{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:41:22Z","timestamp":1784770882893,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFC2504800"],"award-info":[{"award-number":["2022YFC2504800"]}]},{"name":"National Key Research and Development Program of China","award":["2020GXNSFGA238001"],"award-info":[{"award-number":["2020GXNSFGA238001"]}]},{"name":"National Key Research and Development Program of China","award":["AD23026325"],"award-info":[{"award-number":["AD23026325"]}]},{"name":"National Key Research and Development Program of 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Young and Middle-aged Teacher Basic Research Ability Improvement Project","award":["Z20170595"],"award-info":[{"award-number":["Z20170595"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["2022YFC2504800"],"award-info":[{"award-number":["2022YFC2504800"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["2020GXNSFGA238001"],"award-info":[{"award-number":["2020GXNSFGA238001"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["AD23026325"],"award-info":[{"award-number":["AD23026325"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["G22C2020173"],"award-info":[{"award-number":["G22C2020173"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["2022KY0095"],"award-info":[{"award-number":["2022KY0095"]}]},{"name":"Health and Family Planning Commission of Guangxi","award":["Z20170595"],"award-info":[{"award-number":["Z20170595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Staphylococcal scalded skin syndrome (SSSS) is a rare, toxin-mediated, desquamating bacterial infectious dermatosis. So far, data from Southwestern China is scarce. This study aimed to investigate the clinical characteristics of SSSS patients in our hospital, the relative proportion of methicillin-resistant Staphylococcus aureus (MRSA) in skin and soft tissue secretions, and the drug sensitivity of S. aureus to better assist dermatologists in the diagnosis and treatment of SSSS. We reviewed the demographic characteristics, clinical manifestations, treatment regimens, therapeutic efficacy, laboratory test results, drug sensitivity, and outcome data of 79 SSSS patients from January 2012 to December 2021. Statistical analysis was performed using t tests and chi-square tests. Among the 79 SSSS patients, MRSA was detected in 35 (44.3%) isolates: 34 community-acquired (CA)-MRSA (97.1%) and 1 hospital-acquired (HA)-MRSA. The SSSS incidence increased annually from 2012 to 2014 and then decreased gradually after peaking in 2015. All the isolates were sensitive to vancomycin, tigecycline, linezolid, moxifloxacin, levofloxacin, and ciprofloxacin; were completely resistant to penicillin; and had low sensitivity to clindamycin and erythromycin. Interestingly, the sensitivity of MRSA to tetracycline increased annually after 2015. The resistance rates to common drugs previously used to treat SSSS increased. These findings may accelerate diagnosis and improve empirical antibiotic use, suggesting that clinicians should prescribe drugs according to antimicrobial susceptibility.<\/jats:p>","DOI":"10.3390\/antibiotics13060516","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:43:48Z","timestamp":1717155828000},"page":"516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Clinical Characteristics and Antimicrobial Resistance of Staphylococcus aureus Isolated from Patients with Staphylococcal Scalded Skin Syndrome (SSSS) in Southwestern China"],"prefix":"10.3390","volume":"13","author":[{"given":"Yidan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning 530021, China"},{"name":"Guangxi Scientific and Technological Innovation Cooperation Base of Mycosis Prevention and Control, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunwei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning 530021, China"},{"name":"Guangxi Scientific and Technological Innovation Cooperation Base of Mycosis Prevention and Control, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of Mycosis Prevention and Treatment, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s12519-018-0150-x","article-title":"Staphylococcal-scalded skin syndrome: Evaluation, diagnosis, and management","volume":"14","author":"Leung","year":"2018","journal-title":"World J. 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