{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:34:52Z","timestamp":1790253292822,"version":"4.1.0"},"reference-count":204,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. They occur in the urinary system when a microorganism, commonly present on the perineal skin or rectum, reaches the bladder through the urethra, and adheres to the luminal surface of uroepithelial cells, forming biofilms. The treatment of UTIs includes antibiotics, but their indiscriminate use has favored the development of multidrug-resistant bacteria strains, which represent a serious challenge to today\u2019s microbiology. The pathogenesis of the infection and antibiotic resistance synergistically contribute to hindering the eradication of the disease while favoring the establishment of persistent infections. The repeated requirement for antibiotic treatment and the limited therapeutic options have further contributed to the increase in antibiotic resistance and the occurrence of potential relapses by therapeutic failure. To limit antimicrobial resistance and broaden the choice of non-antibiotic preventive approaches, this review reports studies focused on the bacteriostatic\/bactericidal activity, inhibition of bacterial adhesion and quorum sensing, restoration of uroepithelial integrity and immune response of molecules, vitamins, and compounds obtained from plants. To date, different supplementations are recommended by the European Association of Urology for the management of UTIs as an alternative approach to antibiotic treatment, while a variety of bioactive compounds are under investigation, mostly at the level of in vitro and preclinical studies. Although the evidence is promising, they are far from being included in the clinical practice of UTIs.<\/jats:p>","DOI":"10.3390\/antibiotics14020144","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:36:51Z","timestamp":1738557411000},"page":"144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bioactive Compounds as Alternative Approaches for Preventing Urinary Tract Infections in the Era of Antibiotic Resistance"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-4966","authenticated-orcid":false,"given":"Chiara","family":"Cipriani","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carilli","sequence":"additional","affiliation":[{"name":"Robotic and Minimally Invasive Urology Unit, Azienda Ospedaliera Universitaria, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-5429","authenticated-orcid":false,"given":"Martino Tony","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sinibaldi-Vallebona","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-1092","authenticated-orcid":false,"given":"Claudia","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-2982","authenticated-orcid":false,"given":"Pierluigi","family":"Bove","sequence":"additional","affiliation":[{"name":"Robotic and Minimally Invasive Urology Unit, Azienda Ospedaliera Universitaria, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Department of Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"key":"ref_1","unstructured":"(2024, September 27). Available online: https:\/\/uroweb.org\/guidelines\/urological-infections."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.euros.2022.07.009","article-title":"Adherence to European Association of Urology Guidelines and State of the Art of Glycosaminoglycan Therapy for the Management of Urinary Tract Infections: A Narrative Review and Expert Meeting Report","volume":"44","author":"Bonkat","year":"2022","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary Tract Infections: Epidemiology, Mechanisms of Infection and Treatment Options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gambrill, B., Pertusati, F., Hughes, S.F., Shergill, I., and Prokopovich, P. (2024). Materials-Based Incidence of Urinary Catheter Associated Urinary Tract Infections and the Causative Micro-Organisms: Systematic Review and Meta-Analysis. BMC Urol., 24.","DOI":"10.1186\/s12894-024-01565-x"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41579-024-01092-4","article-title":"Urinary Tract Infections: Pathogenesis, Host Susceptibility and Emerging Therapeutics","volume":"23","author":"Timm","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","first-page":"10","article-title":"Comparative Genomics of Antibiotic-Resistant Uropathogens Implicates Three Routes for Recurrence of Urinary Tract Infections","volume":"10","author":"Reske","year":"2019","journal-title":"mBio"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jgar.2019.07.019","article-title":"Uropathogens and Antibiotic Resistance in the Community and Hospital-Induced Urinary Tract Infected Children","volume":"20","author":"Demir","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/QCO.0000000000000228","article-title":"Global Epidemiology of Urinary Tract Infections","volume":"29","author":"Tandogdu","year":"2016","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yang, X., Chen, H., Zheng, Y., Qu, S., Wang, H., and Yi, F. (2022). Disease Burden and Long-Term Trends of Urinary Tract Infections: A Worldwide Report. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.888205"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.puhe.2023.08.016","article-title":"Global Prevalence of Urinary Tract Infection in Pregnant Mothers: A Systematic Review and Meta-Analysis","volume":"224","author":"Salari","year":"2023","journal-title":"Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s12126-024-09569-6","article-title":"Global Prevalence of Urinary Tract Infections in the Older Persons: A Systematic Review and Meta-Analysis","volume":"49","author":"Kalhori","year":"2024","journal-title":"Ageing Int."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mancuso, G., Midiri, A., Gerace, E., Marra, M., Zummo, S., and Biondo, C. (2023). Urinary Tract Infections: The Current Scenario and Future Prospects. Pathogens, 12.","DOI":"10.3390\/pathogens12040623"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijid.2014.03.1393","article-title":"Detection of Virulence Genes in Escherichia Coli Isolated from Patients with Cystitis and Pyelonephritis","volume":"29","author":"Firoozeh","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/IAI.00323-09","article-title":"Urothelial Cultures Support Intracellular Bacterial Community Formation by Uropathogenic Escherichia Coli","volume":"77","author":"Berry","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Behzadi, P., Urb\u00e1n, E., and Gajd\u00e1cs, M. (2020). Association between Biofilm-Production and Antibiotic Resistance in Uropathogenic Escherichia Coli (UPEC): An in Vitro Study. Diseases, 8.","DOI":"10.3390\/diseases8020017"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sarshar, M., Behzadi, P., Ambrosi, C., Zagaglia, C., Palamara, A.T., and Scribano, D. (2020). FimH and Anti-Adhesive Therapeutics: A Disarming Strategy against Uropathogens. Antibiotics, 9.","DOI":"10.3390\/antibiotics9070397"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"aad3292","DOI":"10.1126\/science.aad3292","article-title":"Multidrug Evolutionary Strategies to Reverse Antibiotic Resistance","volume":"351","author":"Baym","year":"2016","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nasrollahian, S., Graham, J.P., and Halaji, M. (2024). A Review of the Mechanisms That Confer Antibiotic Resistance in Pathotypes of E. coli. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1387497"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mare\u0219, C., Petca, R.-C., Popescu, R.-I., Petca, A., Mul\u021bescu, R., Bulai, C.A., Ene, C.V., Geavlete, P.A., Geavlete, B.F., and Jinga, V. (2024). Update on Urinary Tract Infection Antibiotic Resistance\u2014A Retrospective Study in Females in Conjunction with Clinical Data. Life, 14.","DOI":"10.3390\/life14010106"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Terlizzi, M.E., Gribaudo, G., and Maffei, M.E. (2017). UroPathogenic Escherichia Coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-Antibiotic Antimicrobial Strategies. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01566"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/5584_2020_566","article-title":"The Role of Gram-Negative Bacteria in Urinary Tract Infections: Current Concepts and Therapeutic Options","volume":"1323","author":"Behzadi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_22","unstructured":"(2024, September 30). Available online: https:\/\/www.who.int\/health-topics\/one-health#tab=tab_1."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s00345-019-03071-4","article-title":"Epidemiology of urological infections: A global burden","volume":"38","author":"Murt","year":"2020","journal-title":"World J. Urol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Han, Z., Yi, X., Li, J., Liao, D., and Ai, J. (2024). Nonantibiotic Prophylaxis for Urinary Tract Infections: A Network Meta-Analysis of Randomized Controlled Trials. Infection.","DOI":"10.1007\/s15010-024-02357-z"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Scaglione, F., Musazzi, U.M., and Minghetti, P. (2021). Considerations on D-Mannose Mechanism of Action and Consequent Classification of Marketed Healthcare Products. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.636377"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"De Nunzio, C., Bartoletti, R., Tubaro, A., Simonato, A., and Ficarra, V. (2021). Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040373"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.euf.2020.09.004","article-title":"Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature","volume":"7","author":"Kyriakides","year":"2021","journal-title":"Eur. Urol. Focus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12937-022-00769-x","article-title":"Role of D-Mannose in Urinary Tract Infections\u2014A Narrative Review","volume":"21","author":"Laitila","year":"2022","journal-title":"Nutr. J."},{"key":"ref_29","first-page":"CD013608","article-title":"D-Mannose for Preventing and Treating Urinary Tract Infections","volume":"8","author":"Cooper","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2165\/00003495-200969070-00002","article-title":"Cranberry and Urinary Tract Infections","volume":"69","author":"Guay","year":"2009","journal-title":"Drugs"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.phytochem.2005.05.022","article-title":"A-Type Cranberry Proanthocyanidins and Uropathogenic Bacterial Anti-Adhesion Activity","volume":"66","author":"Howell","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Howell, A.B., Botto, H., Combescure, C., Blanc-Potard, A.-B., Gausa, L., Matsumoto, T., Tenke, P., Sotto, A., and Lavigne, J.-P. (2010). Dosage Effect on Uropathogenic Escherichia Coli Anti-Adhesion Activity in Urine Following Consumption of Cranberry Powder Standardized for Proanthocyanidin Content: A Multicentric Randomized Double Blind Study. BMC Infect. Dis., 10.","DOI":"10.1186\/1471-2334-10-94"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Babar, A., Moore, L., Leblanc, V., Dudonn\u00e9, S., Desjardins, Y., Lemieux, S., Bochard, V., Guyonnet, D., and Dodin, S. (2021). High Dose versus Low Dose Standardized Cranberry Proanthocyanidin Extract for the Prevention of Recurrent Urinary Tract Infection in Healthy Women: A Double-Blind Randomized Controlled Trial. BMC Urol., 21.","DOI":"10.1186\/s12894-021-00811-w"},{"key":"ref_34","first-page":"CD001321","article-title":"Cranberries for Preventing Urinary Tract Infections","volume":"10","author":"Jepson","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3945\/an.115.011197","article-title":"Cranberries and Urinary Tract Infections: How Can the Same Evidence Lead to Conflicting Advice?","volume":"7","author":"Liska","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.juro.2017.03.078","article-title":"Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical Trials","volume":"198","author":"Domingues","year":"2017","journal-title":"J. Urol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/MCG.0000000000002002","article-title":"World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics","volume":"58","author":"Guarner","year":"2024","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.euf.2018.06.011","article-title":"The Urinary Tract Microbiome: The Answer to All Our Open Questions?","volume":"5","author":"Magistro","year":"2019","journal-title":"Eur. Urol. Focus"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"104544","DOI":"10.1016\/j.micpath.2020.104544","article-title":"Understanding the Potential of Lactobacilli in Recurrent UTI Prevention","volume":"148","author":"Vagios","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1479-5876-10-174","article-title":"Integrated Next-Generation Sequencing of 16S rDNA and Metaproteomics Differentiate the Healthy Urine Microbiome from Asymptomatic Bacteriuria in Neuropathic Bladder Associated with Spinal Cord Injury","volume":"10","author":"Fouts","year":"2012","journal-title":"J. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41585-018-0106-x","article-title":"Nonantibiotic Prevention and Management of Recurrent Urinary Tract Infection","volume":"15","author":"Sihra","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kenneally, C., Murphy, C.P., Sleator, R.D., and Culligan, E.P. (2022). The Urinary Microbiome and Biological Therapeutics: Novel Therapies for Urinary Tract Infections. Microbiol. Res., 259.","DOI":"10.1016\/j.micres.2022.127010"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/cid\/cir183","article-title":"Randomized, Placebo-Controlled Phase 2 Trial of a Lactobacillus Crispatus Probiotic given Intravaginally for Prevention of Recurrent Urinary Tract Infection","volume":"52","author":"Stapleton","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/archinternmed.2012.777","article-title":"Lactobacilli vs. antibiotics to prevent urinary tract infections: A randomized, double-blind, noninferiority trial in postmenopausal women","volume":"172","author":"Beerepoot","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1086\/318070","article-title":"Assessment of the capacity of Lactobacillus to inhibit the growth of uro-pathogens and block their adhesion to vaginal epithelial cells","volume":"183","author":"Osset","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1067\/mob.2001.115867","article-title":"Defense factors of vaginal lactobacil-li","volume":"185","author":"Aroutcheva","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0928-8244(02)00465-0","article-title":"Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: Randomized, placebo-controlled trial in 64 healthy women","volume":"35","author":"Reid","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_48","first-page":"CD008772","article-title":"Probiotics for Preventing Urinary Tract Infections in Adults and Children","volume":"2015","author":"Schwenger","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-5347(17)39897-X","article-title":"Bladder Surface Glycosaminoglycans: An Epithelial Permeability Barrier","volume":"143","author":"Parsons","year":"1990","journal-title":"J. Urol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1128\/iai.27.3.876-881.1980","article-title":"Antibacterial Activity of Bladder Surface Mucin Duplicated in the Rabbit Bladder by Exogenous Glycosaminoglycan (Sodium Pentosanpolysulfate)","volume":"27","author":"Parsons","year":"1980","journal-title":"Infect. Immun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/iju.12430","article-title":"Restoring the Glycosaminoglycans Layer in Recurrent Cystitis: Experimental and Clinical Foundations: GAG and UTI, from Lab to Clinic","volume":"21","author":"Cicione","year":"2014","journal-title":"Int. J. Urol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/bju.15756","article-title":"Guideline of Guidelines: Management of Recurrent Urinary Tract Infections in Women","volume":"130","author":"Kwok","year":"2022","journal-title":"BJU Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00192-017-3508-z","article-title":"Intravesical Hyaluronic Acid and Chondroitin Sulfate for Recurrent Urinary Tract Infections: Systematic Review and Meta-Analysis","volume":"29","author":"Goddard","year":"2018","journal-title":"Int. Urogynecol. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/SPV.0000000000000560","article-title":"Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Postcoital Recurrent Urinary Tract Infections: Analysis of 98 Women in Reproductive Age after 6 Months of Treatment","volume":"25","author":"Schiavi","year":"2019","journal-title":"Female Pelvic. Med. Reconstr. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/jsxmed\/qdae052","article-title":"Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: A randomized crossover trial","volume":"21","author":"Boeri","year":"2024","journal-title":"J. Sex. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/jb.86.3.445-448.1963","article-title":"Action of Formaldehyde on Microorganisms. Iii. Bactericidal Action of Sublethal Concentrations of Formaldehyde on Aerobacter Aerogenes: Bactericidal Action of Sublethal Concentrations of Formaldehyde on Aerobacter Aerogenes","volume":"86","author":"Neely","year":"1963","journal-title":"J. Bacteriol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ogc.2021.05.005","article-title":"Recurrent Urinary Tract Infections: Diagnosis, Treatment, and Prevention","volume":"48","author":"Peck","year":"2021","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_58","first-page":"CD003265","article-title":"Methenamine Hippurate for Preventing Urinary Tract Infections","volume":"10","author":"Lee","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e068229","DOI":"10.1136\/bmj-2021-0068229","article-title":"Alternative to Prophylactic Antibiotics for the Treatment of Recurrent Urinary Tract Infections in Women: Multicentre, Open Label, Randomised, Non-Inferiority Trial","volume":"376","author":"Harding","year":"2022","journal-title":"BMJ"},{"key":"ref_60","first-page":"231","article-title":"Metabolic and Functional Stimulation of Lymphocytes and Macrophages by an Escherichia Coli Extract (OM-89): In Vitro Studies","volume":"9","author":"Kreis","year":"1990","journal-title":"J. Biol. Response Mod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijantimicag.2007.07.018","article-title":"Immunostimulation with Escherichia Coli Extract: Prevention of Recurrent Urinary Tract Infections","volume":"31","author":"Ha","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/bju.14606","article-title":"Vaccines for the Prevention of Recurrent Urinary Tract Infections: A Systematic Review","volume":"123","author":"Aziminia","year":"2019","journal-title":"BJU Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.euf.2019.11.002","article-title":"Role of Vaccines for Recurrent Urinary Tract Infections: A Systematic Review","volume":"6","author":"Prattley","year":"2020","journal-title":"Eur. Urol. Focus"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000371894","article-title":"A Randomized, Double-Blind, Parallel-Group, Multicenter Clinical Study of Escherichia Coli-Lyophilized Lysate for the Prophylaxis of Recurrent Uncomplicated Urinary Tract Infections","volume":"95","author":"Wagenlehner","year":"2015","journal-title":"Urol. Int."},{"key":"ref_65","first-page":"EVIDoa2100018","article-title":"Sublingual MV140 for Prevention of Recurrent Urinary Tract Infections","volume":"1","author":"Foley","year":"2022","journal-title":"NEJM Evid."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_67","first-page":"1000104","article-title":"Psidium guajava (Guava): A Plant of Multipurpose Medicinal Applications","volume":"1","author":"Barbalho","year":"2012","journal-title":"Med. Aromat. Plants"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","article-title":"Plant Products as Antimicrobial Agents","volume":"12","author":"Cowan","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on Plant Antimicrobials: A Mechanistic Viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.foodcont.2014.05.047","article-title":"Natural Products as Antimicrobial Agents","volume":"46","author":"Gyawali","year":"2014","journal-title":"Food Control"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.tips.2016.05.001","article-title":"Natural Products as a Source for Novel Antibiotics","volume":"37","author":"Moloney","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"12415","DOI":"10.1021\/acs.chemrev.7b00283","article-title":"Natural Products as Platforms to Overcome Antibiotic Resistance","volume":"117","author":"Rossiter","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ferdosh, S. (2023). Ethnobotanical Review of Selected Medicinal Plants in Guam for the Treatment of Urinary Tract Ailments and Their Pharmacological Properties. Sci. Pharm., 91.","DOI":"10.3390\/scipharm91030043"},{"key":"ref_74","unstructured":"Morrison, J., Geraghty, P., and Crowl, L. (1994). The Use of traditional medicine & healers on Guam: Suruh\u00e5nas, Suruh\u00e5nos yan i Che\u2019cho niha. Science of Pacific Island Peoples: Fuana, Flora, Food and Medicine, Institute of Pacific Studies, University of the South Pacific."