{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:03:40Z","timestamp":1793088220711,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Airlangga Research Fund 2024","award":["672\/UN3\/2024"],"award-info":[{"award-number":["672\/UN3\/2024"]}]},{"name":"Airlangga Research Fund 2024","award":["JPMH23HA2005"],"award-info":[{"award-number":["JPMH23HA2005"]}]},{"name":"Health and Labour Science Research Grant","award":["672\/UN3\/2024"],"award-info":[{"award-number":["672\/UN3\/2024"]}]},{"name":"Health and Labour Science Research Grant","award":["JPMH23HA2005"],"award-info":[{"award-number":["JPMH23HA2005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: The prevalence of ESBL-producing Escherichia coli (E. coli) has increased significantly, impacting prognoses due to delayed or limited treatment options. We aimed to determine the demographic patterns, risk factors, and clinical outcomes of ESBL-producing E. coli in a top-referral hospital in Indonesia. Methods: This study was observational in design and focused on hospitalized patients with bacteremia due to E. coli during 2022\u20132024. Results: We identified 224 patients during the study period. The median of length of stay was 7 (3\u201313) days. Mortality occurred in 149 (66.55%) patients, and there was no difference in the mortality between patients with ESBL E. coli and those with non-ESBL E. coli. The severity of illness, as defined by the Pitt bacteremia score (PBS), was higher in the ESBL E. coli group. Urinary tract infection (UTI), previous antibiotic use, and central venous catheter (CVC) insertion were independent risk factors for bacteremia due to ESBL E. coli bacteremia. Male gender, shorter length of stay (LOS), solid tumor, pneumonia, mechanical ventilation, CVC insertion, inappropriate initial antibiotic therapy (IIAT), and sequential organ failure assessment (SOFA) score were risk factors for mortality in bacteremia caused by E. coli, including both ESBL and non-ESBL producers. Male gender, shorter LOS, CVC usage, and SOFA score were independent risk factors for mortality in bacteremia due to ESBL E. coli. Conclusions: ESBL-producing E. coli increases the severity of bacteremia. Recognizing patients at high risk for ESBL-producing E. coli infections is crucial for initiating appropriate empirical antibiotic treatment targeting ESBL-producing pathogens.<\/jats:p>","DOI":"10.3390\/antibiotics14090882","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:02:57Z","timestamp":1756825377000},"page":"882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors and Clinical Impact of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Bacteremia Among Hospitalized Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-5098","authenticated-orcid":false,"given":"Tri Pudy","family":"Asmarawati","sequence":"first","affiliation":[{"name":"Doctoral Programme of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia"},{"name":"Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya 60115, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-5454","authenticated-orcid":false,"given":"Fikri Sasongko","family":"Widyatama","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Basuki","family":"Notobroto","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Population Studies, Faculty of Public Health, Universitas Airlangga, Surabaya 60115, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasronudin","family":"Nasronudin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia"},{"name":"Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya 60115, Indonesia"},{"name":"Institute Tropical of Diseases, Universitas Airlangga, Surabaya 60115, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Sugai","sequence":"additional","affiliation":[{"name":"AMR Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 102-0071, Japan"},{"name":"Department of Antimicrobial Resistance, Hiroshima University Graduate School of Biomedical Science, Hiroshima 739-0046, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-8879","authenticated-orcid":false,"given":"Kuntaman","family":"Kuntaman","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia"},{"name":"Institute Tropical of Diseases, Universitas Airlangga, Surabaya 60115, Indonesia"},{"name":"Department of Clinical Microbiology, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Husna, A., Rahman, M.M., Badruzzaman, A.T.M., Sikder, M.H., Islam, M.R., Rahman, M.T., Alam, J., and Ashour, H.M. 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