{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:13:40Z","timestamp":1793661220265,"version":"4.5.1"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: This intervention study compared the impact of the PA-100 AST System (PA-100) with the standard of care on antibiotic-prescribing behaviour for community-acquired urinary tract infections in a Spanish primary care setting. Methods: Women seeking care for symptoms of uncomplicated urinary tract infections were recruited based on the last digit of their regional personal identification number in a control (no PA-100 result available) or intervention (PA-100 result available) arm. Differences in antibiotic-prescribing behaviour were analysed using Fisher\u2019s exact test, with the sample size powered to detect a change in prescription in \u22656% of patients. Results: Availability of the PA-100 revealed resistance to fosfomycin in 21.5% of confirmed infections. This significantly shifted prescription away from fosfomycin towards nitrofurantoin and amoxycillin\/clavulanic acid (p &lt; 0.001). In accordance with local guidelines, fosfomycin was the most frequently prescribed antibiotic in the control arm (65.9%), whereas a significantly lower rate (37.7%) was observed in the intervention arm. Conclusions: The PA-100 shows potential to support antimicrobial stewardship by enabling targeted antibiotic treatment at the first visit and improving care in primary care settings.<\/jats:p>","DOI":"10.3390\/antibiotics15050520","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:53:24Z","timestamp":1779371604000},"page":"520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of PA-100 AST System Rapid Antibiotic Susceptibility Test on Antibiotic Prescription for Community-Acquired Urinary Tract Infections in Spanish Primary Care Settings"],"prefix":"10.3390","volume":"15","author":[{"given":"Lourdes","family":"Mart\u00ednez-Berganza Asensio","sequence":"first","affiliation":[{"name":"Centro de Salud Ensanche de Vallecas, Servicio Madrile\u00f1o de Salud, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Largo-Rojo","sequence":"additional","affiliation":[{"name":"Centro de Salud Ensanche de Vallecas, Servicio Madrile\u00f1o de Salud, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Men\u00e9ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Salud Ensanche de Vallecas, Servicio Madrile\u00f1o de Salud, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Solano-Villarrubia","sequence":"additional","affiliation":[{"name":"Centro de Salud Ensanche de Vallecas, Servicio Madrile\u00f1o de Salud, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fuentes-Romero","sequence":"additional","affiliation":[{"name":"Centro de Salud Ensanche de Vallecas, Servicio Madrile\u00f1o de Salud, 28051 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-8669","authenticated-orcid":false,"given":"Jos\u00e9","family":"Medina-Polo","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario 12 de Octubre (imas12), 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.euros.2025.03.010","article-title":"Classification of Urinary Tract Infections in 2025: Moving Beyond Uncomplicated and Complicated","volume":"75","author":"Bonkat","year":"2025","journal-title":"Eur. 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