{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:56Z","timestamp":1760060396415,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: Veillonella species are Gram-negative, non-motile, non-fermentative, obligate anaerobic cocci. They are typically considered commensals of the oral cavity, respiratory tract, genitourinary tract, and gastrointestinal tract. It may be a rare cause of dental infections and discitis\/spondylodiscitis. Methods: We report the case of an 80-year-old patient diagnosed with discitis caused by Veillonella parvula, isolated from blood. In addition, we performed a comprehensive literature review summarizing all reported cases of discitis or spondylodiscitis caused by Veillonella species. Results: In our case, antimicrobial susceptibility testing was performed using the Kirby\u2013Bauer disc diffusion method. Based on the results, the patient was treated with amoxicillin\/clavulanate, which led to a favourable clinical outcome. A review of the literature revealed that, to date, only 14 cases of spondylodiscitis or discitis caused by Veillonella spp. have been reported. Potential risk factors for Veillonella spp. bacteremia were identified in only 9 cases. The most commonly affected site was the lumbar or lumbosacral spine. Magnetic resonance imaging was consistently regarded as the diagnostic gold standard. Most patients presented with localized pain. The overall therapeutic approach generally consisted of an initial course of intravenous antibiotics, typically ceftriaxone administered either as monotherapy or in combination with metronidazole, followed by an oral regimen with amoxicillin\/clavulanate, given alone or alongside metronidazole. Conclusions: Spondylodiscitis due to V. parvula remains extremely rare. Although antimicrobial susceptibility patterns remain heterogeneous, beta-lactams, particularly amoxicillin\/clavulanate, appear effective in most cases, and treatment regimens typically involve an initial intravenous phase followed by oral therapy.<\/jats:p>","DOI":"10.3390\/antibiotics14090854","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:10:36Z","timestamp":1756080636000},"page":"854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Veillonella parvula as a Causative Agent of Discitis: Insights from a Clinical Case and Literature Overview"],"prefix":"10.3390","volume":"14","author":[{"given":"Giulio","family":"D\u2019Agati","sequence":"first","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Mignone","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Bartolone","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppa","family":"Sciortino","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Maria Assunta","family":"Fasciana","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Microbiology and Virology Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Cal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Microbiology and Virology Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bonura","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Carini","sequence":"additional","affiliation":[{"name":"Biomedicine, Neurosciences and Advanced Diagnostics BIND, School of Medicine, University of Palermo, 90133 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Pipit\u00f2","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-1796","authenticated-orcid":false,"given":"Antonio","family":"Cascio","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG D\u2019Alessandro\u201d, University of Palermo, 90127 Palermo, Italy"},{"name":"Infectious and Tropical Disease Unit, AOU Policlinico \u201cP. Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1099\/00207713-32-1-28","article-title":"Taxonomy of the genus Veillonella prevot","volume":"32","author":"Mays","year":"1982","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.medmal.2018.10.001","article-title":"Veillonella parvula spondylodiscitis","volume":"49","author":"Gouze","year":"2019","journal-title":"Med. Mal. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.25259\/SNI_769_2021","article-title":"Spondylodiscitis due to anaerobic bacteria Veillonella parvula: Case report and literature review","volume":"12","author":"Ziga","year":"2021","journal-title":"Surg. Neurol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/JB.02512-14","article-title":"The interaction between Streptococcus spp. and Veillonella tobetsuensis in the early stages of oral biofilm formation","volume":"197","author":"Mashima","year":"2015","journal-title":"J. Bacteriol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/JCM.01633-06","article-title":"Veillonella parvula discitis and secondary bacteremia: A rare infection complicating endoscopy and colonoscopy?","volume":"45","author":"Marriott","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e005108","DOI":"10.1099\/jmmcr.0.005108","article-title":"Lytic lesions: Looking lethal but leaving room for a simple cure? A case of Veillonella spinal osteomyelitis","volume":"4","author":"Baker","year":"2017","journal-title":"JMM Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/154405910808700308","article-title":"Diversity of Veillonella spp. from sound and carious sites in children","volume":"87","author":"Arif","year":"2008","journal-title":"J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e04660","DOI":"10.1002\/ccr3.4660","article-title":"Epidural abscess and spondylitis caused by Veillonella parvula in a man on hemodialysis","volume":"9","author":"Kurihara","year":"2021","journal-title":"Clin. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jinf.2003.11.008","article-title":"Prosthetic valve endocarditis caused by Veillonella parvula","volume":"50","author":"Boo","year":"2005","journal-title":"J. Infect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7326\/0003-4819-86-1-63","article-title":"Veillonella parvula septicemia and osteomyelitis","volume":"86","author":"Borchardt","year":"1977","journal-title":"Ann. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1752-1947-8-365","article-title":"Non-vertebral Veillonella species septicemia and osteomyelitis in a patient with diabetes: A case report and review of the literature","volume":"8","year":"2014","journal-title":"J. Med. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1086\/314046","article-title":"Veillonella parvula meningitis: Case report and review of Veillonella infections","volume":"31","author":"Bhatti","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1097\/MS9.0000000000002278","article-title":"Emerging liver infection of Veillonella parvula associated with acute respiratory distress syndrome: A case report","volume":"86","author":"Malkoc","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102879","DOI":"10.1016\/j.anaerobe.2024.102879","article-title":"Bacteremia caused by Veillonella parvula: Two case reports and a review of the literature","volume":"88","author":"Cobo","year":"2024","journal-title":"Anaerobe"},{"key":"ref_15","first-page":"524","article-title":"Decubitus ulcer infection and bacteremia due to tazobactam\/piperacillin-resistant Veillonella parvula","volume":"86","author":"Sahara","year":"2024","journal-title":"Nagoya J. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jbspin.2003.10.019","article-title":"Total hip prosthetic joint infection due to Veillonella species","volume":"71","author":"Genevay","year":"2004","journal-title":"Jt. Bone Spine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/PL00011273","article-title":"Prosthetic joint infection due to Veillonella dispar","volume":"20","author":"Marchandin","year":"2001","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF01584370","article-title":"Two fatal cases of Veillonella bacteremia","volume":"17","author":"Liu","year":"1998","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jiac.2015.12.015","article-title":"Osteomyelitis caused by Veillonella species: Case report and review of the literature","volume":"22","author":"Hirai","year":"2016","journal-title":"J. Infect. Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0732-8893(03)00082-8","article-title":"Age-related frequency of penicillin resistance of oral Veillonella","volume":"46","author":"Nyfors","year":"2003","journal-title":"Diagn. Microbiol. Infect. Dis."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/14\/9\/854\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:35:02Z","timestamp":1760034902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/14\/9\/854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["antibiotics14090854"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics14090854","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2025,8,24]]}}}