{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:26:34Z","timestamp":1791235594426,"version":"4.1.0"},"reference-count":137,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health for the IRCCS Rizzoli Orthopedic Institute of Bologna","award":["5 \u00d7 1000 2022 (n. 2024\/731138, CUPD33C23001460001. PI: CR Arciola)"],"award-info":[{"award-number":["5 \u00d7 1000 2022 (n. 2024\/731138, CUPD33C23001460001. PI: CR Arciola)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>To address the challenges in wound healing, clinical management increasingly demands targeted, adaptive, responsive, and patient-centered strategies. This is especially true for wounds characterized by delayed healing and a high risk of infection. Advances in regenerative medicine and biomaterial technologies are fostering the development of multifunctional approaches that integrate tissue regeneration, antibacterial\/antibiofilm activity, immunomodulation, and real-time monitoring. This paper surveys emerging platforms, including both natural and synthetic scaffolds, hydrogels enriched with platelet-derived growth factors, glycosaminoglycan mimetics, bioactive peptides (such as GHK-Cu and antimicrobial peptides), nanoscaffolds, and stimuli-responsive systems. The paper also explores cutting-edge technologies such as water-powered, electronics-free dressings that deliver localized electrical stimulation; biodegradable bioelectric sutures that produce self-sustained mechano-electrical signals; and sensory bandages that monitor pH, moisture, temperature, and bacterial contamination in real-time while enabling on-demand drug release with pro-regenerative, antibacterial, and other therapeutic functionalities. Further therapeutic approaches include natural matrices, exosomes, gene editing, 3D bioprinting, and AI-assisted design. Particular attention is paid to orthopedic applications and orthopedic implant infection. A brief section addresses the still unresolved challenge of articular cartilage regeneration. Interdisciplinary innovation, integrating insights from molecular biology through engineering, plays a central role in translating novel strategies into tailored, clinically effective wound management solutions.<\/jats:p>","DOI":"10.3390\/antibiotics15010036","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:11:46Z","timestamp":1767352306000},"page":"36","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-0066","authenticated-orcid":false,"given":"Carla Renata","family":"Arciola","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy"},{"name":"Laboratory of Immunorheumatology and Tissue Regeneration, Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-182X","authenticated-orcid":false,"given":"Veronica","family":"Panichi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunorheumatology and Tissue Regeneration, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-3713","authenticated-orcid":false,"given":"Gloria","family":"Bua","sequence":"additional","affiliation":[{"name":"Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7898-2720","authenticated-orcid":false,"given":"Silvia","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9866-3692","authenticated-orcid":false,"given":"Giulia","family":"Bottau","sequence":"additional","affiliation":[{"name":"Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-6196","authenticated-orcid":false,"given":"Stefano","family":"Ravaioli","sequence":"additional","affiliation":[{"name":"Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Capponi","sequence":"additional","affiliation":[{"name":"Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-0219","authenticated-orcid":false,"given":"Davide","family":"Campoccia","sequence":"additional","affiliation":[{"name":"Laboratory on Pathology of Implant Infections, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1\/10, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of observational studies","volume":"29","author":"Martinengo","year":"2019","journal-title":"Ann. Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.clindermatol.2010.03.009","article-title":"Chronic wound infection: Facts and controversies","volume":"28","author":"Siddiqui","year":"2010","journal-title":"Clin. