{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:30:01Z","timestamp":1784601001292,"version":"3.55.0"},"reference-count":6,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T00:00:00Z","timestamp":1556409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Otosyphilis is one contributing cause of hearing loss in adult patients. There are limited studies on the treatment regimens of otosyphilis. Penicillin G sodium (PGS) plus additional medications, such as benzathine penicillin and probenecid, is an effective regimen. This study investigated the efficacy of PGS alone for the treatment of otosyphilis. We conducted a retrospective study and included all consecutive patients diagnosed with otosyphilis who received only PGS treatment. The study period was from 2009 to 2013. The PGS treatment regimen was PGS 4 mu intravenously every four hours (24 mu\/day) for 14 days. Clinical and audiogram outcomes were evaluated one year after treatment. There were 34 otosyphilis patients that were treated with PGS. After one year of treatment, 18 patients (52.9%) had a clinical improvement and 11 patients (32.4%) had an audiogram improvement. In conclusion, PGS at 24 mu\/day for two weeks provided an audiogram improvement one year after treatment in one-third of the patients.<\/jats:p>","DOI":"10.3390\/antibiotics8020047","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T02:57:32Z","timestamp":1556506652000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Penicillin G Sodium as a Treatment of Otosyphilis with Hearing Loss"],"prefix":"10.3390","volume":"8","author":[{"given":"Verajit","family":"Chotmongkol","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"North-Eastern Stroke Research Group, Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Research and Training Center for Enhancing Quality of Life of Working Age People, and Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sittichai","family":"Khamsai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patravoot","family":"Vatanasapt","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittisak","family":"Sawanyawisuth","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"North-Eastern Stroke Research Group, Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Research and Training Center for Enhancing Quality of Life of Working Age People, and Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.otohns.2006.08.026","article-title":"Otosyphilis: A review of 85 cases. Otolaryngol","volume":"136","author":"Yimtae","year":"2007","journal-title":"Head. Neck. Surg."},{"key":"ref_2","first-page":"1135","article-title":"Luetic hydrops\u2014diagnosis and therapy","volume":"89","author":"Pillsbury","year":"1979","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/000348947908800202","article-title":"Treatment of syphilitic hearing loss. Combined penicillin and steroid therapy in 29 patients","volume":"88","author":"Zoller","year":"1979","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_4","first-page":"1","article-title":"Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski","year":"2010","journal-title":"MMWR. Recomm. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/sextrans-2011-050201","article-title":"Doxycycline treatment of otosyphilis with hearing loss","volume":"88","author":"Chotmongkol","year":"2012","journal-title":"Sex. Transm. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1288\/00005537-199211000-00010","article-title":"Otosyphilis: A diagnostic and therapeutic dilemma","volume":"102","author":"Gleich","year":"1992","journal-title":"Laryngoscope"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/8\/2\/47\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:47:43Z","timestamp":1760186863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/8\/2\/47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,28]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["antibiotics8020047"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics8020047","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,28]]}}}