{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:19:39Z","timestamp":1792606779417,"version":"4.5.0"},"reference-count":21,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Seven analogs of the natural, \u03b1-helix peptides IsCT1 and IsCT2\u2014found in the venom of scorpion Opithancatus Madagascariensis\u2014have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with alanine, valine, and leucine, enhances antibacterial activity. However, this also increases hemolytic activity. The analog with an increased net positive charge from +1 to +3 produces moderate bacterial growth inhibition but also has high hemolytic activity. On the other hand, the analog with a negative net charge (\u22121) has low antibacterial properties but also no cytotoxicity under the tested conditions, a similar result was found for five of the seven studied analogs.<\/jats:p>","DOI":"10.3390\/antibiotics6030013","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T10:25:56Z","timestamp":1498645556000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides"],"prefix":"10.3390","volume":"6","author":[{"given":"Roberto","family":"De la Salud Bea","sequence":"first","affiliation":[{"name":"Department of Chemistry, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Petraglia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ascuitto","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Buck","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nhung, N.T., Cuong, N.V., Thwaites, G., and Carrique-Mas, J. 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