{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:32:27Z","timestamp":1772465547949,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"US Centre for Disease Control and Prevention (CDC) Cooperative Agreement for Global Health Security","award":["6NU2GGH001871-02-01"],"award-info":[{"award-number":["6NU2GGH001871-02-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>A comparative cross-sectional study was undertaken in organized and unorganized dairy sectors to evaluate the prevalence of bovine mastitis and the antibiotic resistance in Staphylococcus spp. of dairy animals and their associated personnel. A total of 391 households (HH) consisting of 211 and 180 HHs from organized and unorganized sectors, respectively, were selected based on 30-cluster sampling methodology in southern and northeastern regions of India. From 391 HHs, a total of 1920 milking cows (organized dairy\u2014533; unorganized dairy\u20141387) were screened for subclinical and clinical mastitis by the California Mastitis Test (CMT). Out of 1920 milk samples, 1002 milk samples, 362 associated personnel hand and nasal swabs, and 27 milking machine swabs were sourced. The samples were subjected to Staphylococcus spp. by isolation and identification by multiplex polymerase chain reactions (mPCRs) and antibiotic sensitivity testing (ABST) to determine antimicrobial resistance (AMR) profiles. CMT results showed high mastitis prevalence (54.65%) in unorganized farms compared to organized ones (45.78%), with a significant association of mastitis to dairy sectors (p = 0.0004). On speciation, S. aureus isolates were comparatively less than those of coagulase-negative staphylococci (CoNS) (3.5% and 7.7%, respectively) in the organized dairy sector, and the same was recorded for the unorganized dairy sector (0.85% and 13.19%, respectively). In both the dairy sectors, the highest antibiotic resistance for Staphylococcus spp. was observed against the \u03b2-lactams (penicillins and cephalosporins) group (71.36% and 76.59%) and the lowest for nitrofurans (3.5% and 3%), oxazolidines (0.7% and 5.1%), and rifamycin (0.7% and 5.1%), respectively. In both the sectors, human isolates had comparatively high mecA positives (15.70% and 15.96%) compared to the animal isolates (8.36% and 12.94%). Based on mPCR, a smaller number of methicillin-resistant S. aureus (MRSA) isolates (3.95%) than methicillin-resistant coagulase-negative Staphylococci (MRCoNS) was detected in milk samples (6.05%), and the same was observed for associated personnel samples (MRCoNS (14.63%) compared to MRSA (1.05%)). In four HHs, mecA positives were detected in both animal and human samples, and this highlights the transmission dynamics of mecA between animals and humans in households. The resistance of Staphylococcus spp. to \u03b2-lactams highlights the need for cautious antibiotic use to prevent AMR.<\/jats:p>","DOI":"10.3390\/antibiotics15030256","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:06:56Z","timestamp":1772460416000},"page":"256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bovine Mastitis Vis a Vis Staphylococcus spp. Mediated Antimicrobial Resistance at Animal-Human Interface in Organized and Unorganized Dairy Sectors: A Study from Two Indian States"],"prefix":"10.3390","volume":"15","author":[{"given":"Devi","family":"Murugesan","sequence":"first","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibek R.","family":"Shome","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimita","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen K. A.","family":"Muninarayanaswamy","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rituparna","family":"Tewari","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan K.","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-1717","authenticated-orcid":false,"given":"Nagalingam","family":"Mohandoss","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-6997","authenticated-orcid":false,"given":"Somy","family":"Skariah","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogisharadhya","family":"Revanaiah","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2856-3300","authenticated-orcid":false,"given":"Snigdha M.","family":"Maharana","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-2675","authenticated-orcid":false,"given":"Gandu","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-5886","authenticated-orcid":false,"given":"Shivasharanappa","family":"Nayakwadi","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Papanna","sequence":"additional","affiliation":[{"name":"Crestwood Medical Center, Huntsville, AL 35801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-8789","authenticated-orcid":false,"given":"Rajeswari","family":"Shome","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics (ICAR-NIVEDI), Yelahanka, Bengaluru 560119, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s44372-024-00082-3","article-title":"Sustainable mastitis management in dairy cattle: A review and commentary focused on countries that use ethnoveterinary medicine and validation strategies","volume":"1","author":"Pathak","year":"2024","journal-title":"Discov. 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