{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:33:13Z","timestamp":1791408793448,"version":"4.3.3"},"reference-count":122,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["20048-2014"],"award-info":[{"award-number":["20048-2014"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["933-2023"],"award-info":[{"award-number":["933-2023"]}]},{"name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n de Colombia (MINCIENCIAS)","award":["20048-2014"],"award-info":[{"award-number":["20048-2014"]}]},{"name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n de Colombia (MINCIENCIAS)","award":["933-2023"],"award-info":[{"award-number":["933-2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Amphibians use their skin as an effective defense mechanism against predators and microorganisms. Specialized glands produce antimicrobial peptides (AMPs) that possess antioxidant properties, effectively reducing reactive oxygen species (ROS) levels. These peptides are promising candidates for treating diseases associated with oxidative stress (OS) and redox imbalance, including neurodegenerative disorders such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), and amyotrophic lateral sclerosis (ALS), as well as age-related conditions, like cardiovascular diseases and cancer. This review highlights the multifaceted roles of AMPs and antioxidant peptides (AOPs) in amphibians, emphasizing their protective capabilities against oxidative damage. They scavenge ROS, activate antioxidant enzyme systems, and inhibit cellular damage. AOPs often share structural characteristics with AMPs, suggesting a potential evolutionary connection and similar biosynthetic pathways. Peptides such as brevinin-1FL and Cath-KP demonstrate neuroprotective effects, indicating their therapeutic potential in managing oxidative stress-related diseases. The antioxidant properties of amphibian-derived peptides pave the way for novel therapeutic developments. However, a deeper understanding of the molecular mechanisms underlying these peptides and their interactions with oxidative stress is essential to addressing ROS-related diseases and advancing therapeutic strategies in clinical practice.<\/jats:p>","DOI":"10.3390\/antibiotics14020126","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T03:54:27Z","timestamp":1737950067000},"page":"126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Amphibian AMPs Against Oxidative Stress and Related Diseases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8518-6310","authenticated-orcid":false,"given":"Yudy Lorena","family":"Silva Ort\u00edz","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Productos Naturales Amaz\u00f3nicos (GIPRONAZ), Facultad de Ciencias B\u00e1sicas, Universidad de la Amazonia, Florencia 180001, Caquet\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-0625","authenticated-orcid":false,"given":"Tha\u00eds Campos","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia, Bras\u00edlia 71966-160, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3034-8699","authenticated-orcid":false,"given":"Nat\u00e1lia Elisabeth","family":"Kruklis","sequence":"additional","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia, Bras\u00edlia 71966-160, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-4020","authenticated-orcid":false,"given":"Paula","family":"Galeano Garc\u00eda","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Productos Naturales Amaz\u00f3nicos (GIPRONAZ), Facultad de Ciencias B\u00e1sicas, Universidad de la Amazonia, Florencia 180001, Caquet\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-9770","authenticated-orcid":false,"given":"Jos\u00e9","family":"Brango-Vanegas","sequence":"additional","affiliation":[{"name":"Center for Proteomic and Biochemical Analyses, Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia, Bras\u00edlia 70790-160, DF, Brazil"},{"name":"S-Inova Biotech, Graduate Program in Biotechnology, Dom Bosco Catholic University, Campo Grande 79117-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-3412","authenticated-orcid":false,"given":"Marcelo Henrique","family":"Soller Ramada","sequence":"additional","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia, Bras\u00edlia 71966-160, DF, Brazil"},{"name":"Graduate Program in Gerontology, Catholic University of Bras\u00edlia, Bras\u00edlia 71966-700, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-0525","authenticated-orcid":false,"given":"Oct\u00e1vio Luiz","family":"Franco","sequence":"additional","affiliation":[{"name":"Center for Proteomic and Biochemical Analyses, Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia, Bras\u00edlia 70790-160, DF, Brazil"},{"name":"S-Inova Biotech, Graduate Program in Biotechnology, Dom Bosco Catholic University, Campo Grande 79117-900, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.1.06293","article-title":"Skin Secretions of Rana saharica Frogs Reveal Antimicrobial Peptides Esculentins-1 and -1B and Brevinins-1E and -2EC with Novel Insulin Releasing Activity","volume":"188","author":"Marenah","year":"2006","journal-title":"J. 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