{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:27Z","timestamp":1760146647275,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tohoku University"},{"name":"Moraine Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: In environments with high-frequency contact surfaces, drug-resistant bacteria, such as carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus (MRSA), can survive for extended periods, contributing to healthcare-associated infections. Ultraviolet (UV)-C irradiation often fails to adequately disinfect shadowed areas, leading to a persistent contamination risk. We evaluated the effectiveness of using a UV-C containment unit (UVCCU) in conjunction with UV-C irradiation to improve the sterilization effects on both direct and indirect surfaces, including shadowed areas, and to assess the leakage of UV radiation to the surroundings. Methods: In a model patient room, agar media inoculated with carbapenem-resistant Enterobacter cloacae and MRSA were placed at multiple locations on direct and indirect surfaces around the bed. We used the UV-C irradiation system, UVDI-360, to irradiate the bedroom-environment surfaces with and without a UVCCU. The reduction in bacterial colony counts with and without the UVCCU was measured by counting colony-forming units and calculating the log reduction values, and the UV radiation leakage outside the UVCCU was measured. Results: The use of the UVCCU led to a significant reduction in MRSA colony counts, even in shadowed areas that had previously been inadequately disinfected (with the UVCCU: 2.7 [2.7\u20132.8]; without the UVCCU: 0.6 [0.5\u20130.7]; p &lt; 0.01). Additionally, the use of the UVCCU kept the UV radiation leakage to the surrounding environment within regulated limits. Conclusions: These findings suggest that a UVCCU can enhance the disinfection efficacy for multidrug-resistant organisms on healthcare environmental surfaces. The portability and ease of use of the UVCCU indicate its promise as an auxiliary device for UV-C disinfection in healthcare settings.<\/jats:p>","DOI":"10.3390\/antibiotics13121115","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:21:36Z","timestamp":1732249296000},"page":"1115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Effect of Patient Room Disinfection Against Carbapenem-Resistant Enterobacter cloacae and Methicillin-Resistant Staphylococcus aureus Using UV-C Irradiation in Conjunction with UV-C Containment Unit"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-1338","authenticated-orcid":false,"given":"Shiori","family":"Kitaya","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Laboratory Medicine, Kanazawa University, Kanazawa 920-8641, Japan"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan"},{"name":"Department of Infectious Diseases, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-062X","authenticated-orcid":false,"given":"Kentarou","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitomo","family":"Honda","sequence":"additional","affiliation":[{"name":"Moraine Corporation, Nakano 164-0003, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-5272","authenticated-orcid":false,"given":"Hajime","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Laboratory Medicine, Kanazawa University, Kanazawa 920-8641, Japan"},{"name":"Department of Infectious Diseases, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ajic.2014.12.012","article-title":"Can pulsed xenon ultraviolet light systems disinfect aerobic bacteria in the absence of manual disinfection?","volume":"43","author":"Jinadatha","year":"2015","journal-title":"Am. 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