{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:44:24Z","timestamp":1760240664281,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>A novel protocol has been established to prepare the kanamycin ring II\/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6\u2032) and APH-(3\u2032) binder, and as a poor substrate for the ravenous ANT-(4\u2032), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes.<\/jats:p>","DOI":"10.3390\/antibiotics8030109","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T11:58:16Z","timestamp":1564747096000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis of Ring II\/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-388X","authenticated-orcid":false,"given":"Sandra G.","family":"Z\u00e1rate","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain"},{"name":"Facultad de Tecnolog\u00eda, Carrera de Ingenier\u00eda Qu\u00edmica, Universidad Mayor, Real y Pontificia de San Francisco Xavier de Chuquisaca, Regimiento Campos 180, Casilla 60-B Sucre, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-9595","authenticated-orcid":false,"given":"Agatha","family":"Bastida","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-7714","authenticated-orcid":false,"given":"Andr\u00e9s G.","family":"Santana","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-7336","authenticated-orcid":false,"given":"Julia","family":"Revuelta","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3181\/00379727-57-14769","article-title":"Effect of streptomycin and other antibiotic substances upon Mycobacterium tuberculosis and related organisms","volume":"57","author":"Schatz","year":"1944","journal-title":"Proc. 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