{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:24Z","timestamp":1760146884582,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: This study investigates bacterial etiology and antibiotic resistance in pediatric leukemia patients to determine the impact of chronic pathology on treatment efficacy. Methods: Thirty cases of children aged 1\u201316 years (18 boys, 12 girls) were analyzed, identifying 13 pathogens, including 8 Gram-positive and 5 Gram-negative bacteria. Results: Among the patients, 11 girls presented with acute lymphoblastic leukemia (ALL) type B, while one boy and one girl had acute myeloid leukemia, and, as for boys, three had ALL type T and two had pre-B ALL. The most common pathogens were methicillin-resistant Staphylococcus aureus (MRSA, 11 patients), methicillin-sensitive Staphylococcus aureus (MSSA, 6 patients), Klebsiella spp., and Staphylococcus epidermidis. Due to the patients\u2019 compromised health, most required intensive care and strong antibiotic regimens, including linezolid, vancomycin, and ertapenem, which showed limited resistance. Conclusions: These findings highlight the critical importance of understanding bacterial resistance patterns to guide effective treatments in vulnerable populations. Knowing specific resistance profiles can be lifesaving, allowing for tailored therapies that improve survival rates in children with leukemia facing serious bacterial infections. Focusing on the dual aspects of pediatric patients and multidrug-resistant bacterial infections, this study aims to highlight the importance of addressing these factors together to enhance therapeutic approaches in vulnerable populations.<\/jats:p>","DOI":"10.3390\/antibiotics13121234","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T02:39:56Z","timestamp":1734921596000},"page":"1234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristina Elena","family":"Singer","sequence":"first","affiliation":[{"name":"Department of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin Iulian Silviu","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Maria","family":"V\u0103ru\u021b","sequence":"additional","affiliation":[{"name":"Research Methodology Department, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5054-520X","authenticated-orcid":false,"given":"Dira","family":"Loredana","sequence":"additional","affiliation":[{"name":"Department of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Radivojevic","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petrescu Ileana","family":"Octavia","sequence":"additional","affiliation":[{"name":"Department of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,22]]},"reference":[{"key":"ref_1","first-page":"156","article-title":"Advances in paediatric cancer treatment","volume":"3","author":"Saletta","year":"2014","journal-title":"Transl. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1182\/asheducation-2015.1.414","article-title":"How can we improve on the already impressive results in pediatric ALL?","volume":"2015","author":"Thomas","year":"2015","journal-title":"Hematology Am. Soc. Hematol. Educ. Program."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s11684-020-0759-8","article-title":"Precision medicine in acute lymphoblastic leukemia","volume":"14","author":"Pui","year":"2020","journal-title":"Front. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.htct.2018.05.010","article-title":"Revisiting the complete blood count and clinical findings at diagnosis of childhood acute lymphoblastic leukemia: 10-year experience at a single center","volume":"41","year":"2019","journal-title":"Hematol. Transfus. Cell Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3324\/haematol.2015.141101","article-title":"New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia","volume":"101","author":"Moorman","year":"2016","journal-title":"Haematologica"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mancuso, G., Midiri, A., Gerace, E., and Biondo, C. (2021). Bacterial antibiotic resistance: The most critical pathogens. Pathogens, 10.","DOI":"10.3390\/pathogens10101310"},{"key":"ref_7","first-page":"1","article-title":"Antimicrobial resistance: Tackling a crisis for the health and wealth of nations","volume":"11","year":"2014","journal-title":"Rev. Antimicrob. Resist."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2147\/IDR.S173867","article-title":"Antibiotic resistance: A rundown of a global crisis","volume":"11","author":"Aslam","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hernando-Amado, S., Coque, T.M., Baquero, F., and Mart\u00ednez, J.L. (2020). Antibiotic resistance: Moving from individual health norms to social norms in one health and global health. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.01914"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmi.2021.10.017","article-title":"Non-biomedical factors affecting antibiotic use in the community: A mixed-methods systematic review and meta-analysis","volume":"28","author":"Sun","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijid.2020.12.087","article-title":"Antibiotics and antimicrobial resistance in the COVID-19 era: Perspective from resource-limited settings","volume":"104","author":"Lucien","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_12","first-page":"1","article-title":"Predictors of antibiogram performance and antibiotic resistance patterns in the northern Syrian region: A cross-sectional investigation","volume":"13","author":"Bourgi","year":"2024","journal-title":"Explor. Res. Clin. Soc. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood-2014-03-560847","article-title":"Infection-related mortality in children with acute lymphoblastic leukemia: An analysis of infectious deaths on UKALL2003","volume":"124","author":"Bate","year":"2014","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the Children\u2019s Oncology Group","volume":"30","author":"Hunger","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/pbc.20469","article-title":"Few but severe viral infections in children with cancer: A prospective RT-PCR and PCR-based 12-month study","volume":"45","author":"Christensen","year":"2005","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2141.2005.05736.x","article-title":"Treatment-related death in childhood acute lymphoblastic leukaemia in the Nordic countries: 1992\u20132001","volume":"131","author":"Christensen","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102745","DOI":"10.1016\/j.bjid.2023.102745","article-title":"Safety of levofloxacin as an antibiotic prophylaxis in the induction phase of children newly diagnosed with acute lymphoblastic leukemia: An interim analysis of a randomized, open-label trial in Brazil","volume":"27","author":"Dufrayer","year":"2023","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/cid\/ciz1082","article-title":"Guideline for antibacterial prophylaxis administration in pediatric cancer and hematopoietic stem cell transplantation","volume":"71","author":"Lehrnbecher","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1002\/pbc.29275","article-title":"Invasive fungal disease in children with acute myeloid leukaemia: An Australian multicentre 10-year review","volume":"68","author":"Yeoh","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_20","first-page":"3532","article-title":"8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation","volume":"2045","author":"Lehrnbecher","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1182\/blood-2007-05-091942","article-title":"Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia","volume":"110","author":"Sung","year":"2007","journal-title":"Blood"},{"key":"ref_22","first-page":"30","article-title":"Life-threatening and fatal infections in children with acute myeloid leukemia: A report from the Children\u2019s Oncology Group","volume":"34","author":"Sung","year":"2012","journal-title":"Life-Threat. Fatal Infect. Child."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s40124-013-0023-7","article-title":"Update on epidemiology and treatment of MRSA infections in children","volume":"1","author":"David","year":"2013","journal-title":"Curr. Pediatr. Rep."},{"key":"ref_24","first-page":"45","article-title":"Efficacy of carbapenems against Gram-negative bacteria in pediatric patients","volume":"29","author":"Jones","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_25","first-page":"56","article-title":"Prevalence and antibiotic resistance patterns of strains of Staphylococcus aureus isolated at the Yaound\u00e9 Military Hospital, Cameroon","volume":"3","author":"Njoungang","year":"2015","journal-title":"Microbiol. Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"FSO464","DOI":"10.2144\/fsoa-2019-0122","article-title":"Antibiotic resistance pattern of Staphylococcus aureus with reference to MRSA isolates from pediatric patients","volume":"6","author":"Gurung","year":"2020","journal-title":"Future Sci. OA"},{"key":"ref_27","first-page":"789","article-title":"Role of carbapenems and linezolid in treating severe pediatric infections","volume":"76","author":"Williams","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","unstructured":"Lee, C., Kim, S., and Park, J. (2022). Effectiveness of linezolid and ertapenem against resistant pediatric strains. Ann. Clin. Microbiol. Antimicrob., 21."},{"key":"ref_29","unstructured":"Kim, J., Oh, H., and Jung, Y. (2022). Resistance levels of lower-generation cephalosporins in pediatric infections. J. Clin. Microbiol., 60."},{"key":"ref_30","first-page":"103","article-title":"Comparative efficacy of linezolid and ertapenem in pediatric infections","volume":"70","author":"Garcia","year":"2023","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103734","DOI":"10.1016\/j.bjid.2024.103734","article-title":"Serotype distribution and antimicrobial resistance of pediatric Streptococcus pneumoniae isolated from inpatients and outpatients at Beijing Children\u2019s Hospital","volume":"28","author":"Lyu","year":"2024","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wu, X., Wang, C., He, L., Xu, H., Jing, C., Chen, Y., Lin, A., Deng, J., Cao, Q., and Deng, H. (2023). Antimicrobial resistance profile of methicillin-resistant Staphylococcus aureus isolates in children reported from the ISPED surveillance of bacterial resistance, 2016\u20132021. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1102779"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/12\/1234\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:57:50Z","timestamp":1760115470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/12\/1234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,22]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["antibiotics13121234"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics13121234","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2024,12,22]]}}}