":"Wagenlehner","year":"2024","journal-title":"Lancet"},{"key":"ref_34","first-page":"728","article-title":"Pharmacokinetics of trometamol-fosfomycin in patients with renal insufficiency","volume":"36","author":"Fillastre","year":"1988","journal-title":"Pathol. Biol."},{"key":"ref_35","first-page":"177","article-title":"Pharmacokinetics of fosfomycin in normal and burn patients. Effect of probenecid","volume":"15","author":"Potel","year":"1989","journal-title":"Drugs Exp. Clin. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"469580231168746","DOI":"10.1177\/00469580231168746","article-title":"Incidence of Urinary Tract Infection among Patients: Systematic Review and Meta-Analysis","volume":"60","author":"Mengistu","year":"2023","journal-title":"Inquiry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/acem.14545","article-title":"High prevalence of fluoroquinolone-resistant UTI among US emergency department patients diagnosed with urinary tract infection, 2018\u20132020","volume":"29","author":"Faine","year":"2022","journal-title":"Acad. Emerg. Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rafat, D., Agrawal, A., Khalid, S., Khan, A.U., Nawab, T., and Sultan, A. (2024). Bacterial abundance and antimicrobial resistance patterns of uropathogens among pregnant women with asymptomatic bacteriuria: Association with glycemic status. Eur. J. Obstet. Gynecol. Reprod. Biol. X, 21.","DOI":"10.1016\/j.eurox.2023.100263"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"dlad040","DOI":"10.1093\/jacamr\/dlad040","article-title":"Intravesical aminoglycoside instillations as prophylaxis for recurrent urinary tract infection: Patient satisfaction, long-term safety and efficacy","volume":"5","author":"Bilsen","year":"2023","journal-title":"JAC Antimicrob. Resist."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"ofaa182","DOI":"10.1093\/ofid\/ofaa182","article-title":"Decreased Outpatient Fluoroquinolone Prescribing Using a Multimodal Antimicrobial Stewardship Initiative","volume":"7","author":"Lin","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"ofz544","DOI":"10.1093\/ofid\/ofz544","article-title":"Antibiotic Prescribing in New York State Medicare Part B Beneficiaries Diagnosed with Cystitis Between 2016 and 2017","volume":"7","author":"Yu","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jgar.2021.10.007","article-title":"India\u2019s National Action Plan on Antimicrobial Resistance: A critical perspective","volume":"27","author":"Nair","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1016\/S2666-5247(23)00285-9","article-title":"Innovations in genomic antimicrobial resistance surveillance","volume":"4","author":"Wheeler","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"(2015). NICE antimicrobial stewardship: Right drug, dose, and time?. Lancet, 386, 717.","DOI":"10.1016\/S0140-6736(15)61522-7"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/ajcp\/15.10.446","article-title":"Penicillin resistance of Staphylococcus aureus and its clinical implications","volume":"15","author":"Plough","year":"1945","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/mdr.2021.0010","article-title":"Antimicrobial Resistance Trends of Escherichia coli Isolates from Outpatient and Inpatient Urinary Infections over a 20-Year Period","volume":"28","author":"Milano","year":"2022","journal-title":"Microb. Drug Resist."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s40801-022-00323-5","article-title":"Prophylactic Antimicrobial Prescribing in Australian Residential Aged-Care Facilities: Improvement is Required","volume":"9","author":"Bennett","year":"2022","journal-title":"Drugs Real World Outcomes"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1017\/ash.2023.497","article-title":"Characterization of antibiotic overuse for common infectious disease states at hospital discharge","volume":"3","author":"Zodrow","year":"2023","journal-title":"Antimicrob. Steward. Healthc. Epidemiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jhin.2023.10.006","article-title":"Appropriateness of acute-care antibiotic prescriptions for community-acquired infections and surgical antibiotic prophylaxis in England: Analysis of 2016 national point prevalence survey data","volume":"142","author":"Higgins","year":"2023","journal-title":"J. Hosp. Infect."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00240-006-0058-0","article-title":"Does the composition of voided urine reflect that of the renal pelvis?","volume":"34","author":"Shafik","year":"2006","journal-title":"Urol. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/ndt\/15.8.1155","article-title":"Dissociation between urine osmolality and urinary excretion of aquaporin-2 in healthy volunteers","volume":"15","author":"Baumgarten","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_53","first-page":"299","article-title":"Absorption from the Mucous Membrane of the Urinary Bladder","volume":"21","author":"Ashdown","year":"1887","journal-title":"J. Anat. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/luts.12412","article-title":"Assessment of bladder function for stabilizing urinary volume overnight with recording of brain waves (ABSORB study)","volume":"14","author":"Torimoto","year":"2022","journal-title":"Low. Urin. Tract Symptoms"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000418147","article-title":"The permeability of the human bladder to water assessed using tritiated water","volume":"79","author":"Hilson","year":"1990","journal-title":"Contrib. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/iju.12999","article-title":"Periodical measurement of urine volume in the bladder during sleep: Temporary volume reduction suggestive of absorption","volume":"23","author":"Watanabe","year":"2016","journal-title":"Int. J. Urol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/nau.25267","article-title":"Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype","volume":"42","author":"Shah","year":"2023","journal-title":"Neurourol. Urodyn."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"120203","DOI":"10.1016\/j.lfs.2021.120203","article-title":"Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype","volume":"289","author":"Singh","year":"2022","journal-title":"Life Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/luts.12319","article-title":"Sodium plays an important role in the absorption of intravesical fluid","volume":"13","author":"Morizawa","year":"2021","journal-title":"Low Urin. Tract Symptoms"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1520-6777(1997)16:2<125::AID-NAU6>3.0.CO;2-G","article-title":"Decrease in intravesical saline volume during isovolumetric cystometry in the rat","volume":"16","author":"Sugaya","year":"1997","journal-title":"Neurourol. Urodyn."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F548","DOI":"10.1152\/ajprenal.00213.2016","article-title":"Elevated CXC chemokines in urine noninvasively discriminate OAB from UTI","volume":"311","author":"Tyagi","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.juro.2009.06.039","article-title":"Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy","volume":"182","author":"Sonn","year":"2009","journal-title":"J. Urol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1001\/jama.2023.23651","article-title":"Effect of Dietary Sodium on Blood Pressure: A Crossover Trial","volume":"330","author":"Gupta","year":"2023","journal-title":"JAMA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41564-023-01346-6","article-title":"Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome","volume":"8","author":"Russell","year":"2023","journal-title":"Nat. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1464-410X.1983.tb03354.x","article-title":"Permeability and ultrastructure of human bladder epithelium","volume":"55","author":"Eldrup","year":"1983","journal-title":"Br. J. Urol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1083\/jcb.53.1.73","article-title":"Lumenal plasma membrane of the urinary bladder. I. Three-dimensional reconstruction from freeze-etch images","volume":"53","author":"Staehelin","year":"1972","journal-title":"J. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00261955","article-title":"The reabsorption of creatinine from the rabbit bladder","volume":"3","author":"Volter","year":"1975","journal-title":"Urol. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"105817","DOI":"10.1016\/j.micpath.2022.105817","article-title":"Intracellular uropathogenic Escherichia coli are undetectable in urinary bladders after oral mecillinam treatment: An experimental study in a pig model of cystitis","volume":"173","author":"Staerk","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0090-4295(79)90486-2","article-title":"Mechanisms of urinary tract infection","volume":"14","author":"Lapides","year":"1979","journal-title":"Urology"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Islam, M.M., and Takeyama, N. (2023). Role of Neutrophil Extracellular Traps in Health and Disease Pathophysiology: Recent Insights and Advances. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.1883.v1"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1154139","DOI":"10.3389\/fped.2023.1154139","article-title":"Neutrophil extracellular traps in urinary tract infection","volume":"11","author":"Krivosikova","year":"2023","journal-title":"Front. Pediatr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1164\/rccm.201511-2281OC","article-title":"Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome","volume":"194","author":"Schmidt","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/2249-4863.154672","article-title":"Reliability of dipstick assay in predicting urinary tract infection","volume":"4","author":"Mambatta","year":"2015","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Bogovic Crncic, T., Girotto, N., Ilic Tomas, M., Kristofic, I., Klobucar, S., Baticic, L., Curko-Cofek, B., and Sotosek, V. (2023). Innate Immunity in Autoimmune Thyroid Disease during Pregnancy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015442"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejogrb.2006.12.013","article-title":"Total and differential leukocyte counts percentiles in normal pregnancy","volume":"136","author":"Lurie","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10753-016-0458-4","article-title":"The Diverse Biological Functions of Neutrophils, Beyond the Defense Against Infections","volume":"40","author":"Yang","year":"2017","journal-title":"Inflammation"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/pros.23439","article-title":"Molecular correlates in urine for the obesity and prostatic inflammation of BPH\/LUTS patients","volume":"78","author":"Tyagi","year":"2018","journal-title":"Prostate"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1020554817047","article-title":"Sequential measurements of chemokines in urosepsis and experimental endotoxemia","volume":"19","author":"Olszyna","year":"1999","journal-title":"J. Clin. Immunol."},{"key":"ref_79","first-page":"CD001209","article-title":"Antibiotics for preventing recurrent urinary tract infection in non-pregnant women","volume":"2004","author":"Albert","year":"2004","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/imammb\/dqy004","article-title":"Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry","volume":"36","author":"Smith","year":"2019","journal-title":"Math. Med. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00192-018-3710-7","article-title":"Clinical implications of the anatomical position of the urethra meatus in women with recurrent post-coital cystitis: A case-control study","volume":"30","author":"Gyftopoulos","year":"2019","journal-title":"Int. Urogynecol. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19440","DOI":"10.1038\/s41598-021-98504-9","article-title":"Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate","volume":"11","author":"Saito","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1054\/tice.2001.0175","article-title":"Succession of events in desquamation of superficial urothelial cells as a response to stress induced by prolonged constant illumination","volume":"33","author":"Veranic","year":"2001","journal-title":"Tissue Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-9255-6-23","article-title":"Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis","volume":"6","author":"Tyagi","year":"2009","journal-title":"J. Inflamm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.3390\/curroncol30050350","article-title":"Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging","volume":"30","author":"Tyagi","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"102048","DOI":"10.1016\/j.clgc.2024.01.020","article-title":"Recurrent Bacteriuria as a Prognosis Marker in the Adjuvant Treatment of Non-Muscle Invasive Bladder Cancer","volume":"22","author":"Szczesniewski","year":"2024","journal-title":"Clin. Genitourin. Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1128\/AAC.32.11.1640","article-title":"Pharmacodynamic evaluation of ofloxacin and trimethoprim-sulfamethoxazole in vaginal fluid of women treated for acute cystitis","volume":"32","author":"Tartaglione","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_88","first-page":"mgen000535","article-title":"Genomic relatedness and clinical significance of Streptococcus mitis strains isolated from the urogenital tract of sexual partners","volume":"7","author":"Mores","year":"2021","journal-title":"Microb. Genom."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4111\/icu.20200240","article-title":"Single-dose amikacin plus 7 days of amoxicillin\/clavulanate to treat acute cystitis caused by extended-spectrum beta-lactamase-producing Escherichia coli: A retrospective cohort study","volume":"62","author":"Ahn","year":"2021","journal-title":"Investig. Clin. Urol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1073\/pnas.1115006109","article-title":"How Staphylococcus aureus biofilms develop their characteristic structure","volume":"109","author":"Periasamy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","first-page":"3","article-title":"Biofilm-producing potential of urinary pathogens isolated from chronic and recurrent urinary tract infections and impact of biofilm on gentamicin and colistin in vitro efficacy","volume":"69","author":"Vaskova","year":"2020","journal-title":"Epidemiol. Mikrobiol. Imunol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Macesic, N., Dennis, A., Hawkey, J., Vezina, B., Wisniewski, J.A., Cottingham, H., Blakeway, L.V., Harshegyi, T., Pragastis, K., and