{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:21:54Z","timestamp":1784229714325,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The aim of the study was two-fold: first, to collect data on the use of antibiotics in Germany for dogs and cats and, second, their owners\u2019 experiences and opinions. Using an anonymous online survey, dog and cat owners were asked about the last antibiotic administration in their pet. The inclusion criterion was any antibiotic administration within the last year. A total of 708 questionnaires from 463 dogs and 245 cats could be evaluated. Diarrhea was reported as the most common reason for antibiotic administration in dogs (18.4%). Wound infection\/abscess\/bite injury was the second most common reason in dogs (16.0%). In cats wound infection\/abscess\/bite injury was the most common reason (23.3%), followed by dental treatment (21.2%) and upper respiratory tract infections (16.7%). The most common antibiotics used systemically in both species were amoxicillin\/clavulanic acid (32.5%), amoxicillin (14.8%), metronidazole (6.9%), and doxycycline (6.8%). While efficacy (99.9%) and tolerability (94.8%) were rated as most important for the choice of antibiotics, costs (51.6%) were cited as predominantly unimportant. First-line antibiotics were used significantly more often than critically important antibiotics. The majority of animal owners show awareness for avoidance of antibiotic resistance and the use of critically important antibiotics.<\/jats:p>","DOI":"10.3390\/antibiotics13050382","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T07:38:51Z","timestamp":1713944331000},"page":"382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Online-Assisted Survey on Antibiotic Use by Pet Owners in Dogs and Cats"],"prefix":"10.3390","volume":"13","author":[{"given":"Clara","family":"Rocholl","sequence":"first","affiliation":[{"name":"Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Zablotski","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-6206","authenticated-orcid":false,"given":"Bianka","family":"Schulz","sequence":"additional","affiliation":[{"name":"Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report: 2022, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis","volume":"399","author":"Collaborators","year":"2022","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","unstructured":"World Health Organization (2000). World Health Organization Report on Infectious Diseases 2000, World Health Organization."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/microbiolspec.ARBA-0018-2017","article-title":"Optimization of Antimicrobial Treatment to Minimize Resistance Selection","volume":"6","author":"Guardabassi","year":"2018","journal-title":"Microbiol. Spectr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Marco-Fuertes, A., Marin, C., Lorenzo-Rebenaque, L., Vega, S., and Montoro-Dasi, L. (2022). Antimicrobial Resistance in Companion Animals: A New Challenge for the One Health Approach in the European Union. Vet. Sci., 9.","DOI":"10.3390\/vetsci9050208"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Joosten, P., Ceccarelli, D., Odent, E., Sarrazin, S., Graveland, H., Van Gompel, L., Battisti, A., Caprioli, A., Franco, A., and Wagenaar, J.A. (2020). Antimicrobial Usage and Resistance in Companion Animals: A Cross-Sectional Study in Three European Countries. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020087"},{"key":"ref_8","first-page":"957","article-title":"Public health risk of antimicrobial resistance transfer from companion animals","volume":"72","author":"Pomba","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104891","DOI":"10.1016\/j.micpath.2021.104891","article-title":"Bacterial zoonoses transmitted by household pets and as reservoirs of antimicrobial resistant bacteria","volume":"155","author":"Bhat","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_10","unstructured":"Zentralverband Zoologischer Fachbetriebe Deutschlands e.V. (ZZF), Industrieverband Heimtierbedarf (IVH) e.V (2024, March 23). Available online: https:\/\/www.ivh-online.de\/der-verband\/daten-fakten\/der-deutsche-heimtiermarkt.html."},{"key":"ref_11","unstructured":"Bundestier\u00e4rztekammer, Federal Veterinary Surgeons\u2019 Association (2015). Guidelines for the Prudent Use of Veterinary Antimicrobial Drugs, Schl\u00fctersche Fachmedien GmbH. Addendum to the German Veterinary Gazette 3\/2015."},{"key":"ref_12","unstructured":"Bundestier\u00e4rztekammer (2018). Die neue T\u00c4HAV ist in Kraft, Deutsches Tier\u00e4rzteblatt, Bundestier\u00e4rztekammer e.V."},{"key":"ref_13","unstructured":"World Health Organization (2019). Critically Important Antimicrobials for Human Medicine, World Health Organization. [6th ed.]."},{"key":"ref_14","unstructured":"World Organisation for Animal Health (2021). OIE List of Antimicrobial Agents of Veterinary Importance, OIE-World Organisation for Animal Health."