{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:41:24Z","timestamp":1793835684655,"version":"4.6.1"},"reference-count":164,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agriculture and Agri-Food Canada (AAFC) and the Genomic Research and Development Initiative on AMR (GRDI-AMR) mitigation project.","award":["2411 & 1858"],"award-info":[{"award-number":["2411 & 1858"]}],"id":[{"id":"https:\/\/ror.org\/051dzs374","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The Enterobacteriales order consists of seven families including Enterobacteriaceae, Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and Budviciaceae and 60 genera encompassing over 250 species. The Enterobacteriaceae is currently considered as the most taxonomically diverse among all seven recognized families. The emergence of carbapenem resistance (CR) in Enterobacteriaceae caused by hydrolytic enzymes called carbapenemases has become a major concern worldwide. Carbapenem-resistant Enterobacteriaceae (CRE) isolates have been reported not only in nosocomial and community-acquired pathogens but also in food-producing animals, companion animals, and the environment. The reported carbapenemases in Enterobacteriaceae from different sources belong to the Ambler class A (blaKPC), class B (blaIMP, blaVIM, blaNDM), and class D (blaOXA-48) \u03b2-lactamases. The carbapenem encoding genes are often located on plasmids or associated with various mobile genetic elements (MGEs) like transposons and integrons, which contribute significantly to their spread. These genes are most of the time associated with other antimicrobial resistance genes such as other \u03b2-lactamases, as well as aminoglycosides and fluoroquinolones resistance genes leading to multidrug resistance phenotypes. Control strategies to prevent infections due to CRE and their dissemination in human, animal and food have become necessary. Several factors involved in the emergence of CRE have been described. This review mainly focuses on the molecular epidemiology of carbapenemases in members of Enterobacteriaceae family from humans, animals, food and the environment.<\/jats:p>","DOI":"10.3390\/antibiotics9100693","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T08:55:53Z","timestamp":1602579353000},"page":"693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment"],"prefix":"10.3390","volume":"9","author":[{"given":"Gurleen","family":"Taggar","sequence":"first","affiliation":[{"name":"Guelph Research and Development Center, Agriculture and Agri-Food Canada (AAFC), 93, Stone Road West, Guelph, ON N1G 5C6, Canada"},{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-1969","authenticated-orcid":false,"given":"Muhammad","family":"Attiq Rehman","sequence":"additional","affiliation":[{"name":"Guelph Research and Development Center, Agriculture and Agri-Food Canada (AAFC), 93, Stone Road West, Guelph, ON N1G 5C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Boerlin","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Diarra","sequence":"additional","affiliation":[{"name":"Guelph Research and Development Center, Agriculture and Agri-Food Canada (AAFC), 93, Stone Road West, Guelph, ON N1G 5C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"ref_1","unstructured":"WHO (2017). World Health Organization. Gloval Priority List of Antiviotic-Resistand Bacteria to Guide Research, Discovery, and Development of New Antibiotics, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1099\/ijsem.0.001485","article-title":"Genome-based phylogeny and taxonomy of the \u2018Enterobacteriales\u2019: Proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov","volume":"66","author":"Adeolu","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3201\/eid1710.110655","article-title":"Global spread of Carbapenemase-producing Enterobacteriaceae","volume":"17","author":"Nordmann","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1017\/ice.2016.31","article-title":"Colistin and tigecycline resistance in Carbapenem-resistant Enterobacteriaceae: Checkmate to our last line of defense","volume":"37","author":"Kumar","year":"2016","journal-title":"Infect. Control. Hosp. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fmicb.2019.00080","article-title":"Infections caused by Carbapenem-resistant Enterobacteriaceae: An update on therapeutic options","volume":"10","author":"Sheu","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1128\/AAC.00296-11","article-title":"Carbapenems: Past, present, and future","volume":"55","author":"Endimiani","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_7","unstructured":"Dowd, F.J., Johnson, B.S., and Mariotti, A.J. (2017). Pharmacology of specific drug groups. Pharmacology and Therapeutics for Dentistry, Elsevier."