{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:26:57Z","timestamp":1789576017513,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["WI223052 (IIR2016-03)"],"award-info":[{"award-number":["WI223052 (IIR2016-03)"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>We aimed to evaluate tigecycline on the clinical effectiveness in treating complicated skin and soft tissue infections (cSSTI), complicated intra-abdominal infections (cIAI), and pneumonia, caused by extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae, as data are limited. From three medical centers in Taiwan, we retrospectively studied the cSSTI, cIAI, and\/or pneumonia caused by ESBL-producing Enterobacteriaceae. Among the 71 patients, including 39 patients infected with Klebsiella pneumoniae, 30 infected with Escherichia coli and others, the clinical success rate of tigecycline-based therapy was 80\u201390% for pneumonia and cSSTI caused by E. coli and 50\u201360% for cIAI caused by K. pneumoniae and E. coli. Microbiological and clinical outcome of pneumonia caused by carbapenem-resistant K. pneumoniae was poor. Univariate Cox analysis showed that dyspnea, SOFA score, septic shock, thrombocytopenia, prolonged prothrombin time, and lesser microbiological eradication were significant factors associated with 30-day mortality after the end of therapy. Cox regression proportional hazards model revealed dyspnea and a SOFA score &gt; 8 to be independently associated with time to death. For ESBL producers, tigecycline showed good effects for cSSTI and pneumonia by E. coli, ordinary for cIAI, but ineffective for pneumonia by K. pneumoniae. Dyspnea and a high SOFA score predict a poor outcome.<\/jats:p>","DOI":"10.3390\/antibiotics9050231","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T03:10:38Z","timestamp":1588821038000},"page":"231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tigecycline Therapy for Infections Caused by Extended-Spectrum \u03b2-Lactamase-Producing Enterobacteriaceae in Critically Ill Patients"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7345-800X","authenticated-orcid":false,"given":"Wen-Liang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan 710, Taiwan"},{"name":"Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-842X","authenticated-orcid":false,"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Infection Control, National Cheng Kung University Hospital, Tainan 710, Taiwan"},{"name":"Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann-Tay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan"},{"name":"Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Infection Control, National Cheng Kung University Hospital, Tainan 710, Taiwan"},{"name":"Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-8477","authenticated-orcid":false,"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan"},{"name":"Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy &amp; Science, Tainan 717, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1517\/14656560902900853","article-title":"Management of complicated infections in the era of antimicrobial resistance: The role of tigecycline","volume":"10","author":"Nicolau","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diagmicrobio.2015.06.011","article-title":"Tigecycline activity tested against carbapenem-resistant Enterobacteriaceae from 18 European nations: Results from the SENTRY surveillance program (2010\u20132013)","volume":"83","author":"Sader","year":"2015","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1128\/AAC.02684-13","article-title":"Variation in potency and spectrum of tigecycline activity against bacterial strains from U.S. medical centers since its approval for clinical use (2006 to 2012)","volume":"58","author":"Sader","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_4","unstructured":"Clinical and Laboratory Standard Institute (2016). Performance Standards for Antimicrobial Susceptibility Testing, 26th (M100-S26), Clinical and Laboratory Standards Institute."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s15010-014-0691-4","article-title":"Clinical efficacy of tigecycline used as monotherapy or in combination regimens for complicated infections with documented involvement of multiresistant bacteria","volume":"43","author":"Heizmann","year":"2015","journal-title":"Infection"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/jac\/dkn249","article-title":"A Phase 3, open-label, non-comparative study of tigecycline in the treatment of patients with selected serious infections due to resistant Gram-negative organisms including Enterobacter species, Acinetobacter baumannii and Klebsiella pneumoniae","volume":"62","author":"Vasilev","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0924-8579(12)70007-9","article-title":"Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010","volume":"40","author":"Lee","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wang, J.-T., Chang, S.-C., Chang, F.-Y., Fung, C.-P., Chuang, Y.-C., Chen, Y.-S., Shiau, Y.-R., Tan, M.-C., Wang, H.-Y., and Lai, J.-F. (2015). Antimicrobial non-susceptibility of Escherichia coli from outpatients and patients visiting emergency rooms in Taiwan. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144103"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jmii.2017.08.005","article-title":"Extended-spectrum \u03b2-lactamase-producing Escherichia coli bacteremia: Comparison of pediatric and adult populations","volume":"51","author":"Tsai","year":"2018","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1586\/eri.12.164","article-title":"Carbapenem-resistant Gram-negative bacteria: How to prioritize infection prevention and control interventions in resource-limited settings?","volume":"11","author":"Apisarnthanarak","year":"2013","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e764","DOI":"10.1016\/j.ijid.2010.02.2254","article-title":"A multicenter study of risk factors and outcome of hospitalized patients with infections due to carbapenem-resistant Acinetobacter baumannii","volume":"14","author":"Sheng","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1128\/AAC.00365-16","article-title":"A multinational, preregistered cohort study of \u03b2-lactam\/\u03b2-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-\u03b2-lactamase-producing Enterobacteriaceae","volume":"60","author":"Salamanca","year":"2016","journal-title":"Antimicrob. Agent Chemother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jmii.2015.08.012","article-title":"Fluoroquinolone therapy for bloodstream infections caused by extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella pneumoniae","volume":"50","author":"Lo","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijantimicag.2005.08.016","article-title":"Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991\u20132003 at a university hospital in Taiwan","volume":"26","author":"Hsueh","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jmii.2016.08.022","article-title":"Risk factors and outcomes for the acquisition of carbapenem-resistant Gram-negative bacillus bacteremia: A retrospective propensity-matched case control study","volume":"51","author":"Ting","year":"2018","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jmii.2012.03.007","article-title":"Combating antimicrobial resistance: Antimicrobial stewardship program in