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41579-018-0019-y","article-title":"Implant infections: Adhesion, biofilm formation and immune evasion","volume":"16","author":"Arciola","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s42003-024-07219-w","article-title":"Cellular and molecular roles of reactive oxygen species in wound healing","volume":"7","author":"Hunt","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2147\/JMDH.S457498","article-title":"Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis","volume":"17","author":"Lang","year":"2024","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/wound.2023.0149","article-title":"Macrophage and Neutrophil Dysfunction in Diabetic Wounds","volume":"13","author":"Clayton","year":"2024","journal-title":"Adv. Wound Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"McIllhatton, A., Lanting, S., and Chuter, V. (2024). The Effect of Overweight\/Obesity on Cutaneous Microvascular Reactivity as Measured by Laser-Doppler Fluxmetry: A Systematic Review. Biomedicines, 12.","DOI":"10.3390\/biomedicines12112488"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Garg, S.P., Sandepudi, K., Shah, K.V., Putnam, G.L., Chintalapati, N.V., Weissman, J.P., and Galiano, R.D. (2025). Evaluating the Effect of BMIs on Wound Complications After the Surgical Closure of Pressure Injuries. Surgeries, 6.","DOI":"10.3390\/surgeries6010005"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clindermatol.2021.10.002","article-title":"Nutrition and cutaneous wound healing","volume":"40","author":"Grada","year":"2022","journal-title":"Clin. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjcn.2013.18.Sup12.S6","article-title":"Vitamin C: A wound healing perspective","volume":"18","author":"Moores","year":"2013","journal-title":"Br. J. Community Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1089\/wound.2021.0150","article-title":"The Relationship Between Autoimmune Disease and Disease-Modifying Antirheumatic Drugs on Wound Healing","volume":"11","author":"Kirloskar","year":"2022","journal-title":"Adv. Wound Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.12968\/jowc.2022.0291","article-title":"Advanced wound therapies to promote healing in patients with severe peripheral arterial disease: Two case reports","volume":"34","author":"Meagher","year":"2025","journal-title":"J. Wound Care"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Raffetto, J.D., Ligi, D., Maniscalco, R., Khalil, R.A., and Mannello, F. (2020). Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment. J. Clin. Med., 10.","DOI":"10.3390\/jcm10010029"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5114\/ada.2018.72585","article-title":"Wound healing complications in oncological patients: Perspectives for cellular therapy","volume":"36","author":"Deptula","year":"2019","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pena","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.4049\/jimmunol.1801466","article-title":"Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces","volume":"202","author":"Wang","year":"2019","journal-title":"J. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e20190103","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-beta in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1038\/s41598-020-69008-9","article-title":"TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1","volume":"10","author":"Carreca","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8945","DOI":"10.2147\/JIR.S527764","article-title":"Macrophages as Multifaceted Orchestrators of Tissue Repair: Bridging Inflammation, Regeneration, and Therapeutic Innovation","volume":"18","author":"Wang","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100466","DOI":"10.1016\/j.jorep.2024.100466","article-title":"Khatri Kavin Antimicrobial resistance (AMR) in Orthopaedic surgeries: A Complex issue and global threat","volume":"4","year":"2025","journal-title":"J. Orthop. Rep."},{"key":"ref_23","first-page":"e022","article-title":"Surgical Wound Classification and Surgical Site Infections in the Orthopaedic Patient","volume":"1","author":"Onyekwelu","year":"2017","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2106\/00004623-197658040-00004","article-title":"Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: Retrospective and prospective analyses","volume":"58","author":"Gustilo","year":"1976","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00005373-198408000-00009","article-title":"Problems in the management of type III (severe) open fractures: A new classification of type III open fractures","volume":"24","author":"Gustilo","year":"1984","journal-title":"J. Trauma"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00402-024-05704-9","article-title":"Diabesity is associated with a worse joint specific functional outcome following primary total knee replacement","volume":"145","author":"Lovie","year":"2025","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13018-023-03644-5","article-title":"Diabetes mellitus impairs bone regeneration and biomechanics","volume":"18","author":"Cai","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_28","first-page":"51","article-title":"Diabetes as a Risk Factor for Orthopedic Implant Surface Performance: A Retrieval and In Vitro Study","volume":"7","author":"Arteaga","year":"2021","journal-title":"J. Bio Tribocorros"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/154405910608500805","article-title":"Stress and inflammation as a detrimental combination for peri-implant bone loss","volume":"85","author":"Heckmann","year":"2006","journal-title":"J. Dent. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Dawi, J., Tumanyan, K., Tomas, K., Misakyan, Y., Gargaloyan, A., Gonzalez, E., Hammi, M., Tomas, S., and Venketaraman, V. (2025). Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and Emerging Therapeutic Strategies. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051076"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Shah, J., Patel, D., Rananavare, D., Hudson, D., Tran, M., Schloss, R., Langrana, N., Berthiaume, F., and Kumar, S. (2025). Recent Advancements in Chitosan-Based Biomaterials for Wound Healing. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16020045"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Feng, P., Luo, Y., Ke, C., Qiu, H., Wang, W., Zhu, Y., Hou, R., Xu, L., and Wu, S. (2021). Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.650598"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5025341","DOI":"10.1155\/2023\/5025341","article-title":"Study on the Physicochemical Properties of Chitosan and their Applications in the Biomedical Sector","volume":"2023","author":"Alemu","year":"2023","journal-title":"Int. J. Polym. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Vlad-Bubulac, T., Hamciuc, C., Rimbu, C.M., Aflori, M., Butnaru, M., Enache, A.A., and Serbezeanu, D. (2022). Fabrication of Poly(vinyl alcohol)\/Chitosan Composite Films Strengthened with Titanium Dioxide and Polyphosphonate Additives for Packaging Applications. Gels, 8.","DOI":"10.3390\/gels8080474"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"151129","DOI":"10.1016\/j.bbrc.2024.151129","article-title":"In-vitro investigation of chitosan\/polyvinyl alcohol\/TiO(2) composite membranes for wound regeneration","volume":"742","author":"Gobi","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"122865","DOI":"10.1016\/j.carbpol.2024.122865","article-title":"Quaternized chitosan-based biomimetic nanozyme hydrogels with ROS scavenging, oxygen generating, and antibacterial capabilities for diabetic wound repair","volume":"348","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.reth.2025.04.020","article-title":"A temperature-sensitive chitosan hydrogels loaded with nano-zinc oxide and exosomes from human umbilical vein endothelial cells accelerates wound healing","volume":"30","author":"Yu","year":"2025","journal-title":"Regen. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"121260","DOI":"10.1016\/j.biomaterials.2021.121260","article-title":"An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties","volume":"280","author":"Chen","year":"2022","journal-title":"Biomaterials"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100330","DOI":"10.1016\/j.mtbio.2022.100330","article-title":"A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections","volume":"15","author":"Lin","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e70368","DOI":"10.1111\/iwj.70368","article-title":"Clinical Efficacy of Ovine Forestomach Matrix and Collagen\/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real-World Evidence Study","volume":"22","author":"Aburn","year":"2025","journal-title":"Int. Wound J."},{"key":"ref_41","first-page":"e66","article-title":"Ovine Forestomach Matrix in the Surgical Management of Complex Volumetric Soft Tissue Defects: A Retrospective Pilot Case Series","volume":"23","author":"Cormican","year":"2023","journal-title":"Eplasty"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e6406","DOI":"10.1097\/GOX.0000000000006406","article-title":"Limb Salvage via Surgical Soft-tissue Reconstruction with Ovine Forestomach Matrix Grafts: A Prospective Study","volume":"12","author":"Lawlor","year":"2024","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7547\/22-081","article-title":"Ovine Forestomach Matrix in the Surgical Management of Complex Lower-Extremity Soft-Tissue Defects","volume":"113","author":"Bosque","year":"2023","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liang, R., Pan, R., He, L., Dai, Y., Jiang, Y., He, S., Li, B., and Li, Y. (2025). Decellularized Extracellular Matrices for Skin Wound Treatment. Materials, 18.","DOI":"10.3390\/ma18122752"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/08853282211045770","article-title":"Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair","volume":"36","author":"Smith","year":"2022","journal-title":"J. Biomater. Appl."