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/305784","article-title":"Epidemiology of Carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries","volume":"2014","author":"Djahmi","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_9","first-page":"3","article-title":"Carbapenemase-producing Enterobacteriaceae in animals and methodologies for their detection","volume":"84","author":"Anderson","year":"2020","journal-title":"Can. J. Vet. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12606","DOI":"10.1074\/jbc.RA118.003835","article-title":"Evolution of New Delhi metallo-\u03b2-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity","volume":"293","author":"Cheng","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1073\/pnas.91.16.7693","article-title":"Analysis of a Carbapenem-hydrolyzing class A beta-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein","volume":"91","author":"Naas","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: The versatile \u03b2-Lactamases","volume":"20","author":"Queenan","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of \u03b2-Lactamases","volume":"54","author":"Bush","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e00397-20","DOI":"10.1128\/AAC.00397-20","article-title":"Metallo-\u03b2-lactamases: Structure, function, epidemiology, treatment options, and the development pipeline","volume":"10","author":"Boyd","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e01823-16","DOI":"10.1128\/AAC.01823-16","article-title":"Chromosomal integration of the Klebsiella pneumoniae Carbapenemase gene, blaKPC, in Klebsiella species is elusive but not rare","volume":"61","author":"Mathers","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13100-018-0141-4","article-title":"Carbapenemases on the move: It\u2019s good to be on ICEs","volume":"9","author":"Botelho","year":"2018","journal-title":"Mob. DNA"},{"key":"ref_17","first-page":"19045","article-title":"Emergence of extensively drug-resistant and pandrug-resistant Gram-negative bacilli in Europe","volume":"13","author":"Souli","year":"2008","journal-title":"Euro Surveill. Eur. Commun. Dis. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/CMR.00117-13","article-title":"OXA-Lactamases","volume":"27","author":"Evans","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Codjoe, F.S., and Donkor, E.S. (2017). Carbapenem resistance: A review. Med. Sci., 6.","DOI":"10.3390\/medsci6010001"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jinf.2016.04.021","article-title":"Beta-lactamases in Enterobacteriaceae infections in children","volume":"72","author":"Moxon","year":"2016","journal-title":"J. Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","article-title":"Novel Carbapenem-hydrolyzing \u03b2-Lactamase, KPC-1, from a Carbapenem-resistant strain of Klebsiella pneumoniae","volume":"45","author":"Yigit","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jhin.2013.05.003","article-title":"Emergence of Carbapenem-resistant Enterobacteriaceae in a UK paediatric hospital","volume":"84","author":"Drew","year":"2013","journal-title":"J. Hosp. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tim.2006.07.008","article-title":"The \u03b2-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter","volume":"14","author":"Livermore","year":"2006","journal-title":"Trends Microbiol."},{"key":"ref_24","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2011). Risk Assessment on the Spread of Carbapenemase-Producing Enterobacteriaceae (CPE) through Patient Transfer between Healthcare Facilities, with Special Emphasis on Cross-Border Transfer, ECDC. ECDC Technical Report."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5152\/balkanmedj.2013.7499","article-title":"Detection of OXA-48-like Carbapenemase-producing Klebsiella pneumoniae in a tertiary care center in Turkey: Molecular characterization and epidemiology","volume":"30","author":"Azap","year":"2013","journal-title":"Balk. Med. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1056\/NEJMra0904124","article-title":"Hospital-acquired infections due to gram-negative bacteria","volume":"362","author":"Peleg","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3947\/ic.2015.47.3.175","article-title":"In vitro antibacterial activity of Doripenem against gram-negative blood isolates in a Korean tertiary care center","volume":"47","author":"Choi","year":"2015","journal-title":"Infect. Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1469-0691.2010.03225.x","article-title":"Metallo-\u03b2-lactamases among Enterobacteriaceae from routine samples in an Italian tertiary care hospital and long-term care facilities during 2008","volume":"17","author":"Aschbacher","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.diagmicrobio.2014.06.010","article-title":"Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system","volume":"80","author":"Ahn","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/ofid\/ofy224","article-title":"Epidemiology of Carbapenem-resistant Enterobacteriaceae at a long-term acute care hospital","volume":"5","author":"Chopra","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Tamma, P.D., Kazmi, A., Bergman, Y., Goodman, K.E., Ekunseitan, E., Amoah, J., and Simner, P.J. (2019). The likelihood of developing a Carbapenem-resistant infection during the hospital stay. Antimicrob Agents Chemother.","DOI":"10.1128\/AAC.00757-19"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.diagmicrobio.2018.10.004","article-title":"Diversity of resistance mechanisms in Carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016","volume":"93","author":"Senchyna","year":"2019","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3201\/eid2409.180164","article-title":"Emergence of Carbapenemase-producing Enterobacteriaceae, South-Central Ontario, Canada1","volume":"24","author":"Kohler","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1086\/649865","article-title":"An outbreak of infection due to \u03b2-Lactamase Klebsiella pneumoniae Carbapenemase 2\u2013producing K. pneumoniae in a Greek University Hospital: Molecular characterization, epidemiology, and outcomes","volume":"50","author":"Souli","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/jac\/dkr166","article-title":"An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009\u201310)","volume":"66","author":"Giakkoupi","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2807\/ese.15.46.19711-en","article-title":"Carbapenem-non-susceptible Enterobacteriaceae in Europe: Conclusions from a meeting of national experts","volume":"15","author":"Grundmann","year":"2010","journal-title":"Eurosurveillance"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19734","DOI":"10.2807\/ese.15.48.19734-en","article-title":"Control of a multi-hospital outbreak of KPC-producing Klebsiella pneumoniae type 2 in France, September to October 2009","volume":"15","author":"Carbonne","year":"2010","journal-title":"Eurosurveillance"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1128\/AAC.01513-13","article-title":"Carbapenemase-producing Enterobacteriaceae in Spain in 2012","volume":"57","author":"Oteo","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","article-title":"The real threat of Klebsiella pneumoniae Carbapenemase-producing bacteria","volume":"9","author":"Nordmann","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhin.2014.11.012","article-title":"Large hospital outbreak of KPC-2-producing Klebsiella pneumoniae: Investigating mortality and the impact of screening for KPC-2 with polymerase chain reaction","volume":"89","author":"Ducomble","year":"2015","journal-title":"J. Hosp. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3389\/fmicb.2020.01563","article-title":"Carbapenemase-producing Klebsiella pneumoniae from transplanted patients in Brazil: Phylogeny, resistome, virulome and mobile genetic elements harboring blaKPC-2 or blaNDM-1","volume":"11","author":"Raro","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/jac\/dku356","article-title":"The spread of Carbapenemase-producing bacteria in Africa: A systematic review","volume":"70","author":"Manenzhe","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Singh-Moodley, A., and Perovic, O. (2016). Antimicrobial susceptibility testing in predicting the presence of carbapenemase genes in Enterobacteriaceae in South Africa. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1858-7"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/17460913.2.5.501","article-title":"Carbapenemases: Molecular diversity and clinical consequences","volume":"2","author":"Poirel","year":"2007","journal-title":"Futur. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/AAC.05289-11","article-title":"Genetic features of the widespread plasmid coding for the Carbapenemase OXA-48","volume":"56","author":"Poirel","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3389\/fmicb.2016.00895","article-title":"Global dissemination of Carbapenemase-producing Klebsiella pneumoniae: Epidemiology, genetic context, treatment options, and detection methods","volume":"7","author":"Lee","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jhin.2016.10.006","article-title":"Control of Carbapenemase-producing Enterobacteriaceae outbreaks in acute settings: An evidence review","volume":"95","author":"French","year":"2017","journal-title":"J. Hosp. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Senchyna, F., Gaur, R., Sandlund, J., Truong, C., Tremintin, G., K\u00fceltz, D., Gomez, C.A., Tamburini, F.B., Andermann, T.M., and Bhatt, A.S. (2018). Diverse mechanisms of resistance in Carbapenem-resistant Enterobacteriaceae at a health care system in Silicon Valley, California. bioRxiv.","DOI":"10.1101\/298513"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.3389\/fmicb.2019.01156","article-title":"Detection and genomic characterization of a Morganella morganii isolate from China that produces NDM-5","volume":"10","author":"Guo","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/AAC.01180-07","article-title":"Plasmid-mediated Carbapenem-hydrolyzing \u03b2-Lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece","volume":"52","author":"Cuzon","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1128\/AAC.49.10.4423-4424.2005","article-title":"Plasmid-mediated Carbapenem-hydrolyzing \u03b2-Lactamase KPC in a Klebsiella pneumoniae isolate from France","volume":"49","author":"Naas","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1473-3099(10)70143-2","article-title":"Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: A molecular, biological, and epidemiological study","volume":"10","author":"Kumarasamy","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jiph.2013.06.006","article-title":"Prevalence of metallo-\u03b2-lactamase NDM-1-producing multi-drug resistant bacteria at two Pakistani hospitals and implications for public health","volume":"6","author":"Nahid","year":"2013","journal-title":"J. Infect. Public Heal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/jac\/dks214","article-title":"The role of international travel in the worldwide spread of multiresistant Enterobacteriaceae","volume":"67","author":"Pitout","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3201\/eid1702.101561","article-title":"New Delhi Metallo-\u03b2-Lactamase, Ontario, Canada","volume":"17","author":"Tijet","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jogc.2019.02.008","article-title":"Endometritis and bacteremia with a New Delhi Metallo-Beta-Lactamase 1 (NDM-1)-containing organism in a remote traveler","volume":"41","author":"Bernick","year":"2019","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mataseje, L.F., Boyd, D.A., Mulvey, M.R., and Longtin, Y. (2019). Report on two hypervirulent Klebsiella pneumoniae producing a blaKPC-2 Carbapenemase from a Canadian patient. Antimicrob Agents Chemother.","DOI":"10.1128\/AAC.00517-19"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e00321-20","DOI":"10.1128\/AAC.00321-20","article-title":"KPC-50 confers resistance to Ceftazidime-Avibactam associated with reduced Carbapenemase activity","volume":"64","author":"Poirel","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1469-0691.2010.03209.x","article-title":"Intercontinental spread from Israel to Colombia of a KPC-3-producing klebsiella pneumoniae strain","volume":"17","author":"Correa","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1093\/jac\/dkr382","article-title":"Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism","volume":"66","author":"Adler","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_61","unstructured":"ECDC (2019). European Centre for Disease Prevention and Control. Outbreak of VIM-Producing Carbapenem Resistant Pseudomonas aeruginosa Linked to medical Tourism to Mexico, ECDC."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.eclinm.2018.12.008","article-title":"Control of Carbapenemase-producing Enterobacteriaceae: Beyond the hospital","volume":"6","author":"Cheng","year":"2019","journal-title":"EClinicalMedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.3389\/fmicb.2018.02872","article-title":"Hospitalized pets as a source of Carbapenem-resistance","volume":"9","author":"Gentilini","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1089\/mdr.2018.0237","article-title":"First detection of New Delhi Metallo-\u03b2-Lactamase-5-producing Escherichia coli from companion animals in Korea","volume":"25","author":"Hong","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/zph.12462","article-title":"Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments","volume":"65","author":"Adams","year":"2018","journal-title":"Zoonoses Public Health"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/jac\/dkt259","article-title":"Emergence of OXA-48 Carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs","volume":"68","author":"Stolle","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_67","first-page":"1700497","article-title":"Sharing more than friendship-transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015","volume":"23","author":"Eklund","year":"2018","journal-title":"Eurosurveillance"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/jac\/dks515","article-title":"Fluoroquinolone-resistant extraintestinal pathogenic Escherichia coli, including O25b-ST131, isolated from faeces of hospitalized dogs in an Australian veterinary referral centre","volume":"68","author":"Guo","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1128\/JCM.00980-08","article-title":"Multiple-host sharing, long-term persistence, and virulence of Escherichia coli clones from human and animal