{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:23:45Z","timestamp":1790519025159,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010784","name":"Banco Santander","doi-asserted-by":"publisher","award":["Becas Iberoam\u00e9rica J\u00f3venes Profesores e Investigadores, Espa\u00f1a"],"award-info":[{"award-number":["Becas Iberoam\u00e9rica J\u00f3venes Profesores e Investigadores, Espa\u00f1a"]}],"id":[{"id":"10.13039\/100010784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Phytophthora cinnamomi, responsible for \u201croot rot\u201d or \u201cdieback\u201d plant disease, causes a significant amount of economic and environmental impact. In this work, the fungicide action of nanocomposites based on silver nanoparticles and polyphenol inclusion compounds, which feature enhanced bioavailability and water solubility, was assayed for the control of this soil-borne water mold. Inclusion compounds were prepared by an aqueous two-phase system separation method through extraction, either in an hydroalcoholic solution with chitosan oligomers (COS) or in a choline chloride:urea:glycerol deep eutectic solvent (DES). The new inclusion compounds were synthesized from stevioside and various polyphenols (gallic acid, silymarin, ferulic acid and curcumin), in a [6:1] ratio in the COS medium and in a [3:1] ratio in the DES medium, respectively. Their in vitro response against Phytophthora cinnamomi isolate MYC43 (at concentrations of 125, 250 and 500 \u00b5g\u00b7mL\u22121) was tested, which found a significant mycelial growth inhibition, particularly high for the composites prepared using DES. Therefore, these nanocomposites hold promise as an alternative to fosetyl-Al and metalaxyl conventional systemic fungicides.<\/jats:p>","DOI":"10.3390\/antibiotics7030076","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T10:54:25Z","timestamp":1534503265000},"page":"76","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Silver Nanoparticles and Polyphenol Inclusion Compounds Composites for Phytophthora cinnamomi Mycelial Growth Inhibition"],"prefix":"10.3390","volume":"7","author":[{"given":"Petruta Mihaela","family":"Matei","sequence":"first","affiliation":[{"name":"Department of Bioengineering of Horticultural and Viticultural Systems, University of Agricultural Sciences and Veterinary Medicine of Bucharest, Bulevardul M\u0103r\u0103\u0219ti 59, Bucure\u0219ti 011464, Romania"},{"name":"Agriculture and Forestry Engineering Department, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mart\u00edn-Gil","sequence":"additional","affiliation":[{"name":"Agriculture and Forestry Engineering Department, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Michaela Iacomi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering of Horticultural and Viticultural Systems, University of Agricultural Sciences and Veterinary Medicine of Bucharest, Bulevardul M\u0103r\u0103\u0219ti 59, Bucure\u0219ti 011464, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez-Lebe\u00f1a","sequence":"additional","affiliation":[{"name":"Agriculture and Forestry Engineering Department, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Barrio-Arredondo","sequence":"additional","affiliation":[{"name":"Centro de Salud Barrio Espa\u00f1a, Sanidad de Castilla y Le\u00f3n (SACYL), Calle de la Costa Brava, 4, 47010 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-2786","authenticated-orcid":false,"given":"Pablo","family":"Mart\u00edn-Ramos","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, EPS, Instituto de Investigaci\u00f3n en Ciencias Ambientales (IUCA), University of Zaragoza, Carretera de Cuarte, s\/n, 22071 Huesca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/jsfa.8749","article-title":"Recent developments in nanotechnology transforming the agricultural sector: A transition replete with opportunities","volume":"98","author":"Kim","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1128\/AAC.9.2.357","article-title":"Electrically generated silver ions: Quantitative effects on bacterial and mammalian cells","volume":"9","author":"Berger","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmii.2014.04.013","article-title":"The antifungal effect of silver nanoparticles on Trichosporon asahii","volume":"49","author":"Xia","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5941\/MYCO.2012.40.1.053","article-title":"Antifungal effects of silver nanoparticles (AgNPs) against various plant pathogenic fungi","volume":"40","author":"Kim","year":"2018","journal-title":"Mycobiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tibtech.2013.01.003","article-title":"The greener synthesis of nanoparticles","volume":"31","author":"Kharissova","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.indcrop.2015.03.015","article-title":"Plant extract synthesized silver nanoparticles: An ongoing source of novel biocompatible materials","volume":"70","author":"Rajan","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/17518253.2015.1111431","article-title":"The application of different Stevia rebaudiana leaf extracts in the \u201cgreen synthesis\u201d of AgNPs","volume":"8","author":"Bujak","year":"2015","journal-title":"Green Chem. Lett. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1016\/j.biortech.2010.05.051","article-title":"Immobilization of silver nanoparticles synthesized using Curcuma longa tuber powder and extract on cotton cloth for bactericidal activity","volume":"101","author":"Sathishkumar","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF03353627","article-title":"Extracellular synthesis of silver nanoparticles using dried leaves of Pongamia pinnata (L.) Pierre","volume":"2","author":"Raut","year":"2010","journal-title":"Nano Micro Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/157341309787314674","article-title":"Phytosynthesis of silver nanoparticle using Gliricidia sepium (Jacq.)","volume":"5","author":"Raut","year":"2009","journal-title":"Curr. Nanosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1080\/14786419.2014.918124","article-title":"Green synthesis of silver nanoparticles using Eucalyptus leucoxylon leaves extract and evaluating the antioxidant activities of extract","volume":"28","author":"Pourmortazavi","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_12","first-page":"1","article-title":"Eco-friendly method for green recovery of silver nano particles from effluent fixer solution through interacting with Q. brantii (oak) peel hydro alcoholic extract","volume":"5","author":"Safaei","year":"2017","journal-title":"J. Adv. Eng. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.procbio.2015.01.002","article-title":"Green synthesis of gallic acid-coated silver nanoparticles with high antimicrobial activity and low cytotoxicity to normal cells","volume":"50","author":"Li","year":"2015","journal-title":"Process Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ultsonch.2017.11.001","article-title":"Ultrasound-assisted extraction of antimicrobial compounds from Thymus daenensis and Silybum marianum: Antimicrobial activity with and without the presence of natural silver nanoparticles","volume":"42","author":"Safarpoor","year":"2018","journal-title":"Ultrason. Sonochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1208\/s12249-017-0832-z","article-title":"Association of silver nanoparticles and curcumin solid dispersion: Antimicrobial and antioxidant properties","volume":"19","author":"Alves","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.msec.2017.03.226","article-title":"Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives","volume":"77","author":"Hussain","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1039\/C5PY01912E","article-title":"Enhancing the therapeutic effects of polyphenols with macromolecules","volume":"7","author":"Oliver","year":"2016","journal-title":"Polym. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.carbpol.2017.07.014","article-title":"Synthesis, characterization, bioactivity and potential application of phenolic acid grafted chitosan: A review","volume":"174","author":"Liu","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ijbiomac.2017.06.021","article-title":"Antioxidant, antimicrobial, cell viability and enzymatic inhibitory of antioxidant polymers as biological macromolecules","volume":"104","author":"Niakousari","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ijbiomac.2017.12.044","article-title":"Synthesis, characterisation and biomedical applications of curcumin conjugated chitosan microspheres","volume":"110","author":"Saranya","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ijbiomac.2017.06.096","article-title":"Nano cellulose dispersed chitosan film with Ag NPs\/curcumin: An in vivo study on albino rats for wound dressing","volume":"104","author":"Bajpai","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.msec.2016.07.077","article-title":"Multifunctional soft hybrid bio-platforms based on nano-silver and natural compounds","volume":"69","author":"Badea","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.foodchem.2016.07.102","article-title":"Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides","volume":"214","author":"Nguyen","year":"2017","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.foodchem.2016.07.025","article-title":"Hybridization of polyvinylpyrrolidone to a binary composite of curcumin\/\u03b1-glucosyl stevia improves both oral absorption and photochemical stability of curcumin","volume":"213","author":"Kadota","year":"2016","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1021\/acs.jafc.7b01054","article-title":"Application of deep eutectic solvents (DES) for phenolic compounds extraction: Overview, challenges, and opportunities","volume":"65","author":"Durand","year":"2017","journal-title":"J. Agric. Food. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Georgantzi, C., Lioliou, A.