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Known for its array of virulence factors, including surface proteins that promote adhesion to host tissues, enzymes that break down host barriers, and toxins that contribute to immune evasion and tissue destruction, S. aureus poses a serious health threat. Both the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) classify S. aureus as an ESKAPE pathogen, recognizing it as a critical threat to global health. The increasing prevalence of drug-resistant S. aureus underscores the need for new therapeutic strategies. This review discusses a promising approach that combines monoclonal antibodies targeting multiple S. aureus epitopes, offering synergistic efficacy in treating infections. Such strategies aim to reduce the capacity of the pathogen to develop resistance, presenting a potent adjunct or alternative to conventional antibiotic treatments.<\/jats:p>","DOI":"10.3390\/antibiotics13111046","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T05:30:53Z","timestamp":1730784653000},"page":"1046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential Therapeutic Targets for Combination Antibody Therapy Against Staphylococcus aureus Infections"],"prefix":"10.3390","volume":"13","author":[{"given":"Sharon","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyein","family":"Kil","sequence":"additional","affiliation":[{"name":"Department of Surgery, Virtua Health, Camden, NJ 08103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner","family":"Roggy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Community Memorial Healthcare, Ventura, CA 93003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa P.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-517X","authenticated-orcid":false,"given":"James M.","family":"Small","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francina D.","family":"Towne","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-5969","authenticated-orcid":false,"given":"Amanda E.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7456-3074","authenticated-orcid":false,"given":"Benjamin D.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, Rocky Vista University, Parker, CO 80134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2022.09.017","article-title":"The Golden Grapes of Wrath\u2013Staphylococcus aureus Bacteremia: A Clinical Review","volume":"136","author":"Lam","year":"2023","journal-title":"Am. 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