{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:35:50Z","timestamp":1770737750464,"version":"3.49.0"},"reference-count":72,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","award":["SAMRC-UFH-P790"],"award-info":[{"award-number":["SAMRC-UFH-P790"]}],"id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Foundation of South Africa","award":["RCHDI241119283812"],"award-info":[{"award-number":["RCHDI241119283812"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Multidrug-resistant bacteria have quadrupled globally, impacting effective treatment of infectious diseases. A growing concern is that many Gram-negative and Gram-positive bacteria harbor genes conferring resistance to various antibiotics including colistin. The alarming emergence of colistin resistance is exacerbated by the growing threat of MDR Salmonella species and Listeria monocytogenes (LMO), which pose an escalating risk to global public health. Materials and Methods: In the present study, red meat samples were collected from randomly selected key retail markets in the Eastern Cape province, South Africa, and were evaluated for the incidence of LMO and the Salmonella species using standard culture-based and molecular methods. The confirmed isolates were subjected to antibiotic susceptibility testing. Results: This study demonstrated the occurrence of multidrug-resistant LMO (62%) and Salmonella species (spp.) (58%) in the red meat specimen. There were high resistance rates in both LMO and Salmonella isolates, with LMO exhibiting resistance to penicillin (89%), colistin (81%), nitrofurantoin (78%), and erythromycin (29%), while Salmonella showed resistance to trimethoprim (96.87%), tetracycline, and colistin (90.62%). Antibiotic resistance genes were also detected including BlaTem, erm, Sul1, Sul2 and mcr 1\u20136. Notably, Salmonella did not harbor any mcr genes that were screened in this study, whereas Listeria isolates harbored the mcr 2 (10%), 3 (7%), 4 (10%), and 6 (3%), with mcr 5 being the most prevalent with 57%. Conclusions: These findings highlight a threat to food security and public health, emphasizing the need for sturdier food handling procedures to ensure safety, enhanced antimicrobial stewardship, and alternative therapeutic strategies to combat antibiotic-resistant pathogens.<\/jats:p>","DOI":"10.3390\/antibiotics15020175","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:30:47Z","timestamp":1770309047000},"page":"175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Appraisal of Multidrug-Resistant Listeria monocytogenes and Salmonella spp. Recovered from Commercial Meat Samples in the Eastern Cape, South Africa: Implications for Public Health Safety"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7272-437X","authenticated-orcid":false,"given":"Luyanda","family":"Msolo","sequence":"first","affiliation":[{"name":"SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice 5700, South Africa"},{"name":"DSTI-NRF SARChI in Water Quality and Environmental Genomics, University of Fort Hare, Alice 5700, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanda","family":"Mbiko","sequence":"additional","affiliation":[{"name":"SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice 5700, South Africa"},{"name":"DSTI-NRF SARChI in Water Quality and Environmental Genomics, University of Fort Hare, Alice 5700, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindisiwe","family":"Nokhatyana","sequence":"additional","affiliation":[{"name":"SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice 5700, South Africa"},{"name":"DSTI-NRF SARChI in Water Quality and Environmental Genomics, University of Fort Hare, Alice 5700, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-085X","authenticated-orcid":false,"given":"Antony Ifeanyi","family":"Okoh","sequence":"additional","affiliation":[{"name":"SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice 5700, South Africa"},{"name":"DSTI-NRF SARChI in Water Quality and Environmental Genomics, University of Fort Hare, Alice 5700, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12992-024-01046-8","article-title":"AMR and Sustainable Development Goals: At a crossroads","volume":"20","author":"Aslam","year":"2024","journal-title":"Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/14787210.2021.1945922","article-title":"Proposed amendments regarding the definitions of multidrug-resistant and extensively drug-resistant bacteria","volume":"20","author":"Rafailidis","year":"2022","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"de Kraker, M.E.A., Stewardson, A.J., and Harbarth, S. (2016). Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002184"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Habib, I., Mohamed, M.-Y.I., and Khan, M. (2021). Current State of Salmonella, Campylobacter and Listeria in the Food Chain across the Arab Countries: A Descriptive Review. Foods, 10.","DOI":"10.3390\/foods10102369"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Miller, S.A., Ferreira, J.P., and LeJeune, J.T. (2022). Antimicrobial Use and Resistance in Plant Agriculture: A One Health Perspective. Agriculture, 12.","DOI":"10.3390\/agriculture12020289"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100997","DOI":"10.1016\/j.mam.2021.100997","article-title":"Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects","volume":"81","author":"Rana","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wilson, M., and Wilson, P.J.K. (2021). Gastroenteritis due to Salmonella. Close Encounters of the Microbial Kind: Everything You Need to Know About Common Infections, Springer.","DOI":"10.1007\/978-3-030-56978-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s42770-019-00213-z","article-title":"Characterization of non-typhoidal Salmonella isolates from children with acute gastroenteritis, Kolkata, India, during 2000\u20132016","volume":"51","author":"Jain","year":"2020","journal-title":"Braz. J. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12691\/ajmbr-12-1-1","article-title":"Salmonellosis Remains the Hidden Menace in Our Global Food Supply: A Comprehensive Review","volume":"12","author":"Pal","year":"2024","journal-title":"Am. J. Med. Biol. Res."},{"key":"ref_10","first-page":"4","article-title":"Listeria\u2014Review of epidemiology and pathogenesis","volume":"40","author":"Ramaswamy","year":"2007","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e0006019","DOI":"10.1128\/cmr.00060-19","article-title":"Human Listeriosis","volume":"36","author":"Koopmans","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_12","first-page":"319","article-title":"Global Prevalence of Listeriosis","volume":"Volume 4","author":"Zahid","year":"2023","journal-title":"Zoonosis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1089\/fpd.2018.2586","article-title":"Outbreak of Listeria monocytogenes in South Africa, 2017\u20132018: Laboratory Activities and Experiences Associated with Whole-Genome Sequencing Analysis of Isolates","volume":"16","author":"Smith","year":"2019","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Upmanyu, N., and Malviya, V.N. (2020). Antibiotics: Mechanisms of action and modern challenges. Microorganisms for Sustainable Environment and Health, Elsevier.","DOI":"10.1016\/B978-0-12-819001-2.00018-8"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41579-020-00443-1","article-title":"Proximate and ultimate causes of the bactericidal action of antibiotics","volume":"19","author":"Baquero","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Belay, W.Y., Getachew, M., Tegegne, B.A., Teffera, Z.H., Dagne, A., Zeleke, T.K., Abebe, R.B., Gedif, A.A., Fenta, A., and Yirdaw, G. (2024). Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: A review. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1444781"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Turner, J., Muraoka, A., Bedenbaugh, M., Childress, B., Pernot, L., Wiencek, M., and Peterson, Y.K. (2022). The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.807955"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20447","DOI":"10.1039\/C3CP50868D","article-title":"Penicillin\u2019s catalytic mechanism revealed by inelastic neutrons and quantum chemical theory","volume":"15","author":"Mucsi","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Elshobary, M.E., Badawy, N.K., Ashraf, Y., Zatioun, A.A., Masriya, H.H., Ammar, M.M., Mohamed, N.A., Mourad, S., and Assy, A.M. (2025). Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030402"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.51585\/gjvr.2025.1.0123","article-title":"Role of Enterococcus in spreading antimicrobial resistance genes and its public health significance","volume":"5","author":"Fahim","year":"2025","journal-title":"Ger. J. Vet. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.2147\/IDR.S211618","article-title":"Molecular Detection of Multidrug-Resistant Salmonella Isolated from Livestock Production Systems in South Africa","volume":"12","author":"Mthembu","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3934\/microbiol.2021004","article-title":"Listeria monocytogenes isolates from Western Cape, South Africa exhibit resistance to multiple antibiotics and contradicts certain global resistance patterns","volume":"7","author":"Keet","year":"2021","journal-title":"AIMS Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.18191\/2015-08-2-025","article-title":"Incidence and molecular detection of Salmonella enterica serogroups and spvC virulence gene in raw and processed meats from selected wet markets in Metro Manila, Philippines","volume":"8","author":"Rosario","year":"2015","journal-title":"Int. J. Philipp. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.5455\/vetworld.2010.353-359","article-title":"Occurrence of Listeria species in meat, chicken products and human stools in Assiut city, Egypt with PCR use for rapid identification of Listeria monocytogenes","volume":"3","author":"ElMalek","year":"2010","journal-title":"Vet. World"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijfoodmicro.2014.10.022","article-title":"Identification of non-Listeria spp. bacterial isolates yielding a \u03b2-d-glucosidase-positive phenotype on Agar Listeria according to Ottaviani and Agosti (ALOA)","volume":"193","author":"Angelidis","year":"2015","journal-title":"Int. J. Food Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1472-765X.2010.02959.x","article-title":"Conventional and molecular methods to detect bacterial pathogens in mussels","volume":"52","author":"Gugliandolo","year":"2011","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tvjl.2009.03.032","article-title":"Use of a phospholipase-C assay, in vivo pathogenicity assays and PCR in assessing the virulence of Listeria spp.","volume":"184","author":"Kaur","year":"2010","journal-title":"Vet. J."},{"key":"ref_28","first-page":"42","article-title":"Outer membrane protein C (ompC) gene as the target for diagnosis of Salmonella species isolated from human and animal sources","volume":"8","author":"Jawad","year":"2016","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.meatsci.2016.04.037","article-title":"Prevalence, virulence and antibiotic susceptibility of Salmonella spp. strains, isolated from beef in Greater Tunis (Tunisia)","volume":"119","author":"Oueslati","year":"2016","journal-title":"Meat Sci."