Badoordeen, G.Z. (2024). Genomic investigation of multispecies and multivariant blaNDM outbreak reveals key role of horizontal plasmid transmission. Infect. Control Hosp. Epidemiol., 1\u20138. online ahead of print.","DOI":"10.1017\/ice.2024.8"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Saini, P., Bandsode, V., Singh, A., Mendem, S.K., Semmler, T., Alam, M., and Ahmed, N. (2024). Genomic insights into virulence, antimicrobial resistance, and adaptation acumen of Escherichia coli isolated from an urban environment. mBio, 15.","DOI":"10.1128\/mbio.03545-23"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.79.2.137","article-title":"Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type Iii","volume":"79","author":"Avery","year":"1944","journal-title":"J. Exp. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"107851","DOI":"10.1016\/j.clineuro.2023.107851","article-title":"Common comorbid and secondary conditions leading to hospitalization in multiple sclerosis patients in the United States","volume":"232","author":"Asemota","year":"2023","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40265-020-01257-4","article-title":"Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent","volume":"80","author":"Zhanel","year":"2020","journal-title":"Drugs"},{"key":"ref_97","first-page":"411","article-title":"Relative bioavailability of fosfomycin and of trometamol after administration of single dose by oral route of fosfomycin trometamol in fasting conditions and after a meal","volume":"27","author":"Borgia","year":"1989","journal-title":"Int. J. Clin. Pharmacol. Ther. Toxicol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2174\/1389200215666140605130935","article-title":"A 30-years review on pharmacokinetics of antibiotics: Is the right time for pharmacogenetics?","volume":"15","author":"Baietto","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Stocco, G., Lucafo, M., and Decorti, G. (2020). Pharmacogenomics of Antibiotics. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21175975"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s40265-022-01688-1","article-title":"Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria","volume":"82","author":"Zhanel","year":"2022","journal-title":"Drugs"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2125.1983.tb02242.x","article-title":"Effect of posture on ampicillin pharmacokinetics, glomerular filtration rate and renal plasma flow in resting subjects","volume":"16","author":"Breiby","year":"1983","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00561587","article-title":"Effect of posture and sleep on pharmacokinetics. I. Amoxycillin","volume":"18","author":"Roberts","year":"1980","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/08971900221100205","article-title":"Bioavailability of Orally Administered Drugs in Critically Ill Patients","volume":"36","author":"Forsberg","year":"2023","journal-title":"J. Pharm. Pract."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.medmal.2016.07.007","article-title":"In vitro susceptibility to mecillinam of Escherichia coli strains isolated from the urine of pregnant women","volume":"46","author":"Duployez","year":"2016","journal-title":"Med. Mal. Infect."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1007\/BF01643430","article-title":"Degree of absorption, pharmacokinetics of fosfomycin trometamol and duration of urinary antibacterial activity","volume":"18","author":"Bergan","year":"1990","journal-title":"Infection"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/bcpt.13783","article-title":"Population kinetic-pharmacodynamic analysis of serum potassium in patients receiving sulfamethoxazole\/trimethoprim","volume":"131","author":"Hirai","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10096-016-2586-z","article-title":"Predictors of ertapenem therapeutic efficacy in the treatment of urinary tract infections (UTIs) in hospitalized adults: The importance of renal insufficiency and urinary pH","volume":"35","author":"Cunha","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"dlad145","DOI":"10.1093\/jacamr\/dlad145","article-title":"Resistance to first-line antibiotic therapy among patients with uncomplicated acute cystitis in Melbourne, Australia: Prevalence, predictors and clinical impact","volume":"6","author":"Curtis","year":"2024","journal-title":"JAC Antimicrob. Resist."