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tache, A.M., Dinu, L.D., and Vamanu, E. (2022). Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections. Appl. Sci., 12.","DOI":"10.3390\/app12052635"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12301-020-00111-z","article-title":"Deep insights into urinary tract infections and effective natural remedies","volume":"27","author":"Bazzaz","year":"2021","journal-title":"Afr. J. Urol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/14787210.2021.1828061","article-title":"Medicinal Plants Consumption against Urinary Tract Infections: A Narrative Review of the Current Evidence","volume":"19","author":"Poulios","year":"2021","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00345-002-0293-0","article-title":"Botanical Medicines for the Urinary Tract","volume":"20","author":"Yarnell","year":"2002","journal-title":"World J. Urol."},{"key":"ref_79","first-page":"277","article-title":"Medicinal Plants and Urinary Tract Infections: An Update","volume":"2","author":"Bag","year":"2008","journal-title":"Pharmacogn. Rev."},{"key":"ref_80","unstructured":"European Medicines Agency (EMA) (2012). Assessment Report on Arctostaphylos Uva-ursi (L.) Spreng., Folium, EMA\/HMPC\/573462\/2009 Rev. 1 Committee on Herbal Medicinal Products (HMPC)."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/009127002401102740","article-title":"Urinary Excretion and Metabolism of Arbutin after Oral Administration of Arctostaphylos Uvae Ursi Extract as Film-Coated Tablets and Aqueous Solution in Healthy Humans","volume":"42","author":"Schindler","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1055\/s-2005-837782","article-title":"Urinary Excretion of Arbutin Metabolites after Oral Administration of Bearberry Leaf Extracts","volume":"71","author":"Quintus","year":"2005","journal-title":"Planta Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408440701638970","article-title":"Hydroquinone: An Evaluation of the Human Risks from Its Carcinogenic and Mutagenic Properties","volume":"37","author":"McGregor","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/1091581813507721","article-title":"Risk Assessment of Free Hydroquinone Derived from Arctostaphylos uva-ursi Folium Herbal Preparations","volume":"32","author":"Naser","year":"2013","journal-title":"Int. J. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/(SICI)1099-1573(199905)13:3<222::AID-PTR447>3.0.CO;2-P","article-title":"Effect of Extracts of Orthosiphon Stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in Rats","volume":"13","author":"Beaux","year":"1999","journal-title":"Phytother. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1139\/Y07-106","article-title":"In Vitro Activity of Uva-Ursi against Cytochrome P450 Isoenzymes and P-Glycoprotein","volume":"85","author":"Chauhan","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0011-393X(05)80204-8","article-title":"Prophylactic Effect of UVA-E in Women with Recurrent Cystitis: A Preliminary Report","volume":"53","author":"Larsson","year":"1993","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cmi.2019.01.011","article-title":"Uva-Ursi Extract and Ibuprofen as Alternative Treatments for Uncomplicated Urinary Tract Infection in Women (ATAFUTI): A Factorial Randomized Trial","volume":"25","author":"Moore","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.cmi.2021.05.032","article-title":"Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: A randomized controlled trial","volume":"27","author":"Hummers","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Villanueva, X., Zhen, L., Ares, J.N., Vackier, T., Lange, H., Crestini, C., and Steenackers, H.P. (2022). Effect of Chemical Modifications of Tannins on Their Antimicrobial and Antibiofilm Effect against Gram-Negative and Gram-Positive Bacteria. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.987164"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1248\/bpb.27.1965","article-title":"Antimicrobial Activity of 10 Different Plant Polyphenols against Bacteria Causing Food-Borne Disease","volume":"27","author":"Taguri","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/ptr.5616","article-title":"Scope of Hydrolysable Tannins as Possible Antimicrobial Agent: Scope of Hydrolysable Tannins as Antimicrobial Agents","volume":"30","author":"Ekambaram","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Slobodn\u00edkov\u00e1, L., Fialov\u00e1, S., Rendekov\u00e1, K., Kov\u00e1\u010d, J., and Mu\u010daji, P. (2016). Antibiofilm Activity of Plant Polyphenols. Molecules, 21.","DOI":"10.3390\/molecules21121717"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/jac\/48.4.487","article-title":"Antibacterial Action of Several Tannins against Staphylococcus Aureus","volume":"48","author":"Akiyama","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Trentin, D.S., Silva, D.B., Amaral, M.W., Zimmer, K.R., Silva, M.V., Lopes, N.P., Giordani, R.B., and Macedo, A.J. (2013). Tannins Possessing Bacteriostatic Effect Impair Pseudomonas Aeruginosa Adhesion and Biofilm Formation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066257"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ulrey, R.K., Barksdale, S.M., Zhou, W., and van Hoek, M.L. (2014). Cranberry Proanthocyanidins Have Anti-Biofilm Properties against Pseudomonas aeruginosa. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-499"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"28511","DOI":"10.1021\/acsami.6b10491","article-title":"Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing","volume":"8","author":"Ninan","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/0976-237X.149289","article-title":"Comparative Assessment of Cranberry and Chlorhexidine Mouthwash on Streptococcal Colonization among Dental Students: A Randomized Parallel Clinical Trial","volume":"6","author":"Khairnar","year":"2015","journal-title":"Contemp. Clin. Dent."