{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:38:39Z","timestamp":1773081519596,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Infections caused by carbapenem-resistant Enterobacterales have steadily multiplied over time, becoming a major threat to healthcare systems due to limited therapeutic options and high case-fatality rates. Case report: We studied a patient who, after being discharged from an ICU, developed salmonellosis caused by an antibiotic-susceptible S. enteritidis. After undergoing treatment with ciprofloxacin, the patient presented an episode of asymptomatic bacteriuria originated by a carbapenem and ciprofloxacin-resistant S. enteritidis. Results: Whole genome sequencing analysis revealed that both Salmonella isolates belonged to the same strain, and that isolate SEn_T2 acquired a plasmid carrying both blaNDM-1 and qnrA1 genes (pIncCSEn) which was previously present in the patient\u2019s gut in at least one Enterobacter cloacae isolate. Additionally, pIncCSEN was identified as a putatively new sub-lineage of IncC2 plasmids which lacked the first copy of the methyltransferase gene dcm and the rhs gene. The resistance genes blaNDM-1 and qnrA1 were incorporated into a Tn21-derived transposon that included a complex class 1 integron whose genetic arrangement was: intI1- dfrA12- orfF- aadA2- qacE\u03941-sul1-ISCR1- trpF- ble- blaNDM-1 (in reverse direction)- ISAba125-ISCR1- qnrA- cmlA1- qacE\u03941-sul1. Conclusions: Antimicrobial persistence and co-selection of antibiotic resistance play an important role in the dissemination of antimicrobial resistance genes; in this regard, a joint effort involving the infection control team, effective antibiotic stewardship, and genomic surveillance could help mitigate the spread of these multidrug resistant microorganisms.<\/jats:p>","DOI":"10.3390\/antibiotics14060620","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:11:07Z","timestamp":1750313467000},"page":"620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-3879","authenticated-orcid":false,"given":"Nicol\u00e1s F.","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Bacteriolog\u00eda y Virolog\u00eda, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-783X","authenticated-orcid":false,"given":"Romina","family":"Papa-Ezdra","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Bacteriolog\u00eda y Virolog\u00eda, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-5311","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Traglia","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00f3mica y Bioinform\u00e1tica, Departamento de Ciencias Biol\u00f3gicas, CENUR Litoral Norte, Universidad de la Rep\u00fablica, Salto 50000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Bado","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Bacteriolog\u00eda y Virolog\u00eda, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Garc\u00eda-Fulgueiras","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Bacteriolog\u00eda y Virolog\u00eda, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda N.","family":"Cortinas","sequence":"additional","affiliation":[{"name":"Departamentos de Laboratorios de Salud P\u00fablica, Ministerio de Salud P\u00fablica, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Caiata","sequence":"additional","affiliation":[{"name":"Departamentos de Laboratorios de Salud P\u00fablica, Ministerio de Salud P\u00fablica, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"L\u00f3pez-Vega","sequence":"additional","affiliation":[{"name":"Departamentos de Laboratorios de Salud P\u00fablica, Ministerio de Salud P\u00fablica, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Otero","sequence":"additional","affiliation":[{"name":"Departamentos de Laboratorios de Salud P\u00fablica, Ministerio de Salud P\u00fablica, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Sanatorio C\u00edrculo Cat\u00f3lico, Montevideo 11800, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hitateguy","sequence":"additional","affiliation":[{"name":"Sanatorio C\u00edrculo Cat\u00f3lico, Montevideo 11800, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mogdasy","sequence":"additional","affiliation":[{"name":"Departamentos de Laboratorios de Salud P\u00fablica, Ministerio de Salud P\u00fablica, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-9966","authenticated-orcid":false,"given":"Rafael","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Bacteriolog\u00eda y Virolog\u00eda, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Andino, A., and Hanning, I. (2015). Salmonella Enterica: Survival, Colonization, and Virulence Differences among Serovars. Sci. World J., 2015.","DOI":"10.1155\/2015\/520179"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/cid\/cix669","article-title":"2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea","volume":"65","author":"Shane","year":"2017","journal-title":"Clin. Infect. 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