{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:02:04Z","timestamp":1792101724530,"version":"4.4.0"},"reference-count":89,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brasil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brasil (CAPES)","award":["3\/2021"],"award-info":[{"award-number":["3\/2021"]}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","award":["3\/2021"],"award-info":[{"award-number":["3\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: This study aimed to develop gel nanoemulsions (NEs) of Brazilian essential oils (EOs) from Eugenia uniflora and Psidium guajava, as well as to perform chemical characterization and investigate the antimicrobial activity of the EOs and NEs. Results\/Conclusions: The main chemical compounds of E. uniflora EO were curzerene (34.80%) and germacrene B (11.92%), while those of P. guajava EO were \u03b2-caryophyllene (25.92%), \u03b2-selinene (22.64%), and \u03b3-selinene (19.13%). The NEs of E. uniflora and P. guajava had droplet sizes of 105.30 and 99.50 nm and polydispersity index (PDI) values of 0.32 and 0.43, respectively. The NEs remained stable for 30 days of storage at 25 \u00b0C, with droplet sizes of 104.7 and 103.8 nm, PDI values below 0.50, and no phase separation. The NE of E. uniflora exhibited inhibition zones ranging from 8.41 to 15.13 mm against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. Additionally, the NE of E. uniflora showed the largest inhibition zones against Candida albicans (20.97 mm) and Candida krusei (15.20 mm), along with low minimum inhibitory concentration (MIC) values (0.54\u20131.22 mg\/mL) and minimal bactericidal concentration (MBC) values (4.84\u201311.02 mg\/mL) against these pathogenic yeasts. The NE of P. guajava demonstrated low MIC (1.26 mg\/mL) and MBC (11.35 mg\/mL) values for C. krusei. The time\u2013growth inhibition assay also suggests the effectiveness of the NE against the tested pathogens S. aureus and E. coli, highlighting its potential as a novel alternative therapeutic agent.<\/jats:p>","DOI":"10.3390\/antibiotics14010093","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T11:28:31Z","timestamp":1736854111000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Chemical Characterization and Antimicrobial Activity of Essential Oils and Nanoemulsions of Eugenia uniflora and Psidium guajava"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-2618","authenticated-orcid":false,"given":"Rebeca Dias","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"},{"name":"Laboratory of Food, Drugs, and Cosmetics, University of Bras\u00edlia (UNB\/FS), Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno Noronha","family":"Matos","sequence":"additional","affiliation":[{"name":"Laboratory of Food, Drugs, and Cosmetics, University of Bras\u00edlia (UNB\/FS), Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-7862","authenticated-orcid":false,"given":"Daniel Oliveira","family":"Freire","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklyn Santos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"},{"name":"Laboratory of Food, Drugs, and Cosmetics, University of Bras\u00edlia (UNB\/FS), Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Alc\u00e2ntara","family":"do Prado","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"},{"name":"Laboratory of Food, Drugs, and Cosmetics, University of Bras\u00edlia (UNB\/FS), Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina Oliveira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3755","authenticated-orcid":false,"given":"Marta Oliveira","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-3655","authenticated-orcid":false,"given":"Carla Azevedo","family":"Bilac","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-7339","authenticated-orcid":false,"given":"Let\u00edcia Fernandes Silva","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-3583","authenticated-orcid":false,"given":"Izabel Cristina Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Cristina Lira","family":"de S\u00e1 Barreto","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control, University of Bras\u00edlia (UNB\/FCE), Centro Metropolitano, Conjunto A, Lote 01, Ceil\u00e2ndia, Bras\u00edlia 72220-900, DF, 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