{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:40:58Z","timestamp":1791229258793,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the European Development Regional Fund"},{"name":"Subprograma Juan Rod\u00e9s","award":["JR22\/00049"],"award-info":[{"award-number":["JR22\/00049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: Outpatient Parenteral Antimicrobial Therapy (OPAT) programs provide a safe and cost-effective strategy for administering intravenous antimicrobials in the home setting. Aztreonam\/avibactam (ATM\/AVI) is a reserve antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria. The aim of this study was to evaluate the physicochemical stability of ATM\/AVI in elastomeric pumps for OPAT use. Methods: ATM\/AVI was diluted in a 0.9% sodium chloride solution to a concentration of 25\/8.33 mg\/mL and stored in elastomeric pumps (Infusor LV 10 mL\/h, 240 mL; Baxter Healthcare S.A, Zurich, Switzerland). The devices were maintained at 4 \u00b0C for 14 days and at 25, 32, and 37 \u00b0C for 48 h. Three independent elastomeric devices were prepared for each temperature condition and sampled in duplicate at each time point. Solutions were considered stable if the color, clarity, and pH remained unchanged and if the percentage of intact drug remained \u226590%, as determined via UHPLC-MS\/MS. Results: ATM\/AVI in polyisoprene elastomeric devices remained physicochemically stable for up to 14 days under refrigerated conditions and for 48 h at 25 \u00b0C, 32 \u00b0C, and 37 \u00b0C. Conclusions: ATM\/AVI solutions demonstrated prolonged stability under the evaluated conditions, supporting their potential use in OPAT programs via 24 h continuous infusion.<\/jats:p>","DOI":"10.3390\/antibiotics15070708","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:16:39Z","timestamp":1784650599000},"page":"708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physicochemical Stability of Aztreonam\/Avibactam in Elastomeric Devices for Outpatient Parenteral Antimicrobial Therapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Cristina","family":"Toro Blanch","sequence":"first","affiliation":[{"name":"Pharmacy Department, Hospital Universitari de Girona Doctor Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xabier","family":"Larrea Urtaran","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitari de Girona Doctor Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Aguilar Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitari de Girona Doctor Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Prat Riera","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitari de Girona Doctor Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Serveis T\u00e8cnics de Recerca, Universitat de Girona, Parc de Recerca i Innovaci\u00f3, 17003 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Costa Pou","sequence":"additional","affiliation":[{"name":"Serveis T\u00e8cnics de Recerca, Universitat de Girona, Parc de Recerca i Innovaci\u00f3, 17003 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-2879","authenticated-orcid":false,"given":"Beatriz","family":"Fern\u00e1ndez-Rubio","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Investigation Institute i+12, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-944X","authenticated-orcid":false,"given":"Laura","family":"Herrera-Hidalgo","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Farmacia, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo, 41013 Seville, Spain"},{"name":"Unidad Cl\u00ednica de Enfermedades Infecciosas, Microbiolog\u00eda y Parasitolog\u00eda (UCEIMP), Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo, 41013 Seville, Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Qui\u00f1ones Ribas","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitari de Girona Doctor Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102938","DOI":"10.1016\/j.jiph.2025.102938","article-title":"Implementation of outpatient parenteral antimicrobial therapy program in the contemporary health care system: A narrative review of the evidence","volume":"18","author":"Mohammed","year":"2025","journal-title":"J. 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