{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:34:38Z","timestamp":1787668478311,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>To clarify the clinical efficacy of a single oral 2 g dose of azithromycin extended-release for heterosexual male patients with urethritis, and the current antimicrobial sensitivity of Neisseria gonorrhoeae to azithromycin, a prospective clinical trial was conducted from 2011\u20132013. In patients with gonococcal urethritis, the eradication rate was 90.9% (30 of 33). The susceptibility rates of isolated Neisseria gonorrhoeae strains to ceftriaxone, spectinomycin, cefixime and azithromycin were 100%, 100%, 95.3% (41\/43) and 37.2% (16\/43), respectively. In the patients with nongonococcal urethritis, the eradication rate was 90.0% (45 of 50). The microbiological eradication rates for the pathogens were 90.9% (30\/33) for Neisseria gonorrhoeae, 91.5% (43\/47) for Chlamydia trachomatis, 71.4% (5\/7) for Mycoplasma genitalium, and 100% (13\/13) for Ureaplasma urealyticum. The main adverse event was diarrhea and its manifestation rate was 35.2% (32 of 120). The symptom of diarrhea was mostly temporary and resolved spontaneously. The conclusion was that the treatment regimen with a single oral 2 g dose of azithromycin extended-release would be effective for patients with urethritis. However, the antimicrobial susceptibilities of Neisseria gonorrhoeae and Mycoplasma genitalium should be carefully monitored because of possible treatment failure.<\/jats:p>","DOI":"10.3390\/antibiotics3020109","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T11:09:47Z","timestamp":1396436987000},"page":"109-120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Efficacy of a Single Two Gram Dose of Azithromycin Extended Release for Male Patients with Urethritis"],"prefix":"10.3390","volume":"3","author":[{"given":"Satoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Urology, the Jikei University Katsushika Medical Center, 6-41-2 Aoto Katsushika-ku, Tokyo 1258506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ito","sequence":"additional","affiliation":[{"name":"iClinic, 5-9-6, Nagamachi, Taihaku-ku, Sendai, Miyagi 9820011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Iwasawa","sequence":"additional","affiliation":[{"name":"Iwasawa Clinic, Sapporo Medical University School of Medicine, S. 1, W. 16, Chuo-ku,  Sapporo, Hokkaido 0600061, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhisa","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Masumori","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapporo Medical University School of Medicine,  S. 1, W. 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sunaoshi","sequence":"additional","affiliation":[{"name":"Teine Urologic Clinic, 1-12, Maeda 6-7, Teine-ku, Sapporo 0060816, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Teine Urologic Clinic, 1-12, Maeda 6-7, Teine-ku, Sapporo 0060816, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Teine Urologic Clinic, 1-12, Maeda 6-7, Teine-ku, Sapporo 0060816, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Hosobe","sequence":"additional","affiliation":[{"name":"Hosobe Clinic, 1-1-15, Nezu, Bunkyo-ku, Tokyo 1130031, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Urology, Fuji City General Hospital, 50 Takashima-Cho, Fuji,  Shizuoka 4178567, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology, Fuji City General Hospital, 50 Takashima-Cho, Fuji,  Shizuoka 4178567, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Onodera","sequence":"additional","affiliation":[{"name":"Department of Urology, Fuji City General Hospital, 50 Takashima-Cho, Fuji,  Shizuoka 4178567, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/OLQ.0b013e3182040de9","article-title":"Demographic, behavioral, and clinical characteristics of men with nongonococcal urethritis differ by etiology: A case-comparison study","volume":"38","author":"Wetmore","year":"2011","journal-title":"Sex. 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