{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:14:03Z","timestamp":1783660443618,"version":"3.55.0"},"reference-count":8,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance (AMR) is a global threat to both human and animal health. Carbapenems are last-resort antimicrobials used to treat severe infections with multidrug-resistant Gram-negative nosocomial pathogens in humans. Therefore, the dissemination of carbapenemase-producing Enterobacterales (CPE) has emerged as a major concern worldwide. Although carbapenems are not routinely used in veterinary medicine, CPE, including OXA-48-like-producing Escherichia coli, are increasingly being reported in companion animals. We document the first report of E. coli-harbouring blaOXA-484 isolated from a urine sample from a dog with a history of chronic thoracolumbar myelopathy. Using a combined Oxford Nanopore (ONT) long-reads and Illumina short-reads sequencing approach, the isolate was characterized and an IncF plasmid containing blaOXA-484 was reconstructed. The isolate belonged to sequence type (ST)167, which is an emerging high-risk clone frequently reported among human clinical isolates. The blaOXA-484 gene was harboured in a composite transposon bracketed by IS26 identical to that of blaOXA-484 carried on an IncX plasmid pOXA-484-JS316 from a human clinical E. coli ST410 from Germany. The isolation of the epidemic clone ST167 harbouring blaOXA-484 from a canine infection raises the hypothesis of a transmission event between humans and companion animals.<\/jats:p>","DOI":"10.3390\/antibiotics15070652","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:50:37Z","timestamp":1782867037000},"page":"652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Report of a blaOXA-484-Harbouring Escherichia coli ST167 Isolated from the Urine Sample of a Dog of Italian Origin"],"prefix":"10.3390","volume":"15","author":[{"given":"Michael","family":"Biggel","sequence":"first","affiliation":[{"name":"Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3242-9739","authenticated-orcid":false,"given":"Magdalena","family":"N\u00fcesch-Inderbinen","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Section of Veterinary Bacteriology, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Schneeberger","sequence":"additional","affiliation":[{"name":"Section of Veterinary Bacteriology, Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Hofer","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jule Anna","family":"Horlbog","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-4762","authenticated-orcid":false,"given":"Roger","family":"Stephan","sequence":"additional","affiliation":[{"name":"Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, June 25). Critically Important Antimicrobials for Human Medicine 6th Revision 2018. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241515528."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.mcna.2025.01.003","article-title":"Management of severe infections: Multidrug-resistant and carbapenem-resistant Gram-negative bacteria","volume":"109","author":"Perez","year":"2025","journal-title":"Med. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jac\/dkx012","article-title":"OXA-48-like carbapenemases in the UK: An analysis of isolates and cases from 2007 to 2014","volume":"72","author":"Findlay","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3201\/eid3010.240814","article-title":"Oxacillinase-484-producing Enterobacterales, France, 2018\u20132023","volume":"30","author":"Emeraud","year":"2024","journal-title":"Emerg. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e0040322","DOI":"10.1128\/spectrum.00403-22","article-title":"Spread of the blaOXA-48\/IncL plasmid within and between dogs in city parks, France","volume":"10","author":"Haenni","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sommer, J., Gerbracht, K.M., Krause, F.F., Wild, F., Tietgen, M., Riedel-Christ, S., Sattler, J., Hamprecht, A., Kempf, V.A.J., and G\u00f6ttig, S. (2021). OXA-484, an OXA-48-type carbapenem-hydrolyzing class D \u03b2-lactamase from Escherichia coli. Front. 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