{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:14:32Z","timestamp":1791825272386,"version":"4.3.4"},"reference-count":164,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Nowadays, infectious diseases of bacterial and viral origins represent a serious medical problem worldwide. In fact, the development of antibiotic resistance is responsible for the emergence of bacterial strains that are refractory even to new classes of antibiotics. Furthermore, the recent COVID-19 pandemic suggests that new viruses can emerge and spread all over the world. The increase in infectious diseases depends on multiple factors, including malnutrition, massive migration of population from developing to industrialized areas, and alteration of the human microbiota. Alternative treatments to conventional antibiotics and antiviral drugs have intensively been explored. In this regard, plants and marine organisms represent an immense source of products, such as polyphenols, alkaloids, lanthipeptides, and terpenoids, which possess antibacterial and antiviral activities. Their main mechanisms of action involve modifications of bacterial cell membranes, with the formation of pores, the release of cellular content, and the inhibition of bacterial adherence to host cells, as well as of the efflux pump. Natural antivirals can interfere with viral replication and spreading, protecting the host with the enhanced production of interferon. Of note, these antivirals are not free of side effects, and their administration to humans needs more research in terms of safety. Preclinical research with natural antibacterial and antiviral compounds confirms their effects against bacteria and viruses, but there are still only a few clinical trials. Therefore, their full exploitation and more intensive clinical studies represent the next steps to be pursued in this area of medicine.<\/jats:p>","DOI":"10.3390\/antibiotics13070603","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:42:30Z","timestamp":1719546150000},"page":"603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current View on Major Natural Compounds Endowed with Antibacterial and Antiviral Effects"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-4346","authenticated-orcid":false,"given":"Roberto","family":"Arrigoni","sequence":"first","affiliation":[{"name":"CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-1415","authenticated-orcid":false,"given":"Andrea","family":"Ballini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Jirillo","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-8124","authenticated-orcid":false,"given":"Luigi","family":"Santacroce","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20240038","DOI":"10.1098\/rsif.2024.0038","article-title":"A behaviour and disease transmission model: Incorporating the Health Belief Model for human behaviour into a simple transmission model","volume":"21","author":"Ryan","year":"2024","journal-title":"J. R. Soc. Interface"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e417","DOI":"10.1016\/S1473-3099(24)00352-9","article-title":"Sleeper frameworks for Pathogen X: Surveillance, risk stratification, and the effectiveness and safety of therapeutic interventions","volume":"24","author":"Shi","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/14787210.2022.2013809","article-title":"The war against bacteria, from the past to present and beyond","volume":"20","author":"Bottalico","year":"2022","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.2174\/1381612828666220920114723","article-title":"Current Issues and Perspectives in Antimicrobials use in Dental Practice","volume":"28","author":"Santacroce","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"ref_5","unstructured":"(2024, April 30). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"Brower","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/jama.1996.03530270074035","article-title":"Strategies to Prevent and Control the Emergence and Spread of Antimicrobial-Resistant Microorganisms in Hospitals. A challenge to hospital leadership","volume":"275","author":"Goldmann","year":"1996","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.7326\/0003-4819-134-4-200102200-00014","article-title":"Antibiotic Resistance in the Intensive Care Unit: Strategies for Management","volume":"134","author":"Kollef","year":"2001","journal-title":"Ann. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.52586\/4930","article-title":"Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review","volume":"26","author":"Santacroce","year":"2021","journal-title":"Front. Biosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.molcel.2020.03.001","article-title":"Immune-Microbiota Interplay and Colonization Resistance in Infection","volume":"78","author":"Leshem","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.it.2020.12.005","article-title":"Systemic Immunoregulatory Consequences of Gut Commensal Translocation","volume":"42","author":"McPherson","year":"2021","journal-title":"Trends Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/1381612829666221219093450","article-title":"Antibiotic Resistance and Microbiota Response","volume":"29","author":"Santacroce","year":"2023","journal-title":"Curr. Pharm. Des."