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.cmi.2022.10.004","article-title":"Highly versus less bioavailable oral antibiotics in the treatment of gram-negative bloodstream infections: A propensity-matched cohort analysis","volume":"29","author":"Mponponsuo","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.1038\/s41598-022-09946-8","article-title":"Antimicrobial prescription practices for outpatients with uncomplicated cystitis in Japan","volume":"12","author":"Takahashi","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijantimicag.2016.11.021","article-title":"Revival of old antibiotics: Needs, the state of evidence and expectations","volume":"49","author":"Zayyad","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/2013.jamainternmed.829","article-title":"Urinary tract infection in male veterans: Treatment patterns and outcomes","volume":"173","author":"Drekonja","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4266\/acc.2021.01256","article-title":"Measured versus estimated creatinine clearance in critically ill patients with acute kidney injury: An observational study","volume":"37","author":"Kadivarian","year":"2022","journal-title":"Acute Crit. Care"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.tjog.2015.03.005","article-title":"Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis","volume":"54","author":"Gugliotta","year":"2015","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/1120009X.2017.1393587","article-title":"Effects of a new combination of plant extracts plus d-mannose for the management of uncomplicated recurrent urinary tract infections","volume":"30","author":"Genovese","year":"2018","journal-title":"J. Chemother."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1080\/10790268.2022.2089816","article-title":"Intravesical hyaluronic acid with chondroitin sulphate to prevent urinary tract infection after spinal cord injury","volume":"46","author":"King","year":"2023","journal-title":"J. Spinal Cord Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Rahnama\u2019i, M.S., Javan Balegh Marand, A., Roschmann-Doose, K., Steffens, L., and Arendsen, H.J. (2022). The efficacy and safety of intravesical chondroitin sulphate solution in recurrent urinary tract infections. BMC Urol., 22.","DOI":"10.1186\/s12894-022-01149-7"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2165\/00003088-200544100-00001","article-title":"Pregnancy-induced changes in pharmacokinetics: A mechanistic-based approach","volume":"44","author":"Anderson","year":"2005","journal-title":"Clin. Pharmacokinet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1002\/jps.21698","article-title":"Effect of pregnancy on nitrofurantoin disposition in mice","volume":"98","author":"Zhang","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref_120","first-page":"121","article-title":"Does large volume of distribution of lidocaine masks its systemic uptake from bladder?","volume":"11","author":"Tyagi","year":"2023","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1073\/pnas.53.4.797","article-title":"The Order of Induction and Deinduction of the Enzymes of the Lactose Operon in E. coli","volume":"53","author":"Alpers","year":"1965","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s40262-019-00791-z","article-title":"What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review","volume":"58","author":"Sumi","year":"2019","journal-title":"Clin. Pharmacokinet."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"64-e1","DOI":"10.1016\/j.jpurol.2022.09.001","article-title":"Intravesical gentamicin instillation in the prevention of recurrent urinary tract infections in children with neurogenic bladder\u2014A single-center retrospective observational study","volume":"19","author":"Mouhssine","year":"2023","journal-title":"J. Pediatr. Urol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"106167","DOI":"10.1016\/j.ejps.2022.106167","article-title":"Emerging molecular mechanisms and genetic targets for developing novel therapeutic strategies for treating bladder diseases","volume":"173","author":"Zoqlam","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/JU.0000000000003744","article-title":"Predicting Antibiotic Susceptibility among Patients with Recurrent Urinary Tract Infection Using a Prior Culture","volume":"211","author":"Trautner","year":"2024","journal-title":"J. Urol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Tyagi, P., Biatta, S., Moon, C.H., Yoshimura, N., Fitzgerald, J., Maranchie, J., and Chermansky, C. (2024). A Virtual Method for Measuring Bladder Blood Flow Relative to Femoral Artery. J. Urol., 211, in press.","DOI":"10.1097\/01.JU.0001008772.30001.48.07"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Tyagi, P., Ganguly, A., Foley, L., Hitchens, T., and Yoshimura, N. (2024). A Radiation-Free, Virtual Measurement of Mouse Bladder Blood Flow. J. Urol., 211, in press.","DOI":"10.1097\/01.JU.0001008772.30001.48.08"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/00004424-199712000-00004","article-title":"Preclinical evaluation of the pharmacokinetics, biodistribution, and elimination of MS-325, a blood pool agent for magnetic resonance imaging","volume":"32","author":"Parmelee","year":"1997","journal-title":"Investig. Radiol."