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"136340","DOI":"10.1016\/j.ijbiomac.2024.136340","article-title":"Fabrication and characterization of nanohydroxyapatite\/chitosan\/decellularized placenta scaffold for bone tissue engineering applications","volume":"281","author":"Khazaei","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"142816","DOI":"10.1016\/j.ijbiomac.2025.142816","article-title":"A 3D bioprinted gelatin\/quaternized chitosan\/decellularized extracellular matrix based hybrid bionic scaffold with multifunctionality for infected full-thickness skin wound healing","volume":"309","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12951-025-03614-5","article-title":"Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration","volume":"23","author":"Gupta","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.actbio.2021.09.043","article-title":"A platelet-derived hydrogel improves neovascularisation in full thickness wounds","volume":"136","author":"Rahman","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s13287-022-02934-9","article-title":"Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"123491","DOI":"10.1016\/j.ijbiomac.2023.123491","article-title":"PDGF and VEGF-releasing bi-layer wound dressing made of sodium tripolyphosphate crosslinked gelatin-sponge layer and a carrageenan nanofiber layer","volume":"233","author":"Alizadeh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","first-page":"100193","article-title":"Advances in bone regeneration with growth factors for spinal fusion: A literature review","volume":"13","author":"Tateiwa","year":"2023","journal-title":"N. Am. Spine Soc. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00264-007-0418-6","article-title":"A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft)","volume":"31","author":"McKay","year":"2007","journal-title":"Int. Orthop."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jot.2015.08.001","article-title":"Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing","volume":"4","author":"Cecchi","year":"2016","journal-title":"J. Orthop. Translat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"112466","DOI":"10.1016\/j.msec.2021.112466","article-title":"FDA-approved bone grafts and bone graft substitute devices in bone regeneration","volume":"130","author":"Gillman","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.actbio.2024.10.044","article-title":"Nanofibrous 3D scaffolds capable of individually controlled BMP and FGF release for the regulation of bone regeneration","volume":"190","author":"Rambhia","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_58","first-page":"116","article-title":"Orchestration of energy metabolism and osteogenesis by Mg(2+) facilitates low-dose BMP-2-driven regeneration","volume":"18","author":"Lin","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"117195","DOI":"10.1016\/j.bone.2024.117195","article-title":"Local FK506 delivery induces osteogenesis in in vivo rat bone defect and rabbit spine fusion models","volume":"187","author":"Harrer","year":"2024","journal-title":"Bone"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/term.3260","article-title":"Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model","volume":"16","author":"Hu","year":"2022","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"123553","DOI":"10.1016\/j.biomaterials.2025.123553","article-title":"Tenascin-c functionalised self-assembling peptide hydrogels for critical-sized bone defect reconstruction","volume":"325","author":"Williams","year":"2026","journal-title":"Biomaterials"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"122357","DOI":"10.1016\/j.biomaterials.2023.122357","article-title":"A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor","volume":"302","author":"McClendon","year":"2023","journal-title":"Biomaterials"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1039\/C7RA13510F","article-title":"A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing","volume":"8","author":"Liu","year":"2018","journal-title":"RSC Adv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"104858","DOI":"10.1016\/j.jddst.2023.104858","article-title":"Synthesis and characterization of chitosan nanofibers for wound healing and drug delivery application","volume":"87","author":"Kumar","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijbiomac.2021.02.216","article-title":"Chitosan-based nanocarriers for encapsulation and delivery of curcumin: A review","volume":"179","author":"Hu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"808202","DOI":"10.1155\/2015\/808202","article-title":"Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors","volume":"2015","author":"Zhao","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"136938","DOI":"10.1016\/j.ijbiomac.2024.136938","article-title":"3D-printed biomimetic bone scaffold loaded with lyophilized concentrated growth factors promotes bone defect repair by regulation the VEGFR2\/PI3K\/AKT signaling pathway","volume":"282","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.reth.2024.03.018","article-title":"Promotion of hMDSC differentiation by combined action of scaffold material and TGF-beta superfamily growth factors","volume":"27","author":"Vailionyte","year":"2024","journal-title":"Regen. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gansevoort, M., Wentholt, S., Li Vecchi, G., de Vries, M., Versteeg, E.M.M., Boekema, B., Choppin, A., Barritault, D., Chiappini, F., and van Kuppevelt, T.H. (2025). Next-Generation Biomaterials for Wound Healing: Development and Evaluation of Collagen Scaffolds Functionalized with a Heparan Sulfate Mimic and Fibroblast Growth Factor 2. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16020051"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s13770-024-00667-9","article-title":"Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model","volume":"21","author":"Gansevoort","year":"2024","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2400346","DOI":"10.1002\/mabi.202400346","article-title":"Bioengineered Silk Fibroin Hydrogel Reinforced with Collagen-Like Protein Chimeras for Improved Wound Healing","volume":"25","author":"Hemalatha","year":"2025","journal-title":"Macromol. Biosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7494","DOI":"10.1039\/C9TB01683J","article-title":"A redox-responsive hyaluronic acid-based hydrogel for chronic wound management","volume":"7","author":"Gao","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"100823","DOI":"10.1016\/j.mtbio.2023.100823","article-title":"Cerium oxide nanoparticles: Synthesis methods and applications in wound healing","volume":"23","author":"Nosrati","year":"2023","journal-title":"Mater. Today Bio"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"36511","DOI":"10.1021\/acsami.5c07229","article-title":"Prussian Blue Nanozyme-Functionalized Hydrogel with Self-Enhanced Redox Regulation for Accelerated Wound Healing","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/acsnano.1c11040","article-title":"pH\/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing","volume":"16","author":"Liang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actbio.2024.11.008","article-title":"Incorporation of cerium oxide nanoparticles into the micro-arc oxidation layer promotes bone formation and achieves structural integrity in magnesium orthopedic implants","volume":"191","author":"Wu","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Antezana, P.E., Municoy, S., Ostapchuk, G., Catalano, P.N., Hardy, J.G., Evelson, P.A., Orive, G., and Desimone, M.F. (2023). 4D Printing: The Development of Responsive Materials Using 3D-Printing Technology. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15122743"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Abdel-Mageed, H.M., AbuelEzz, N.Z., Ali, A.A., Abdelaziz, A.E., Nada, D., Abdelraouf, S.M., Fouad, S.A., Bishr, A., and Radwan, R.A. (2025). Newly designed curcumin-loaded hybrid nanoparticles: A multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration. BMC Biotechnol., 25.","DOI":"10.1186\/s12896-025-00989-z"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"19256","DOI":"10.1038\/s41598-024-70295-9","article-title":"Electrospun nanofibrous wound dressings with enhanced efficiency through carbon quantum dots and citrate incorporation","volume":"14","author":"Partovi","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"13973","DOI":"10.2147\/IJN.S501970","article-title":"Electrospun Nanofibers from Plant Natural Products: A New Approach Toward Efficient Wound Healing","volume":"19","author":"Liu","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/acsbiomaterials.3c00030","article-title":"Sprayable Berberine-Silk Fibroin Microspheres with Extracellular Matrix Anchoring Function Accelerate Infected Wound Healing through Antibacterial and Anti-inflammatory Effects","volume":"9","author":"Sang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.actbio.2023.05.044","article-title":"A hyaluronic acid\/silk fibroin\/poly-dopamine-coated biomimetic hydrogel scaffold with incorporated neurotrophin-3 for spinal cord injury repair","volume":"167","author":"Sha","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"130373","DOI":"10.1016\/j.ijbiomac.2024.130373","article-title":"Regenerated silk fibroin coating stable liquid metal nanoparticles enhance photothermal antimicrobial activity of hydrogel for wound infection repair","volume":"263","author":"Cheng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"48408","DOI":"10.1021\/acsami.0c15612","article-title":"Electrospun Nanodiamond-Silk Fibroin Membranes: A Multifunctional Platform for Biosensing and Wound-Healing Applications","volume":"12","author":"Khalid","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_85","unstructured":"Ghimire, S., Wu, Y., Chug, M.K., Brisbois, E.J., Kim, K., and Mukhopadhyay, K. (2025). Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy. arXiv."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Cherednichenko, K., Kopitsyn, D., Batasheva, S., and Fakhrullin, R. (2021). Probing Antimicrobial Halloysite\/Biopolymer Composites with Electron Microscopy: Advantages and Limitations. Polymers, 13.","DOI":"10.3390\/polym13203510"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/17425247.2024.2329641","article-title":"Recent advances in the application of clay-containing hydrogels for hemostasis and wound healing","volume":"21","author":"Huang","year":"2024","journal-title":"Expert. Opin. Drug Deliv."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"127408","DOI":"10.1016\/j.jtemb.2024.127408","article-title":"Polymer-clay nanofibrous wound dressing materials containing different boron compounds","volume":"83","author":"Dilmani","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Krajisnik, D., Uskokovic-Markovic, S., and Dakovic, A. (2024). Chitosan-Clay Mineral Nanocomposites with Antibacterial Activity for Biomedical Application: Advantages and Future Perspectives. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910377"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.2147\/IJN.S521956","article-title":"Nano-Biomimetic Fibronectin\/Lysostaphin-Co-Loaded Silk Fibroin Dressing Accelerates Full-Thickness Wound Healing via ECM-Mimicking Microarchitecture and Dual-Function Modulation","volume":"20","author":"Liu","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e02804","DOI":"10.1002\/adhm.202502804","article-title":"Translational Extracellular Matrix Spray-Coating Approach for Large-Scale Bioactive Surface Functionalization and Tissue Repair","volume":"14","author":"Brilian","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11279","DOI":"10.1038\/s41598-025-88150-w","article-title":"A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects","volume":"15","author":"Sawaragi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101968","DOI":"10.1016\/j.mtbio.2025.101968","article-title":"Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration","volume":"33","author":"Peng","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0142-9612(93)90161-T","article-title":"Heparin surface treatment of poly(methylmethacrylate) alters adhesion of a Staphylococcus aureus strain: Utility of bacterial fatty acid analysis","volume":"14","author":"Arciola","year":"1993","journal-title":"Biomaterials"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"27814","DOI":"10.1038\/s41598-025-95437-5","article-title":"Efficacy of topical heparin spray on donor site wound healing after split thickness skin grafting","volume":"15","author":"Adil","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e2501745","DOI":"10.1002\/adhm.202501745","article-title":"Electrospun Scaffold Co-Modified with YIGSR Peptide and Heparin for Enhanced Skin Wound Healing","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1021\/acsaenm.5c00246","article-title":"Bio-MOF-Polymeric Hybrid Wound Healing Patch for Enhanced Transdermal Codelivery of Curcumin and Heparin","volume":"3","author":"Pandya","year":"2025","journal-title":"ACS Appl. Eng. Mater."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Boateng, J., and Khan, S. (2025). Composite HPMC-Gelatin Films Loaded with Cameroonian and Manuka Honeys Show Antibacterial and Functional Wound Dressing Properties. Gels, 11.","DOI":"10.3390\/gels11070557"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Papanikolaou, G.E., Gousios, G., Cremers, N.A.J., and Peters, L.J.F. (2024). Treating Infected Non-Healing Venous Leg Ulcers with Medical-Grade Honey: A Prospective Case Series. Antibiotics, 13.","DOI":"10.3390\/antibiotics13070614"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Servin de la Mora-Lopez, D., Olivera-Castillo, L., Lopez-Cervantes, J., Sanchez-Machado, D.I., Ayala-Zavala, J.F., Soto-Valdez, H., and Madera-Santana, T.J. (2025). Bioengineered Chitosan-Collagen-Honey Sponges: Physicochemical, Antibacterial, and In Vitro Healing Properties for Enhanced Wound Healing and Infection Control. Polymers, 17.","DOI":"10.3390\/polym17172379"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"20715","DOI":"10.1038\/s41598-024-71466-4","article-title":"Synergistic nanocoating with layer-by-layer functionalized PCL membranes enhanced by manuka honey and essential oils for advanced wound healing","volume":"14","author":"Gallo","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jhin.2025.04.026","article-title":"Silver-based dressings for the prevention of surgical site infections: Evidence from randomized trials","volume":"162","author":"Younes","year":"2025","journal-title":"J. Hosp. Infect."