},{"key":"ref_30","first-page":"363","article-title":"The presence of Listeria monocytogenes in raw milk samples in Mashhad, Iran","volume":"11","author":"Jami","year":"2010","journal-title":"Iran. J. Vet. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Iwu, C.D., and Okoh, A.I. (2020). Characterization of antibiogram fingerprints in Listeria monocytogenes recovered from irrigation water and agricultural soil samples. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228956"},{"key":"ref_32","unstructured":"Clinical Laboratory Standard Institute (CLSI) (2018). Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute. [28th ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"30280","DOI":"10.2807\/1560-7917.ES.2016.21.27.30280","article-title":"Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016","volume":"21","author":"Xavier","year":"2016","journal-title":"Euro Surveill."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e00543-17","DOI":"10.1128\/mBio.00543-17","article-title":"Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli","volume":"8","author":"Yin","year":"2017","journal-title":"mBio"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30589","DOI":"10.2807\/1560-7917.ES.2017.22.31.30589","article-title":"Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016","volume":"22","author":"Carattoli","year":"2017","journal-title":"Euro Surveill."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1093\/jac\/dkx327","article-title":"Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar","volume":"72","author":"Borowiak","year":"2017","journal-title":"Paratyphi B. J. Antimicrob. Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2147\/IDR.S194635","article-title":"Plasmid-mediated colistin resistance gene mcr-1 in Escherichia coli and Klebsiella pneumoniae isolated from market retail fruits in Guangzhou, China","volume":"12","author":"Yang","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.2147\/IDR.S269219","article-title":"Antimicrobial Resistance Profiles of Diarrheagenic E. coli (DEC) and Salmonella Species Recovered from Diarrheal Patients in Selected Rural Communities of the Amathole District Municipality, Eastern Cape Province, South Africa","volume":"13","author":"Msolo","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"679109","DOI":"10.1155\/2015\/679109","article-title":"Antibacterial Mechanisms of Polymyxin and Bacterial Resistance","volume":"2015","author":"Yu","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rhouma, M., Beaudry, F., Th\u00e9riault, W., and Letellier, A. (2016). Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01789"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yu, Z., Zhu, Y., Fu, J., Qiu, J., and Yin, J. (2019). Enhanced NADH Metabolism Involves Colistin-Induced Killing of Bacillus subtilis and Paenibacillus polymyxa. Molecules, 24.","DOI":"10.3390\/molecules24030387"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/22221751.2020.1754133","article-title":"Colistin and its role in the Era of antibiotic resistance: An extended review (2000\u20132019)","volume":"9","author":"Zhong","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e12629","DOI":"10.1111\/jfs.12629","article-title":"Occurrence, serotypes, and characteristics of Listeria monocytogenes in meat and meat products in South Africa between 2014 and 2016","volume":"39","author":"Matle","year":"2019","journal-title":"J. Food Saf."},{"key":"ref_45","first-page":"267","article-title":"Salmonella enteritidis in broiler chickens: Isolation, anti-biotic resistance phenotyping and efficacy of colistin on control of experimental infection","volume":"9","author":"Amer","year":"2020","journal-title":"Int. J. Vet. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"001894","DOI":"10.1099\/jmm.0.001894","article-title":"Assessing antimicrobial resistance profiles of Salmonella enterica in the pork production system","volume":"73","author":"Prasertsee","year":"2024","journal-title":"J. Med. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Caneschi, A., Bardhi, A., Barbarossa, A., and Zaghini, A. (2023). The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: A narrative review. Antibiotics, 12.","DOI":"10.3390\/antibiotics12030487"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100882","DOI":"10.1016\/j.cofs.2022.100882","article-title":"Role of horizontal gene transfer in the dissemination of antimicrobial resistance in food animal production","volume":"47","author":"Vinayamohan","year":"2022","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e01173-18","DOI":"10.1128\/AEM.01173-18","article-title":"Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure","volume":"84","author":"Peng","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodcont.2016.11.024","article-title":"Isolation and characterization of Listeria monocytogenes in Chinese food obtained from the central area of China","volume":"74","author":"Du","year":"2017","journal-title":"Food Control."},{"key":"ref_51","first-page":"100082","article-title":"Antibiotic susceptibility pattern of Listeria spp. isolated from cattle farm environment in Bangladesh","volume":"2","author":"Shourav","year":"2020","journal-title":"J. Agric. Food Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"109513","DOI":"10.1016\/j.ijfoodmicro.2021.109513","article-title":"Incidence and genetic diversity of multi-drug resistant Listeria monocytogenes isolates recovered from fruits and vegetables in the Eastern Cape Province, South Africa","volume":"363","author":"Kayode","year":"2022","journal-title":"Int. J. Food Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Jeli\u0107, D., and Antolovi\u0107, R. (2016). From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics, 5.","DOI":"10.3390\/antibiotics5030029"},{"key":"ref_54","first-page":"1110","article-title":"Antimicrobial Resistance in Listeria Species","volume":"6","author":"Arroyo","year":"2018","journal-title":"Microbiol. Spectr."