{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:51:11Z","timestamp":1787161871580,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial stewardship in the neonatal intensive care unit is a critically important tool to optimize clinical outcomes. The ideal duration of antimicrobial treatment is a key area that contains many knowledge gaps. This narrative review has three aims. One, to highlight the existing evidence for empiric and definitive antibiotic treatment durations for infants; two, to focus on clinical situations where further studies are needed; and three, to propose a rational, goal-based approach to clinical studies that provide for infant safety as shorter treatment durations are investigated.<\/jats:p>","DOI":"10.3390\/antibiotics15020228","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T13:08:23Z","timestamp":1771592903000},"page":"228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Angel in the Marble: Antibiotic Duration in the Neonatal Intensive Care Unit"],"prefix":"10.3390","volume":"15","author":[{"given":"Joseph B.","family":"Cantey","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Divisions of Neonatology and Immunology & Infectious Diseases, University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalyn B.","family":"Guinn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref_1","unstructured":"Gayford, M. 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