},{"key":"ref_15","unstructured":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (BVL) (2024, February 01). Deutlich Geringere Abgabemengen von Antibiotika in der Tiermedizin. Available online: https:\/\/www.bvl.bund.de\/SharedDocs\/Pressemitteilungen\/05_tierarzneimittel\/2022\/2022_PM_Abgabemengen_Antibiotika_Tiermedizin.html."},{"key":"ref_16","unstructured":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (2024, February 01). Abgabemengen von Antibiotika in Tiermedizin Gehen Weiter Zur\u00fcck; Weiterer R\u00fcckgang auch bei Fluorchinolonen, Cephalosporinen der 3. und 4. Generation Sowie bei Polypeptidantibiotika. Available online: https:\/\/www.bvl.bund.de\/SharedDocs\/Pressemitteilungen\/05_tierarzneimittel\/2023\/2023_PM_Abgabemengen_Antibiotika_Tiermedizin.html."},{"key":"ref_17","first-page":"337","article-title":"Influence of the Verordnung \u00fcber Tier\u00e4rztliche Hausapotheken on antimicrobial use in dogs and cats in Bavaria","volume":"50","author":"Mohr","year":"2022","journal-title":"Tieraerztliche Prax. Ausg. K Kleintiere\/Heimtiere"},{"key":"#cr-split#-ref_18.1","unstructured":"Moerer, M., Merle, R., and B\u00e4umer, W. (2022). A Cross-Sectional Study of Veterinarians in Germany on the Impact of the T&Auml"},{"key":"#cr-split#-ref_18.2","unstructured":"HAV Amendment 2018 on Antimicrobial Use and Development of Antimicrobial Resistance in Dogs and Cats. Antibiotics, 11."},{"key":"ref_19","first-page":"1","article-title":"Antibiotikaeinsatz und Resistenzentwicklung bei Hund und Katze unter dem Einfluss der T\u00c4HAV-Novelle 2018\u2014Ein Stimmungsbild Berliner Tier\u00e4rzte","volume":"135","author":"Moerer","year":"2022","journal-title":"Berl. Und M\u00fcnchener Tier\u00e4rztliche Wochenschr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13756-018-0341-1","article-title":"Pet owner and vet interactions: Exploring the drivers of AMR","volume":"7","author":"Smith","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2460\/javma.254.5.626","article-title":"Pet owners\u2019 knowledge of and attitudes toward the judicious use of antimicrobials for companion animals","volume":"254","author":"Redding","year":"2019","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/vr.101454","article-title":"Factors influencing antibiotic prescribing habits and use of sensitivity testing amongst veterinarians in Europe","volume":"173","author":"Atkinson","year":"2013","journal-title":"Vet. Rec."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/1098612X16656706","article-title":"Use of cefovecin in a UK population of cats attending first-opinion practices as recorded in electronic health records","volume":"19","author":"Burke","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1177\/1098612X221090456","article-title":"Knowledge, attitudes and influencers of cat owners in North America around antimicrobials and antimicrobial stewardship","volume":"24","author":"Stein","year":"2022","journal-title":"J. Feline Med. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jsap.13297","article-title":"Knowledge, attitudes and influencers of North American dog-owners surrounding antimicrobials and antimicrobial stewardship","volume":"62","author":"Stein","year":"2021","journal-title":"J. Small Anim. Pr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/1098612X19826353","article-title":"A UK-based survey of cat owners\u2019 perceptions and experiences of antibiotic usage","volume":"22","author":"Stallwood","year":"2020","journal-title":"J. Feline Med. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User\u2019s guide to correlation coefficients","volume":"18","author":"Akoglu","year":"2018","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Candellone, A., Badino, P., Girolami, F., Ala, U., Mina, F., and Odore, R. (2023). Dog Owners\u2019 Attitude toward Veterinary Antibiotic Use and Antibiotic Resistance with a Focus on Canine Diarrhea Management. Animals, 13.","DOI":"10.3390\/ani13061061"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fvets.2020.00110","article-title":"Antimicrobial Prescribing Practices in Small Animal Emergency and Critical Care","volume":"7","author":"Robbins","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_30","first-page":"110","article-title":"Use of antimicrobials in acute canine diarrhea\u2014Overview of potential risks, indications and alternatives","volume":"49","author":"Werner","year":"2021","journal-title":"Tieraerztliche Prax. Ausg. K Kleintiere\/Heimtiere"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/jvim.15775","article-title":"Effect of amoxicillin-clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin-resistant Escherichia coli in dogs with uncomplicated acute diarrhea","volume":"34","author":"Werner","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"ref_32","unstructured":"Beckmann, K., Favrot, C., Fischer, N., Francey, T., Gerber, B., Glaus, T., Grundmann, S., Hettlich, B., Hofmann-Lehmann, R., and Knell, S. (2024, March 23). Strategie Antibiotikaresistenzen. Umsichtiger Einsatz von Antibiotika bei Hunden und Katzen. Available online: https:\/\/www.blv.admin.ch\/dam\/blv\/de\/dokumente\/tiere\/tierkrankheiten-und-arzneimittel\/tierarzneimittel\/therapieleitfaden-antibiotika-hunde-katzen.pdf.download.pdf\/Leitfaden_Kleintier_final_publ_d.pdf."