},{"key":"ref_129","unstructured":"Zhang, H. (2004). Molecular Imaging and Contrast Agent Database (MICAD), National Center for Biotechnology Information (US)."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/(SICI)1097-0185(19990301)254:3<375::AID-AR8>3.0.CO;2-R","article-title":"Microvascular architecture of the human urinary bladder wall: A corrosion casting study","volume":"254","author":"Miodonski","year":"1999","journal-title":"Anat. Rec."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/luts.12280","article-title":"High incidence of lower urinary tract dysfunction in women with recurrent urinary tract infections","volume":"12","author":"Lee","year":"2020","journal-title":"Low. Urin. Tract Symptoms"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"731.e1","DOI":"10.1016\/j.urology.2014.04.048","article-title":"The influence of urinary pH on antibiotic efficacy against bacterial uropathogens","volume":"84","author":"Yang","year":"2014","journal-title":"Urology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/jpet.118.251413","article-title":"Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance","volume":"368","author":"Matsuzaki","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"901164","DOI":"10.3389\/fphys.2022.901164","article-title":"The effect of regular aerobic exercise on renal function in patients with CKD: A systematic review and meta-analysis","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/jac\/dkl041","article-title":"Urine bactericidal activity against resistant Escherichia coli in an in vitro pharmacodynamic model simulating urine concentrations obtained after 2000\/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin administration","volume":"57","author":"Alou","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diagmicrobio.2017.04.007","article-title":"Pharmacodynamic activity of fosfomycin simulating urinary concentrations achieved after a single 3-g oral dose versus Escherichia coli using an in vitro model","volume":"88","author":"Zhanel","year":"2017","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Andretta, E., Longo, R., Balladelli, M., Sgarabotto, C., and Sgarabotto, D. (2022). Intravesical Gentamicin: An Option for Therapy and Prophylaxis against Recurrent UTIs and Resistant Bacteria in Neurogenic Bladder Patients on Intermittent Catheterization. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101335"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"102493","DOI":"10.1016\/j.aprim.2022.102493","article-title":"Improved management of cystitis in primary care following the implementation of a simple multifaceted intervention","volume":"54","author":"Gallardo","year":"2022","journal-title":"Aten. Primaria"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/00185787231159578","article-title":"Impact of a Multifaceted Intervention on Antibiotic Prescribing for Cystitis and Asymptomatic Bacteriuria in 23 Community Hospital Emergency Departments","volume":"58","author":"Ingalls","year":"2023","journal-title":"Hosp. Pharm."},{"key":"ref_140","first-page":"20499361221129415","article-title":"Long-term impact of fluoroquinolone-sparing strategies for empirical treatment of acute uncomplicated cystitis among ambulatory patients","volume":"9","author":"Kon","year":"2022","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s10900-020-00893-x","article-title":"Nocturia is an Independent Predictor of Abdominal Aortic Calcification in Women: Results from the National Health and Nutrition Examination Survey","volume":"45","author":"Khan","year":"2020","journal-title":"J. Community Health"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1017\/ash.2023.498","article-title":"Older adults\u2019 and caregivers\u2019 perceptions about urinary tract infection and asymptomatic bacteriuria guidelines: A qualitative exploration","volume":"3","author":"Durkin","year":"2023","journal-title":"Antimicrob. Steward. Healthc. Epidemiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1080\/14787210.2023.2279104","article-title":"Treating urinary tract infections in the era of antibiotic resistance","volume":"21","author":"Bjerrum","year":"2023","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_144","unstructured":"Antibiotic therapy for acute uncomplicated pyelonephritis in women (2014). Take resistance into account. Prescrire Int., 23, 296\u2013300."