{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:20:32Z","timestamp":1770963632341,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>This study aimed to reevaluate the Acute Cystitis Symptom Score (ACSS). The ACSS is a simple and standardized self-reporting questionnaire for the diagnosis of acute uncomplicated cystitis (AC) assessing typical and differential symptoms, quality of life, and possible changes after therapy in female patients with AC. This paper includes literature research, development and evaluation of the ACSS, an 18-item self-reporting questionnaire including (a) six questions about \u201ctypical\u201d symptoms of AC, (b) four questions regarding differential diagnoses, (c) three questions on quality of life, and (d) five questions on additional conditions that may affect therapy. The ACSS was evaluated in 228 women (mean age 31.49 \u00b1 11.71 years) in the Russian and Uzbek languages. Measurements of reliability, validity, predictive ability, and responsiveness were performed. Cronbach\u2019s alpha for ACSS was 0.89, split-half reliability was 0.76 and 0.79 for first and second halves, and the correlation between them was 0.87. Mann-Whitney U test revealed a significant difference in scores of the \u201ctypical\u201d symptoms between patients and controls (10.50 vs. 2.07, p &lt; 0.001). The optimal threshold score was 6 points, with a 94% sensitivity and 90% specificity to predict AC. The \u201ctypical\u201d symptom score decreased significantly when comparing before and after therapy (10.4 and 2.5, p &lt; 0.001). The reevaluated Russian and Uzbek ACSS are accurate enough and can be recommended for clinical studies and practice for initial diagnosis and monitoring the process of the treatment of AC in women. Evaluation in German, UK English, and Hungarian languages was also performed and in other languages evaluation of the ACSS is in progress<\/jats:p>","DOI":"10.3390\/antibiotics7010006","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T12:30:36Z","timestamp":1516019436000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reevaluation of the Acute Cystitis Symptom Score, a Self-Reporting Questionnaire. Part I. Development, Diagnosis and Differential Diagnosis"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-4877","authenticated-orcid":false,"given":"Jakhongir","family":"Alidjanov","sequence":"first","affiliation":[{"name":"The Republican Specialized Center of Urology, 100109 Tashkent, Uzbekistan"},{"name":"Clinic of Urology, Paediatric Urology and Andrology, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Naber","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Technical University of Munich, D-80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulugbek","family":"Abdufattaev","sequence":"additional","affiliation":[{"name":"The Republican Specialized Center of Urology, 100109 Tashkent, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Pilatz","sequence":"additional","affiliation":[{"name":"Clinic of Urology, Paediatric Urology and Andrology, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Wagenlehner","sequence":"additional","affiliation":[{"name":"Clinic of Urology, Paediatric Urology and Andrology, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0891-5520(03)00005-9","article-title":"Epidemiology of urinary tract infections: Transmission and risk factors, incidence, and costs","volume":"17","author":"Foxman","year":"2003","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0924-8579(01)00303-X","article-title":"Urinary tract infection in adults: Research priorities and strategies","volume":"17","author":"Ronald","year":"2001","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_3","first-page":"1","article-title":"Ambulatory medical care utilization estimates for 2007","volume":"13","author":"Schappert","year":"2011","journal-title":"Vital Health Stat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2165\/00044011-200424010-00007","article-title":"Survey of symptom burden in women with uncomplicated urinary tract infections","volume":"24","author":"Colgan","year":"2004","journal-title":"Clin. Drug Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1477-7525-3-45","article-title":"Women\u2019s quality of life is decreased by acute cystitis and antibiotic adverse effects associated with treatment","volume":"3","author":"Ernst","year":"2005","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/oxfordjournals.aje.a010170","article-title":"Risk factors for second urinary tract infection among college women","volume":"151","author":"Foxman","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/315827","article-title":"Risk factors for recurrent urinary tract infection in young women","volume":"182","author":"Scholes","year":"2000","journal-title":"J. Inf. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000335554","article-title":"Prevalence of urinary tract infections and its risk factors in elementary school students","volume":"88","author":"Zincir","year":"2012","journal-title":"Urol. Int."},{"key":"ref_9","first-page":"327","article-title":"Variations among family physicians\u2019 management strategies for lower urinary tract infection in women: A report from the washington family physicians collaborative research network","volume":"4","author":"Berg","year":"1991","journal-title":"J. Am. Board Fam. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1525-1497.1999.05398.x","article-title":"Variation by specialty in the treatment of urinary tract infection in women","volume":"14","author":"Wigton","year":"1999","journal-title":"J. Gen. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000334976","article-title":"Relationship between urinary tract infection categorization and pathogens\u2019 antimicrobial susceptibilities","volume":"88","author":"Yamamichi","year":"2012","journal-title":"Urol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1001\/jama.287.20.2701","article-title":"Does this woman have an acute uncomplicated urinary tract infection?","volume":"287","author":"Bent","year":"2002","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20S","DOI":"10.1016\/S0002-9343(02)01056-2","article-title":"The optimal use of diagnostic testing in women with acute uncomplicated cystitis","volume":"113","author":"Bent","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_14","first-page":"326","article-title":"Acute cystitis in women: Experience with a telephone-based algorithm","volume":"106","author":"Schauberger","year":"2007","journal-title":"WMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1464-410X.2005.05630.x","article-title":"Validation of a patient-administered questionnaire to measure the severity and bothersomeness of lower urinary tract symptoms in uncomplicated urinary tract infection (UTI): The UTI Symptom Assessment questionnaire","volume":"96","author":"Clayson","year":"2005","journal-title":"BJU Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1477-7525-3-42","article-title":"Validation of a patient-administered questionnaire to measure the activity impairment experienced by women with uncomplicated urinary tract infection: The Activity Impairment Assessment (AIA)","volume":"3","author":"Wild","year":"2005","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_17","first-page":"49","article-title":"Evaluation of suspected urinary tract infection in ambulatory women: A cost-utility analysis of office-based strategies","volume":"44","author":"Barry","year":"1997","journal-title":"J. Fam. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000356177","article-title":"New self-reporting questionnaire to assess urinary tract infections and differential diagnosis: Acute cystitis symptom score","volume":"92","author":"Alidjanov","year":"2014","journal-title":"Urol. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000448591","article-title":"The Acute Cystitis Symptom Score for Patient- Reported Outcome assessment","volume":"97","author":"Alidjanov","year":"2016","journal-title":"Urol. Int."},{"key":"ref_20","unstructured":"Akilov, F.A., Naber, K.G., Rakhmonov, O.M., Alidjanov, J.F., and Abdufattaev, U.A. (2011). Development and validation of self-administered questionnaire to assess severity of acute cystitis symptoms and their influence to quality of life: Urinary Symptoms and Quality of Life Assessment Tool (USQOLAT). Collected Articles of the Congress \u201cCurrent Problems of Theoretical and Practical Medicine\u201d, The Research Center of Urology named after B.U. Dzharbussynov."},{"key":"ref_21","unstructured":"Alidjanov, J.F., Abdufattaev, U.A., Pilatz, A., Naber, K.G., and Wagenlehner, F.M. Reevaluation of the Acute Cystitis Symptom Score, a Self-reporting Questionnaire for Patient-Reported Outcome Assessment (Part II), (in preparation)."},{"key":"ref_22","first-page":"121","article-title":"Leukocyte and erythrocyte counts in 1 mL of urine","volume":"2","author":"Nechiporenko","year":"1969","journal-title":"Lab. Delo"},{"key":"ref_23","first-page":"1153","article-title":"Urinalysis: A comprehensive review","volume":"71","author":"Simerville","year":"2005","journal-title":"Am. Fam. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02289289","article-title":"Test \u201creliability\u201d: Its meaning and determination","volume":"12","author":"Cronbach","year":"1947","journal-title":"Psychometrika"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3001968","article-title":"Individual comparisons by ranking methods","volume":"1","author":"Wilcoxon","year":"1945","journal-title":"Biom. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Student (1908). The probable error of a mean. Biometrika, 6, 1\u201325.","DOI":"10.1093\/biomet\/6.1.1"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bleidorn, J., Gagyor, I., Kochen, M.M., Wegscheider, K., and Hummers-Pradier, E. (2010). Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?\u2014Results of a randomized controlled pilot trial. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-30"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/00365540410019642","article-title":"The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study","volume":"36","author":"Ferry","year":"2004","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/028134399750002908","article-title":"Peeing barbed wire. Symptom experiences in women with lower urinary tract infection","volume":"17","author":"Malterud","year":"1999","journal-title":"Scand. J. Prim. Health Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijgo.2006.02.019","article-title":"Bladder tenderness as a physical sign for diagnosing cystitis in women","volume":"93","author":"Savaris","year":"2006","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1056\/NEJM198208193070802","article-title":"Diagnosis of coliform infection in acutely dysuric women","volume":"307","author":"Stamm","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1302186","article-title":"Voided midstream urine culture and acute cystitis in premenopausal women","volume":"369","author":"Hooton","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_33","unstructured":"Novick, A.A., Ionova, T.I., and Kaind, P. (1999). Conception of Life Quality Research in Medicine, Elby. (In Russian)."},{"key":"ref_34","unstructured":"Spilker, B. (1996). Quality of Life and Pharmacoeconomics in Clinical Trials, Lippincott-Raven. [2nd ed.]."},{"key":"ref_35","unstructured":"Staquet, M.J. (1998). Quality of Life Assessment in Clinical Trials: Methods and Practice, Oxford University Press."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/BF00540022","article-title":"Guidelines for reporting results of quality of life assessments in clinical trials","volume":"5","author":"Staquet","year":"1996","journal-title":"Qual. Life Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0022-5347(17)36966-5","article-title":"The American Urological Association symptom index for benign prostatic hyperplasia. The measurement committee of the American Urological Association","volume":"148","author":"Barry","year":"1992","journal-title":"J. Urol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-5347(05)68562-X","article-title":"The National Institutes of Health Chronic Prostatitis Symptom Index: Development and validation of a new outcome measure. Chronic prostatitis collaborative research network","volume":"162","author":"Litwin","year":"1999","journal-title":"J. Urol."},{"key":"ref_39","first-page":"1","article-title":"Generalized symptoms in adult women with acute uncomplicated lower urinary tract infection: An observational study","volume":"5","author":"Baerheim","year":"2003","journal-title":"MedGenMed"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3122\/15572625-13-6-392","article-title":"Quality of life in women with urinary tract infections: Is benign disease a misnomer?","volume":"13","author":"Ellis","year":"2000","journal-title":"J. Am. Board Fam. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Little, P., Merriman, R., Turner, S., Rumsby, K., Warner, G., Lowes, J.A., Smith, H., Hawke, C., Leydon, G., and Mullee, M. (2010). Presentation, pattern, and natural course of severe symptoms, and role of antibiotics and antibiotic resistance among patients presenting with suspected uncomplicated urinary tract infection in primary care: Observational study. BMJ.","DOI":"10.1136\/bmj.b5633"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00120-015-3873-5","article-title":"German validation of the Acute Cystitis Symptom Score","volume":"54","author":"Alidjanov","year":"2015","journal-title":"Urologe A"},{"key":"ref_43","first-page":"555561","article-title":"Preliminary Clinical Validation of the UK English Version of the Acute Cystitis Symptom Score in UK English-speaking female population of Newcastle, Great Britain","volume":"1","author":"Alidjanov","year":"2017","journal-title":"JOJ Urol. Nephrol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/7\/1\/6\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:51:17Z","timestamp":1760194277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/7\/1\/6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["antibiotics7010006"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics7010006","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,15]]}}}