},{"key":"ref_33","unstructured":"Brissot, H., Cervantes, S., Guardabassi, L., Hibbert, A., Lefebvre, H., Mateus, A.L.P., Noli, C., Nuttall, T., Pomba, C., and Schulz, B. (2016). GRAM: Guidance for the Rational Use of Antimicrobials: Recommendations for Dogs and Cats, Ceva Sant\u00e9 Animale. [2nd ed.]."},{"key":"ref_34","unstructured":"Federation of European Companion Animal Veterinary Associations (FECAVA) (2023, September 06). FECAVA Advice on Responsible Use of Antimicrobials. Available online: https:\/\/www.fecava.org\/wp-content\/uploads\/2020\/01\/FECAVA-Advice-on-Responsible-use-of-Antimicrobials-ENGLISH.pdf."},{"key":"ref_35","unstructured":"Federation of European Companion Animal Veterinary Associations (FECAVA) (2024, February 01). FECAVA Recommendations for Appropriate Antimicrobial Therapy. Available online: https:\/\/www.fecava.org\/wp-content\/uploads\/2020\/01\/FECAVA-Recommendations-for-Appropriate-Antimicrobial-ENGLISH-1.pdf."},{"key":"ref_36","unstructured":"Jessen, L., Damborg, P., Spohr, A., Goericke-Pesch, S., Langhorn, R., Houser, G., Willesen, J., Schjaerff, M., S\u00f8erensen, T., and Eriksen, T. (2018). Antibiotic Use Guidelines for Companion Animal Practice, Companion Animal Group, Danish Veterinary Association. [2nd ed.]."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fvets.2019.00163","article-title":"A Randomized Double Blinded Placebo-Controlled Clinical Trial of a Probiotic or Metronidazole for Acute Canine Diarrhea","volume":"6","author":"Shmalberg","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"ref_38","first-page":"620","article-title":"Antimicrobial treatment of simple cutaneous abscesses","volume":"236","author":"Hall","year":"2010","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5326\/1547-3317-58.4.1","article-title":"2022 AAFP\/AAHA Antimicrobial Stewardship Guidelines","volume":"58","author":"Frey","year":"2022","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_40","unstructured":"Davis, E.M. (2023). The Use of Antibiotics in Veterinary Dentistry. Today\u2019s Vet. Pract., 87\u2013107. Available online: https:\/\/todaysveterinarypractice.com\/dentistry\/antibiotics-in-veterinary-dentistry\/."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/jvim.14627","article-title":"Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases","volume":"31","author":"Lappin","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_42","first-page":"270","article-title":"Bacterial urinary tract infection and subclinical bacteriuria in the dog: A current review","volume":"48","author":"Harrer","year":"2020","journal-title":"Tieraerztliche Prax. Ausg. K Kleintiere\/Heimtiere"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1177\/1098612X19880435","article-title":"Urinary tract infection and subclinical bacteriuria in cats: A clinical update","volume":"21","author":"Dorsch","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1748-5827.2005.tb00288.x","article-title":"Evaluation of clinical signs and causes of lower urinary tract disease in European cats","volume":"46","author":"Gerber","year":"2005","journal-title":"J. Small Anim. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-0038-1623769","article-title":"Feline lower urinary tract disease in a German cat population. A retrospective analysis of demographic data, causes and clinical signs","volume":"42","author":"Dorsch","year":"2014","journal-title":"Tieraerztliche Prax. Ausg. K Kleintiere\/Heimtiere"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2019.02.008","article-title":"International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats","volume":"247","author":"Weese","year":"2019","journal-title":"Vet. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"689018","DOI":"10.3389\/fvets.2021.689018","article-title":"Evaluation of Antimicrobial Usage in Dogs and Cats at a Veterinary Teaching Hospital in Germany in 2017 and 2018","volume":"8","author":"Schnepf","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hur, B.A., Hardefeldt, L.Y., Verspoor, K.M., Baldwin, T., and Gilkerson, J.R. (2020). Describing the antimicrobial usage patterns of companion animal veterinary practices; free text analysis of more than 4.4 million consultation records. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230049"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/vr.103830","article-title":"Characterisation of antimicrobial usage in cats and dogs attending UK primary care companion animal veterinary practices","volume":"179","author":"Buckland","year":"2016","journal-title":"Vet. Rec."