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.3748\/wjg.v29.i28.4368","article-title":"Microbiota revolution: How gut microbes regulate our lives","volume":"29","author":"Colella","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature07250","article-title":"Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits","volume":"455","author":"Brandl","year":"2008","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/infdis\/jiv256","article-title":"Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection with Oral Vancomycin Compared with Metronidazole","volume":"212","author":"Lewis","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1473-3099(01)00066-4","article-title":"Effect of antimicrobial agents on the ecological balance of human microflora","volume":"1","author":"Sullivan","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Arrigoni, R., Ballini, A., Topi, S., Bottalico, L., Jirillo, E., and Santacroce, L. (2022). Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101431"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chin, T., Foxman, E.F., Watkins, T.A., and Lipsitch, M. (2024). Considerations for viral co-infection studies in human populations. mBio.","DOI":"10.1128\/mbio.00658-24"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.antiviral.2018.07.020","article-title":"Comparison of antiviral resistance across acute and chronic viral infections","volume":"158","author":"Mason","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Arrigoni, R., Ballini, A., Santacroce, L., and Palese, L.L. (2023). The Dynamics of OXA-23 \u03b2-Lactamase from Acinetobacter baumannii. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417527"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on Plant Antimicrobials: A Mechanistic Viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pacyga, K., Pacyga, P., Topola, E., Viscardi, S., and Duda-Madej, A. (2024). Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042100"},{"key":"ref_23","unstructured":"Gabbianelli, R., Damiani, E., Scarabelli, S., Principi, F., Gioacchini, A.M., and Rocchi, M.B.L. (2023). EGCG and Its Antiviral Effects. Nutrients, 15."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115726","DOI":"10.1016\/j.ejmech.2023.115726","article-title":"Natural Products as Potential Lead Compounds to Develop New Antiviral Drugs Over the Past Decade","volume":"260","author":"Zhao","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","unstructured":"Antimicrobial Resistance Collaborators (2022). Global Burden of Bacterial Resistance in 2019: A Systematic Analysis. Lancet, 399, 629\u2013655."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100409","DOI":"10.1016\/j.envadv.2023.100409","article-title":"Emergence of environmental antibiotic resistance: Mechanism, monitoring and management","volume":"13","author":"Bobate","year":"2023","journal-title":"Environ. Adv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.medin.2022.02.004","article-title":"Resistance mechanisms in Gram-negative bacteria","volume":"46","author":"Lepe","year":"2022","journal-title":"Med. Intensiv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482","article-title":"An overview of the antimicrobial resistance mechanisms of bacteria","volume":"4","author":"Reygaert","year":"2018","journal-title":"AIMS Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jgar.2021.12.016","article-title":"Glycopeptide resistance in Enterococcus spp. and coagulase-negative staphylococci from hospitalised patients in Germany: Occurrence, characteristics and dalbavancin susceptibility","volume":"28","author":"Kresken","year":"2022","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Urban-Chmiel, R., Marek, A., St\u0119pie\u0144-Py\u015bniak, D., Wieczorek, K., Dec, M., Nowaczek, A., and Osek, J. (2022). Antibiotic Resistance in Bacteria\u2014A Review. Antibiotics, 11.","DOI":"10.3390\/antibiotics11081079"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41429-023-00649-4","article-title":"Mechanisms of emerging resistance associated with non-antibiotic antimicrobial agents: A state-of-the-art review","volume":"76","author":"Baig","year":"2023","journal-title":"J. Antibiot."},{"key":"ref_33","unstructured":"WHO Pathogens Priority List Working Group (2018). Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. Dis., 18, 318\u2013327."},{"key":"ref_34","first-page":"932","article-title":"Antimicrobial plant metabolites: Structural diversity and mechanism of action","volume":"20","author":"Radulovic","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1099\/0022-1317-51-7-567","article-title":"Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils","volume":"51","author":"Stewart","year":"2002","journal-title":"J. Med Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.3390\/ijms15034415","article-title":"Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro","volume":"15","author":"Mooyottu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jpha.2019.11.002","article-title":"Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification","volume":"10","author":"Seukep","year":"2020","journal-title":"J. Pharm. Anal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/pathophysiology31010002","article-title":"Current