{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:00:25Z","timestamp":1792170025015,"version":"4.4.0"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The rise in resistance and changes in the spectrum of Candida infections have generated enormous interest in developing new antifungal drugs using natural molecules such as plant essential oils (EOs). Antimicrobial activity against foodborne pathogenic and spoilage microorganisms has been reported for EOs. The goal of this study was to assess the effect of Mentha \u00d7 piperita essential oil (EO) on C. albicans growth, transition (change from blastospore to hyphae forms), and biofilm formation as well as on the expression of certain virulent genes. We show that whole EO and its vapor attenuated the yeast\u2019s growth, compared to that in the control. The effect of the EO was comparable to that of amphotericin-B (AmB). The EO and its vapor significantly decreased the morphological changes of C. albicans, reduced biofilm formation, and disrupted mature C. albicans biofilms. The effect produced by whole EO on biofilm formation\/disruption was notably comparable to that observed with AmB. Exposure of C. albicans to EO and its vapor downregulated the expression of various genes, such as secreted aspartyl proteinases (SAP 1, 2, 3, 9, 10) and hyphal wall protein 1 (HWP1). Altogether, these results provide new insight into the efficacy of Mentha \u00d7 piperita EO against C. albicans and suggest the potential of Mentha \u00d7 piperita EO for use as an antifungal therapy in multiple applications.<\/jats:p>","DOI":"10.3390\/antibiotics8010010","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T10:58:27Z","timestamp":1548845907000},"page":"10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Effects of Mentha \u00d7 piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes"],"prefix":"10.3390","volume":"8","author":[{"given":"Chahrazed","family":"Benzaid","sequence":"first","affiliation":[{"name":"Groupe de Recherche en \u00c9cologie Buccale (GREB), Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, 2420 rue de la Terrasse, Quebec, QC G1V 0A6, Canada"},{"name":"Groupe de Recherche sur les Biofilms et la Biocontamination des Mat\u00e9riaux, Facult\u00e9 des Sciences, Universit\u00e9 d\u2019Annaba, Annaba 23000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Belmadani","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en \u00c9cologie Buccale (GREB), Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, 2420 rue de la Terrasse, Quebec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryad","family":"Djeribi","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Biofilms et la Biocontamination des Mat\u00e9riaux, Facult\u00e9 des Sciences, Universit\u00e9 d\u2019Annaba, Annaba 23000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Rouabhia","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en \u00c9cologie Buccale (GREB), Facult\u00e9 de m\u00e9decine dentaire, Universit\u00e9 Laval, 2420 rue de la Terrasse, Quebec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3109\/1040841X.2013.813904","article-title":"Candida albicans, plasticity and pathogenesis","volume":"41","author":"Poulain","year":"2015","journal-title":"Crit. 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