{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:43:00Z","timestamp":1790916180796,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Pseudomonas aeruginosa strains with potential for degrading n-alkanes are frequently cultured from hydrocarbon-contaminated sites. The initial hydroxylation step of long-chain n-alkanes is mediated by the chromosomally encoded AlkB1 and AlkB2 alkane hydroxylases. The acquisition of an additional P. putida GPo1-like alkane hydroxylase gene cluster can extend the substrate range assimilated by P. aeruginosa to &lt;C12 n-alkanes. Efficient niche colonization of hydrocarbon-contaminated sites is facilitated by avid iron-uptake systems, such as pyoverdine, and the production of several compounds with antimicrobial activities. A GPo1-like gene cluster can facilitate detoxification and solvent tolerance in P. aeruginosa. The overproduction of various multidrug efflux pumps, in particular, the MexAB-OprM system, can also contribute to solvent tolerance, which is often associated with reduced susceptibility or full resistance to certain clinically relevant antibiotics. These characteristics, together with the remarkable conservation of P. aeruginosa virulence determinants among human, animal, and environmental isolates, necessitate further studies from a One Health perspective into the acquired antibiotic resistance mechanisms of environmental P. aeruginosa strains and possible ways for their dissemination into the human population.<\/jats:p>","DOI":"10.3390\/antibiotics13111028","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T08:44:04Z","timestamp":1730364244000},"page":"1028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["N-Alkane Assimilation by Pseudomonas aeruginosa and Its Interactions with Virulence and Antibiotic Resistance"],"prefix":"10.3390","volume":"13","author":[{"given":"Bal\u00e1zs","family":"Libisch","sequence":"first","affiliation":[{"name":"Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhazmat.2018.01.041","article-title":"Remediation of heavy hydrocarbon impacted soil using biopolymer and polystyrene foam beads","volume":"349","author":"Wilton","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_2","unstructured":"(2024, September 15). MOL Group Integrated Annual Reports (2012\u20132023). Available online: https:\/\/molgroup.info\/en\/investor-relations\/publications."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1007\/s12665-015-4326-6","article-title":"Analyzing geophysical signature of a hydrocarbon-contaminated soil using geoelectrical surveys","volume":"74","author":"Koroma","year":"2015","journal-title":"Environ. Earth Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106051","DOI":"10.1016\/j.landusepol.2022.106051","article-title":"Implementing contaminated land remediation in Nigeria: Insights from the Ogoni remediation project","volume":"115","author":"Sam","year":"2022","journal-title":"Land Use Policy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1039\/C9CP06059F","article-title":"Interleaflet coupling of n-alkane incorporated bilayers","volume":"22","author":"Usuda","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Misuraca, L., LoRicco, J., Oger, P., Peters, J., and Dem\u00e9, B. (2023). Incorporation and localisation of alkanes in a protomembrane model by neutron diffraction. Biochim. Biophys. Acta (BBA) Biomembr., 1865.","DOI":"10.1016\/j.bbamem.2023.184119"},{"key":"ref_7","first-page":"S665","article-title":"N-hexane neuropathy: From addiction to disability","volume":"66","author":"Hlioui","year":"2023","journal-title":"Eur. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.ant.2022.05.004","article-title":"Neurotoxicity of organic solvents: An update on mechanisms and effects","volume":"Volume 7","author":"Boyes","year":"2022","journal-title":"Advances in Neurotoxicology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.taap.2012.11.016","article-title":"Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence","volume":"266","author":"Lock","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_10","first-page":"38","article-title":"Biodegradation alternative in the cleanup of petroleum hydrocarbon pollutants","volume":"1","author":"Okoh","year":"2006","journal-title":"Biotechnol. Mol. Biol. Rev."},{"key":"ref_11","first-page":"397","article-title":"Alkane degradation by Pseudomonads","volume":"Volume 3","author":"Ramos","year":"2004","journal-title":"Pseudomonas"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1128\/AEM.70.7.4004-4011.2004","article-title":"Effect of Pyocyanin on a Crude-Oil-Degrading Microbial Community","volume":"70","author":"Norman","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1021\/es800030f","article-title":"Assessing Soil Microbial Populations Responding to Crude-Oil Amendment at Different Temperatures Using Phylogenetic, Functional Gene (alkB) and Physiological Analyses","volume":"42","author":"Hamamura","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1128\/AEM.68.10.5096-5103.2002","article-title":"Variability in Pseudomonas aeruginosa Lipopolysaccharide Expression during Crude Oil Degradation","volume":"68","author":"Norman","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cai, M., Nie, Y., Chi, C.