{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:49:31Z","timestamp":1792648171116,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: The integration of silver nanoparticles (AgNPs) into plastic materials has emerged as a promising strategy to provide biomedical and dental devices with an active antimicrobial barrier. In this review, we aimed to synthesize the scientific evidence published between 2013 and 2024 regarding the therapeutic efficacy, biocompatibility, and safety of AgNP-functionalized plastics by following the 2020 PRISMA guidelines. Methods: Searches were conducted in PubMed, Scopus, Web of Science, SciELO, and ScienceDirect. A total of 634 records were identified, of which 21 studies met the inclusion criteria after full-text evaluation. Results: Plastics containing AgNPs show a significant reduction in microbial load (Escherichia coli, Stafilococcus aureus, and Candida albicans) and exhibit controlled release of Ag+ ions, with generally low cytotoxicity levels. The most frequent applications included catheters, dental prostheses, dressings, and orthodontic resins. However, methodological heterogeneity and the scarcity of clinical trials limit the extrapolation of findings. Conclusions: AgNPs confer relevant therapeutic advantages to polymers, but long-term clinical studies are needed to confirm their safety and effectiveness.<\/jats:p>","DOI":"10.3390\/antibiotics14121267","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:15:08Z","timestamp":1765811708000},"page":"1267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Silver Nanoparticles Used in Medical\u2013Dental Plastics for Therapeutic Purposes: A Comprehensive Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3136-9381","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Maruri-Casas","sequence":"first","affiliation":[{"name":"Doctoral Student in Health Sciences Program, Research Center and Advanced Studies in Dentistry \u201cDr. Keisaburo Miyata\u201d, Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-7790","authenticated-orcid":false,"given":"Edith","family":"Lara-Carrillo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Research Center and Advanced Studies in Dentistry \u201cDr. Keisaburo Miyata\u201d, Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-0771","authenticated-orcid":false,"given":"V\u00edctor Hugo","family":"Toral-Rizo","sequence":"additional","affiliation":[{"name":"Head of the Department of Oral Medicine and Bucal Pathology, Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-8650","authenticated-orcid":false,"given":"Ra\u00fal Alberto","family":"Morales-Luckie","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Center for Research in Sustainable Chemistry, Autonomous University of the State of Mexico, Toluca 50200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-4558","authenticated-orcid":false,"given":"Gloria Elena","family":"Guzm\u00e1n-Celaya","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Sinaloa, Culiac\u00e1n 80010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-4850","authenticated-orcid":false,"given":"Norma Guadalupe","family":"Iba\u00f1ez-Mancera","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Health Sciences CICS-UST, National Polytechnic Institute, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-6644","authenticated-orcid":false,"given":"Francisco Javier","family":"Tejeda-Nava","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of San Luis Potos\u00ed, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9230-2068","authenticated-orcid":false,"given":"Sara\u00ed Carmina","family":"Guadarrama-Reyes","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-6388","authenticated-orcid":false,"given":"El\u00edas Nah\u00fam","family":"Salmer\u00f3n-Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0471-5316","authenticated-orcid":false,"given":"Ana Miriam","family":"Santill\u00e1n-Reyes","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca 50130, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M., and Rizzolio, F. 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