Views about the Inflammatory Damage Triggered by Bacterial Superantigens and Experimental Attempts to Neutralize Superantigen-Mediated Toxic Effects with Natural and Biological Products","volume":"31","author":"Santacroce","year":"2024","journal-title":"Pathophysiology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Perz, M., Szymanowska, D., Janeczko, T., and Kostrzewa-Sus\u0142ow, E. (2024). Antimicrobial Properties of Flavonoid Derivatives with Bromine, Chlorine, and Nitro Group Obtained by Chemical Synthesis and Biotransformation Studies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105540"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Meure, C.M., Steer, B., and Porter, J. (2023). Interrelationships between Dietary Outcomes, Readmission Rates and Length of Stay in Hospitalised Oncology Patients: A Scoping Review. Nutrients, 15.","DOI":"10.3390\/nu15020400"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Magrone, T., Magrone, M., Russo, M.A., and Jirillo, E. (2019). Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies. Antioxidants, 9.","DOI":"10.20944\/preprints201912.0030.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2174\/1871530320666200313152648","article-title":"Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis","volume":"21","author":"Magrone","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Santacroce, L., Colella, M., Charitos, I.A., Di Domenico, M., Palmirotta, R., and Jirillo, E. (2023). Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications. Metabolites, 13.","DOI":"10.3390\/metabo13030461"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/jam.14388","article-title":"Quercetin potentiates meropenem activity among pathogenic carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii","volume":"127","author":"Pal","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jafc.7b05035","article-title":"Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa","volume":"66","author":"Zhou","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","first-page":"827","article-title":"Inhibitory effects of silybin on the efflux pump of methicillin-resistant Staphylococcus aureus","volume":"18","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.jpha.2023.09.014","article-title":"Interactions of naturally occurring compounds with antimicrobials","volume":"13","author":"Malczak","year":"2023","journal-title":"J. Pharm. Anal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000343044","article-title":"Phenolic compounds and interaction between aminoglycosides and natural products of Lygodium venustum SW against multiresistant bacteria","volume":"58","author":"Souza","year":"2012","journal-title":"Chemotherapy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1111\/jcmm.13910","article-title":"Quercetin impairs Streptococcus pneumoniae biofilm formation by inhibiting sortase A activity","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/jam.13073","article-title":"Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa","volume":"120","author":"Ouyang","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Xiong, G., Ji, W., Wang, F., Zhang, F., Xue, P., Cheng, M., Sun, Y., Wang, X., and Zhang, T. (2019). Quercetin Inhibits Inflammatory Response Induced by LPS from Porphyromonas gingivalis in Human Gingival Fibroblasts via Suppressing NF-\u03baB Signaling Pathway. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/6282635"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.psj.2019.12.001","article-title":"Effect of curcumin on laying performance, egg quality, endocrine hormones, and immune activity in heat-stressed hens","volume":"99","author":"Liu","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_53","first-page":"3","article-title":"In vitro antibacterial activity of curcumin-meropenem combination against extensively drug-resistant (XDR) bacteria isolated from burn wound infections","volume":"10","author":"Sharahi","year":"2020","journal-title":"Avicenna J. Phytomed."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Al-Dulaimi, M.M.K., Mutalib, S.A., Ghani, M.A., Zaini, N.A.M., and Ariffin, A.A. (2019). Multiple Antibiotic Resistance (MAR), Plasmid Profiles, and DNA Polymorphisms among Vibrio vulnificus Isolates. Antibiotics, 8.","DOI":"10.3390\/antibiotics8020068"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104445","DOI":"10.1016\/j.micpath.2020.104445","article-title":"Simultaneous inhibition of MarR by salicylate and efflux pumps by curcumin sensitizes colistin resistant clinical isolates of Enterobacteriaceae","volume":"148","author":"Sundaramoorthy","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Izui, S., Sekine, S., Murai, H., Takeuchi, H., and Amano, A. (2021). Inhibitory effects of curcumin against cytotoxicity of Porphyromonas gingivalis outer membrane vesicles. Arch. Oral Biol., 124.","DOI":"10.1016\/j.archoralbio.2021.105058"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10266-020-00514-y","article-title":"Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis","volume":"109","author":"Kumbar","year":"2021","journal-title":"Odontology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Liu, Q., Wang, C., Guo, X., Du, Q., and Keshavarzi, M. (2024). Curcumin and its nano-formulations combined with exercise: From molecular mechanisms to clinic. Cell Biochem. Funct., 42.","DOI":"10.1002\/cbf.4061"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Reygaert, W.C. (2018). Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/9105261"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105585","DOI":"10.1016\/j.micpath.2022.105585","article-title":"Anti-virulence properties of catechin-in-cyclodextrin-in-phospholipid liposome through down-regulation of gene expression in MRSA strains","volume":"167","author":"Sinsinwar","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.2174\/138161208786264179","article-title":"Molecular effects elicited in vitro by red wine on human healthy peripheral blood mononuclear cells: Potential therapeutical application of polyphenols to diet-related chronic diseases","volume":"14","author":"Magrone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1021\/jf501266s","article-title":"Antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content","volume":"62","author":"Friedman","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kim, G., Xu, Y., Zhang, J., Sui, Z., and Corke, H. (2022). Antibacterial Activity and Multi-Targeting Mechanism of Dehydrocorydaline from Corydalis turtschaninovii Bess. Against Listeria monocytogenes. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.799094"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Albini, A., Albini, F., Corradino, P., Dugo, L., Calabrone, L., and Noonan, D.M. (2023). From antiquity to contemporary times: How olive oil by-products and waste water can contribute to health. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1254947"},{"key":"ref_65","first-page":"714138","article-title":"Olive Mill Waste Extracts: Polyphenols Content, Antioxidant, and Antimicrobial Activities","volume":"2015","author":"Leouifoudi","year":"2015","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Sar, T., and Akbas, M.Y. (2023). Antimicrobial Activities of Olive Oil Mill Wastewater Extracts against Selected Microorganisms. Sustainability, 15.","DOI":"10.3390\/su15108179"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Cappelli, K., Ferlisi, F., Mecocci, S., Maranesi, M., Trabalza-Marinucci, M., Zerani, M., Bosco, A.D., and Acuti, G. (2021). Dietary Supplementation of Olive Mill Waste Water Polyphenols in Rabbits: Evaluation of the Potential Effects on Hepatic Apoptosis, Inflammation and Metabolism through RT-qPCR Approach. Animals, 11.","DOI":"10.3390\/ani11102932"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"T\u0103b\u0103cariu, A.S.-B., Ifrim, I.-L., Patriciu, O.-I., \u0218tef\u0103nescu, I.-A., and F\u00eenaru, A.-L. (2024). Walnut By-Products and Elderberry Extracts\u2014Sustainable Alternatives for Human and Plant Health. Molecules, 29.","DOI":"10.3390\/molecules29020498"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ferreira-Santos, P., Badim, H., Salvador, C., Silvestre, A.J.D., Santos, S.A.O., Rocha, S.M., Sousa, A.M., Pereira, M.O., Wilson, C.P., and Rocha, C.M.R. (2021). Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications. Biomolecules, 11.","DOI":"10.3390\/biom11081222"},{"key":"ref_70","first-page":"1061","article-title":"Quality analysis of semisolid formulations with the liquid extract of elderflower (Sambucus nigra L.)","volume":"76","author":"Ramanauskiene","year":"2019","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_71","first-page":"1805","article-title":"Antibacterial activity of elder (Sambucus nigra L.) flower or berry against hospital pathogens","volume":"4","author":"Hearst","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jff.2017.11.025","article-title":"Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry","volume":"40","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jpha.2013.01.006","article-title":"In vitro antibacterial and free radical scavenging activity of green hull of Juglans regia","volume":"3","author":"Sharma","year":"2013","journal-title":"J. Pharm. Anal."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"\u017burek, N., Pycia, K., Paw\u0142owska, A., Potocki, L., and Kapusta, I.T. (2023). Chemical Profiling, Bioactive Properties, and Anticancer and Antimicrobial Potential of Juglans regia L. Leaves. Molecules, 28.","DOI":"10.3390\/molecules28041989"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.matpr.2020.07.516","article-title":"An investigation on antibacterial filler property of silver nanoparticles generated from Walnut shell powder by insitu process","volume":"39","author":"Mohan","year":"2021","journal-title":"Mater. Today Proc."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hulea, A., Obi\u0219tioiu, D., Cocan, I., Alexa, E., Negrea, M., Neac\u0219u, A.