-Q., Tang, Y.-Q., Li, Y., Wang, X.-B., Liu, Z.-S., Yang, Y., Zhou, J., and Wu, X.-L. (2015). Crude oil as a microbial seed bank with unexpected functional potentials. Sci. Rep., 5.","DOI":"10.1038\/srep16057"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102262","DOI":"10.1016\/j.coph.2022.102262","article-title":"The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa","volume":"65","author":"Greenwald","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00284-008-9285-7","article-title":"Identification of Two Multidrug-Resistant Pseudomonas aeruginosa Clonal Lineages with a Countrywide Distribution in Hungary","volume":"58","author":"Libisch","year":"2008","journal-title":"Curr. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rojo, F., and Mart\u00ednez, J.L. (2010). Oil Degraders as Pathogens. Handbook of Hydrocarbon and Lipid Microbiology, Springer.","DOI":"10.1007\/978-3-540-77587-4_250"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1007\/s00253-015-6748-1","article-title":"Profiling microbial community structures across six large oilfields in China and the potential role of dominant microorganisms in bioremediation","volume":"99","author":"Sun","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114129","DOI":"10.1016\/j.ecoenv.2022.114129","article-title":"Petroleum pollution affects soil chemistry and reshapes the diversity and networks of microbial communities","volume":"246","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"117211","DOI":"10.1016\/j.envres.2023.117211","article-title":"Bioremediation of environmental organic pollutants by Pseudomonas aeruginosa: Mechanisms, methods and challenges","volume":"239","author":"Hu","year":"2023","journal-title":"Environ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Song, Y.J., Zhao, N.L., Dai, D.R., and Bao, R. (2024). Prospects of Pseudomonas in Microbial Fuel, Bioremediation, and Sustainability. ChemSusChem, e202401324.","DOI":"10.1002\/cssc.202401324"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/j.1462-2920.2005.00891.x","article-title":"The rhizosphere as a reservoir for opportunistic human pathogenic bacteria","volume":"7","author":"Berg","year":"2005","journal-title":"Environ. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lebaron, P., Cournoyer, B., Lemarchand, K., Nazaret, S., and Servais, P. (2015). Environmental and human pathogenic microorganisms. Environmental Microbiology: Fundamentals and Applications, Springer.","DOI":"10.1007\/978-94-017-9118-2_15"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s40506-020-00234-5","article-title":"Bloodstream Infections Caused by Waterborne Bacteria","volume":"12","year":"2020","journal-title":"Curr. Treat. Options Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1128\/AAC.00300-06","article-title":"Molecular Epidemiology of VIM-4 Metallo-\u03b2-Lactamase-Producing Pseudomonas sp. Isolates in Hungary","volume":"50","author":"Libisch","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1099\/00207713-50-4-1563","article-title":"Phylogenetic affiliation of the pseudomonads based on 16S rRNA sequence","volume":"50","author":"Anzai","year":"2000","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"De Filippis, I., and McKee, M. (2013). Molecular Typing Methods for the Genus Pseudomonas. Molecular Typing in Bacterial Infections. Infectious Disease, Humana Press.","DOI":"10.1007\/978-1-62703-185-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jbiotec.2010.09.151","article-title":"Identification and characterisation of bacterial strains capable to degrade aircraft de-icing fluids at four degrees","volume":"150","author":"Libisch","year":"2010","journal-title":"J. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/09593330.2011.592222","article-title":"Laboratory-scale evaluation of a combined soil amendment for the enhanced biodegradation of propylene glycol-based aircraft de-icing fluids","volume":"33","author":"Libisch","year":"2011","journal-title":"Environ. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wood, S.J., Kuzel, T.M., and Shafikhani, S.H. (2023). Pseudomonas aeruginosa: Infections, animal modeling, and therapeutics. Cells, 12.","DOI":"10.3390\/cells12010199"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Klockgether, J., Cramer, N., Wiehlmann, L., Davenport, C.F., and T\u00fcmmler, B. (2011). Pseudomonas aeruginosa Genomic Structure and Diversity. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00150"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Grace, A., Sahu, R., Owen, D.R., and Dennis, V.A. (2022). Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1023523"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, D., Gomila, M., Bennasar, A., Lalucat, J., and Garc\u00eda-Vald\u00e9s, E. (2014). Genome Analysis of Environmental and Clinical P. aeruginosa Isolates from Sequence Type-1146. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107754"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-15-737","article-title":"Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt","volume":"15","author":"Ozer","year":"2014","journal-title":"BMC Genom."