{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:41:46Z","timestamp":1793356906457,"version":"4.5.0"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IPS USM Fellowship; USM RUI Grant","award":["1001.PPSP.8012259"],"award-info":[{"award-number":["1001.PPSP.8012259"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Vancomycin-Resistant Enterococci (VRE) are on the rise worldwide. Here, we report the first prevalence of VRE in Nigeria using systematic review and meta-analysis. International databases MedLib, PubMed, International Scientific Indexing (ISI), Web of Science, Scopus, Google Scholar, and African journals online (AJOL) were searched. Information was extracted by two independent reviewers, and results were reviewed by the third. Two reviewers independently assessed the study quality using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. OpenMeta analyst was used. The random effect was used, and publication bias was assessed using a funnel plot. Between-study heterogeneity was assessed, and the sources were analysed using the leave-one-out meta-analysis, subgroup analysis, and meta-regression. Nineteen studies met the eligibility criteria and were added to the final meta-analysis, and the study period was from 2009\u20132018. Of the 2552 isolates tested, 349 were VRE, and E. faecalis was reported the most. The pooled prevalence of VRE in Nigeria was estimated at 25.3% (95% CI; 19.8\u201330.8%; I2 = 96.26%; p &lt; 0.001). Between-study variability was high (t2 = 0.011; heterogeneity I2 = 96.26% with heterogeneity chi-square (Q) = 480.667, degrees of freedom (df) = 18, and p = 0.001). The funnel plot showed no publication bias, and the leave-one-out forest plot did not affect the pooled prevalence. The South-East region had a moderate heterogeneity though not significant (I2 = 51.15%, p = 0.129). Meta-regression showed that all the variables listed contributed to the heterogeneity except for the animal isolate source (p = 0.188) and studies that were done in 2013 (p = 0.219). Adherence to proper and accurate antimicrobial usage, comprehensive testing, and continuous surveillance of VRE are required.<\/jats:p>","DOI":"10.3390\/antibiotics9090565","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T08:53:43Z","timestamp":1598950423000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vancomycin-Resistant Enterococci (VRE) in Nigeria: The First Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"9","author":[{"given":"Yusuf","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"},{"name":"Department of Zoology, Faculty of Life Sciences, Ahmadu Bello University, Zaria 810211, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azian Binti","family":"Harun","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"},{"name":"Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-7624","authenticated-orcid":false,"given":"Chan Yean","family":"Yean","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rahman","family":"Zaidah","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"},{"name":"Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"ref_1","first-page":"1021","article-title":"Vancomycin-Resistant Enterococcus: Issues in Human Health, Animal Health, Resistant Mechanisms and the Malaysian Paradox","volume":"7","author":"Wada","year":"2019","journal-title":"Adv. Anim. Veter-Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Iseppi, R., Di Cerbo, A., Messi, P., and Sabia, C. (2020). Antibiotic Resistance and Virulence Traits in Vancomycin-Resistant Enterococci (VRE) and Extended-Spectrum \u03b2-Lactamase\/AmpC-producing (ESBL\/AmpC) Enterobacteriaceae from Humans and Pets. Antibiotics, 9.","DOI":"10.3390\/antibiotics9040152"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Adapa, S., Naramala, S., Boken, D., Moreno, A., and Konala, V.M. (2019). Peritonitis from Anaerobic Gram-positive Cocci Likely Due to Translocation of Bacteria from Gut in a Patient Undergoing Peritoneal Dialysis. Cureus, 11.","DOI":"10.7759\/cureus.6060"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Argud\u00edn, M. (2017). \u00c1ngeles; Deplano, A.; Meghraoui, A.; Dod\u00e9mont, M.; Heinrichs, A.; Denis, O.; Nonhoff, C.; Roisin, S. Bacteria from Animals as a Pool of Antimicrobial Resistance Genes. Antibiotics, 6.","DOI":"10.3390\/antibiotics6020012"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rostkowska, O.M., Kuthan, R., Burban, A., Sali\u0144ska, J., Ciebiera, M., Mlynarczyk, G., and Durlik, M. (2020). Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060284"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Folliero, V., Caputo, P., Della Rocca, M.T., Chianese, A., Galdiero, M., Iovene, M.R., Hay, C., Franci, G., and Galdiero, M. (2020). Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania \u201cLuigi Vanvitelli\u201d between 2017 and 2018. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050215"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Banik, A., Halder, S.K., Ghosh, C., and Mondal, K.C. (2020). Enterococcal Infections, Drug Resistance, and Application of Nanotechnology, Springer Science and Business Media LLC.","DOI":"10.1007\/978-3-030-40337-9_18"},{"key":"ref_8","unstructured":"Bhardwaj, S.B. (2019). Enterococci: An Important Nosocomial Pathogen. Pathogenic Bacteria [Working Title], IntechOpen."