{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:51:59Z","timestamp":1782417119161,"version":"3.54.5"},"reference-count":14,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Invasive pulmonary aspergillosis (IPA) is typically considered a disease of immunocompromised patients, but, recently, many cases have been reported in patients without typical risk factors. The aim of our study is to develop a risk predictive model for IPA through machine learning techniques (decision trees) in patients with influenza. We conducted a retrospective observational study analyzing data regarding patients diagnosed with influenza hospitalized at the University Hospital \u201cUmberto I\u201d of Rome during the 2018-2019 season. We collected five IPA cases out of 77 influenza patients. Although the small sample size is a limit, the most vulnerable patients among the influenza-infected population seem to be those with evidence of lymphocytopenia and those that received corticosteroid therapy.<\/jats:p>","DOI":"10.3390\/antibiotics9100644","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T22:24:42Z","timestamp":1601245482000},"page":"644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preliminary Attempt to Predict Risk of Invasive Pulmonary Aspergillosis in Patients with Influenza: Decision Trees May Help?"],"prefix":"10.3390","volume":"9","author":[{"given":"Valeria","family":"Bellelli","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Siccardi","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Celani","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Congeduti","sequence":"additional","affiliation":[{"name":"Electrical Engineering Mathematics and Computer Science, Delft University of Technology, 2628 XE Delft, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-898X","authenticated-orcid":false,"given":"Cristian","family":"Borrazzo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-058X","authenticated-orcid":false,"given":"Letizia","family":"Santinelli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Pietro","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pinacchio","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-3180","authenticated-orcid":false,"given":"Giancarlo","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-0281","authenticated-orcid":false,"given":"Mario","family":"Venditti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5677","authenticated-orcid":false,"given":"Gabriella","family":"d\u2019Ettorre","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00182 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/cid\/ciz391","article-title":"Influenza coinfection: Be(a)ware of invasive aspergillosis","volume":"70","author":"Verweij","year":"2020","journal-title":"Clin. 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