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1128\/MMBR.00027-10","article-title":"The Accessory Genome of Pseudomonas aeruginosa","volume":"74","author":"Kung","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1073\/pnas.0832438100","article-title":"Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa","volume":"100","author":"Wolfgang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"de Sousa, T., H\u00e9braud, M., Dapkevicius, M.L.N.E., Maltez, L., Pereira, J.E., Capita, R., Alonso-Calleja, C., Igrejas, G., and Poeta, P. (2021). Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312892"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ji, Y., Mao, G., Wang, Y., and Bartlam, M. (2013). Structural insights into diversity and n-alkane biodegradation mechanisms of alkane hydroxylases. Front. Microbiol., 4.","DOI":"10.3389\/fmicb.2013.00058"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/bbrc.2000.4023","article-title":"Chimeras of \u03946-Fatty Acid and \u03948-Sphingolipid Desaturases","volume":"279","author":"Libisch","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"162951","DOI":"10.1016\/j.scitotenv.2023.162951","article-title":"Medium-chain alkane biodegradation and its link to some unifying attributes of alkB genes diversity","volume":"877","author":"Fenibo","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1073\/pnas.0702919104","article-title":"Crystal structure of the electron transfer complex rubredoxin\u2013rubredoxin reductase of Pseudomonas aeruginosa","volume":"104","author":"Hagelueken","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ivanova, A.A., Sazonova, O.I., Zvonarev, A.N., Delegan, Y.A., Streletskii, R.A., Shishkina, L.A., Bogun, A.G., and Vetrova, A.A. (2023). Genome analysis and physiology of Pseudomonas sp. strain OVF7 degrading naphthalene and n-dodecane. Microorganisms, 11.","DOI":"10.3390\/microorganisms11082058"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1026000622765","article-title":"Functional characterization of genes involved in alkane oxidation by Pseudomonas aeruginosa","volume":"84","author":"Smits","year":"2003","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10532-021-09970-x","article-title":"LcaR: A regulatory switch from Pseudomonas aeruginosa for bioengineering alkane degrading bacteria","volume":"33","author":"Hemamali","year":"2022","journal-title":"Biodegradation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1462-2920.1999.00052.x","article-title":"Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin","volume":"1","author":"Alonso","year":"1999","journal-title":"Environ. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/35023079","article-title":"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen","volume":"406","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"ref_48","first-page":"1621","article-title":"Analysis of Pseudomonas putida alkane-degradation gene clusters and flanking insertion sequences: Evolution and regulation of the alk genes","volume":"147","author":"Panke","year":"2001","journal-title":"Microbiology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1128\/AEM.72.1.950-952.2006","article-title":"Propane and n-Butane Oxidation by Pseudomonas putida GPo1","volume":"72","author":"Johnson","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/JB.187.1.19-22.2005","article-title":"Specificity at the End of the Tunnel: Understanding Substrate Length Discrimination by the AlkB Alkane Hydroxylase","volume":"187","author":"Rojo","year":"2005","journal-title":"J. Bacteriol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00253-005-0234-0","article-title":"Rhamnolipid production by a novel thermophilic hydrocarbon-degrading Pseudomonas aeruginosa AP02-1","volume":"72","author":"Perfumo","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3934\/microbiol.2017.1.25","article-title":"Soil bioremediation approaches for petroleum hydrocarbon polluted environments","volume":"3","author":"Koshlaf","year":"2017","journal-title":"AIMS Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1128\/am.17.4.520-523.1969","article-title":"Biosynthesis of Pyocyanine by a Paraffin Hydrocarbon-oxidizing Strain of Pseudomonas aeruginosa","volume":"17","author":"Lee","year":"1969","journal-title":"Appl. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF03175067","article-title":"Oxidation of solid paraffin (C11\u221240) by Pseudomonas aeruginosa MGP-1","volume":"57","author":"Neria","year":"2007","journal-title":"Ann. Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.biortech.2006.05.032","article-title":"Crude petroleum-oil biodegradation efficiency of Bacillus subtilis and Pseudomonas aeruginosa strains isolated from a petroleum-oil contaminated soil from North-East India","volume":"98","author":"Das","year":"2007","journal-title":"Bioresour. Technol."},{"key":"ref_56","first-page":"51","article-title":"Effects of salinity, temperature, pH and crude oil concentration on biodegradation of crude oil by Pseudomonas aeruginosa","volume":"1","author":"Thavasi","year":"2007","journal-title":"J. Biol. Environ. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11274-004-3630-1","article-title":"Characterization of a diesel-degrading bacterium, Pseudomonas aeruginosa IU5, isolated from oil-contaminated soil in Korea","volume":"21","author":"Hong","year":"2005","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.30638\/eemj.2018.262","article-title":"Physiological, phylogenetic and functional identification of crude oil-degrading microbial populations","volume":"17","author":"Liang","year":"2018","journal-title":"Environ. Eng. Manag. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1128\/JB.01499-12","article-title":"Genome sequence of Pseudomonas aeruginosa DQ8, an efficient degrader of n-alkanes and polycyclic aromatic hydrocarbons","volume":"194","author":"Gai","year":"2012","journal-title":"J. Bacteriol."},{"key":"ref_60","first-page":"247","article-title":"Comparison of virulence between clinical and environmental Pseudomonas aeruginosa isolates","volume":"9","author":"Garnica","year":"2006","journal-title":"Int. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e11566","DOI":"10.1016\/j.heliyon.2022.e11566","article-title":"Genome sequence of Pseudomonas aeruginosa PA1-Petro\u2014A role model of environmental adaptation and a potential biotechnological tool","volume":"8","author":"Dias","year":"2022","journal-title":"Heliyon"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e01113","DOI":"10.1128\/genomeA.01113-14","article-title":"Draft Genome Sequence of Pseudomonas aeruginosa ATCC 33988, a Bacterium Highly Adapted to Fuel-Polluted Environments","volume":"2","author":"Brown","year":"2014","journal-title":"Genome Announc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12934-021-01676-2","article-title":"Glycerol or crude glycerol as substrates make Pseudomonas aeruginosa achieve anaerobic production of rhamnolipids","volume":"20","author":"Zhao","year":"2021","journal-title":"Microb. Cell Factories"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.15381\/rpb.v24i3.13902","article-title":"Presencia de genes rhlAB, rhlR y rhlC en Pseudomonas aeruginosa nativas sobreproductoras de ramnol\u00edpidos","volume":"24","author":"Palomino","year":"2017","journal-title":"Rev. Peru. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00248-009-9551-7","article-title":"The occurrence of multidrug-resistant Pseudomonas aeruginosa on hydrocarbon-contaminated sites","volume":"59","author":"Kaszab","year":"2010","journal-title":"Microb. Ecol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.resmic.2013.10.004","article-title":"Diversity among strains of Pseudomonas aeruginosa from manure and soil, evaluated by multiple locus variable number tandem repeat analysis and antibiotic resistance profiles","volume":"165","author":"Youenou","year":"2014","journal-title":"Res. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0923-2508(02)01333-5","article-title":"Alkane biodegradation in Pseudomonas aeruginosa strains isolated from a polluted zone: Identification of alkB and alkB-related genes","volume":"153","author":"Belhaj","year":"2002","journal-title":"Res. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2516\/ogst:2003026","article-title":"Diversity of Alkane Hydroxylase Systems in the Environment","volume":"58","author":"Li","year":"2003","journal-title":"Oil Gas Sci. Technol. Rev. D\u2019ifp Energ. Nouv."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1099\/00221287-142-9-2333","article-title":"Environmental gasoline-utilizing isolates and clinical isolates of Pseudomonas aeruginosa are taxonomically indistinguishable by chemotaxonomic and molecular techniques","volume":"142","author":"Foght","year":"1996","journal-title":"Microbiology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"18266","DOI":"10.1021\/acs.energyfuels.3c02541","article-title":"Advanced Progress and Prospects for Producing High-Octane Gasoline Fuel toward Market Development: State-of-the-Art and Outlook","volume":"37","author":"Abdellatief","year":"2023","journal-title":"Energy Fuels"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-3040.2000.00592.x","article-title":"Root hydrocarbons as potential markers for determining species composition","volume":"23","author":"Dawson","year":"2000","journal-title":"Plant Cell Environ."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1128\/JB.184.6.1733-1742.2002","article-title":"Functional Analysis of Alkane Hydroxylases from Gram-Negative and Gram-Positive Bacteria","volume":"184","author":"Smits","year":"2002","journal-title":"J. Bacteriol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1128\/IAI.00546-06","article-title":"Extensive Genomic Plasticity in Pseudomonas aeruginosa Revealed by Identification and Distribution Studies of Novel Genes among Clinical Isolates","volume":"74","author":"Shen","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1128\/JB.181.5.1610-1616.1999","article-title":"The P alkBFGHJKL Promoter Is under Carbon Catabolite Repression Control in Pseudomonas oleovorans but Not in Escherichia coli alk+ Recombinants","volume":"181","author":"Staijen","year":"1999","journal-title":"J. Bacteriol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/jb.96.3.706-712.1968","article-title":"Paraffin oxidation in Pseudomonas aeruginosa I. Induction of paraffin oxidation","volume":"96","author":"Bartels","year":"1968","journal-title":"J. Bacteriol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2958.2000.01751.x","article-title":"A positive feedback mechanism controls expression of AlkS, the transcriptional regulator of the Pseudomonas oleovorans alkane degradation pathway","volume":"35","author":"Canosa","year":"2000","journal-title":"Mol. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1128\/jb.178.18.5508-5512.1996","article-title":"Physiological changes and alk gene instability in Pseudomonas oleovorans during induction and expression of alk genes","volume":"178","author":"Chen","year":"1996","journal-title":"J. Bacteriol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Landa MV, R., De Anda, V., Waldram, G., Rohwer, R., Angelova, A., Gutierrez, T., and Baker, B.J. (2022). Novel hydrocarbon-degradation pathways in uncultured bacteria in industrial-impacted ocean waters. Res. Sq.","DOI":"10.21203\/rs.3.rs-2060586\/v1"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"34014","DOI":"10.1039\/D0RA04953K","article-title":"Recent advancements in the production of rhamnolipid biosurfactants by Pseudomonas aeruginosa","volume":"10","author":"Eslami","year":"2020","journal-title":"RSC Adv."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Kumar, V., Prasad, R., and Kumar, M. (2021). Biosurfactants: A green and sustainable remediation alternative. Rhizobiont in Bioremediation of Hazardous Waste, Springer.","DOI":"10.1007\/978-981-16-0602-1"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1128\/AEM.66.8.3262-3268.2000","article-title":"Rhamnolipid-Induced Removal of Lipopolysaccharide from Pseudomonas aeruginosa: Effect on Cell Surface Properties and Interaction with Hydrophobic Substrates","volume":"66","author":"Sandrin","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00284-008-9139-3","article-title":"Rhamnolipid\u2013Biosurfactant Permeabilizing Effects on Gram-Positive and Gram-Negative Bacterial Strains","volume":"56","author":"Sotirova","year":"2008","journal-title":"Curr. Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1128\/AEM.67.8.3406-3412.2001","article-title":"Effects of Iron Limitation on the Degradation of Toluene by Pseudomonas Strains Carrying the TOL (pWWO) Plasmid","volume":"67","author":"Dinkla","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrmicro1129","article-title":"Biological control of soil-borne pathogens by fluorescent pseudomonads","volume":"3","author":"Haas","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1097-0290(19980120)57:2<228::AID-BIT12>3.0.CO;2-C","article-title":"Synthesis of alkane hydroxylase of Pseudomonas oleovorans increases the iron requirement of alk bacterial strains","volume":"57","author":"Staijen","year":"1998","journal-title":"Biotechnol. Bioeng."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1139\/w98-127","article-title":"Organic solvent-tolerant mutants of Pseudomonas aeruginosa display multiple antibiotic resistance","volume":"45","author":"Li","year":"1999","journal-title":"Can. J. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/0929866530666221226100221","article-title":"An Overview of the Role of Membrane Proteins in Microbial Solvents Tolerance","volume":"30","author":"Peng","year":"2023","journal-title":"Protein Pept. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1128\/JB.180.11.2987-2991.1998","article-title":"Role of the Multidrug Efflux Systems of Pseudomonas aeruginosa in Organic Solvent Tolerance","volume":"180","author":"Li","year":"1998","journal-title":"J. Bacteriol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0924-8579(03)00209-7","article-title":"Solvent tolerance in bacteria: Role of efflux pumps and cross-resistance with antibiotics","volume":"22","author":"Fernandes","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1574-695X.2008.00483.x","article-title":"Identification of PER-1 extended-spectrum \u03b2-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia","volume":"54","author":"Libisch","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Gunasekera, T.S., Bowen, L.L., Zhou, C.E., Howard-Byerly, S.C., Foley, W.S., Striebich, R.C., Dugan, L.C., and Ruiz, O.N. (2017). Transcriptomic Analyses Elucidate Adaptive Differences of Closely Related Strains of Pseudomonas aeruginosa in Fuel. Appl. Environ. Microbiol., 83.","DOI":"10.1128\/AEM.03249-16"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/09603129773733","article-title":"Influence of hydrocarbons on the virulence and antibiotic sensitivity associated with Pseudomonas aeruginosa","volume":"7","author":"Asthana","year":"1997","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2323\/jgam.57.1","article-title":"Multidrug resistance in hydrocarbon-tolerant Gram-positive and Gram-negative bacteria","volume":"57","author":"Stancu","year":"2011","journal-title":"J. Gen. Appl. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1128\/AAC.01072-08","article-title":"MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: Involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor","volume":"52","author":"Fraud","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5897\/AJB2003.000-1021","article-title":"Biodegradation of Bonny light crude oil in soil microcosm by some bacterial strains isolated from crude oil flow stations saver pits in Nigeria","volume":"2","author":"Okoh","year":"2003","journal-title":"Afr. J. Biotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0924-8579(03)00149-3","article-title":"Effects on adhesiveness and hydrophobicity of sub-inhibitory concentrations of netilmicin","volume":"22","author":"Furneri","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/j.1365-2672.2007.03422.x","article-title":"Effect of antibiotic-induced morphological changes on surface properties, motility and adhesion of nosocomial Pseudomonas aeruginosa strains under different physiological states","volume":"103","author":"Fonseca","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.20546\/ijcmas.2019.806.156","article-title":"Evaluation of Native Bacterial Consortium from Crude Oil-Impacted Tropical Environment for Integration into Bioremediation Process","volume":"8","author":"Omoniyi","year":"2019","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"ref_99","first-page":"33","article-title":"Antibiotics susceptibility and hydrocarbon degradative ability of bacteria isolated from diesel-contaminated soil","volume":"1","author":"Anuoluwa","year":"2024","journal-title":"Adv. Environ. Health Sci. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s11274-008-9790-7","article-title":"Pyrene-degradation potentials of Pseudomonas species isolated from polluted tropical soils","volume":"24","author":"Obayori","year":"2008","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Serweci\u0144ska, L. (2020). Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health. Water, 12.","DOI":"10.3390\/w12123313"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"12178","DOI":"10.1007\/s11356-020-12171-3","article-title":"Enrichment of antibiotic resistance genes (ARGs) in polyaromatic hydrocarbon\u2013contaminated soils: A major challenge for environmental health","volume":"28","author":"Maurya","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"118949","DOI":"10.1016\/j.envres.2024.118949","article-title":"Assessment of antibiotic resistance genes in soils polluted by chemical and technogenic ways with poly-aromatic hydrocarbons and heavy metals","volume":"252","author":"Wong","year":"2024","journal-title":"Environ. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Tamma, P.D., Heil, E.L., Justo, J.A., Mathers, A.J., Satlin, M.J., and A Bonomo, R. (2024). Infectious Diseases Society of America 2024 Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections. Clin. Infect. Dis., ciae403.","DOI":"10.1093\/cid\/ciae403"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Karlowsky, J.A., Wise, M.G., Hackel, M.A., Six, D.A., Uehara, T., Daigle, D.M., Pevear, D.C., Moeck, G., and Sahm, D.F. (2024). Cefepime\u2013taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018\u20132022. J. Antimicrob. Chemother., dkae329.","DOI":"10.1093\/jac\/dkae329"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Svedholm, E., Bruce, B., Parcell, B.J., and Coote, P.J. (2024). Repurposing Mitomycin C in Combination with Pentamidine or Gentamicin to Treat Infections with Multi-Drug-Resistant (MDR) Pseudomonas aeruginosa. Antibiotics, 13.","DOI":"10.3390\/antibiotics13020177"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Simpson, E., Sarwar, H., Jack, I., and Lowry, D. (2024). Evaluation of the Potential of Chitosan Nanoparticles as a Delivery Vehicle for Gentamicin for the Treatment of Osteomyelitis. Antibiotics, 13.","DOI":"10.3390\/antibiotics13030208"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"B\u0101rzdi\u0146a, A., Plotniece, A., Sobolev, A., Pajuste, K., Bandere, D., and Brangule, A. (2024). From Polymeric Nanoformulations to Polyphenols\u2014Strategies for Enhancing the Efficacy and Drug Delivery of Gentamicin. Antibiotics, 13.","DOI":"10.3390\/antibiotics13040305"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e00190","DOI":"10.1128\/msphere.00190-23","article-title":"A novel ruthenium-silver based antimicrobial potentiates aminoglycoside activity against Pseudomonas aeruginosa","volume":"8","author":"Donkor","year":"2023","journal-title":"mSphere"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","article-title":"Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis","volume":"19","author":"Rossi","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1556\/AMicr.56.2009.4.9","article-title":"Virulence and antimicrobial resistance determinants of human pathogenic and commensal strains of Pseudomonas aeruginosa","volume":"56","author":"Szmolka","year":"2009","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-017-0753-2","article-title":"Microbial production of rhamnolipids: Opportunities, challenges and strategies","volume":"16","author":"Chong","year":"2017","journal-title":"Microb. Cell Factories"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1369-5274(03)00008-0","article-title":"P. aeruginosa quorum-sensing systems and virulence","volume":"6","author":"Smith","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e0040723","DOI":"10.1128\/iai.00407-23","article-title":"Cytotoxic rhamnolipid micelles drive acute virulence in Pseudomonas aeruginosa","volume":"92","author":"Xu","year":"2024","journal-title":"Infect. Immun."