-G., Hulea, C., Pascu, C., Costinar, L., and Iancu, I. (2022). Diversity of Monofloral Honey Based on the Antimicrobial and Antioxidant Potential. Antibiotics, 11.","DOI":"10.3390\/antibiotics11050595"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10096-010-1077-x","article-title":"Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogens","volume":"30","author":"Kwakman","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.job.2018.12.003","article-title":"Honey in oral health and care: A mini review","volume":"61","author":"Ramsay","year":"2019","journal-title":"J. Oral Biosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"19610","DOI":"10.3390\/molecules191219610","article-title":"Recent advances in the chemical composition of propolis. Propolis: Composition and Antibacterial Properties","volume":"19","author":"Huang","year":"2014","journal-title":"Molecules"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8537","DOI":"10.1021\/acsanm.0c01586","article-title":"A Review of Nanomaterials and Technologies for Enhancing the Antibiofilm Activity of Natural Products and Phytochemicals","volume":"3","author":"Barros","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Iseppi, R., Mariani, M., Cond\u00f2, C., Sabia, C., and Messi, P. (2021). Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040417"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Haro-Gonz\u00e1lez, J.N., Castillo-Herrera, G.A., Mart\u00ednez-Vel\u00e1zquez, M., and Espinosa-Andrews, H. (2021). Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health. Molecules, 26.","DOI":"10.20944\/preprints202108.0386.v1"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Stoleru, E., Vasile, C., Irimia, A., and Brebu, M. (2021). Towards a Bioactive Food Packaging: Poly(Lactic Acid) Surface Functionalized by Chitosan Coating Embedding Clove and Argan Oils. Molecules, 26.","DOI":"10.3390\/molecules26154500"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13756-018-0303-7","article-title":"Synergistic effect of eugenol with Colistin against clinical isolated Colistin-resistant Escherichia coli strains","volume":"7","author":"Wang","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.micpath.2017.10.054","article-title":"Antibacterial and antibiofilm activities of eugenol from essential oil of Syzygium aromaticum (L.) Merr. & L. M. Perry (clove) leaf against periodontal pathogen Porphyromonas gingivalis","volume":"113","author":"Zhang","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e22783","DOI":"10.1016\/j.heliyon.2023.e22783","article-title":"Comparative study of antioxidant and antimicrobial activity of berberine-derived Schiff bases, nitro-berberine and amino-berberine","volume":"9","author":"Noghabi","year":"2023","journal-title":"Heliyon"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Pavlova, J.A., Tereshchenkov, A.G., Nazarov, P.A., Lukianov, D.A., Skvortsov, D.A., Polshakov, V.I., Vasilieva, B.F., Efremenkova, O.V., Kaiumov, M.Y., and Paleskava, A. (2022). Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents. Antibiotics, 12.","DOI":"10.3390\/antibiotics12010015"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Alharthi, S., Popat, A., Ziora, Z.M., and Moyle, P.M. (2023). Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides. Molecules, 28.","DOI":"10.3390\/molecules28052114"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.2147\/IDR.S357077","article-title":"In vitro Antimicrobial Activity and the Mechanism of Berberine Against Methicillin-Resistant Staphylococcus aureus Isolated from Bloodstream Infection Patients","volume":"15","author":"Xia","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.2147\/IDR.S431256","article-title":"Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria","volume":"16","author":"Zhou","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, C., Li, Z., Pan, Q., Fan, L., Pan, T., Zhu, F., Pan, Q., Shan, L., and Zhao, L. (2022). Berberine at sub-inhibitory concentration inhibits biofilm dispersal in Staphylococcus aureus. Microbiology, 168.","DOI":"10.1099\/mic.0.001243"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Lade, H., Chung, S.H., Lee, Y., Kumbhar, B.V., Joo, H.-S., Kim, Y.-G., Yang, Y.-H., and Kim, J.-S. (2022). Thymol Reduces agr-Mediated Virulence Factor Phenol-Soluble Modulin Production in Staphylococcus aureus. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/8221622"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/jam.14872","article-title":"Enhanced in vitro antimicrobial activity of amphotericin B with berberine against dual-species biofilms of Candida albicans and Staphylococcus aureus","volume":"130","author":"Gao","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"104542","DOI":"10.1016\/j.micpath.2020.104542","article-title":"Potentiating the activity of berberine for Staphylococcus aureus in a combinatorial treatment with thymol","volume":"149","author":"Aksoy","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ja.2016.15","article-title":"In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumonia e","volume":"69","author":"Zhou","year":"2016","journal-title":"J. Antibiot."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Li, X., Song, Y., Wang, L., Kang, G., Wang, P., Yin, H., and Huang, H. (2021). A Potential Combination Therapy of Berberine Hydrochloride with Antibiotics Against Multidrug-Resistant Acinetobacter baumannii. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.660431"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejmech.2018.01.038","article-title":"Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii","volume":"146","author":"Gao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_98","first-page":"132","article-title":"The Inhibitory Effect of Thioridazine on adeB Efflux Pump Gene Expression in Multidrug-Resistant Acinetobacter baumannii Isolates Using Real Time PCR","volume":"14","author":"Ahmadi","year":"2022","journal-title":"Avicenna J. Med Biotechnol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/a-1890-5559","article-title":"Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria","volume":"89","author":"Herman","year":"2023","journal-title":"Planta Medica"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1995-7645(13)60063-2","article-title":"Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks (Poephagus grunniens) with haemorrhagic diarrhoea","volume":"6","author":"Patra","year":"2013","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Li, Y., and Ge, X. (2023). Role of Berberine as a Potential Efflux Pump Inhibitor against MdfA from Escherichia coli: In Vitro and In Silico Studies. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.03324-22"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Morita, Y., Nakashima, K.-I., Nishino, K., Kotani, K., Tomida, J., Inoue, M., and Kawamura, Y. (2016). Berberine Is a Novel Type Efflux Inhibitor Which Attenuates the MexXY-Mediated Aminoglycoside Resistance in Pseudomonas aeruginosa. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01223"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1159\/000479411","article-title":"Synergistic Activity of Berberine with Azithromycin against Pseudomonas Aeruginosa Isolated from Patients with Cystic Fibrosis of Lung In Vitro and In Vivo","volume":"42","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3858500","DOI":"10.1155\/2022\/3858500","article-title":"In Vitro Synergistic Inhibitory Activity of Natural Alkaloid Berberine Combined with Azithromycin against Alginate Production by Pseudomonas aeruginosa PAO1","volume":"2022","author":"Zhao","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Kavanaugh, L.G., Mahoney, A.R., Dey, D., Wuest, W.M., and Conn, G.L. (2023). Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition. bioRxiv.","DOI":"10.1101\/2023.03.24.533986"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1080\/07391102.2019.1704884","article-title":"Phytomolecules against bacterial biofilm and efflux pump: An in silico and in vitro study","volume":"38","author":"Jhanji","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/14787210.2019.1645597","article-title":"A successful history: Probiotics and their potential as antimicrobials","volume":"8","author":"Santacroce","year":"2019","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1021\/acs.jctc.1c00666","article-title":"Lipid II Binding and Transmembrane Properties of Various Antimicrobial Lanthipeptides","volume":"18","author":"Pokhrel","year":"2022","journal-title":"J. Chem. Theory Comput."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1007\/s11033-023-08880-w","article-title":"The untapped potential of actinobacterial lanthipeptides as therapeutic agents","volume":"50","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.chembiol.2007.11.009","article-title":"Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens","volume":"15","author":"Castiglione","year":"2008","journal-title":"Chem. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.M113.537449","article-title":"The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions","volume":"289","author":"Schneider","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/jac\/dkx395","article-title":"Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: Synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells","volume":"73","author":"Brunati","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.1008285107","article-title":"Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes","volume":"107","author":"Foulston","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1517\/17460441.2015.1016496","article-title":"Perspectives on lantibiotic discovery\u2014Where have we failed and what improvements are required?","volume":"10","author":"Sandiford","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00253-023-12388-5","article-title":"Class II two-peptide lanthipeptide proteases: Exploring LicTP for biotechnological applications","volume":"107","author":"Barbosa","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbrc.2014.06.129","article-title":"Dissecting the catalytic and substrate binding activity of a class II lanthipeptide synthetase BovM","volume":"450","author":"Ma","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/open.201800130","article-title":"Genome Mining-Mediated Discovery of a New Avermipeptin Analogue in Streptomyces actuosus ATCC 25421","volume":"7","author":"Liu","year":"2018","journal-title":"ChemistryOpen"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","article-title":"Bacterial biofilm and associated infections","volume":"81","author":"Jamal","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm Matrixome: Extracellular Components in Structured Microbial Communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1073\/pnas.1503058112","article-title":"Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudo-monas aeruginosa biofilm matrix","volume":"112","author":"Jennings","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/femsre\/fux001","article-title":"Formation, physiology, ecology, evolution and clinical importance of bacterial persisters","volume":"41","author":"Fauvart","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Dombach, J.L., Quintana, J.L.J., and Detweiler, C.S. (2021). Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule. mBio, 12.","DOI":"10.1128\/mBio.01801-21"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1039\/D0NP00022A","article-title":"Natural products as inspiration for the development of bacterial antibiofilm agents","volume":"37","author":"Melander","year":"2020","journal-title":"Nat. Prod. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Behzadnia, A., Moosavi-Nasab, M., and Oliyaei, N. (2024). Anti-biofilm activity of marine algae-derived bioactive compounds. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1270174"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Jimoh, A.A., Booysen, E., van Zyl, L., and Trindade, M. (2023). Do biosurfactants as anti-biofilm agents have a future in industrial water systems?. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1244595"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e00450-17","DOI":"10.1128\/AEM.00450-17","article-title":"Pumilacidin-Like Lipopeptides Derived from Marine Bacterium Bacillus sp. Strain 176 Suppress the Motility of Vibrio alginolyticus","volume":"83","author":"Xiu","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1038\/srep19267","article-title":"Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bcp.2004.04.012","article-title":"Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin","volume":"68","author":"Alves","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Chen, J., Wang, B., Lu, Y., Guo, Y., Sun, J., Wei, B., Zhang, H., and Wang, H. (2019). Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives. Mar. Drugs, 17.","DOI":"10.3390\/md17020080"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1021\/acsomega.1c00020","article-title":"A Cyclic Dipeptide from Marine Fungus Penicillium chrysogenum DXY-1 Exhibits Anti-quorum Sensing Activity","volume":"6","author":"Yu","year":"2021","journal-title":"ACS Omega"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"104923","DOI":"10.1016\/j.micpath.2021.104923","article-title":"A novel anti-infective molecule nesfactin identified from sponge associated bacteria Nesterenkonia sp. MSA31 against multidrug resistant Pseudomonas aeruginosa","volume":"157","author":"Kiran","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4014\/jmb.1609.09053","article-title":"Screening of Anti-Biofilm Compounds from Marine-Derived Fungi and the Effects of Secalonic Acid D on Staphylococcus aureus Biofilm","volume":"27","author":"Wang","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lorizate, M., and Kr\u00e4usslich, H.-G. (2011). Role of lipids in virus replication. Cold Spring Harb. Perspect. Biol., 3.","DOI":"10.1101\/cshperspect.a004820"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-031-40086-5_4","article-title":"The Art of Viral Membrane Fusion and Penetration","volume":"106","author":"Winter","year":"2023","journal-title":"Subcell Biochem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/ptr.7039","article-title":"Medicinal plants: Treasure for antiviral drug discovery","volume":"35","author":"Ali","year":"2021","journal-title":"Phytotherapy Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3748\/wjg.v23.i34.6252","article-title":"Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation","volume":"23","author":"Wei","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Jennings, M.R., and Parks, R.J. (2020). Curcumin as an Antiviral Agent. Viruses, 12.","DOI":"10.3390\/v12111242"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jep.2009.04.046","article-title":"Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication","volume":"124","author":"Kim","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ijc.20668","article-title":"Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin","volume":"113","author":"Prusty","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Wang, Z., Song, X.-Q., Xu, W., Lei, S., Zhang, H., and Yang, L. (2023). Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Nutrients, 15.","DOI":"10.3390\/nu15183885"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.12009","article-title":"Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea","volume":"168","author":"Steinmann","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jinf.2014.08.013","article-title":"Mir-194 is a hepatocyte gate keeper hindering HCV entry through targeting CD81 receptor","volume":"70","author":"Mekky","year":"2015","journal-title":"J. Infect."