{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:59:01Z","timestamp":1792799941288,"version":"4.5.0"},"reference-count":477,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Serratia marcescens is a highly adaptable Gammaproteobacterium with broad ecological distribution and growing clinical importance. Advances in whole-genome sequencing (WGS) and pangenome analysis reveal extensive genomic plasticity, driven by mobile genetic elements (MGEs) such as plasmids, transposons, integrons, prophages, and extracellular vesicles, which collectively accelerate virulence and antimicrobial resistance (AMR) evolution. S. marcescens displays a dynamic accessory genome enriched in resistance and virulence determinants, supporting persistence in diverse environments, including hospital water systems. Clinically, S. marcescens is an emerging opportunistic pathogen associated with severe healthcare-associated infections, ICU outbreaks, and multidrug-resistant \u201csuperbug\u201d phenotypes. Its resistome includes intrinsic AmpC \u03b2-lactamase, broad efflux systems, and chromosomal determinants conferring resistance to \u03b2-lactams, polymyxins, and multiple additional drug classes, while acquired ESBLs and carbapenemases urther limit therapeutic options. Integrating genomic, evolutionary, and clinical insights underscores the urgent need for improved surveillance, mechanistic understanding, and targeted interventions against carbapenem-resistant S. marcescens (CRSM).<\/jats:p>","DOI":"10.3390\/antibiotics15040359","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:08:34Z","timestamp":1775030914000},"page":"359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carbapenem-Resistant Serratia marcescens: Genomic Plasticity, Virulence Architecture, and the Expanding Threat of Multidrug Resistance"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-3193","authenticated-orcid":false,"given":"Theodoros","family":"Karampatakis","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Kerry, V92 NX94 Tralee, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6552-1585","authenticated-orcid":false,"given":"Katerina","family":"Tsergouli","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital Kerry, V92 NX94 Tralee, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-3976","authenticated-orcid":false,"given":"Payam","family":"Behzadi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Shahr-e Qods 37541-374, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1016\/j.ygeno.2021.08.009","article-title":"The global population structure and beta-lactamase repertoire of the opportunistic pathogen Serratia marcescens","volume":"113","author":"Matteoli","year":"2021","journal-title":"Genomics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1038\/s41467-022-32929-2","article-title":"The genus Serratia revisited by genomics","volume":"13","author":"Williams","year":"2022","journal-title":"Nat. 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