{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:38:56Z","timestamp":1778704736570,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015311","name":"Novartis Institutes for BioMedical Research","doi-asserted-by":"publisher","award":["250"],"award-info":[{"award-number":["250"]}],"id":[{"id":"10.13039\/100015311","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca (MIUR) under the programme &quot;Dipartimenti di Eccellenza ex L.232\/2016","award":["232"],"award-info":[{"award-number":["232"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The breeding of meat rabbits is an important sector in the livestock industry in Italy. The focus of this study was to describe the antibiotic resistance profile distribution among the Methicillin-sensitive Staphylococcus aureus isolated in a rabbit farm. From 400 animals of different ages and three farm workers, 96 randomly selected strains isolated from various anatomical sites and lesions were analysed. According to spa typing and the resistance profiles towards veterinary and human antibiotics, 26 pathotypes were identified. The highest resistance was observed against Tetracyclines (92.3%) and Macrolides (80.8%), while almost all were susceptible to Penicillins, according to the limited use of \u03b2-lactams on the farm. In total, 92.3% of pathotypes were multidrug resistant (MDRs). Two MDR pathotypes belonging to the t2802 spa type were isolated from both farmers and rabbits. Age categories harboured significantly different pathotypes (p = 0.019), while no association was found between pathotypes and lesions (p = 0.128) or sampling sites (p = 0.491). The antibiotic resistance was observed to increase with the time spent in the farm environment (age category). The selective pressure exerted by antibiotic use acted by giving advantage to more resistant strains rather than by lowering susceptibility to various drug categories within strains.<\/jats:p>","DOI":"10.3390\/antibiotics9100673","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T08:35:57Z","timestamp":1601886957000},"page":"673","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9085-7125","authenticated-orcid":false,"given":"Anna-Rita","family":"Attili","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-3861","authenticated-orcid":false,"given":"Alessandro","family":"Bellato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, 10095 Grugliasco (TO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Robino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, 10095 Grugliasco (TO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-8359","authenticated-orcid":false,"given":"Livio","family":"Galosi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Papeschi","sequence":"additional","affiliation":[{"name":"Interdepartmental Animal Facility, University of Tuscia, Largo dell\u2019Universit\u00e0 snc, 01100 Viterbo (VT), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-5984","authenticated-orcid":false,"given":"Giacomo","family":"Rossi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Fileni","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Linardi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-3506","authenticated-orcid":false,"given":"Vincenzo","family":"Cuteri","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica (MC), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6781-682X","authenticated-orcid":false,"given":"Francesco","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, 10095 Grugliasco (TO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-0413","authenticated-orcid":false,"given":"Patrizia","family":"Nebbia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, 10095 Grugliasco (TO), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"EFSA ECDC (2018). The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016. 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