{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:55:49Z","timestamp":1778003749975,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Osteomyelitis is a challenging condition caused by infection and inflammation of the bone, presenting a significant economic burden to healthcare systems. Calcium sulfate\/hydroxyapatite (CaS\/HA) is a bone void filler composed of 60% calcium sulfate and 40% hydroxyapatite. This case series aimed to report the efficacy and infection-related outcomes of CaS\/HA combined with Gentamicin (CaS\/HA-G) in treating osteomyelitis. Methods: Patients aged 18 and older diagnosed with osteomyelitis requiring surgical intervention and treated with CaS\/HA-G during their procedure were included in the study, with a median (Q1\u2013Q3) = 10 (7\u201316)-month follow-up period of time. Data collected included demographic, surgical, and outcome information. Infection eradication was determined by the normalization of the C-reactive protein, erythrocyte sedimentation rate levels, or the absence of clinical infection symptoms. Results: The case series involved 21 patients (twelve male, nine female) with a mean (SD) age of 54.8 (16.6) years. Vancomycin or\/and Tobramycin were used as an additional antibiotic in 17 patients. At the last follow-up, 20 out of 21 patients (95.2%) had eradicated the infection, with a median (Q1\u2013Q3) eradication time of 128 (71.8\u2013233.5) days. Conclusions: In conclusion, this study demonstrates that CaS\/HA-G is effective in controlling osseous infection in osteomyelitis while acting as an absorbable bone void filler.<\/jats:p>","DOI":"10.3390\/antibiotics13111068","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:52:07Z","timestamp":1731297127000},"page":"1068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Efficacy of Calcium Sulfate\/Hydroxyapatite (CaS\/HA) Gentamicin in Osteomyelitis Treatment: A Case Series"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-354X","authenticated-orcid":false,"given":"Amir Human","family":"Hoveidaei","sequence":"first","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 2125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanoj","family":"Shahul","sequence":"additional","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 2125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Sina University Hospital, Tehran University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasra","family":"Pirahesh","sequence":"additional","affiliation":[{"name":"Sina University Hospital, Tehran University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirhossein","family":"Ghaseminejad-Raeini","sequence":"additional","affiliation":[{"name":"Sina University Hospital, Tehran University of Medical Sciences, Tehran 1416753955, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abijith","family":"Annasamudram","sequence":"additional","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 2125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj Krishna","family":"Shrestha","sequence":"additional","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 2125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Conway","sequence":"additional","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 2125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2106\/JBJS.N.01350","article-title":"Trends in the epidemiology of osteomyelitis: A population-based study, 1969 to 2009","volume":"97","author":"Kremers","year":"2015","journal-title":"J. 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