{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:23:28Z","timestamp":1783686208583,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Carbapenem-resistant Klebsiella spp. have emerged as major healthcare-associated pathogens worldwide, posing significant therapeutic and infection control challenges. Despite the growing burden of antimicrobial resistance, contemporary multicenter epidemiological data regarding carbapenem-resistant Klebsiella spp. in T\u00fcrkiye remain limited. This study aimed to determine the culture-based prevalence of carbapenem-resistant Klebsiella spp. and to describe the clinical, microbiological, and institutional characteristics associated with these organisms. Materials and Methods: This multicenter cross-sectional point-prevalence study was conducted in seven tertiary-care hospitals located in different regions of T\u00fcrkiye. On 19 February 2026, all hospitalized adult patients and microbiological cultures obtained on the study day were evaluated. Demographic, clinical, microbiological, antimicrobial treatment, infection control, and hospital-level data were collected using a standardized case report form. Culture-based prevalence estimates were calculated with 95% confidence intervals (CIs). Results: A total of 26 patients with carbapenem-resistant Klebsiella spp. colonization and\/or infection were included. The mean age was 68.5 \u00b1 14.1 years, and 61.5% were male. Most patients had at least one comorbidity (84.6%), and recent antibiotic exposure was common (88.5%). Urinary tract infection was the most frequently identified infection type (53.8%), followed by pneumonia (19.5%) and bloodstream infection (19.2%). Urinary catheterization was present in 73.1% of patients, while central venous catheters and mechanical ventilation were present in 46.2% and 34.6%, respectively. Ceftazidime\u2013avibactam susceptibility results were available for 20 isolates, of which 12 (60.0%; 95% CI, 38.66\u201378.12) were resistant. Colistin susceptibility results were available for 17 isolates, of which four (23.5%; 95% CI, 9.56\u201347.26) were resistant. The culture-based prevalence of carbapenem-resistant Klebsiella spp. was 1.69% (95% CI, 1.16\u20132.46) among all cultures obtained on the study day and 8.94% (95% CI, 6.17\u201312.77) among culture-positive specimens. Conclusions: Carbapenem-resistant Klebsiella spp. remain important healthcare-associated pathogens in T\u00fcrkiye, particularly among patients with substantial healthcare exposure, invasive device use, and recent antibiotic treatment. Continued surveillance, strengthened infection prevention measures, and expanded molecular characterization are essential for improving the understanding and control of antimicrobial resistance in the country.<\/jats:p>","DOI":"10.3390\/antibiotics15070679","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:43:34Z","timestamp":1783683814000},"page":"679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Point-Prevalence Study of Carbapenem-Resistant Klebsiella spp. in T\u00fcrkiye: Epidemiology, Antimicrobial Resistance, and Infection Control Practices"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-724X","authenticated-orcid":false,"given":"Esra","family":"Erdem K\u0131vrak","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Manisa Celal Bayar University, Manisa 45140, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Manisa Celal Bayar University, Manisa 45140, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Mermer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u0130zmir University of Economics Medical Point Hospital, \u0130zmir 35100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-0586","authenticated-orcid":false,"given":"Ahmet","family":"Sert\u00e7elik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Division of Epidemiology, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-4877","authenticated-orcid":false,"given":"Hasip","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir 26480, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-2727","authenticated-orcid":false,"given":"M\u00fcge","family":"Toygar Deniz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-5844","authenticated-orcid":false,"given":"Damla","family":"Ert\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7ukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Nazl\u0131","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eyl\u00fcl University, \u0130zmir 35100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin Ayta\u00e7","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, \u0130zmir 35100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6927-7052","authenticated-orcid":false,"given":"Ongun","family":"Yeni\u00e7eri","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7ukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-720X","authenticated-orcid":false,"given":"Meltem","family":"Ta\u015fbakan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, \u0130zmir 35100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024). 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