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e0190321","DOI":"10.1128\/jvi.01903-21","article-title":"MicroRNA 122 Affects both the Initiation and the Maintenance of Hepatitis C Virus Infections","volume":"96","author":"Panigrahi","year":"2022","journal-title":"J. Virol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e12968","DOI":"10.1016\/j.heliyon.2023.e12968","article-title":"The medicinal value of tea drinking in the management of COVID-19","volume":"9","author":"Ge","year":"2023","journal-title":"Heliyon"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1517\/14712598.2014.913564","article-title":"Sinecatechins (Polyphenon E) ointment for treatment of external genital warts and possible future indications","volume":"14","author":"Stockfleth","year":"2014","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Zhu, J., Cheng, X., Naumovski, N., Hu, L., and Wang, K. (2023). Epigenetic regulation by quercetin: A comprehensive review focused on its biological mechanisms. Crit. Rev. Food Sci. Nutr., 1\u201320.","DOI":"10.1080\/10408398.2023.2278760"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ptr.7309","article-title":"Quercetin and its derivates as antiviral potentials: A comprehensive review","volume":"36","author":"Fais","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"111596","DOI":"10.1016\/j.biopha.2021.111596","article-title":"Antiviral activities of flavonoids","volume":"140","author":"Badshah","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Peng, J., Yang, Z., Li, H., Hao, B., Cui, D., Shang, R., Lv, Y., Liu, Y., Pu, W., and Zhang, H. (2023). Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1\/PGC-1\u03b1 Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative Damage. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065542"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Chen, X., Song, X., Li, L., Chen, Y., Jia, R., Zou, Y., Wan, H., Zhao, L., Tang, H., and Lv, C. (2022). Resveratrol Inhibits Pseudorabies Virus Replication by Targeting IE180 Protein. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.891978"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.antiviral.2006.07.004","article-title":"Resveratrol inhibition of varicella-zoster virus replication in vitro","volume":"72","author":"Docherty","year":"2006","journal-title":"Antivir. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1007\/s10753-012-9452-7","article-title":"Resveratrol inhibits respiratory syncytial virus-induced IL-6 production, decreases viral replication, and downregulates TRIF expression in airway epithelial cells","volume":"35","author":"Xie","year":"2012","journal-title":"Inflammation"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000525807","article-title":"Effects of Resveratrol on Hepatitis B Virus Replication: In vitro and in vivo Experiments","volume":"65","author":"Pan","year":"2022","journal-title":"Intervirology"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Kaur, R., Sharma, P., Gupta, G.K., Ntie-Kang, F., and Kumar, D. (2020). Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products. Molecules, 25.","DOI":"10.20944\/preprints202001.0230.v1"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1021\/ol200889s","article-title":"Stelleralides A\u2013C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.","volume":"13","author":"Asada","year":"2011","journal-title":"Org. Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.phytochem.2013.10.005","article-title":"Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum","volume":"96","author":"Cheng","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1080\/14786419.2022.2078820","article-title":"Anti-IAV indole-diterpenoids from the marine-derived fungus Penicillium citrinum","volume":"37","author":"Pang","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/acs.jnatprod.6b00585","article-title":"Antiviral Triterpenes from the Twigs and Leaves of Lyonia ovalifolia","volume":"79","author":"Lv","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/acs.jnatprod.7b00774","article-title":"Anti-Influenza Triterpene Saponins from the Bark of Burkea africana","volume":"81","author":"Mair","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s00705-020-04706-3","article-title":"Antiviral activity of berberine","volume":"165","author":"Warowicka","year":"2020","journal-title":"Arch. Virol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"30315","DOI":"10.1021\/acsomega.0c04847","article-title":"A Screening of Neuraminidase Inhibition Activities of Isoquinolone Alkaloids in Coptis chinensis Using Molecular Docking and Pharmacophore Analysis","volume":"5","author":"Le","year":"2020","journal-title":"ACS Omega"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Tuzimski, T., and Petruczynik, A. (2023). New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases. Biomed. Pharmacother., 168.","DOI":"10.1016\/j.biopha.2023.115704"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12272-022-01401-6","article-title":"Structures, Biomimetic Synthesis, and Anti-SARS-CoV-2 Activity of Two Pairs of Enantiomeric Phenylpropanoid-Conjugated Protoberberine Alkaloids from the Rhizomes of Corydalis decumbens","volume":"45","author":"Lu","year":"2022","journal-title":"Arch. Pharmacal Res."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/7\/603\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:06:43Z","timestamp":1760108803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/7\/603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":164,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["antibiotics13070603"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics13070603","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}