{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:01:20Z","timestamp":1792598480654,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0120800"],"award-info":[{"award-number":["2022YFE0120800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: As probiotics gain prominence in the prevention and treatment of intestinal diseases, their protective effects against pathogens and influence on host health have drawn significant attention. This study investigates the genomic characteristics and functional potential of Pediococcus acidilactici XJ-24 (XJ-24) in the prevention of Listeria monocytogenes (LM) infection in mice. Methods\/Results: Whole-genome analysis confirmed the safety and probiotic properties of XJ-24, including acid and bile salt tolerance, antimicrobial activity, and safety. In vivo, C57BL\/6 mice challenges indicated that XJ-24 significantly reduced LM colonization, suppressed pro-inflammatory cytokines (IL-1\u03b2, IL-6, TNF-\u03b1, IFN-\u03b3), alleviated colon and spleen tissue damage, and maintained intestinal barrier integrity by upregulating tight junction proteins (Occludin, Claudin-1, ZO-1). Moreover, XJ-24 modulated gut microbiota composition by increasing beneficial taxa while reducing harmful bacteria. Correlation analysis highlighted a positive association between Lachnospiraceae and tight junction proteins. Conclusions: These findings demonstrate the potential of XJ-24 as a functional probiotic for preventing LM infection and provide a basis for further clinical exploration.<\/jats:p>","DOI":"10.3390\/antibiotics14030323","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T06:10:53Z","timestamp":1742364653000},"page":"323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Whole Genome Analysis of Pediococcus acidilactici XJ-24 and Its Role in Preventing Listeria monocytogenes ATCC\u00ae 19115TM Infection in C57BL\/6 Mice"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6444-8613","authenticated-orcid":false,"given":"Weizhong","family":"Hu","sequence":"first","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chinese-Hungarian Cooperative Research Center for Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chinese-Hungarian Cooperative Research Center for Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-765X","authenticated-orcid":false,"given":"Amel","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Alexandria University, Alexandria 21500, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass, Southwest University, Chongqing 400716, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-5212","authenticated-orcid":false,"given":"Sameh","family":"Awad","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Alexandria University, Alexandria 21500, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-519X","authenticated-orcid":false,"given":"Jos\u00e9","family":"Ramos-Vivas","sequence":"additional","affiliation":[{"name":"Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Kan","sequence":"additional","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chinese-Hungarian Cooperative Research Center for Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-4635","authenticated-orcid":false,"given":"Muying","family":"Du","sequence":"additional","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chinese-Hungarian Cooperative Research Center for Food Science, Southwest University, Chongqing 400715, China"},{"name":"Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1021\/acs.jafc.3c07931","article-title":"Antibacterial Activity and Mechanism of Action of Osthole against Listeria monocytogenes","volume":"72","author":"Kong","year":"2024","journal-title":"J. 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