-E., Paterakis, N., and Makris, D. (2017). Combination of lactic acid-based deep eutectic solvents (DES) with \u03b2-cyclodextrin: Performance screening using ultrasound-assisted extraction of polyphenols from selected native Greek medicinal plants. Agronomy, 7.","DOI":"10.3390\/agronomy7030054"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.foodhyd.2018.03.025","article-title":"The role of choline chloride-based deep eutectic solvent and curcumin on chitosan films properties","volume":"81","author":"Almeida","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.carbpol.2017.02.047","article-title":"Optimized pH-responsive film based on a eutectic mixture-plasticized chitosan","volume":"165","author":"Pereira","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1094\/PHYTO-01-11-0025","article-title":"The genus Phytophthora anno 2012","volume":"102","author":"Kroon","year":"2012","journal-title":"Phytopathology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0007-1536(84)80149-7","article-title":"Establishment of micro-organisms in fumigated avocado soil to attempt to prevent reinvasion of the soils by Phytophthora cinnamomi","volume":"83","author":"Munnecke","year":"1984","journal-title":"Trans. Br. Mycol. Soc."},{"key":"ref_31","unstructured":"Erwin, D.C., Bartnicki-Garc\u00eda, S., and Tsao, P.H. (1983). The world of Phytophthora. Phytophthora, Its biology, Taxonomy, Ecology and Pathology, American Phytopathological Society."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1094\/PHYTO-01-15-0006-R","article-title":"Inhibition of Phytophthora parasitica and P. capsici by silver nanoparticles synthesized using aqueous extract of Artemisia absinthium","volume":"105","author":"Ali","year":"2015","journal-title":"Phytopathology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/01448765.2005.9755319","article-title":"Antifungal activity of chitosan against Phytophthora infestans and activation of defence mechanisms in tomato to late blight","volume":"23","author":"Atia","year":"2005","journal-title":"Biol. Agric. Hortic."},{"key":"ref_34","first-page":"2685","article-title":"Synthesis and anti-fungal effect of silver nanoparticles-chitosan composite particles","volume":"10","author":"Wang","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_35","first-page":"401","article-title":"Potential control of forest diseases by solutions of chitosan oligomers, propolis and nanosilver","volume":"150","author":"Diez","year":"2017","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_36","unstructured":"Mart\u00edn-Gil, J., Matei Petruta, M., and P\u00e9rez Lebe\u00f1a, E. (2017). Complejo de inclusi\u00f3n para mejorar la biodisponibilidad de compuestos biol\u00f3gicamente activos no hidrosolubles. (P201731489)."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1021\/jf0210369","article-title":"Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse","volume":"51","author":"Kim","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3844\/ajabssp.2009.83.91","article-title":"Anti-Phytopthora capsici activities and potential use as antifungal in agriculture of Alpinia galanga Swartz, Curcuma longa Linn, Boesenbergia pandurata Schut and Chromolaena odorata: Bioactivities guided isolation of active ingredients","volume":"4","author":"Pompimon","year":"2009","journal-title":"Am. J. Agric. Biol. Sci."},{"key":"ref_39","first-page":"42","article-title":"Inhibition of p-isopropyl benzaldehyde and p-isopropyl benzoic acid extracted from Cuminum cyminum against plant pathogens","volume":"11","author":"Hu","year":"2008","journal-title":"Acta Bot. Boreal. Occident. Sin."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5423\/PPJ.2009.25.1.103","article-title":"Anti-oomycete activity of furanocoumarins from seeds of Psoralea corylifolia against Phytophthora infestans","volume":"25","author":"Shim","year":"2009","journal-title":"Plant Pathol. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/2053-1591\/3\/7\/075403","article-title":"Tallow amphopolycarboxyglycinate-stabilized silver nanoparticles: New frontiers in development of plant protection products with a broad spectrum of action against phytopathogens","volume":"3","author":"Krutyakov","year":"2016","journal-title":"Mater. Res. Express"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Banik, S., and P\u00e9rez-de-Luque, A. (2017). In vitro effects of copper nanoparticles on plant pathogens, beneficial microbes and crop plants. Span. J. Agric. Res., 15.","DOI":"10.5424\/sjar\/2017152-10305"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s11356-015-5391-9","article-title":"Histopathological effects of silver and copper nanoparticles on the epidermis, gills, and liver of Siberian sturgeon","volume":"23","author":"Ostaszewska","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4194\/1303-2712-v18_6_04","article-title":"Effect of copper and silver nanoparticles on trunk muscles in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792)","volume":"18","author":"Dobrochna","year":"2018","journal-title":"Turk. J. Fish. Aquat. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6046232","article-title":"Synthesis and antimicrobial activity of N-(6-carboxyl cyclohex-3-ene carbonyl) chitosan with different degrees of substitution","volume":"2016","author":"Badawy","year":"2016","journal-title":"Int. J. Carbohydr. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10534-008-9159-2","article-title":"Antifungal activity and mode of action of silver nano-particles on Candida albicans","volume":"22","author":"Kim","year":"2008","journal-title":"BioMetals"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1155\/MBD.1994.467","article-title":"Antibacterial silver","volume":"1","author":"Clement","year":"1994","journal-title":"Met. Based Drugs"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijpharm.2014.01.035","article-title":"Drug solubilization mechanism of \u03b1-glucosyl stevia by NMR spectroscopy","volume":"465","author":"Zhang","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/343804","article-title":"The inhibitory effects of Curcuma longa L. essential oil and curcumin on Aspergillus flavus Link growth and morphology","volume":"2013","author":"Ferreira","year":"2013","journal-title":"Sci. World J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/iub.1326","article-title":"An antifungal mechanism of curcumin lies in membrane-targeted action within Candida albicans","volume":"66","author":"Lee","year":"2014","journal-title":"IUBMB Life"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"27540","DOI":"10.1039\/C5RA01911G","article-title":"Gallic acid: A versatile antioxidant with promising therapeutic and industrial applications","volume":"5","author":"Badhani","year":"2015","journal-title":"RSC Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/632698","article-title":"Antifungal activity of chitosan nanoparticles and correlation with their physical properties","volume":"2012","author":"Ing","year":"2012","journal-title":"Int. J. Biomater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1007\/s11356-015-6003-4","article-title":"Toxicity profile of choline chloride-based deep eutectic solvents for fungi and Cyprinus carpio fish","volume":"23","author":"Juneidi","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chemosphere.2013.05.013","article-title":"Assessment of cytotoxicity and toxicity for phosphonium-based deep eutectic solvents","volume":"93","author":"Hayyan","year":"2013","journal-title":"Chemosphere"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1007\/s11356-018-1669-z","article-title":"Antimicrobial, cytotoxic and antioxidative evaluation of natural deep eutectic solvents","volume":"25","author":"Markov","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Papaccio, G., Hayyan, M., Looi, C.Y., Hayyan, A., Wong, W.F., and Hashim, M.A. (2015). In vitro and in vivo toxicity profiling of ammonium-based deep eutectic solvents. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117934"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mbous, Y.P., Hayyan, M., Wong, W.F., Looi, C.Y., and Hashim, M.A. (2017). Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems. Sci. Rep., 7.","DOI":"10.1038\/srep41257"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jphotobiol.2017.04.030","article-title":"Investigation of the antimicrobial effect of natural deep eutectic solvents (NADES) as solvents in antimicrobial photodynamic therapy","volume":"171","author":"Wikene","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.seppur.2016.09.001","article-title":"Enhanced extraction of antioxidants from aqueous solutions by ionic liquids","volume":"172","author":"Fan","year":"2017","journal-title":"Sep. Purif. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00217-006-0439-1","article-title":"Preparation of chitosan oligomers and their antioxidant activity","volume":"225","author":"Sun","year":"2007","journal-title":"Eur. Food Res. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.carbpol.2006.04.005","article-title":"Ionic liquids as solvents for biopolymers: Acylation of starch and zein protein","volume":"66","author":"Biswas","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5923\/j.scit.20110101.02","article-title":"Aqueous two phase systems for the recovery of biomolecules\u2014A review","volume":"1","author":"Raja","year":"2012","journal-title":"Sci. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.24326\/asphc.2017.6.15","article-title":"In vitro antifungal activity of some plant extracts against Fusarium oxysporum in blackcurrant (Ribes nigrum L.)","volume":"16","author":"Enache","year":"2017","journal-title":"Acta Sci. Pol. Hortorum Cultus"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/7\/3\/76\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:19:12Z","timestamp":1760195952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/7\/3\/76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["antibiotics7030076"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics7030076","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]}}}