{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:35:54Z","timestamp":1787726154711,"version":"build-2784847793"},"reference-count":48,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u00c7anakkale Onsekiz Mart University The Scientific Research Coordination Unit","award":["TTU-2024-4782"],"award-info":[{"award-number":["TTU-2024-4782"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: This study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR) Acinetobacter baumannii strain. Methods: Thirty-six female Wistar albino rats were inoculated intravesically with XDR A. baumannii to induce cystitis. Twenty-four rats that developed infection were divided into four groups: untreated control, saline irrigation, low-dose tigecycline (6.25 mg\/kg), and high-dose tigecycline (25 mg\/kg). Microbiological clearance was assessed via urine cultures on days 3 and 5. Bladder tissues were analyzed histopathologically and for genotoxicity using the Comet assay. Results: On day 5, microbiological clearance was significantly higher in tigecycline-treated groups compared to controls (p = 0.028). Histopathology revealed significantly more inflammation in the high-dose tigecycline group (p = 0.029). Genotoxicity was observed in both tigecycline groups, independent of dose (p &lt; 0.05). Conclusions: Intravesical tigecycline demonstrated microbiological efficacy against XDR A. baumannii-induced cystitis. However, its inflammatory and genotoxic potential necessitates further preclinical evaluation.<\/jats:p>","DOI":"10.3390\/antibiotics14060611","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T10:47:22Z","timestamp":1750070842000},"page":"611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-9163","authenticated-orcid":false,"given":"Cihan","family":"Y\u00fcksel","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u015f\u0131l D.","family":"Al\u0131ravc\u0131","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Ko\u015fan","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-7910","authenticated-orcid":false,"given":"Sinem","family":"Esen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevin\u00e7","family":"Yenice Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-4691","authenticated-orcid":false,"given":"Neslihan","family":"Kaya Terzi","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-6929","authenticated-orcid":false,"given":"Ahmet Ali","family":"Berber","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-2477","authenticated-orcid":false,"given":"Sevil","family":"Alkan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7anakkale Onsekiz Mart University, 17000 \u00c7anakkale, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/nau.21003","article-title":"Epidemiology and healthcare utilization of neurogenic bladder patients in a US claims database","volume":"30","author":"Manack","year":"2011","journal-title":"Neurourol. 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