{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:21:32Z","timestamp":1789129292281,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background\/Objectives: Routine local gentamicin irrigation has been used during artificial urinary sphincter (AUS) implantation despite limited procedure-specific evidence. We evaluated early outcomes after its calendar-defined discontinuation. Methods: This single-centre retrospective before\u2013after cohort included 173 uncoated AMS 800 procedures in 164 men: 59 under a gentamicin-containing local protocol and 114 after gentamicin withdrawal. Saline device immersion and Betadine-containing intraoperative irrigation of the operative field and both wounds continued in both periods. Clinician-recorded surgical-site infection (SSI) within 90 days was the antimicrobial outcome of greatest direct relevance. Complete explantation within 90 days for SSI and\/or urethral erosion was an exploratory device-related endpoint; all-cause complications at 30 and 90 days were secondary safety outcomes. Results: SSI occurred after 1\/59 (1.7%) gentamicin-protocol and 2\/114 (1.8%) gentamicin-free procedures (risk difference +0.1 percentage points, 95% confidence interval \u22127.4 to +4.7; p = 1.000). Erosion occurred after 0\/59 and 4\/114 (3.5%) procedures; all four led to complete explantation. The explantation endpoint occurred after 1\/59 versus 4\/114 procedures (risk difference +1.8 percentage points, 95% confidence interval \u22125.8 to +7.2; p = 0.662). Thirty-day all-cause complications occurred after 14\/59 versus 16\/114 procedures and 90-day complications after 15\/59 versus 26\/114. Conclusions: No statistically significant between-period difference was detected in SSI, exploratory device-related explantation, or broad all-cause complications. Sparse events, wide confidence intervals and calendar-defined exposure amid concurrent era changes preclude conclusions regarding equivalence or absence of clinically relevant benefit or harm.<\/jats:p>","DOI":"10.3390\/antibiotics15090894","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:51:37Z","timestamp":1789123897000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Outcomes After Discontinuing Routine Gentamicin Irrigation During AMS 800 Artificial Urinary Sphincter Implantation: A Single-Centre Retrospective Before\u2013After Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-3360","authenticated-orcid":false,"given":"Micha\u0142 Andrzej","family":"Skrzypczyk","sequence":"first","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pliszka","sequence":"additional","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-5216","authenticated-orcid":false,"given":"\u0141ukasz","family":"Bia\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rydzi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Karo\u0144","sequence":"additional","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Dobruch","sequence":"additional","affiliation":[{"name":"Department of Urology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-2970","authenticated-orcid":false,"given":"Artur","family":"Lemi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of General and Oncological Urology, Independent Public Provincial Hospital in Szczecin, 71-455 Szczecin, Poland"},{"name":"Department of Biochemical Sciences, Pomeranian Medical University, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.21037\/tau-23-488","article-title":"Artificial urinary sphincter erosion and infection: A contemporary review of perioperative considerations and management","volume":"13","author":"Desai","year":"2024","journal-title":"Transl. 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Pharm."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/15\/9\/894\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:15:54Z","timestamp":1789125354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/15\/9\/894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["antibiotics15090894"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics15090894","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}