{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:46:08Z","timestamp":1793227568090,"version":"4.5.0"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Helicobacter and Microbiota Study Group"},{"DOI":"10.13039\/100031734","name":"Spanish Association of Gastroenterology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100031734","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03cn6tr16","id-type":"ROR","asserted-by":"publisher"}]},{"name":"European Union programme HORIZON","award":["101095359"],"award-info":[{"award-number":["101095359"]}]},{"award":["101095359"],"award-info":[{"award-number":["101095359"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["10058099"],"award-info":[{"award-number":["10058099"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"award":["10058099"],"award-info":[{"award-number":["10058099"]}],"id":[{"id":"https:\/\/ror.org\/001aqnf71","id-type":"ROR","asserted-by":"publisher"}]},{"name":"European Union programme EU4Health","award":["101101252"],"award-info":[{"award-number":["101101252"]}]},{"award":["101101252"],"award-info":[{"award-number":["101101252"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Mayoly Spindler"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objective: Eradication of Helicobacter pylori typically uses acid-suppressing agents plus antimicrobials, but treatment failure may reach 20\u201330%. Adjunctive rebamipide has been proposed as a strategy to improve treatment outcomes. This study aimed to assess the effectiveness and safety of first-line empirical therapy when rebamipide was added to eradication regimens. Methods: Treatment-na\u00efve patient data were collected between January 2020 and August 2024 from the European Registry on Helicobacter pylori Management (Hp-EuReg), an international, prospective, multicentre, observational study. Rebamipide-containing regimens were analysed and compared with those without rebamipide. Effectiveness was assessed using a modified intention-to-treat approach. Results: Overall, 4581 patients (mean age 48 \u00b1 15 years, 64% women) from 15 Russian cities were included. From those, 820 patients received eradication therapy with rebamipide and 3761 without rebamipide. Overall effectiveness was significantly higher with rebamipide (731\/763, 96%) than without it (2785\/3059, 91%) (p = 0.0002). Rebamipide-containing triple therapy consisting of a proton-pump inhibitor (PPI), clarithromycin and amoxicillin was associated with effectiveness above 90%, while rebamipide-containing quadruple therapy consisting of a PPI, clarithromycin, amoxicillin and bismuth yielded a 97% eradication rate, compared with 79% and 95%, respectively, without rebamipide (p &lt; 0.001). Adverse events were significantly more frequent in patients receiving rebamipide-containing regimens (46% vs. 29%, p &lt; 0.0001), though none were serious or caused discontinuation. Compliance was similar in both groups (99% vs. 98.5%; p &gt; 0.05). Conclusions: In this observational registry cohort, first-line empirical triple therapy with amoxicillin\u2013clarithromycin, and quadruple therapy with amoxicillin\u2013clarithromycin\u2013bismuth, both prescribed with rebamipide, were associated with higher eradication rates than regimens without rebamipide.<\/jats:p>","DOI":"10.3390\/antibiotics15060531","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:32:28Z","timestamp":1779676348000},"page":"531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness and Safety of First-Line Empirical Eradication Therapy with Rebamipide: Results from the European Registry on Helicobacter pylori Management (Hp-EuReg)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-3992","authenticated-orcid":false,"given":"Dmitry S.","family":"Bordin","sequence":"first","affiliation":[{"name":"Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia"},{"name":"Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia"},{"name":"Department of Outpatient Therapy and Family Medicine, Tver State Medical University, 170100 Tver, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-7112","authenticated-orcid":false,"given":"Dmitrii N.","family":"Andreev","sequence":"additional","affiliation":[{"name":"Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-3580","authenticated-orcid":false,"given":"Sayar R.","family":"Abdulkhakov","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia"},{"name":"Department of Hospital Therapy, Faculty of Medicine, Kazan State Medical University, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-8514","authenticated-orcid":false,"given":"Irina N.","family":"Voynovan","sequence":"additional","affiliation":[{"name":"Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor G.","family":"Bakulin","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S.M. Ryss, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Bakulina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Pharmacology and Nephrology, I.I. Mechnikov North-Western State Medical University, 191015 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila G.","family":"Vologzhanina","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No. 1, Perm State Medical University named after Academician E.A. Wagner, 614990 Perm, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3286-1882","authenticated-orcid":false,"given":"Boris D.","family":"Starostin","sequence":"additional","affiliation":[{"name":"Interdistrict Gastroenterological Center No. 1, City Polyclinic No. 38, 191015 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman S.","family":"Sarsenbayeva","sequence":"additional","affiliation":[{"name":"Department of Therapy, Institute of Additional Professional Education, South Ural State Medical University, 454092 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-5248","authenticated-orcid":false,"given":"Tatyana A.","family":"Ilchishina","sequence":"additional","affiliation":[{"name":"Medical Holding \u201cSM-Clinic\u201d (Medi Com LLC), 194355 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa V.","family":"Tarasova","sequence":"additional","affiliation":[{"name":"Department of Hospital