{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:09:37Z","timestamp":1793376577487,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Argentinian Society of Infectious Diseases (SADI)"},{"name":"Argentinian Society for Critical Care (SATI)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: Data on multidrug-resistant organism (MDRO) infections in children are scarce, especially in resource-limited regions. This study aimed to estimate the prevalence of MDRO infections in pediatric intensive care units (PICUs) and characterize their epidemiologic and clinical features. Methods: A national, multicenter, point-prevalence study was conducted in 50 PICUs in Argentina over 24 h between 24 and 28 November 2023. The primary study outcome was the prevalence of ICU infections caused by MDROs. Secondary outcomes included the prevalence of carbapenemase-producing Enterobacterales (CPE) colonization, ICU mortality, and ICU length of stay (LOSICU). Results: 304 patients were included. The overall prevalence of infection was 45.1% (137\/304); of these, 50.3% (69\/137) were hospital-acquired. Among the 137 patients with reported infections, 49.6% (n = 68) were classified as definite (microbiologically confirmed) and 50.4% (n = 69) as probable (no confirmatory microbiology). Among definite infections, 20.6% (n = 14) were due to MDROs. The overall prevalence of MDRO infections was 4.6% (14\/304). Extended-spectrum \u03b2-lactamase (ESBL)-producing organisms were the most commonly identified microorganisms (42.9%), followed by CPE (28.6%). Ventilator-associated pneumonia (VAP) was the most frequent location of MDRO infections. The prevalence of CPE colonization was 13.2%. Mortality was low (5.3%) and similar in patients with MDRO and non-MDRO infections. LOSICU was longer in patients with MDRO infections compared to patients with non-MDRO infections (81 [22\u2013150] vs. 25 [12\u201327] days, respectively, p = 0.0007). Conclusions: Among 304 PICU patients, the prevalence of MDRO infections and colonization was relatively low. MDRO infections were not associated with increased mortality but were associated with longer ICU stays, compared to patients with non-MDRO infections.<\/jats:p>","DOI":"10.3390\/antibiotics14050493","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T10:58:07Z","timestamp":1747047487000},"page":"493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Associated Mortality of Infections by Multidrug-Resistant Organisms in Pediatric Intensive Care Units in Argentina (PREV-AR-P)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-8552","authenticated-orcid":false,"given":"Wanda","family":"Cornistein","sequence":"first","affiliation":[{"name":"Hospital Universitario Austral, Buenos Aires 1629, Argentina"},{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Argentinian Society for Critical Care (SATI), Buenos Aires 1414, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-9960","authenticated-orcid":false,"given":"Carina","family":"Balasini","sequence":"additional","affiliation":[{"name":"Argentinian Society for Critical Care (SATI), Buenos Aires 1414, Argentina"},{"name":"Hospital Pirovano, Buenos Aires 1430, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanina","family":"Nuccetelli","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital Interzonal de Agudos San Mart\u00edn de La Plata, Buenos Aires 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7591-5061","authenticated-orcid":false,"given":"Viviana M.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital Torn\u00fa, Buenos Aires 1427, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8900-9774","authenticated-orcid":false,"given":"Norma","family":"Cudmani","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Departamento de Control de Infecciones y Gesti\u00f3n de Antimicrobianos, Ministerio de Salud P\u00fablica, Tucum\u00e1n 4000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7402-0176","authenticated-orcid":false,"given":"Maria Virginia","family":"Roca","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital Zonal Alvear, Comodoro Rivadavia 9001, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Sadino","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Clinica Universitaria Reina Fabiola, C\u00f3rdoba 5000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-449X","authenticated-orcid":false,"given":"Mart\u00edn","family":"Brizuela","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital General de Agudos Dr. Juan A. Fern\u00e1ndez, Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Argentinian Society for Critical Care (SATI), Buenos Aires 1414, Argentina"},{"name":"Hospital Durand, Buenos Aires 1405, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-5667","authenticated-orcid":false,"given":"Soledad","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Ministerio de Salud de la Provincia de Buenos Aires, Buenos Aires 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-3199","authenticated-orcid":false,"given":"Dami\u00e1n","family":"\u00c1guila","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital Provincial del Centenario, Rosario 2000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5235-8976","authenticated-orcid":false,"given":"Alejandra","family":"Macchi","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Sanatorio Las Lomas, Buenos Aires 1609, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-7215","authenticated-orcid":false,"given":"Maria In\u00e9s","family":"Staneloni","sequence":"additional","affiliation":[{"name":"Argentinian Society of Infectious Diseases (SADI), Buenos Aires 1414, Argentina"},{"name":"Hospital Italiano de Buenos Aires, Buenos Aires 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-5688","authenticated-orcid":false,"given":"Elisa","family":"Estenssoro","sequence":"additional","affiliation":[{"name":"Argentinian Society for Critical Care (SATI), Buenos Aires 1414, Argentina"},{"name":"Hospital Interzonal de Agudos San Mart\u00edn de La Plata, Buenos Aires 1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"ref_1","unstructured":"CDC (2025, February 04). 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