{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:56:55Z","timestamp":1793746615203,"version":"4.6.1"},"reference-count":116,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation","award":["2023\/00286-3"],"award-info":[{"award-number":["2023\/00286-3"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["2021\/09134-6"],"award-info":[{"award-number":["2021\/09134-6"]}]},{"name":"Dairy Farmers of Canada, Lactanet, Novalait, and Agriculture and Agri-Food Canada","award":["2023\/00286-3"],"award-info":[{"award-number":["2023\/00286-3"]}]},{"name":"Dairy Farmers of Canada, Lactanet, Novalait, and Agriculture and Agri-Food Canada","award":["2021\/09134-6"],"award-info":[{"award-number":["2021\/09134-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance (AMR) poses an imminent threat to global public health, driven in part by the widespread use of antimicrobials in both humans and animals. Within the dairy cattle industry, Gram-negative coliforms such as Escherichia coli and Klebsiella pneumoniae stand out as major causative agents of clinical mastitis. These same bacterial species are frequently associated with severe infections in humans, including bloodstream and urinary tract infections, and contribute significantly to the alarming surge in antimicrobial-resistant bacterial infections worldwide. Additionally, mastitis-causing coliforms often carry AMR genes akin to those found in hospital-acquired strains, notably the extended-spectrum beta-lactamase genes. This raises concerns regarding the potential transmission of resistant bacteria and AMR from mastitis cases in dairy cattle to humans. In this narrative review, we explore the distinctive characteristics of antimicrobial-resistant E. coli and Klebsiella spp. strains implicated in clinical mastitis and human infections. We focus on the molecular mechanisms underlying AMR in these bacterial populations and critically evaluate the potential for interspecies transmission. Despite some degree of similarity observed in sequence types and mobile genetic elements between strains found in humans and cows, the existing literature does not provide conclusive evidence to assert that coliforms responsible for mastitis in cows pose a direct threat to human health. Finally, we also scrutinize the existing literature, identifying gaps and limitations, and propose avenues for future research to address these pressing challenges comprehensively.<\/jats:p>","DOI":"10.3390\/antibiotics13050391","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:08:32Z","timestamp":1714032512000},"page":"391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Other Antimicrobial-Resistant Gram-Negative Pathogens Isolated from Bovine Mastitis: A One Health Perspective"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-5595","authenticated-orcid":false,"given":"Breno Luis","family":"Nery Garcia","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, SP, Brazil"},{"name":"Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-4677","authenticated-orcid":false,"given":"St\u00e9fani Thais Alves","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7318-1407","authenticated-orcid":false,"given":"Kristian","family":"da Silva Barbosa","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-3961","authenticated-orcid":false,"given":"Thatiane","family":"Mendes Mitsunaga","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Butters","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-0085","authenticated-orcid":false,"given":"Carlos Henrique","family":"Camargo","sequence":"additional","affiliation":[{"name":"Bacteriology Division, Adolfo Lutz Institute, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-1436","authenticated-orcid":false,"given":"Diego Borin","family":"Nobrega","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.3168\/jds.2017-13023","article-title":"A 100-Year Review: Mastitis Detection, Management, and Prevention","volume":"100","author":"Ruegg","year":"2017","journal-title":"J. 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