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"10530","DOI":"10.1021\/acsomega.4c10648","article-title":"Application of Gelatin\/Vanillin\/Fe(3+)\/AGP-AgNPs Hydrogels Promotes Wound Contraction, Enhances Dermal Growth Factor Expression, and Minimizes Skin Irritation","volume":"10","author":"Lapmanee","year":"2025","journal-title":"ACS Omega"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"113785","DOI":"10.1016\/j.colsurfb.2024.113785","article-title":"Tripeptides Ghk and GhkCu-modified silver nanoparticles for enhanced antibacterial and wound healing activities","volume":"236","author":"Islam","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/s41467-025-61141-1","article-title":"Dimeric copper peptide incorporated hydrogel for promoting diabetic wound healing","volume":"16","author":"Cong","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Campoccia, D., Bottau, G., De Donno, A., Bua, G., Ravaioli, S., Capponi, E., Sotgiu, G., Bellotti, C., Costantini, S., and Arciola, C.R. (2024). Assessing Cytotoxicity, Proteolytic Stability, and Selectivity of Antimicrobial Peptides: Implications for Orthopedic Applications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413241"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Melichercik, P., Nesuta, O., and Cerovsky, V. (2018). Antimicrobial Peptides for Topical Treatment of Osteomyelitis and Implant-Related Infections: Study in the Spongy Bone. Pharmaceuticals, 11.","DOI":"10.3390\/ph11010020"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"122465","DOI":"10.1016\/j.biomaterials.2023.122465","article-title":"Bioactive mesoporous silica nanoparticle-functionalized titanium implants with controllable antimicrobial peptide release potentiate the regulation of inflammation and osseointegration","volume":"305","author":"Dong","year":"2024","journal-title":"Biomaterials"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"eado7538","DOI":"10.1126\/sciadv.ado7538","article-title":"Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure","volume":"10","author":"Kaveti","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"344320","DOI":"10.1016\/j.aca.2025.344320","article-title":"Bioelectronic sutures with electrochemical glucose-sensing for real-time wound monitoring","volume":"1370","author":"Yan","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"116365","DOI":"10.1016\/j.bios.2024.116365","article-title":"Self-powered biosensing sutures for real-time wound monitoring","volume":"259","author":"Yan","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"117522","DOI":"10.1016\/j.bios.2025.117522","article-title":"Smart bandages for wound monitoring and treatment","volume":"283","author":"Wu","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Protzman, N.M., Mao, Y., Long, D., Sivalenka, R., Gosiewska, A., Hariri, R.J., and Brigido, S.A. (2023). Placental-Derived Biomaterials and Their Application to Wound Healing: A Review. Bioengineering, 10.","DOI":"10.20944\/preprints202306.0211.v1"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Costela-Ruiz, V.J., Melguizo-Rodriguez, L., Bellotti, C., Illescas-Montes, R., Stanco, D., Arciola, C.R., and Lucarelli, E. (2022). Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116356"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"35538","DOI":"10.1021\/acsomega.1c05022","article-title":"Isolation, Expansion, and Characterization of Placenta Originated Decidua Basalis-Derived Mesenchymal Stromal Cells","volume":"6","author":"Subramani","year":"2021","journal-title":"ACS Omega"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"rbae032","DOI":"10.1093\/rb\/rbae032","article-title":"Biomaterials for immunomodulation in wound healing","volume":"11","author":"Wang","year":"2024","journal-title":"Regen. Biomater."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Eerdekens, H., Pirlet, E., Willems, S., Bronckaers, A., and Pincela Lins, P.M. (2025). Extracellular vesicles: Innovative cell-free solutions for wound repair. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1571461"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Wang, Z., Sun, Y., and Li, C. (2024). Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1483547"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Mirsky, N.A., Ehlen, Q.T., Greenfield, J.A., Antonietti, M., Slavin, B.V., Nayak, V.V., Pelaez, D., Tse, D.T., Witek, L., and Daunert, S. (2024). Three-Dimensional Bioprinting: A Comprehensive Review for Applications in Tissue Engineering and Regenerative Medicine. Bioengineering, 11.","DOI":"10.3390\/bioengineering11080777"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s43939-025-00286-8","article-title":"Harnessing 3D printing in bone tissue engineering","volume":"5","author":"Nishal","year":"2025","journal-title":"Discov. Mater."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.omtn.2022.08.020","article-title":"Gene therapy to enhance angiogenesis in chronic wounds","volume":"29","author":"Shaabani","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1124\/molpharm.124.000899","article-title":"New Perspectives and Prospects of microRNA Delivery in Diabetic Wound Healing","volume":"106","author":"Wang","year":"2024","journal-title":"Mol. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1038\/s41467-023-40519-z","article-title":"Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing","volume":"14","author":"Henn","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.62347\/MYHE3488","article-title":"Progress in the application of artificial intelligence in skin wound assessment and prediction of healing time","volume":"16","author":"Chen","year":"2024","journal-title":"Am. J. Transl. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.reth.2025.10.002","article-title":"Modeling epithelial wound closure dynamics with AI: A comparative study across cell types","volume":"30","author":"Cai","year":"2025","journal-title":"Regen. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12938-025-01399-0","article-title":"Construction of a deep learning-based predictive model to evaluate the influence of mechanical stretching stimuli on MMP-2 gene expression levels in fibroblasts","volume":"24","author":"Xiao","year":"2025","journal-title":"Biomed. Eng. Online"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e69408","DOI":"10.2196\/69408","article-title":"Diabetic Foot Ulcer Classification Models Using Artificial Intelligence and Machine Learning Techniques: Systematic Review","volume":"27","author":"Silva","year":"2025","journal-title":"J. Med. Internet Res."},{"key":"ref_128","first-page":"319","article-title":"Artificial Intelligence-Assisted Conductive Hydrogel Dressings for Refractory Wounds Monitoring","volume":"17","author":"She","year":"2025","journal-title":"Nanomicro Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1524-475X.2011.00701.x","article-title":"Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: A meta-analysis","volume":"19","author":"Driver","year":"2011","journal-title":"Wound Repair Regen."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1302\/0301-620X.107B6.BJJ-2024-0848.R2","article-title":"Effective treatment using a single-stage revision with non-contact low frequency ultrasonic debridement in the treatment of periprosthetic joint infection: A prospective single-arm study","volume":"107","author":"Ji","year":"2025","journal-title":"Bone Jt. J."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Flores-Escobar, S., Garcia-Alvarez, Y., Alvaro-Afonso, F.J., Lopez-Moral, M., Garcia-Madrid, M., and Lazaro-Martinez, J.L. (2025). Clinical Effects of Weekly and Biweekly Low-Frequency Ultrasound Debridement Versus Standard of Wound Care in Patients with Diabetic Foot Ulcers: A Pilot Randomized Clinical Trial. Int. J. Low. Extrem. Wounds, Online ahead of print.","DOI":"10.1177\/15347346251332795"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41584-025-01236-7","article-title":"Restoring articular cartilage: Insights from structure, composition and development","volume":"21","author":"Ito","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"30097","DOI":"10.1021\/acsomega.4c04789","article-title":"Materials Suitable for Osteochondral Regeneration","volume":"9","author":"Novotna","year":"2024","journal-title":"ACS Omega"},{"key":"ref_134","first-page":"510","article-title":"Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects","volume":"43","author":"Lin","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41584-023-00979-5","article-title":"Failure of cartilage regeneration: Emerging hypotheses and related therapeutic strategies","volume":"19","author":"Muthu","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/CORR.0000000000003074","article-title":"Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro","volume":"482","author":"Chang","year":"2024","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Campoccia, D., Montanaro, L., Ravaioli, S., Cangini, I., Testoni, F., Visai, L., and Arciola, C.R. (2018). New Parameters to Quantitatively Express the Invasiveness of Bacterial Strains from Implant-Related Orthopaedic Infections into Osteoblast Cells. 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