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.drup.2018.10.002","article-title":"Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature","volume":"40","author":"Bender","year":"2018","journal-title":"Drug Resist. Updat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100226","DOI":"10.1016\/j.obmed.2020.100226","article-title":"Vancomycin-resistant enterococcus, obesity and antibiotics: Is there a possible link?","volume":"18","author":"Wada","year":"2020","journal-title":"Obes. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/jac\/dkw312","article-title":"Multilevel population genetic analysis ofvanAandvanB Enterococcus faeciumcausing nosocomial outbreaks in 27 countries (1986\u20132012)","volume":"71","author":"Freitas","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1093\/jac\/dky308","article-title":"Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX","volume":"73","author":"Hansen","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ijantimicag.2019.02.009","article-title":"Molecular characterization and evolution of the first outbreak of vancomycin-resistant Enterococcus faecium in Western Australia","volume":"53","author":"Lee","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lee, B.J., Vu, B.N., Seddon, A.N., Hodgson, H.A., and Wang, S.K. (2020). Treatment Considerations for CNS Infections Caused by Vancomycin-Resistant Enterococcus faecium: A Focused Review of Linezolid and Daptomycin. Ann. Pharmacother., 106002802093251.","DOI":"10.1177\/1060028020932513"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/antibiotics4030309","article-title":"Antimicrobial Stewardship Intervention and Feedback to Infectious Disease Specialists: A Case Study in High-Dose Daptomycin","volume":"4","author":"Ross","year":"2015","journal-title":"Antibiotics"},{"key":"ref_16","first-page":"1","article-title":"Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: A systematic review and meta-analysis","volume":"20","author":"Dagnaw","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4314\/ajid.v5i2.66513","article-title":"Prevalence of hospital acquired enterococci infections in two primary-care hospitals in Osogbo, Southwestern Nigeria","volume":"5","author":"Olawale","year":"2011","journal-title":"Afr. J. Infect. Dis."},{"key":"ref_18","unstructured":"Oyedeji, O., Olutiola, P.O., Owolabi, K.D., and Adeojo, K.A. (2011). Multiresistant faecal indicator bacteria in stream and well waters of Ile-ife city, southwestern Nigeria: Public health implications. J. Public Health Epidemiol., Available online: https:\/\/academicjournals.org\/journal\/JPHE\/article-abstract\/5C2D8F51666."},{"key":"ref_19","first-page":"162","article-title":"Transmission of Antibiotic-Resistant Enterococcus faecalis through Currency Notes","volume":"2","author":"Olawale","year":"2014","journal-title":"Am. J. Biol. Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.9734\/BMRJ\/2015\/7348","article-title":"Antibiotic-Resistant Enterococcus faecalis Isolated from Food Canteens in Osun States, Nigeria","volume":"6","author":"Olawale","year":"2015","journal-title":"Br. Microbiol. Res. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/0975-7406.171729","article-title":"Identification and prevalence of tetracycline resistance in enterococci isolated from poultry in Ilishan, Ogun State, Nigeria","volume":"8","author":"Ayeni","year":"2016","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.21010\/ajid.v10i2.8","article-title":"Surveillance for Vancomycin Resistant Enterococci in a Tertiary Institution in South Western Nigeria","volume":"10","author":"Ekuma","year":"2016","journal-title":"Afr. J. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21010\/ajid.v11i2.11","article-title":"Carriage of Multidrug Resistant Enterococcus Faecium and Enterococcus Faecalis among Apparently Healthy Humans","volume":"11","author":"Adesida","year":"2017","journal-title":"Afr. J. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14419\/ijbr.v5i1.6811","article-title":"Virulence Factors and Beta-Lactamase Production among Vancomycin-Resistant Enterococcus Faecalis Isolated from Clinical Samples and Hospital Environment","volume":"5","author":"David","year":"2017","journal-title":"Int. J. Biol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s13213-012-0530-8","article-title":"Prevalence, distribution and antibiotic resistance pattern among enterococci species in two traditional fermented dairy foods","volume":"63","author":"Oguntoyinbo","year":"2012","journal-title":"Ann. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4314\/ajcem.v18i3.4","article-title":"Prevalence and antibiotics susceptibility profile of Enterococcus spp. Isolated from some hospitals in Abuja, Nigeria","volume":"18","author":"Ndubuisi","year":"2017","journal-title":"Afr. J. Clin. Exp. Microbiol."},{"key":"ref_27","first-page":"126","article-title":"Antimicrobial Resistance Pattern of Enterococci Isolated from Stool Samples in a Tertiary Hospital in Nigeria","volume":"10","author":"Shettima","year":"2019","journal-title":"Ann. Trop. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.15835\/nsb749681","article-title":"Prevalence and Antibiogram of Generic Enterococci in Ready-to-Slaughter Beef Cattle","volume":"7","author":"Anyanwu","year":"2015","journal-title":"Not. Sci. Boil."},{"key":"ref_29","first-page":"1","article-title":"High Antibiotic Resistance Pattern Observed in Bacterial Isolates from a Tertiary Hospital in South East Nigeria","volume":"3","author":"Nsofor","year":"2016","journal-title":"Int. J. Res. Pharm. Biosci."},{"key":"ref_30","first-page":"46","article-title":"Occurrence, Antibiogram and Vancomycin Resistance of Generic Enterococci in Horses in Nigeria","volume":"170","author":"Anyanwu","year":"2019","journal-title":"Revue M\u00e9d. V\u00e9t."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Foka, F.E.T., Yah, C.S., and Bissong, M.E.A. (2018). Physico-Chemical Properties and Microbiological Quality of Borehole Water in Four Crowded Areas of Benin City, Nigeria, During Rainfalls. Shiraz E-Med. J., 19.","DOI":"10.5812\/semj.68911"},{"key":"ref_32","first-page":"353","article-title":"Enterococcus Isolates in Clinical Samples from In-Patients in Uyo, Nigeria","volume":"7","author":"Abasiubong","year":"2019","journal-title":"Int. J. Life Sci. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3389\/fmicb.2019.00728","article-title":"Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species from Ready-to-Eat Seafood","volume":"10","author":"Igbinosa","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4314\/ijs.v21i3.8","article-title":"Characterization of Enterococcus species isolated from abattoir environment in Benin city, Nigeria","volume":"21","author":"Igbinosa","year":"2020","journal-title":"Ife J. Sci."},{"key":"ref_35","first-page":"20","article-title":"Antibiotic Resistance Profile of Enterococcus species Isolated from Drinking Water Sources in Zaria, Kaduna State, Nigeria","volume":"12","author":"Enenya","year":"2017","journal-title":"J. Trop. Biosci."},{"key":"ref_36","unstructured":"(2020, August 08). Federal Ministries of Agriculture, Environment and Health, National Action Plan for Antimicrobial Resistance 2017\u20132022, Available online: https:\/\/ncdc.gov.ng\/themes\/common\/docs\/protocols\/77_1511368219.pdf."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wada, Y., Harun, A.B., Chan, Y.Y., Mohamad Nasir, N.S., and Zaidah, A.R. (2020). Prevalence of Vancomycin resistant enterococcus in Malaysia: A meta-analysis and systematic review. Int. J. Infect. Dis., Accepted Manuscript.","DOI":"10.1016\/j.ijid.2020.09.088"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4753460","article-title":"Vancomycin-Resistant Enterococci and Its Associated Risk Factors among HIV-Positive and -Negative Clients Attending Dessie Referral Hospital, Northeast Ethiopia","volume":"2018","author":"Ali","year":"2018","journal-title":"Int. J. Microbiol."},{"key":"ref_39","first-page":"177","article-title":"Prevalence of vancomycin resistance among isolates of enterococci in Iran: A systematic review and meta-analysis","volume":"9","author":"Moghimbeigi","year":"2018","journal-title":"Adolesc. Health Med. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Alevizakos, M., Gaitanidis, A., Nasioudis, D., Tori, K., Flokas, M.E., and Mylonakis, E. (2016). Colonization With Vancomycin-Resistant Enterococci and Risk for Bloodstream Infection Among Patients with Malignancy: A Systematic Review and Meta-Analysis. Open Forum Infect. Dis., 4.","DOI":"10.1093\/ofid\/ofw246"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13756-018-0419-9","article-title":"The importance of adjusting for enterococcus species when assessing the burden of vancomycin resistance: A cohort study including over 1000 cases of enterococcal bloodstream infections","volume":"7","author":"Kramer","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s10096-016-2702-0","article-title":"Prevalence of vancomycin-resistant Enterococcus in Iran: A systematic review and meta-analysis","volume":"35","author":"Emaneini","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4111\/icu.2016.57.2.129","article-title":"Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom","volume":"57","author":"Toner","year":"2016","journal-title":"Investig. Clin. Urol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.47102\/annals-acadmedsg.V36N6p379","article-title":"Predictors of vancomycin-resistant enterococcus (VRE) carriage in the first major VRE outbreak in Singapore","volume":"36","author":"Yang","year":"2007","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-019-4352-1","article-title":"VRE in cirrhotic patients","volume":"19","author":"Barger","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1086\/518971","article-title":"A Population-Based Investigation of Invasive Vancomycin-ResistantEnterococcusInfection in Metropolitan Atlanta, Georgia, and Predictors of Mortality","volume":"28","author":"Camins","year":"2007","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fpubh.2018.00212","article-title":"Antibiotic Resistance in Syria: A Local Problem Turns Into a Global Threat","volume":"6","author":"Jakovljevic","year":"2018","journal-title":"Front. Public Health"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhussupova, G., Skvirskaya, G., Reshetnikov, V.A., Dragojevi\u0107-Simi\u0107, V., Ran\u010di\u0107, N., Utepova, D., and Jakovljevic, M. (2020). The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020057"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Robertson, J., Iwamoto, K., Hoxha, I., Ghazaryan, L., Abilova, V., Cvijanovic, A., Pyshnik, H., Darakhvelidze, M., Makalkina, L., and Jakupi, A. (2019). Antimicrobial Medicines Consumption in Eastern Europeand Central Asia\u2013An Updated Cross-National Study and Assessment of QuantitativeMetrics for Policy Action. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01156"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12992-020-00590-3","article-title":"Real GDP growth rates and healthcare spending \u2013 comparison between the G7 and the EM7 countries","volume":"16","author":"Jakovljevic","year":"2020","journal-title":"Glob. Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1746-1596-8-163","article-title":"High frequency distribution of heterogeneous vancomycin resistant Enterococcous faecium (VREfm) in Iranian hospitals","volume":"8","author":"Shokoohizadeh","year":"2013","journal-title":"Diagn. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1542\/hpeds.2015-0196","article-title":"Rising Vancomycin-Resistant Enterococcus Infections in Hospitalized Children in the United States","volume":"6","author":"Adams","year":"2016","journal-title":"Hosp. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJM198807213190307","article-title":"Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium","volume":"319","author":"Leclercq","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(88)91037-9","article-title":"vancomycin-resistant enterococci","volume":"331","author":"Uttley","year":"1988","journal-title":"Lancet"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"19046","DOI":"10.2807\/ese.13.47.19046-en","article-title":"Emergence and spread of vancomycin resistance among enterococci in Europe","volume":"13","author":"Werner","year":"2008","journal-title":"Eurosurveillance"},{"key":"ref_56","unstructured":"Levitus, M., Rewane, A., and Perera, T.B. (2020). Vancomycin-Resistant Enterococci (VRE). StatPearls 2020 Treasure Island (FL), StatPearls Publishing."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrmicro2761","article-title":"The rise of the Enterococcus: Beyond vancomycin resistance","volume":"10","author":"Arias","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"ofz553","DOI":"10.1093\/ofid\/ofz553","article-title":"Epidemiology of Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis Colonization in Nursing Facilities","volume":"7","author":"Davis","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/JCM.43.1.462-463.2005","article-title":"Emerging Incidence of Enterococcus faecium among Hospital Isolates (1993 to 2002)","volume":"43","author":"Treitman","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diagmicrobio.2006.12.022","article-title":"Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: A report from the SENTRY antimicrobial surveillance program","volume":"58","author":"Deshpande","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/591861","article-title":"NHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006\u20132007","volume":"29","author":"Hidron","year":"2008","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1080\/13696998.2019.1600523","article-title":"Comparative financing analysis and political economy of noncommunicable diseases","volume":"22","author":"Jakovljevic","year":"2019","journal-title":"J. Med. Econ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1586\/14787210.2014.870886","article-title":"Antibiotic resistance inEnterococcus faeciumclinical isolates","volume":"12","author":"Cattoir","year":"2014","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4161\/viru.21282","article-title":"Intrinsic and acquired resistance mechanisms in enterococcus","volume":"3","author":"Hollenbeck","year":"2012","journal-title":"Virulence"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1574-695X.2008.00383.x","article-title":"Emergence of CC17Enterococcus faecium: From commensal to hospital-adapted pathogen","volume":"52","author":"Top","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_66","first-page":"23","article-title":"Insecurity in Northern Nigeria: Causes, Consequences and Resolutions","volume":"2","year":"2015","journal-title":"Int. J. Peace Confl. Stud."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12350-015-0249-6","article-title":"An application of meta-analysis based on DerSimonian and Laird method","volume":"23","author":"George","year":"2015","journal-title":"J. Nucl. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v049.i05","article-title":"Closing the Gap between Methodologists and End-Users:Ras a Computational Back-End","volume":"49","author":"Wallace","year":"2012","journal-title":"J. Stat. 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