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Nadar, S., Khan, T., Patching, S.G., and Omri, A. (2022). Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance. Microorganisms, 10.","DOI":"10.3390\/microorganisms10020303"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Myintzaw, P., Pennone, V., McAuliffe, O., Begley, M., and Callanan, M. (2023). Association of Virulence, Biofilm, and Antimicrobial Resistance Genes with Specific Clonal Complex Types of Listeria monocytogenes. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061603"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/AAC.47.2.704-708.2003","article-title":"Efflux Pump Lde Is Associated with Fluoroquinolone Resistance in Listeria monocytogenes","volume":"47","author":"Godreuil","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1574-6968.2000.tb09158.x","article-title":"A multidrug efflux transporter in Listeria monocytogenes","volume":"187","author":"Mata","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gu\u00e9rin, F., Galimand, M., Tuambilangana, F., Courvalin, P., and Cattoir, V. (2014). Overexpression of the Novel MATE Fluoroquinolone Efflux Pump FepA in Listeria monocytogenes Is Driven by Inactivation of Its Local Repressor FepR. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106340"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/AAC.43.9.2103","article-title":"Antibiotic Resistance in Listeria spp.","volume":"43","author":"Charpentier","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7515","DOI":"10.2147\/IDR.S428837","article-title":"Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review","volume":"16","author":"Endale","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.foodcont.2018.12.046","article-title":"Phenotypic characteristics and genotypic correlation of antimicrobial resistant (AMR) Salmonella isolates from a poultry slaughterhouse and its downstream retail markets","volume":"100","author":"Shang","year":"2019","journal-title":"Food Control."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wu, S., Wu, Q., Zhang, J., Chen, M., Yan, Z., and Hu, H. (2015). Listeria monocytogenes Prevalence and Characteristics in Retail Raw Foods in China. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136682"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41545-020-0051-0","article-title":"Antibiotic resistance genes from livestock waste: Occurrence, dissemination, and treatment","volume":"3","author":"He","year":"2020","journal-title":"NPJ Clean Water"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"McMillan, E.A., Jackson, C.R., and Frye, J.G. (2020). Transferable Plasmids of Salmonella enterica Associated with Antibiotic Resistance Genes. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.562181"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Nazari Moghadam, M., Rahimi, E., Shakerian, A., and Momtaz, H. (2023). Prevalence of Salmonella Typhimurium and Salmonella Enteritidis isolated from poultry meat: Virulence and antimicrobial-resistant genes. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-02908-8"},{"key":"ref_67","first-page":"64","article-title":"Antibiotic resistance pattern and frequency of SHV, CTX, TEM, and OXA resistance gene among Salmonella serotypes","volume":"6","author":"Fatemizadeh","year":"2022","journal-title":"Health Biotechnol. Biopharma"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bsheal.2020.05.001","article-title":"Prevalence and transmission of mobilized colistin resistance (mcr) gene in bacteria common to animals and humans","volume":"2","author":"Luo","year":"2020","journal-title":"Biosaf. Health"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Anyanwu, M.U., Jaja, I.F., and Nwobi, O.C. (2020). Occurrence and Characteristics of Mobile Colistin Resistance (mcr) Gene-Containing Isolates from the Environment: A Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17031028"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zeb, S., Nazir, A., Hameed, M.F., Ikram, S., Naqvi, S.Z.H., Shoaib, M., Butaye, P., Wang, Z., Li, R., and Lu, X. (2026). Colistin Resistance in Gram-Negative Bacteria: Mechanisms, Transmission, and Novel Intervention Strategies. Microorganisms, 14.","DOI":"10.3390\/microorganisms14010173"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Anyanwu, M.U., Jaja, I.F., Okpala, C.O.R., Njoga, E.O., Okafor, N.A., and Oguttu, J.W. (2023). Mobile Colistin Resistance (mcr) Gene-Containing Organisms in Poultry Sector in Low- and Middle-Income Countries: Epidemiology, Characteristics, and One Health Control Strategies. Antibiotics, 12.","DOI":"10.3390\/antibiotics12071117"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Gogry, F.A., Siddiqui, M.T., Sultan, I., and Haq, Q.M.R. (2021). Current update on intrinsic and acquired colistin resistance mechanisms in bacteria. Front. Med., 8.","DOI":"10.3389\/fmed.2021.677720"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/15\/2\/175\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:37:54Z","timestamp":1770309474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/15\/2\/175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["antibiotics15020175"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics15020175","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}