{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:12:13Z","timestamp":1788963133257,"version":"build-2803163510"},"reference-count":80,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced a decrease in interest over time. However, in the last decade, we are seeing a renaissance of aminoglycosides thanks to a better understanding of their chemistry and mode of action, which had led to new trends of application. The purpose of this comprehensive review is to highlight one of these new fields of application: the use of aminoglycosides as building blocks for the development of liposomal and polymeric vectors for gene delivery. The design, synthetic strategies, ability to condensate the genetic material, the efficiency in transfection, and cytotoxicity as well as when available, the antibacterial activity of aminoglycoside-based cationic lipids and polymers are covered and critically analyzed.<\/jats:p>","DOI":"10.3390\/antibiotics9080504","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T10:56:12Z","timestamp":1597143372000},"page":"504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Aminoglycosides: From Antibiotics to Building Blocks for the Synthesis and Development of Gene Delivery Vehicles"],"prefix":"10.3390","volume":"9","author":[{"given":"Maria Cristina","family":"Bellucci","sequence":"first","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences, Universit\u00e0 degli Studi di Milano, via Celoria 2, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-0744","authenticated-orcid":false,"given":"Alessandro","family":"Volonterio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Material and Chemical Engineer \u201cGiulio Natta\u201d, Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/cbic.200900779","article-title":"The future of aminoglycosides: The end or renaissance?","volume":"11","author":"Houghton","year":"2010","journal-title":"ChemBioChem"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0966-842X(97)01033-0","article-title":"Bacterial resistance to aminoglycoside antibiotics","volume":"5","author":"Davies","year":"1997","journal-title":"Trends Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/327389a0","article-title":"Interaction of antibiotics with functional sites in 16S ribosomal RNA","volume":"327","author":"Moazed","year":"1987","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1021\/ja9715105","article-title":"Electrostatic interactions in RNA aminoglycosides binding","volume":"119","author":"Wang","year":"1997","journal-title":"J. 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