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"L\u00f6scher, W., and Richter, A. (2016). Lehrbuch der Pharmakologie und Toxikologie f\u00fcr die Veterin\u00e4rmedizin, Enke Verlag.","DOI":"10.1055\/b-004-129671"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gigu\u00e8re, S., Prescott, J.F., and Dowling, P.M. (2013). Antimicrobial Therapy in Veterinary Medicine, Wiley.","DOI":"10.1002\/9781118675014"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fvets.2020.00192","article-title":"Fecal Microbial and Metabolic Profiles in Dogs With Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole","volume":"7","author":"Chaitman","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/jvim.16846","article-title":"Efficacy of an elemental diet in achieving clinical remission in dogs with chronic enteropathy","volume":"37","author":"Manchester","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/jvim.14739","article-title":"Chronic Diarrhea in Dogs\u2014Retrospective Study in 136 Cases","volume":"31","author":"Volkmann","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Fujishiro, M.A., Lidbury, J.A., Pilla, R., Steiner, J.M., Lappin, M.R., and Suchodolski, J.S. (2020). Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228145"},{"key":"ref_56","first-page":"423","article-title":"Effects of Giardia lamblia Colonization and Fenbendazole Treatment on Canine Fecal Microbiota","volume":"59","author":"Lee","year":"2020","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"626424","DOI":"10.3389\/fvets.2021.626424","article-title":"Effectiveness of Fenbendazole and Metronidazole Against Giardia Infection in Dogs Monitored for 50-Days in Home-Conditions","volume":"8","author":"Ciuca","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1136\/vr.105997","article-title":"Use of cefovecin in dogs and cats attending first-opinion veterinary practices in Australia","volume":"187","author":"Hardefeldt","year":"2020","journal-title":"Vet. Rec."},{"key":"ref_59","first-page":"291","article-title":"Out-patient antimicrobial drug use in dogs and cats for new disease events from community companion animal practices in Ontario","volume":"53","author":"Murphy","year":"2012","journal-title":"Can. Vet. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1177\/1098612X221083752","article-title":"Online survey of owners\u2019 experiences of medicating their cats at home","volume":"24","author":"Taylor","year":"2022","journal-title":"J. Feline Med. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"103841","DOI":"10.1016\/j.jddst.2022.103841","article-title":"Palatability assessment of oral dosage forms for companion animals: A systematic review","volume":"77","author":"Adenot","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/coan.2021.0029","article-title":"Owner compliance in veterinary practice: Recommendations from a roundtable discussion","volume":"26","author":"Maddison","year":"2021","journal-title":"Companion Anim."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1748-5827.1999.tb03781.x","article-title":"Compliance with short-term oral antibacterial drug treatment in dogs","volume":"40","author":"Grave","year":"1999","journal-title":"J. Small Anim. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2460\/javma.2005.226.567","article-title":"Evaluation of client compliance with short-term administration of antimicrobials to dogs","volume":"226","author":"Adams","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1751-0813.1996.tb13774.x","article-title":"Owner compliance with short term antimicrobial medication in dogs","volume":"74","author":"Barter","year":"1996","journal-title":"Aust. Vet. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/diacare.20.10.1512","article-title":"Impact of Dosage Frequency on Patient Compliance","volume":"20","author":"Paes","year":"1997","journal-title":"Diabetes Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0149-2918(01)80109-0","article-title":"A systematic review of the associations between dose regimens and medication compliance","volume":"23","author":"Claxton","year":"2001","journal-title":"Clin. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1001\/archinte.1990.00390200073014","article-title":"The effect of prescribed daily dose frequency on patient medication compliance","volume":"150","author":"Eisen","year":"1990","journal-title":"Arch Intern. Med."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Scarborough, R., Hardefeldt, L., Browning, G., and Bailey, K. (2021). Pet Owners and Antibiotics: Knowledge, Opinions, Expectations, and Communication Preferences. Antibiotics, 10.","DOI":"10.3390\/antibiotics10111326"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/5\/382\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:07Z","timestamp":1760106787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/5\/382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["antibiotics13050382"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics13050382","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]}}}