{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:15:31Z","timestamp":1788455731027,"version":"build-2803163510"},"reference-count":116,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FINEP\u2013MATERIAS AVAN\u00c7ADOS","award":["161\/21"],"award-info":[{"award-number":["161\/21"]}]},{"name":"FINEP\u2013MATERIAS AVAN\u00c7ADOS","award":["01.22.0200-00"],"award-info":[{"award-number":["01.22.0200-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>This review discusses emerging in vitro and in vivo strategies for the control of Acinetobacter baumannii, a critical multidrug-resistant pathogen; the increasing isolation of strains resistant to multiple drugs, including newly developed and last-resort antibiotics, has highlighted the urgent need to pursue adjunctive therapeutic technologies. The article aims to provide an overview of alternative control approaches beyond conventional antibiotics. Emphasis is placed on strategies based on the disruption of essential metabolic pathways, nanotechnology-based approaches such as antibiotic-coated nanoparticles, in vivo bacteriophage therapy, and drug repurposing, specifically compounds such as selective serotonin reuptake inhibitors (SSRIs), as a means of exploiting already approved pharmaceuticals. By synthesizing recent findings, this review highlights current advances in the development of innovative therapeutic strategies against A. baumannii infections.<\/jats:p>","DOI":"10.3390\/antibiotics15030281","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:55:38Z","timestamp":1773136538000},"page":"281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Revisiting the Fight Against Acinetobacter baumannii: Emerging Non-Antibiotic Strategies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-3442","authenticated-orcid":false,"given":"Victor Hugo","family":"Montini","sequence":"first","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1015-9616","authenticated-orcid":false,"given":"Laura Santana","family":"Buso","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4597-8498","authenticated-orcid":false,"given":"Pedro Henrique","family":"Takata","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Henrique Maximino","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-9112","authenticated-orcid":false,"given":"Bruna Carolina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. 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Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana Carolina","family":"Vespero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Analysis and Toxicology, Health Sciences Center, University Hospital of Londrina, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7170-2155","authenticated-orcid":false,"given":"Renata Katsuko Takayama","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","unstructured":"Beijerinck, M.W. (1911). Pigmenten als Oxydatieproducten Door Bacterien Gevormd, Koninklijke Nederlandse Akademie van Wetenschappen Te Amsterdam."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/jb.56.4.379-385.1948","article-title":"A Biochemical and serological study of a group of identical unidentifiable Gram-negative bacilli from human sources","volume":"56","author":"Schaub","year":"1948","journal-title":"J. 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