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Fasinu, P.S., Bouic, P.J., and Rosenkranz, B. (2012). An Overview of the Evidence and Mechanisms of Herb-Drug Interactions. Front. Pharmacol., 3.","DOI":"10.3389\/fphar.2012.00069"},{"key":"ref_100","first-page":"70","article-title":"Possible Herbal-Drug Interactions an Evidenced Base Review","volume":"28","author":"Arora","year":"2022","journal-title":"Altern. Ther. Health Med."},{"key":"ref_101","unstructured":"Watt, M.J., and Breyer-Brandwijk, M.G. (1962). The Medicinal and Poisonous Plants of Southem and Eastern Africa, E. and S. Livingstone. [2nd ed.]."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-8741(98)00143-3","article-title":"Euphorbia Hirta Leaf Extracts Increase Urine Output and Electrolytes in Rats","volume":"65","author":"Johnson","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"72","DOI":"10.9734\/IJTDH\/2012\/1050","article-title":"Antimicrobial Properties of Euphorbia Hyssopifolia and Euphorbia Hirta against Pathogens Complicit in Wound, Typhoid and Urinary Tract Infections","volume":"2","author":"Alisi","year":"2014","journal-title":"Int. J. Trop. Dis. Health"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5251\/abjna.2012.3.4.169.174","article-title":"In-Vitro Antimicrobial Activities of Euphorbia Hirta against Some Clinical Isolates","volume":"3","author":"Titilope","year":"2012","journal-title":"Agric. Biol. J. N. Am."},{"key":"ref_105","first-page":"281","article-title":"An Overview on Phytoconstituents and Multiple Biological Activities of Euphorbia Hirta","volume":"10","author":"Chandel","year":"2023","journal-title":"Plant Sci. Today"},{"key":"ref_106","first-page":"162","article-title":"Cytotoxicity and Antimicrobial Property of the Leaf Extract of Euphorbia hirta (Tawa-Tawa)","volume":"03","author":"Enerva","year":"2015","journal-title":"Open J. Soc. Sci."},{"key":"ref_107","first-page":"17","article-title":"Evaluation of antimicrobial activity of E. hirta and Calotropis procera against MDR patogenes","volume":"3","author":"Pandey","year":"2013","journal-title":"IJPAES."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.3390\/molecules15096008","article-title":"Assessment of Euphorbia Hirta L. Leaf, Flower, Stem and Root Extracts for Their Antibacterial and Antifungal Activity and Brine Shrimp Lethality","volume":"15","author":"Rajeh","year":"2010","journal-title":"Molecules"},{"key":"ref_109","first-page":"439","article-title":"Antibacterial activity of Euphorbia hirta extracts","volume":"3","author":"Saravanan","year":"2012","journal-title":"Int. J. Res. Ayurveda Pharm."},{"key":"ref_110","unstructured":"Burkill, H.M. (1994). The Useful Plants of West Tropical Africa, Royal Botanic Gardens. [2nd ed.]."},{"key":"ref_111","first-page":"793","article-title":"Ethno Medicines Used for Treatment of Prostatic Disease in Foumban, Cameroon","volume":"4","author":"Emmanuel","year":"2010","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Coker, M.E., Oaikhena, A.O., and Ajayi, T.O. (2021). Antimicrobial Activity of Extracts and Fractions of Euphorbia Lateriflora (Schum. and Thonn) on Microbial Isolates of the Urinary Tract. Saudi J. Biol. Sci., 28.","DOI":"10.1016\/j.sjbs.2021.04.086"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jep.2011.09.040","article-title":"Phyllanthus Amarus: Ethnomedicinal Uses, Phytochemistry and Pharmacology: A Review","volume":"138","author":"Patel","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_114","first-page":"19","article-title":"Screening of Antibacterial Activity of the Medicinal Plant Phyllanthus Amarus against Urinary Tract Infection Causing Bacterial Pathogens","volume":"1","author":"Saranraj","year":"2012","journal-title":"Appl. J. Hyg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4314\/ijs.v23i2.16","article-title":"Antimicrobial Activity of Sida Acuta, Phyllanthus Amarus and Phyllanthus Muellerianus against Microorganisms Implicated in Urinary Tract Infections","volume":"23","author":"Obuotor","year":"2021","journal-title":"Ife J. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15406\/icpjl.2019.07.00191","article-title":"Antibacterial effects of Phyllantus amarus on urinary tract pathogens","volume":"7","author":"Oladosu","year":"2019","journal-title":"Int. Clin. Pathol. J."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Prananda, A.T., Dalimunthe, A., Harahap, U., Simanjuntak, Y., Peronika, E., Karosekali, N.E., Hasibuan, P.A.Z., Syahputra, R.A., Situmorang, P.C., and Nurkolis, F. (2023). Phyllanthus emblica: A Comprehensive Review of Its Phytochemical Composition and Pharmacological Properties. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1288618"},{"key":"ref_118","first-page":"142","article-title":"Assessment of the Antimicrobial Activity of the Ethanolic Extract of Phyllanthus emblica in Combination with Different Classes of Antibiotics against Single and Multi-Drug Resistant Strains","volume":"4","author":"Jahan","year":"2015","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_119","first-page":"78","article-title":"Antibacterial Effect of Amlaki (Phyllanthus emblica) Extract against Pseudomonas aeruginosa","volume":"3","author":"Farhana","year":"2022","journal-title":"J. Clin. Images Med. Case Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.14202\/vetworld.2020.1388-1396","article-title":"Harnessing the Antibacterial Activity of Quercus Infectoria and Phyllanthus emblica against Antibiotic-Resistant Salmonella Typhi and Salmonella Enteritidis of Poultry Origin","volume":"13","author":"Nair","year":"2020","journal-title":"Vet. World"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Thembane, N., Hlatshwayo, S., Ngcobo, M., Ngubane, P., and Gqaleni, N. (2024). Review on the Anti-Hyperglycemic Potential of Psidium guajava and Seriphium plumosum L. Plants, 13.","DOI":"10.3390\/plants13121608"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1386207326666230426093315","article-title":"Psidium guajava: An Insight into Ethnomedicinal Uses, Phytochemistry, and Pharmacology","volume":"27","author":"Chechani","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zhu, X., Ouyang, W., Lan, Y., Xiao, H., Tang, L., Liu, G., Feng, K., Zhang, L., Song, M., and Cao, Y. (2020). Anti-Hyperglycemic and Liver Protective Effects of Flavonoids from Psidium guajava L. (Guava) Leaf in Diabetic Mice. Food Biosci., 35.","DOI":"10.1016\/j.fbio.2020.100574"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Tousif, M.I., Nazir, M., Saleem, M., Tauseef, S., Shafiq, N., Hassan, L., Hussian, H., Montesano, D., Naviglio, D., and Zengin, G. (2022). Psidium guajava L. an Incalculable but Underexplored Food Crop: Its Phytochemistry, Ethnopharmacology, and Industrial Applications. Molecules, 27.","DOI":"10.3390\/molecules27207016"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1080\/10408398.2023.2173720","article-title":"Family Myrtaceae: The Treasure Hidden in the Complex\/Diverse Composition","volume":"64","author":"Saber","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Lok, B., Babu, D., Tabana, Y., Dahham, S.S., Adam, M.A.A., Barakat, K., and Sandai, D. (2023). The Anticancer Potential of Psidium guajava (Guava) Extracts. Life, 13.","DOI":"10.3390\/life13020346"},{"key":"ref_127","first-page":"323","article-title":"Medicinal Plants and Traditional Knowledge in the Northern Mariana Islands","volume":"8","author":"Nandwani","year":"2008","journal-title":"J. Appl. Biosci."