Taiwan","volume":"45","author":"Tseng","year":"2012","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ajic.2013.04.004","article-title":"Impact of an antimicrobial stewardship program with multidisciplinary cooperation in a community public teaching hospital in Taiwan","volume":"41","author":"Lin","year":"2013","journal-title":"Am. J. Infect. Control"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ijantimicag.2014.07.025","article-title":"Blood culture-guided de-escalation of empirical antimicrobial regimen for critical patients in an online antimicrobial stewardship programme","volume":"44","author":"Wang","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jmii.2015.05.011","article-title":"Effects of various antimicrobial stewardship programs on antimicrobial usage and resistance among common gram-negative bacilli causing health care-associated infections: A multicenter comparison","volume":"49","author":"Lai","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jmii.2015.10.006","article-title":"Decreased antimicrobial resistance and defined daily doses after implementation of a clinical culture-guided antimicrobial stewardship program in a local hospital","volume":"50","author":"Wu","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jmii.2016.06.007","article-title":"Effects of implementation of an online comprehensive antimicrobial-stewardship program in ICUs: A longitudinal study","volume":"51","author":"Chen","year":"2018","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jmii.2017.10.004","article-title":"Implementation and outcomes of hospital-wide computerized antimicrobial approval system and on-the-spot education in a traumatic intensive care unit in Taiwan","volume":"51","author":"Huang","year":"2018","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jmii.2017.05.006","article-title":"Propensity-matched analysis of the impact of extended-spectrum \u03b2-lactamase production on adults with community-onset Escherichia coli, Klebsiella species, and Proteus mirabilis bacteremia","volume":"51","author":"Lee","year":"2018","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ijantimicag.2011.08.011","article-title":"Implementation and outcomes of a hospital-wide computerised antimicrobial stewardship programme in a large medical centre in Taiwan","volume":"38","author":"Chan","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/jac\/dkr116","article-title":"Antibiotic use and the risk of carbapenem-resistant extended-spectrum-\u03b2-lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: Results of a double case\u2013control study","volume":"66","author":"Roumbelaki","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Huang, P.-Y., Shie, S.-S., Ye, J.-J., Lin, S.-P., Liu, T.-P., Wu, T.-S., Wu, T.-L., Cheng, M.-H., Hsieh, Y.-C., and Chuang, S.-S. (2017). Acquisition and clearance of multidrug resistant Acinetobacter baumannii on healthy young adults concurrently burned in a dust explosion in Taiwan: The implication for antimicrobial stewardship. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2682-4"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1093\/jac\/dkt142","article-title":"Efficacy of tigecycline for the treatment of complicated intra-abdominal infections in real-life clinical practice from five European observational studies","volume":"68","author":"Eckmann","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/sur.2015.075","article-title":"Evaluation of tigecycline efficacy and post-discharge outcomes in a clinical practice population with complicated intra-abdominal infection: A propensity score-matched analysis","volume":"17","author":"Solomkin","year":"2016","journal-title":"Surg. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1503\/cmaj.150100","article-title":"Association between frailty and 30-day outcomes after discharge from hospital","volume":"187","author":"Kahlon","year":"2015","journal-title":"CMAJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1017\/ice.2018.63","article-title":"Comparison of predictors and mortality between bloodstream infections caused by ESBL-producing Escherichia coli and ESBL-producing Klebsiella pneumoniae","volume":"39","author":"Scheuerman","year":"2018","journal-title":"Infect. Control. Hosp. Epidemiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"ofy150","DOI":"10.1093\/ofid\/ofy150","article-title":"Association between carbapenem resistance and mortality among adult, hospitalized patients with serious infections due to Enterobacteriaceae: Results of a systematic literature review and meta-analysis","volume":"5","author":"Martin","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_32","first-page":"332","article-title":"In vitro activity of tigecycline against clinical isolates of extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae, Serratia marcescens and Enterobacter cloacae","volume":"41","author":"Ku","year":"2008","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3855\/jidc.668","article-title":"Nosocomial blood-stream infections from extended-spectrum-\u03b2-lactamase-producing Escherichia coli and Klebsiella pneumoniae from GB Pant Hospital, New Delhi","volume":"4","author":"Taneja","year":"2010","journal-title":"J. Infect. Dev. Ctries"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/jac\/dkm318","article-title":"Mortality and delay in effective therapy associated with extended-spectrum \u03b2-lactamase production in Enterobacteriaceae bacteraemia: A systematic review and meta-analysis","volume":"60","author":"Schwaber","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1128\/AAC.01232-12","article-title":"Randomized phase 2 trial to evaluate the clinical efficacy of two high-dosage tigecycline regimens versus imipenem-cilastatin for treatment of hospital-acquired pneumonia","volume":"57","author":"Ramirez","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/AAC.01154-12","article-title":"The therapeutic effect of tigecycline, unlike that of Ceftazidime, is not influenced by whether the Klebsiella pneumoniae strain produces extended-spectrum \u03b2-lactamases in experimental pneumonia in rats","volume":"57","author":"Goessens","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jmii.2016.12.008","article-title":"Comparison of synergism between colistin, fosfomycin and tigecycline against extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae isolates or with carbapenem resistance","volume":"50","author":"Ku","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10096-017-3156-8","article-title":"Treatment outcome of non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae infections: A multicenter study in Taiwan","volume":"37","author":"Su","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jmii.2016.03.003","article-title":"Colistin-sparing regimens against Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates: Combination of tigecycline or doxycycline and gentamicin or amikacin","volume":"52","author":"Tang","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/9\/5\/231\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:32:39Z","timestamp":1760362359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/9\/5\/231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["antibiotics9050231"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics9050231","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]}}}