{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:07:30Z","timestamp":1789099650328,"version":"build-2803163510"},"reference-count":100,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPEMA, Maranh\u00e3o State Foundation","award":["2885\/17"],"award-info":[{"award-number":["2885\/17"]}]},{"name":"FAPEMA, Maranh\u00e3o State Foundation","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"PDPG CAPES\/FAPEMA Proc. ACT-01784\/21","award":["2885\/17"],"award-info":[{"award-number":["2885\/17"]}]},{"name":"PDPG CAPES\/FAPEMA Proc. ACT-01784\/21","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Brazilian Research Council (CNPq)","award":["2885\/17"],"award-info":[{"award-number":["2885\/17"]}]},{"name":"Brazilian Research Council (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: The increased rates of common fungal diseases are a constant challenge. Therefore, the search for plant-based compounds with antifungal activity, particularly ones against Candida species, is always relevant in the medical context. However, most of the studies have focused on screening the antifungal activity of extracts rather than isolated compounds. Based on this, we aimed to analyze and organize a comprehensive overview of the antifungal and other biological activities of isolated compounds found in Anacardiaceae family vegetal species, covering mechanisms of action and potential therapeutic applications. Results: The extracts, essential oils, and compounds are frequently assayed for anti-Candida activity using the in vitro minimum inhibitory concentration (MIC), minimum fungicide concentration (MFC), and halo inhibition assays. Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata, C. krusei, and C. guilliermondii were the most tested fungus species. Essential oils were the most used form (37% of the studies). The isolated compounds included shikimic acid, 2-hydroxy-1,8-cineole \u03b2-D-glucopyranoside, myricitrin, cardanol, estragole, trans-anethole, \u03b2-caryophyllene, myrcene, catechin-3-O-rhamnoside, \u03b2-sitosterol-3-O-glucoside, 24Z-isomasticadienolic acid, oleanolic acid, pistagremic acid, apigenin, sakuranetin, oleanolic aldehyde, and integriside. Conclusions: Our data indicate that the compounds isolated from Anacardiaceae species show promise for developing new therapeutic antifungal drugs, mainly if we consider their other biological activities, including anti-inflammatory, antioxidant, and apoptotic effects. In this context, they may be candidates for future treatments of fungal infections, especially in combination with conventional antifungals or when used in nanostructured formulations, which may result in a new avenue of using plant extracts and isolated compounds.<\/jats:p>","DOI":"10.3390\/antibiotics14030308","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:49:57Z","timestamp":1742197797000},"page":"308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anacardiaceae Family: Effect of Isolated Compounds and Other Identified Phytochemicals Against Clinically Relevant Candida Species\u2014A Short Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Rosane Nassar Meireles","family":"Guerra","sequence":"first","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-0686","authenticated-orcid":false,"given":"Alu\u00edsio Silva","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josivan Regis","family":"Farias","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Cristine Gomes","family":"Franco","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela Gomes","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle Teixeira","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Batista","family":"Muniz","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-0879","authenticated-orcid":false,"given":"Afonso Gomes","family":"Abreu","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-1806","authenticated-orcid":false,"given":"Flavia Raquel Fernandes","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofisiologia, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o, Campus Bacanga, Av. dos Portugueses, 1966, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15698\/mic2020.06.718","article-title":"Fungal infections in humans: The silent crisis","volume":"7","author":"Kainz","year":"2020","journal-title":"Microb. 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