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"D\u00edaz-de-Cerio, E., Verardo, V., G\u00f3mez-Caravaca, A.M., Fern\u00e1ndez-Guti\u00e9rrez, A., and Segura-Carretero, A. (2017). Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040897"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.peptides.2008.03.013","article-title":"Identification of a Novel Storage Glycine-Rich Peptide from Guava (Psidium guajava) Seeds with Activity against Gram-Negative Bacteria","volume":"29","author":"Pelegrini","year":"2008","journal-title":"Peptides"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.peptides.2012.07.017","article-title":"Antimicrobial Activity of Recombinant Pg-AMP1, a Glycine-Rich Peptide from Guava Seeds","volume":"37","author":"Tavares","year":"2012","journal-title":"Peptides"},{"key":"ref_131","first-page":"47","article-title":"Antibacterial Activity of Guava (Psidium guajava l.) Extracts on Staphylococcus Aureus Isolated from Patients with Urinary Tract Infections Attending a Tertiary-Care Hospital","volume":"14","author":"Yahaya","year":"2019","journal-title":"Sci. World J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2478\/cipms-2019-0029","article-title":"Anticholinesterase and Antioxidant Activities of Foliar Extract from a Tropical Species: Psidium guajava L. (Myrtaceae) Grown in Algeria","volume":"32","author":"Bouchoukh","year":"2019","journal-title":"Curr. Issues Pharm. Med. Sci."},{"key":"ref_133","first-page":"e52345","article-title":"Susceptibility and Synergistic Effects of Guava Plant Extract and Antimicrobial Drugs on Escherichia coli","volume":"16","author":"Mitra","year":"2024","journal-title":"Cureus"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3436940","DOI":"10.1155\/2020\/3436940","article-title":"Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L. Leaf Extracts","volume":"2020","author":"Simamora","year":"2020","journal-title":"Int. J. Food Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-8741(99)00019-7","article-title":"Isolation and Antibacterial Activity of Phenylpropanoid Derivatives from Ballota Nigra","volume":"67","author":"Didry","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF02979128","article-title":"Antibacterial Phenylpropanoid Glycosides from Paulownia Tomentosa Steud","volume":"17","author":"Kang","year":"1994","journal-title":"Arch. Pharm. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3892\/ijmm.2017.2990","article-title":"Forsythoside A Exerts an Anti-Endotoxin Effect by Blocking the LPS\/TLR4 Signaling Pathway and Inhibiting Tregs in Vitro","volume":"40","author":"Zeng","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_138","first-page":"e47659","article-title":"Preparation and Evaluation of Antimicrobial Property and Anti-Inflammatory Activity of Fenugreek Gel against Oral Microbes: An Invitro Study","volume":"15","author":"Sindhusha","year":"2023","journal-title":"Cureus"},{"key":"ref_139","first-page":"236","article-title":"Antibacterial efficacy of Fenugreek Seed Extract Rinse against Streptococcus Mutants Colonies","volume":"9","author":"Quraishi","year":"2021","journal-title":"J. Res. Med. Dent. Sci."},{"key":"ref_140","first-page":"122","article-title":"Screening of antimicrobial activity of fenugreek seeds","volume":"2","author":"Walli","year":"2015","journal-title":"Pharm. Pharmacol. Int. J."},{"key":"ref_141","first-page":"817","article-title":"Evaluating the Antibacterial Activity of Fenugreek (Trigonella Foenum-Graecum) Seed Extract against A Selection of Different Pathogenic Bacteria","volume":"8","author":"Alwhibi","year":"2014","journal-title":"JPAM"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Aldawsari, M.F., Khafagy, E.-S., Saqr, A.A., Alalaiwe, A., Abbas, H.A., Shaldam, M.A., Hegazy, W.A.H., and Goda, R.M. (2021). Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon. Antibiotics, 10.","DOI":"10.3390\/antibiotics10070871"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00203-020-02039-y","article-title":"Sotolon Is a Natural Virulence Mitigating Agent in Serratia Marcescens","volume":"203","author":"Abbas","year":"2021","journal-title":"Arch. Microbiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1021\/jf010818j","article-title":"Sotolone Production by Hairy Root Cultures of Trigonella Foenum-Graecum in Airlift with Mesh Bioreactors","volume":"49","author":"Bessiere","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_145","unstructured":"(2024, September 27). Available online: https:\/\/www.who.int\/tools\/elena\/interventions\/vitamind-infants."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"V20","DOI":"10.1359\/jbmr.07s214","article-title":"Substrate and Enzyme Trafficking as a Means of Regulating 1,25-Dihydroxyvitamin D Synthesis and Action: The Human Innate Immune Response","volume":"22","author":"Adams","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-012-9615-4","article-title":"Vitamin D Bone Health Childhood Adolescence","volume":"92","author":"Winzberg","year":"2013","journal-title":"Calcif. Tiss. Int."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00284-011-0006-2","article-title":"Probiotic Therapy: Immunomodulating Approach Toward Urinary Tract Infection","volume":"63","author":"Amdekar","year":"2011","journal-title":"Curr. Microbiol."},{"key":"ref_149","first-page":"CD011806","article-title":"Vitamin D for the Treatment of Inflammatory Bowel Disease","volume":"10","author":"Wallace","year":"2023","journal-title":"Cochrane Libr."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Cao, M., He, C., Gong, M., Wu, S., and He, J. (2023). The Effects of Vitamin D on All-Cause Mortality in Different Diseases: An Evidence-Map and Umbrella Review of 116 Randomized Controlled Trials. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1132528"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1371\/journal.pone.0015580","article-title":"Vitamin D Induction Human Antimicrobial Peptide Cathelicidin, Urinary Bladder","volume":"5","author":"Hertting","year":"2010","journal-title":"PLoS ONE"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1678S","DOI":"10.1093\/ajcn\/80.6.1678S","article-title":"Sunlight Vitamin D Bone Health Prevention Autoimmune Disease, Cancers, Cardiovascular Disease","volume":"80","author":"Holick","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.sjbs.2020.08.008","article-title":"Vitamin D Deficiency as a Risk Factor for Urinary Tract Infection in Women at Reproductive Age","volume":"27","author":"Ali","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Mercy, D.J., Girigoswami, A., and Girigoswami, K. (2024). Relationship between Urinary Tract Infections and Serum Vitamin D Level in Adults and Children- a Literature Review. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-024-09888-6"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Hassanein, M.M., Huri, H.Z., Abduelkarem, A.R., and Baig, K. (2023). Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women. Nutrients, 15.","DOI":"10.3390\/nu15173804"},{"key":"ref_156","first-page":"240","article-title":"Serum Vitamin D and Zinc Levels in Children with Urinary Tract Infection without Confounding Factors: A Case-Control Study","volume":"38","author":"Seifollahi","year":"2024","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s15010-021-01750-2","article-title":"Lower Serum Levels of Vitamin D in Adults with Urinary Tract Infection","volume":"50","author":"Liu","year":"2022","journal-title":"Infection"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Sori\u0107 Hosman, I., Cvitkovi\u0107 Roi\u0107, A., and Lamot, L. (2022). A Systematic Review of the (Un)Known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection. Front. Med., 9.","DOI":"10.3389\/fmed.2022.931717"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Gan, Y., You, S., Ying, J., and Mu, D. (2023). The Association between Serum Vitamin D Levels and Urinary Tract Infection Risk in Children: A Systematic Review and Meta-Analysis. Nutrients, 15.","DOI":"10.3390\/nu15122690"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41390-018-0092-y","article-title":"Vitamin D Receptor Gene (FokI, TaqI, BsmI, and ApaI) Polymorphisms in Children with Urinary Tract Infection","volume":"84","author":"Mahyar","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/23744235.2016.1201853","article-title":"Prevention of urinary tract infections with vitamin D supplementation 20,000\u2009IU per week for five years. Results from an RCT including 511 subjects","volume":"48","author":"Jorde","year":"2016","journal-title":"Infect. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Merrikhi, A., Ziaei, E., Shahsanai, A., Kelishadi, R., and Maghami-Mehr, A. (2018). Is Vitamin D Supplementation Effective in Prevention of Recurrent Urinary Tract Infections in the Pediatrics? A Randomized Triple-Masked Controlled Trial. Adv. Biomed. Res., 7.","DOI":"10.4103\/abr.abr_149_18"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2310\/JIM.0b013e31821b8755","article-title":"Vitamin D and the Immune System","volume":"59","author":"Aranow","year":"2011","journal-title":"J. Investig. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D Metabolism, Mechanism of Action, and Clinical Applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4110\/in.2011.11.5.245","article-title":"Antimicrobial Peptides in Innate Immunity against Mycobacteria","volume":"11","author":"Shin","year":"2011","journal-title":"Immune Netw."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-981-13-3588-4_3","article-title":"Elementary Processes and Mechanisms of Interactions of Antimicrobial Peptides with Membranes-Single Giant Unilamellar Vesicle Studies","volume":"1117","author":"Hasan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00441-019-03162-z","article-title":"Vitamin D Strengthens the Bladder Epithelial Barrier by Inducing Tight Junction Proteins during E. coli Urinary Tract Infection","volume":"380","author":"Mohanty","year":"2020","journal-title":"Cell Tissue Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jnutbio.2006.10.006","article-title":"Vitamin A Regulation of Gene Expression: Molecular Mechanism of a Prototype Gene","volume":"18","author":"McGrane","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0140-6736(93)92478-C","article-title":"Abnormal T-Cell Subset Proportions in Vitamin-A-Deficient Children","volume":"341","author":"Semba","year":"1993","journal-title":"Lancet"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Ross, A.C., Chen, Q., and Ma, Y. (2011). Vitamin A and Retinoic Acid in the Regulation of B-Cell Development and Antibody Production. Vitamins & Hormones, Elsevier.","DOI":"10.1016\/B978-0-12-386960-9.00005-8"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1079\/PNS2002172","article-title":"Vitamin A as an Anti-Inflammatory Agent","volume":"61","author":"Reifen","year":"2002","journal-title":"Proc. Nutr. Soc."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/0006-291X(89)91369-7","article-title":"Vitamin A and Glutathione-Mediated Free Radical Damage: Competing Reactions with Polyunsaturated Fatty Acids and Vitamin C","volume":"161","author":"Dunster","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1046\/j.1464-410x.1999.00063.x","article-title":"The Role of Vitamin A in Preventing Renal Scarring Secondary to Pyelonephritis","volume":"83","author":"Soylu","year":"1999","journal-title":"BJU Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s004670100577","article-title":"The Effect of Vitamin A on the Course of Renal Ablation Nephropathy","volume":"16","author":"Soylu","year":"2001","journal-title":"Pediatr. Nephrol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00431-010-1297-1","article-title":"The Effect of Vitamin A on Renal Damage Following Acute Pyelonephritis in Children","volume":"170","author":"Ayazi","year":"2011","journal-title":"Eur. J. Pediatr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ctim.2018.12.007","article-title":"Vitamin A Supplementation Is Effective for Improving the Clinical Symptoms of Urinary Tract Infections and Reducing Renal Scarring in Girls with Acute Pyelonephritis: A Randomized, Double-Blind Placebo-Controlled, Clinical Trial Study","volume":"42","author":"Kahbazi","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00467-015-3098-2","article-title":"The Effect of Vitamin A on Renal Damage Following Acute Pyelonephritis in Children: A Meta-Analysis of Randomized Controlled Trials","volume":"31","author":"Zhang","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1442-200X.2007.02370.x","article-title":"Adjuvant Effect of Vitamin A on Recurrent Lower Urinary Tract Infections","volume":"49","author":"Yilmaz","year":"2007","journal-title":"Pediatr. Int."