Therapy, I.N. Ulyanov Chuvash State University, 428015 Cheboksary, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla G.","family":"Kononova","sequence":"additional","affiliation":[{"name":"Department of Outpatient Therapy and Family Medicine, Tver State Medical University, 170100 Tver, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Alekseenko","sequence":"additional","affiliation":[{"name":"Department of Hospital Therapy, Far Eastern State Medical University, 680000 Khabarovsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg V.","family":"Zaytsev","sequence":"additional","affiliation":[{"name":"First Clinical Medical Centre, 601900 Kovrov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya N.","family":"Dekhnich","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy, Smolensk State Medical University, 214019 Smolensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel O.","family":"Bogomolov","sequence":"additional","affiliation":[{"name":"Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia"},{"name":"Private Medical Center \u201cUniversal\u201d LLC, 109382 Moscow, Russia"},{"name":"Hepatology Department, M.F. Vladimirsky Moscow Regional Clinical Research Institute, 129110 Moscow, Russia"},{"name":"Targeted Therapy Center LLC, 125008 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina N.","family":"Tarasova","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Kolokolnikova","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Genetically Engineered Biological Therapy, MEDSI Clinical Hospital No. 1 in Otradnoye, 143442 Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor B.","family":"Khlynov","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy and Geriatrics, Ural State Medical University, 620028 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina Yu.","family":"Plotnikova","sequence":"additional","affiliation":[{"name":"Department of Outpatient Therapy, Postgraduate Education and Nursing Care, Kemerovo State Medical University, 650029 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-0336","authenticated-orcid":false,"given":"Natalia V.","family":"Baryshnikova","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia"},{"name":"Department of Molecular Microbiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-7017","authenticated-orcid":false,"given":"Maria A.","family":"Livzan","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy and Gastroenterology, Omsk State Medical University, 644099 Omsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina F.","family":"Osipenko","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases, Novosibirsk State Medical University, 630091 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya V.","family":"Bakanova","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Medical Center \u201cMedicea\u201d, 426000 Izhevsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Partsvania-Vinogradova","sequence":"additional","affiliation":[{"name":"Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita V.","family":"Chebotareva","sequence":"additional","affiliation":[{"name":"Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. 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Ulyanov Chuvash State University, 428015 Cheboksary, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia V.","family":"Tsyganova","sequence":"additional","affiliation":[{"name":"Department of Hospital Therapy, I.N. Ulyanov Chuvash State University, 428015 Cheboksary, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita D.","family":"Kozlova","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy, Smolensk State Medical University, 214019 Smolensk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei A.","family":"Iakovlev","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Volkov","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Propaedeutics, Rostov State Medical University, 344022 Rostov-on-Don, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta S.","family":"Moroz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Genetically Engineered Biological Therapy, MEDSI Clinical Hospital No. 1 in Otradnoye, 143442 Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9370-4768","authenticated-orcid":false,"given":"Olga V.","family":"Gaus","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy and Gastroenterology, Omsk State Medical University, 644099 Omsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Singla","family":"Alba","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology, Endoscopy and Surgery (GOES) Research Group, Althaia Xarxa Assistencial Universit\u00e0ria de Manresa, Institut de Recerca i Innovaci\u00f3 en Ci\u00e8ncies de la Vida i de la Salut a la Catalunya Central (IRIS-CC), 08243 Manresa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Farr\u00e9s","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology, Endoscopy and Surgery (GOES) Research Group, Althaia Xarxa Assistencial Universit\u00e0ria de Manresa, Institut de Recerca i Innovaci\u00f3 en Ci\u00e8ncies de la Vida i de la Salut a la Catalunya Central (IRIS-CC), 08243 Manresa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-8591","authenticated-orcid":false,"given":"Leticia","family":"Moreira","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Institute of Digestive and Metabolic Diseases (ICMDM), Hospital Cl\u00ednic de Barcelona, CIBEREHD, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8597-2206","authenticated-orcid":false,"given":"Pablo","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-9310","authenticated-orcid":false,"given":"Olga P.","family":"Nyssen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Megraud","sequence":"additional","affiliation":[{"name":"INSERM U1312 BRIC, University of Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-6782","authenticated-orcid":false,"given":"Colm","family":"O\u2019Morain","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Elbehiry, A., Marzouk, E., Aldubaib, M., Abalkhail, A., Anagreyyah, S., Anajirih, N., Almuzaini, A.M., Rawway, M., Alfadhel, A., and Draz, A. 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