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Safari, M.S., Mohabatkar, H., and Behbahani, M. (2024). Novel surface biochemical modifications of urinary catheters to prevent catheter-associated urinary tract infections. J. Biomed. Mater. Res. Part B Appl. Biomater., 112.","DOI":"10.1002\/jbm.b.35372"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1021\/acsbiomaterials.3c01577","article-title":"Comparison of Superhydrophilic, Liquid-Like, Liquid-Infused, and Superhydrophobic Surfaces in Preventing Catheter-Associated Urinary Tract Infection and Encrustation","volume":"10","author":"Teng","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/acsabm.3c00988","article-title":"Protecting the Antibacterial Coating of Urinal Catheters for Improving Safety","volume":"7","author":"Perelshtein","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1021\/acsbiomaterials.3c00210","article-title":"Development and Characterization of Lactobacillus rhamnosus-Containing Bioprints for Application to Catheter-Associated Urinary Tract Infections","volume":"9","author":"Kyser","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jointm.2023.06.003","article-title":"Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study","volume":"4","author":"Zhao","year":"2024","journal-title":"J. Intensive Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/adc.87.2.118","article-title":"Short compared with standard duration of antibiotic treatment for urinary tract infection: A systematic review of randomised controlled trials","volume":"87","author":"Michael","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"ref_151","first-page":"CD003966","article-title":"Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children","volume":"1","author":"Michael","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Parekh, S., Hayes, C.V., Loader, J., Ashiru-Oredope, D., Hand, K., Hicks, G., and Lecky, D. (2023). The Use of the TARGET Antibiotic Checklist to Support Antimicrobial Stewardship in England\u2019s Community Pharmacies. Antibiotics, 12.","DOI":"10.3390\/antibiotics12040647"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13756-024-01385-6","article-title":"Resident-, prescriber-, and facility-level factors associated with antibiotic use in long-term care facilities: A systematic review of quantitative studies","volume":"13","author":"Bocquier","year":"2024","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Morris, C.J., Rohn, J.L., Glickman, S., and Mansfield, K.J. (2023). Effective Treatments of UTI-Is Intravesical Therapy the Future?. Pathogens, 12.","DOI":"10.3390\/pathogens12030417"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"118","DOI":"10.47391\/JPMA.7810","article-title":"Effectiveness and safety of intravesical Gentamicin therapy in patients with recurrent urinary tract infections caused by multidrug resistant organisms","volume":"74","author":"Malik","year":"2024","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/nau.23250","article-title":"The use of intravesical gentamicin to treat recurrent urinary tract infections in lower urinary tract dysfunction","volume":"36","author":"Abrams","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"65.e1","DOI":"10.1016\/j.jpurol.2020.08.007","article-title":"Intravesical gentamicin instillation for the treatment and prevention of urinary tract infections in complex paediatric urology patients: Evidence for safety and efficacy","volume":"17","author":"Marei","year":"2021","journal-title":"J. Pediatr. Urol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.juro.2018.10.004","article-title":"Intravesical Gentamicin Treatment for Recurrent Urinary Tract Infections Caused by Multidrug Resistant Bacteria","volume":"201","author":"Stalenhoef","year":"2019","journal-title":"J. Urol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"E350","DOI":"10.5489\/cuaj.4434","article-title":"Gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on intermittent catheterization","volume":"11","author":"Cox","year":"2017","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1097\/SPV.0000000000001233","article-title":"Intraoperative Gentamicin Intravesical Instillation for Prevention of Urinary Tract Infection after Urogynecologic Surgery: A Randomized Controlled Trial","volume":"28","author":"Rieger","year":"2022","journal-title":"Urogynecology"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0022-5347(17)35725-7","article-title":"Neomycin toxicity in bladder irrigation","volume":"150","author":"Donckerwolcke","year":"1993","journal-title":"J. Urol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1464-410X.1995.tb07750.x","article-title":"Neomycin-induced perception deafness following bladder irrigation in patients with end-stage renal disease","volume":"76","author":"Gerharz","year":"1995","journal-title":"Br. J. Urol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2741\/2853","article-title":"The role of chemokines in neutrophil biology","volume":"13","author":"Kobayashi","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Bosch, B., Hartikainen, A., Ronkainen, A., Scheperjans, F., Arkkila, P., and Satokari, R. (2023). Development of a Protocol for Anaerobic Preparation and Banking of Fecal Microbiota Transplantation Material: Evaluation of Bacterial Richness in the Cultivated Fraction. 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