{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:21:09Z","timestamp":1791058869023,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n de Investigaci\u00f3n del Hospital General Universitario de Valencia","award":["1600 CHF"],"award-info":[{"award-number":["1600 CHF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The multi-resistant yeast Candida auris has become a global public health threat because of its ease to persist and spread in clinical environments, especially in intensive care units. One of the most severe manifestations of invasive candidiasis is candidaemia, whose epidemiology has evolved to more resistant non-albicansCandida species, such as C. auris. It is crucial to establish infection control policies in order to control an outbreak due to nosocomial pathogens, including the implementation of screening colonisation studies. We describe here our experience in managing a C. auris outbreak lasting more than two and a half years which, despite our efforts in establishing control measures and surveillance, is still ongoing. A total of 287 colonised patients and 47 blood stream infections (candidaemia) have been detected to date. The epidemiology of those patients with candidaemia and the susceptibility of C. auris isolates are also reported. Thirty-five patients with candidaemia (74.5%) were also previously colonised. Forty-three patients (91.5%) were hospitalised (61.7%) or had been hospitalised (29.8%) in the ICU before developing candidaemia. Antifungal therapy for candidaemia consisted of echinocandins in monotherapy or in combination with amphotericin B or isavuconazole. The most common underlying disease was abdominal surgery (29.8%). The thirty-day mortality rate was 23.4% and two cases of endophtalmitis due to C. auris were found. All isolates were resistant to fluconazole and susceptible to echinocandins and amphotericin B. One isolate became resistant to echinocandins two months after the first isolate. Although there are no established clinical breakpoints, minimum inhibitory concentrations for isavuconazole were low (\u2264 1 \u03bcg\/mL).<\/jats:p>","DOI":"10.3390\/antibiotics9090558","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T06:06:22Z","timestamp":1598767582000},"page":"558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Characteristics and Management of Candidaemia Episodes in an Established Candida auris Outbreak"],"prefix":"10.3390","volume":"9","author":[{"given":"Juan V.","family":"Mulet Bayona","sequence":"first","affiliation":[{"name":"Microbiology Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Tormo Palop","sequence":"additional","affiliation":[{"name":"Microbiology Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Salvador Garc\u00eda","sequence":"additional","affiliation":[{"name":"Microbiology Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"Herrero Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Abril L\u00f3pez de Medrano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ferrer G\u00f3mez","sequence":"additional","affiliation":[{"name":"Anestesiology and Reanimation Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Gimeno Cardona","sequence":"additional","affiliation":[{"name":"Microbiology Department, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain"},{"name":"Microbiology Department, University of Valencia, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3201\/eid2509.190040","article-title":"Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016\u20132017","volume":"25","author":"Mpembe","year":"2019","journal-title":"Emerg. 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