{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:44:00Z","timestamp":1778039040496,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok, ul. Kili\u0144skiego 1, 15-089 Bialystok, Poland","award":["SUB\/1\/DN\/21\/001\/1164"],"award-info":[{"award-number":["SUB\/1\/DN\/21\/001\/1164"]}]},{"name":"Medical University of Bialystok, ul. Kili\u0144skiego 1, 15-089 Bialystok, Poland","award":["SUB\/1\/DN\/22\/001\/1164"],"award-info":[{"award-number":["SUB\/1\/DN\/22\/001\/1164"]}]},{"name":"Kulzer GmbH Polska","award":["SUB\/1\/DN\/21\/001\/1164"],"award-info":[{"award-number":["SUB\/1\/DN\/21\/001\/1164"]}]},{"name":"Kulzer GmbH Polska","award":["SUB\/1\/DN\/22\/001\/1164"],"award-info":[{"award-number":["SUB\/1\/DN\/22\/001\/1164"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Objectives: Comparison of clinical, radiological, and microbiological outcomes following periodontal regeneration procedures with or without local antibiotic therapy. Methods: Forty patients, each presenting with a single vertical defect, were randomly assigned to either the test (SRP+ANB+MIST\/M-MIST) or the control group (SRP+MIST\/M-MIST). The periodontal regenerative procedures were carried out according to the general minimally invasive surgical technique principles, and the vertical bone defect was filled with an enamel matrix derivative (EMD\u2014Emdogain\u00ae). Periodontal condition assessments were performed two weeks before the procedure, on the day of the surgical procedure, and at follow-up visit after 6 months. Radiographs were taken two weeks before, and 6 months after the surgery. To determine the microbiological profile of the surgical sites, subgingival plaque samples were collected for PCR analysis. Results: In both groups, a statistically significant pocket depth (PD) reduction and clinical attachment level (CAL) gain were observed over the 6-month follow-up period. The difference between the groups for PD and CAL parameters at 6 months was not statistically significant. Both groups showed a statistically significant reduction in the radiological depth and width of intrabony defects. Microbiological analysis revealed a statistically significant difference between the groups two weeks after subgingival antibiotic application for Fusobacterium nucleatum, Tannerella forsythia, and Prevotella intermedia. Conclusions: Periodontal tissue regeneration procedures according to minimally invasive principles (MIST\/M-MIST) with the use of EMD lead to improvements in clinical and radiological parameters. Local antibiotic application results in a reduction in bacterial counts in short-term observations. Its use prior to regeneration procedures does not lead to additional improvements in clinical and radiological parameters.<\/jats:p>","DOI":"10.3390\/antibiotics14090850","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:31:26Z","timestamp":1755865886000},"page":"850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Influence of Local Antibiotic Therapy on the Microbiological, Clinical, and Radiological Outcomes Following Minimally Invasive Periodontal Surgery in the Treatment of Intrabony Defects\u2014A Randomized Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-3552","authenticated-orcid":false,"given":"Anna","family":"Skurska","sequence":"first","affiliation":[{"name":"Department of Integrated Dentistry, Medical University of Bialystok, ul. M. Sk\u0142odowskiej-Curie 24A, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-1978","authenticated-orcid":false,"given":"Amelia","family":"Baczewska","sequence":"additional","affiliation":[{"name":"Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 13, 15-269 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-8283","authenticated-orcid":false,"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Medical University of Bialystok, ul. Szpitalna 37, 15-295 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-4581","authenticated-orcid":false,"given":"Piotr","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bia\u0142ystok, ul. Waszyngtona 15A, 15-269 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-6483","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Charkiewicz","sequence":"additional","affiliation":[{"name":"Center of Experimental Medicine, Medical University of Bialystok, ul. M. Sk\u0142odowskiej-Curie 24a, 15-276 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990\u20132010: A systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/jcpe.13381","article-title":"Periodontal infrabony defects: Systematic review of healing by defect morphology following regenerative surgery","volume":"48","author":"Nibali","year":"2021","journal-title":"J. Clin. 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