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/QCO.0b013e328320a885","article-title":"Prevention of Recurrent Urinary Tract Infection in Children","volume":"22","author":"Williams","year":"2009","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1096\/fasebj.13.9.1007","article-title":"Does vitamin C act as a pro-oxidant under physiological conditions?","volume":"13","author":"Carr","year":"1999","journal-title":"FASEB J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1476-5381.2009.00282.x","article-title":"Vitamin C: Update on physiology and pharmacology","volume":"157","author":"Mandl","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e418","DOI":"10.1186\/s13054-015-1131-2","article-title":"Ascorbate-dependent vasopressor synthesis: A rationale for vitamin C administration in severe sepsis and septic shock?","volume":"19","author":"Carr","year":"2015","journal-title":"Crit. Care"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.nu.06.070186.002053","article-title":"The biochemical functions of ascorbic acid","volume":"6","author":"Englard","year":"1986","journal-title":"Annu. Rev. Nutr."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev-nutr-071714-034228","article-title":"Regulation of the epigenome by vitamin C","volume":"35","author":"Young","year":"2015","journal-title":"Annu. Rev. Nutr."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Carr, A., and Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9.","DOI":"10.3390\/nu9111211"},{"key":"ref_187","first-page":"88","article-title":"Antimicrobial activity of vitamin C demonstrated on uropathogenic Escherichia coli and Klebsiella pneumonia","volume":"3","author":"Verghese","year":"2020","journal-title":"J. Curr. Res. Sci. Med."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Pandit, S., Ravikumar, V., Abdel-Haleem, A.M., Derouiche, A., Mokkapati, V.R.S.S., Sihlbom, C., Mineta, K., Gojobori, T., Gao, X., and Westerlund, F. (2017). Low concentrations of vitamin C reduce the synthesis of extracellular polymers and destabilize bacterial biofilms. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.02599"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"128171","DOI":"10.1016\/j.foodchem.2020.128171","article-title":"In vitro and in situ abrogation of biofilm formation in E. coli by vitamin C through ROS generation, disruption of quorum sensing and exopolysaccharide production","volume":"341","author":"Shivaprasad","year":"2021","journal-title":"Food Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"103894","DOI":"10.1016\/j.isci.2022.103894","article-title":"Bactericidal, anti-biofilm, and anti-virulence activity of vitamin C against carbapenem-resistant hypervirulent Klebsiella pneumonia","volume":"25","author":"Xu","year":"2022","journal-title":"iScience"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"El-Gebaly, E., Essam, T., Hashem, S., and El-Baky, R.A. (2012). Effect of levofloxacin and vitamin C on bacterial adherence and preformed biofilm on urethral catheter surfaces. J. Microb. Biochem. Technol., 4.","DOI":"10.4172\/1948-5948.1000083"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Stolarek, P., Bernat, P., and R\u00f3\u017calski, A. (2022). Combined Application of Aminoglycosides and Ascorbic Acid in the Elimination of Proteus Mirabilis Rods Responsible for Causing Catheter-Associated Urinary Tract Infections (CAUTIs)\u2014A Molecular Approach. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113069"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Hassuna, N.A., Rabie, E.M., Mahd, W.K.M., Refaie, M.M.M., Yousef, R.K.M., and Abdelraheem, W.M. (2023). Antibacterial Effect of Vitamin C against Uropathogenic E. coli in Vitro and in Vivo. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-02856-3"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/2772432817666211230100723","article-title":"Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis","volume":"17","author":"Keya","year":"2022","journal-title":"Curr. Rev. Clin. Exp. Pharmacol."},{"key":"ref_195","first-page":"e57071","article-title":"Efficacy of Ascorbic Acid Supplementation in Relief of Symptoms Due to Febrile Upper Urinary Tract Infection in Children, a Clinical Trial and Hospital Based Study","volume":"6","author":"Yousefichaijan","year":"2018","journal-title":"Arch. Pediatr. Infect. Dis."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/jicm.2021.0300","article-title":"Effects of a Supplement Containing a Cranberry Extract on Recurrent Urinary Tract Infections and Intestinal Microbiota: A Prospective, Uncontrolled Exploratory Study","volume":"28","author":"Jeitler","year":"2022","journal-title":"J. Integr. Complement. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3945\/ajcn.116.130542","article-title":"Consumption of a Cranberry Juice Beverage Lowered the Number of Clinical Urinary Tract Infection Episodes in Women with a Recent History of Urinary Tract Infection","volume":"103","author":"Maki","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.eururo.2016.05.042","article-title":"Effectiveness of Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study","volume":"70","author":"Montorsi","year":"2016","journal-title":"Eur Urol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0003-9861(83)90145-5","article-title":"Is Vitamin E the Only Lipid-Soluble, Chain-Breaking Antioxidant in Human Blood Plasma and Erythrocyte Membranes?","volume":"221","author":"Burton","year":"1983","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/iub.1986","article-title":"Vitamin E: Regulatory Role on Signal Transduction","volume":"71","author":"Zingg","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/09537104.2019.1652262","article-title":"Inhibition of Platelet Activation Using Vitamins","volume":"31","author":"Kobzar","year":"2020","journal-title":"Platelets"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/iub.1976","article-title":"Regulatory Role of Vitamin E in the Immune System and Inflammation","volume":"71","author":"Lewis","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000098074","article-title":"The Inhibitory Effect of Vitamin E on Cigarette Smoke-Induced Oxidative Damage to the Rat Urothelium: Can It Prevent Transitional Cell Carcinoma?","volume":"78","author":"Demir","year":"2007","journal-title":"Urol. Int."},{"key":"ref_204","first-page":"97","article-title":"Vitamin E as Adjuvant Treatment for Urinary Tract Infection in Girls with Acute Pyelonephritis","volume":"9","author":"Yousefichaijan","year":"2015","journal-title":"Iran. J. Kidney Dis."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/14\/2\/144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:25:37Z","timestamp":1760027137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/14\/2\/144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":204,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["antibiotics14020144"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics14020144","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]}}}