},{"key":"ref_115","unstructured":"Yadav, M.K., and Singh, B.P. (2020). Pseudomonas aeruginosa biofilms and infections: Roles of extracellular molecules. New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Biofilms, Elsevier."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/thx.2009.133082","article-title":"Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients","volume":"65","author":"Guanella","year":"2010","journal-title":"Thorax"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Azimi, S., Thomas, J., Cleland, S.E., Curtis, J.E., Goldberg, J.B., and Diggle, S.P. (2021). O-Specific Antigen-Dependent Surface Hydrophobicity Mediates Aggregate Assembly Type in Pseudomonas aeruginosa. mBio, 12.","DOI":"10.1128\/mBio.00860-21"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41579-022-00683-3","article-title":"The biogeography of infection revisited","volume":"20","author":"Azimi","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0005-2760(82)90196-5","article-title":"Lipid composition of tracheaobronchial secretions from normal individuals and patients with cystic fibrosis","volume":"710","author":"Slomiany","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0009-8981(87)90065-9","article-title":"Relationships between the lipid content and the rheological properties of airway secretions in cystic fibrosis","volume":"164","author":"Galabert","year":"1987","journal-title":"Clin. Chim. Acta"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1165\/rcmb.2005-0214OC","article-title":"Restoration of mucociliary transport in the fluid-depletedtrachea by surface-active instillates","volume":"34","author":"Ballard","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Das, T. (2021). Pseudomonas aeruginosa Secreted Biomolecules and Their Diverse Functions in Biofilm Formation and Virulence. Pseudomonas Aeruginosa\u2014Biofilm Formation, Infections and Treatments, InTechOpen Limited. [1st ed.].","DOI":"10.5772\/intechopen.96866"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0960-8524(03)00114-7","article-title":"Enhanced bioremediation of n-alkane in petroleum sludge using bacterial consortium amended with rhamnolipid and micronutrients","volume":"90","author":"Rahman","year":"2003","journal-title":"Bioresour. Technol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00284-004-4347-y","article-title":"Isolation and Characterization of Novel Strains of Pseudomonas aeruginosa and Serratia marcescens Possessing High Efficiency to Degrade Gasoline, Kerosene, Diesel Oil, and Lubricating Oil","volume":"49","author":"Wongsa","year":"2004","journal-title":"Curr. Microbiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00284-005-0133-8","article-title":"Verification of Degradation of n-Alkanes in Diesel Oil by Pseudomonas aeruginosa Strain WatG in Soil Microcosms","volume":"52","author":"Ueno","year":"2006","journal-title":"Curr. Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"13449","DOI":"10.1021\/es403163k","article-title":"Transcriptional Profiling Suggests that Multiple Metabolic Adaptations are Required for Effective Proliferation of Pseudomonas aeruginosa in Jet Fuel","volume":"47","author":"Gunasekera","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Vaillancourt, M., Limsuwannarot, S.P., Bresee, C., Poopalarajah, R., and Jorth, P. (2021). Pseudomonas aeruginosa mexR and mexEF antibiotic efflux pump variants exhibit increased virulence. Antibiotics, 10.","DOI":"10.20944\/preprints202109.0032.v1"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmi.2023.12.026","article-title":"Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: Update from ESGARS-ESCMID\/ISARPAE Group","volume":"30","author":"Oliver","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1084\/jem.20020005","article-title":"Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa","volume":"196","author":"Hirakata","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2009.06.007","article-title":"Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa","volume":"34","author":"Hirakata","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s15010-024-02313-x","article-title":"Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: A microbiological and clinical perspective","volume":"52","author":"Sendra","year":"2024","journal-title":"Infection"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/jac\/dky042","article-title":"Role of bacterial efflux pumps in biofilm formation","volume":"73","author":"Alav","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"115218","DOI":"10.1016\/j.envres.2023.115218","article-title":"Biofilm inhibition based on controlling the transmembrane transport and extracellular accumulation of quorum sensing signals","volume":"221","author":"Wang","year":"2023","journal-title":"Environ. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Xu, A., Wang, D., Ding, Y., Zheng, Y., Wang, B., Wei, Q., Wang, S., Yang, L., and Ma, L.Z. (2020). Integrated Comparative Genomic Analysis and Phenotypic Profiling of Pseudomonas aeruginosa Isolates from Crude Oil. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00519"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1099\/jmm.0.05069-0","article-title":"Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection","volume":"52","author":"Ziegler","year":"2003","journal-title":"J. Med. Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"23582","DOI":"10.1074\/jbc.M112.375378","article-title":"Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa","volume":"287","author":"Whitney","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Dasgupta, D., Ghosh, R., and Sengupta, T.K. (2013). Biofilm-mediated enhanced crude oil degradation by newly isolated pseudomonas species. ISRN Biotechnol., 2013.","DOI":"10.5402\/2013\/250749"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ibiod.2010.01.008","article-title":"Community dynamics and phylogenetics of bacteria fouling Jet A and JP-8 aviation fuel","volume":"64","author":"Brown","year":"2010","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10295-005-0023-x","article-title":"Characterization of microbial contamination in United States Air Force aviation fuel tanks","volume":"33","author":"Rauch","year":"2006","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/acsabm.1c01198","article-title":"Mucoid Coating Provides a Growth Advantage to Pseudomonas aeruginosa at Oil\u2013Water Interfaces","volume":"5","author":"Balmuri","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Gloag, E.S., German, G.K., Stoodley, P., and Wozniak, D.J. (2018). Viscoelastic properties of Pseudomonas aeruginosa variant biofilms. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-28009-5"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jinorgbio.2007.11.017","article-title":"Metal trafficking via siderophores in Gram-negative bacteria: Specificities and characteristics of the pyoverdine pathway","volume":"102","author":"Schalk","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1073\/pnas.092016999","article-title":"Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa","volume":"99","author":"Lamont","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.200408-1044SO","article-title":"Pathogen\u2013Host Interactions in Pseudomonas aeruginosa Pneumonia","volume":"171","author":"Sadikot","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/1462-2920.12013","article-title":"Pyoverdine biosynthesis and secretion in Pseudomonas aeruginosa: Implications for metal homeostasis","volume":"15","author":"Schalk","year":"2013","journal-title":"Environ. Microbiol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Dell\u2019Anno, F., Vitale, G.A., Buonocore, C., Vitale, L., Palma Esposito, F., Coppola, D., Della Sala, G., Tedesco, P., and de Pascale, D. (2022). Novel insights on pyoverdine: From biosynthesis to biotechnological application. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911507"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"00517-17","DOI":"10.1128\/mBio.00517-17","article-title":"Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa","volume":"8","author":"Jorth","year":"2017","journal-title":"mBio"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Mahey, N., Tambat, R., Kalia, R., Ingavale, R., Kodesia, A., Chandal, N., Kapoor, S., Verma, D.K., Thakur, K.G., and Jachak, S. (2024). Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012121"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Jim\u00e9nez, A., Llamas, M.A., and Marcos-Torres, F.J. (2023). Transcriptional Regulators Controlling Virulence in Pseudomonas aeruginosa. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241511895"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.resmic.2007.12.008","article-title":"Molecular typing indicates an important role for two international clonal complexes in dissemination of VIM-producing Pseudomonas aeruginosa clinical isolates in Hungary","volume":"159","author":"Libisch","year":"2008","journal-title":"Res. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1098\/rspb.2009.0320","article-title":"The role of natural environments in the evolution of resistance traits in pathogenic bacteria","volume":"276","author":"Martinez","year":"2009","journal-title":"Proc. R. Soc. B Biol. Sci."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/11\/1028\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:25:32Z","timestamp":1760113532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/11\/1028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":151,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["antibiotics13111028"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics13111028","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}