{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:29:17Z","timestamp":1786768157950,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancia Animal (PPGCA) da EV-UFMG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Bacteria of the genus Providencia are emerging pathogens associated with a wide range of infections, particularly in healthcare settings. In veterinary medicine, infections caused by these organisms are uncommon, and, to date, there have been no reports of carbapenem-resistant Providencia spp. causing infection in companion animals. Methods and Results: This study describes a comprehensive investigation of bacterial endocarditis caused by carbapenem-resistant Providencia rettgeri in a cat, including clinical, imaging, pathological, microbiological, and genomic findings. A 1.5-year-old mixed-breed female cat was admitted to a referral veterinary hospital with an extensive pelvic limb wound and a recent history of laparotomy. During hospitalization, a heart murmur was detected, and echocardiographic examination revealed vegetation-like lesion on the mitral valve. Despite intensive treatment, the patient\u2019s clinical condition progressively deteriorated over a 15-day period, ultimately leading to euthanasia. Necropsy confirmed bacterial endocarditis with evidence of systemic septic embolization. P. rettgeri was isolated from blood collected from both heart ventricles and from an endocardial swab and its identity was confirmed by MALDI-ToF mass spectrometry. Antimicrobial susceptibility testing demonstrated resistance to meropenem. Whole-genome sequencing confirmed the species identification and revealed a Col3M plasmid carrying multiple antimicrobial resistance genes, including the carbapenemase gene blaNDM-1. Discussion: To the best of our knowledge, this is the first report of carbapenem-resistant Providencia spp. causing infection in a companion animal. This case highlights the emergence of Providencia spp. as potential veterinary pathogens capable of causing severe, invasive and fatal infections.<\/jats:p>","DOI":"10.3390\/antibiotics15080778","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:06:16Z","timestamp":1786608376000},"page":"778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feline Endocarditis Caused by Carbapenem-Resistant Providencia rettgeri: Clinicopathological, Echocardiographic, and Genomic Investigation"],"prefix":"10.3390","volume":"15","author":[{"given":"Maisa de","family":"Carvalho","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-9812","authenticated-orcid":false,"given":"Yasmin Gon\u00e7alves de","family":"Castro","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Lucia Muniz","family":"Rezende","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Salarolli","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelise Carvalho","family":"Nepomuceno","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-8249","authenticated-orcid":false,"given":"Thaynara Parente de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-6242","authenticated-orcid":false,"given":"Rog\u00e9ria","family":"Serakides","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-2488","authenticated-orcid":false,"given":"Rodrigo Ot\u00e1vio Silveira","family":"Silva","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-6097","authenticated-orcid":false,"given":"Luiz Eduardo Duarte de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Federal University of Minas Gerais (UFMG), Avenida Antonio Carlos, 6627, Belo Horizonte 30123-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107211","DOI":"10.1016\/j.ijantimicag.2024.107211","article-title":"Identification of a Novel Providencia Species Showing Multi-Drug-Resistant in Three Patients with Hospital-Acquired Infection","volume":"64","author":"Yang","year":"2024","journal-title":"Int. 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