household members","volume":"46","author":"Johnson","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/CMR.00125-13","article-title":"Escherichia coli ST131, an intriguing clonal group","volume":"27","author":"Bertrand","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"35527","DOI":"10.1038\/srep35527","article-title":"Isolation and plasmid characterization of Carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats","volume":"6","author":"Abraham","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cmi.2018.04.004","article-title":"Carbapenem-resistant Enterobacteriaceae in wildlife, food-producing, and companion animals: A systematic review","volume":"24","author":"Becker","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1093\/jac\/dku133","article-title":"IMP-45-producing multidrug-resistant Pseudomonas aeruginosa of canine origin","volume":"69","author":"Wang","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetmic.2014.01.017","article-title":"Extended-spectrum \u03b2-lactamase, Carbapenemase and AmpC producing Enterobacteriaceae in companion animals","volume":"170","author":"Rubin","year":"2014","journal-title":"Veter Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/jac\/dkz017","article-title":"Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK","volume":"74","author":"Reynolds","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-020-00742-5","article-title":"Poor infection prevention and control standards are associated with environmental contamination with Carbapenemase-producing Enterobacterales and other multidrug-resistant bacteria in Swiss companion animal clinics","volume":"9","author":"Schmidt","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1939-1676.2008.00124.x","article-title":"Multidrug-resistant E. coli and Enterobacter extraintestinal infection in 37 dogs","volume":"22","author":"Gibson","year":"2008","journal-title":"J. Veter. Intern. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/jac\/dks108","article-title":"Escherichia coli producing VIM-1 Carbapenemase isolated on a pig farm","volume":"67","author":"Fischer","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3201\/eid1803.111330","article-title":"Carbapenemase-producing Acinetobacter spp. in Cattle, France","volume":"18","author":"Poirel","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/jac\/dks393","article-title":"Salmonella enterica subsp. enterica producing VIM-1 Carbapenemase isolated from livestock farms","volume":"68","author":"Fischer","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.vetmic.2016.04.026","article-title":"Spread and persistence of VIM-1 Carbapenemase-producing Enterobacteriaceae in three German swine farms in 2011 and 2012","volume":"200","author":"Fischer","year":"2017","journal-title":"Veter. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wu, C., Zhang, Q., Qi, J., Liu, H., Wang, Y., He, T., Ma, L., Lai, J., and Shen, Z. (2012). Identification of New Delhi Metallo-\u03b2-lactamase 1 in Acinetobacter lwoffii of food animal origin. PLoS ONE, 7.","DOI":"10.1371\/annotation\/e33066ea-f500-4d34-8981-7cfd68497e73"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vetmic.2017.06.010","article-title":"Characterization of NDM-5-positive extensively resistant Escherichia coli isolates from dairy cows","volume":"207","author":"He","year":"2017","journal-title":"Veter. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fmicb.2018.00248","article-title":"Novel variant of New Delhi Metallo-\u03b2-lactamase, NDM-20, in Escherichia coli","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Morrison, B.J., and Rubin, J. (2015). Carbapenemase producing bacteria in the food supply escaping detection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126717"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Abdallah, H., Reuland, E.A., Wintermans, B.B., Al Naiemi, N., Koek, A., Abdelwahab, A.M., Ammar, A.M., Mohamed, A.A., and Vandenbroucke-Grauls, C.M.J.E. (2015). Extended-spectrum \u03b2-Lactamases and\/or Carbapenemases-producing Enterobacteriaceae isolated from retail chicken meat in Zagazig, Egypt. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136052"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.4315\/0362-028X.JFP-18-045","article-title":"Carbapenemases and extended-spectrum \u03b2-Lactamase-producing multidrug-resistant Escherichia coli isolated from retail chicken in Peshawar: First report from Pakistan","volume":"81","author":"Ahmad","year":"2018","journal-title":"J. Food Prot."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1473-3099(16)00057-8","article-title":"Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1","volume":"16","author":"Yao","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"(2017). VIM-1-producing Salmonella infantis isolated from swine and minced pork meat in Germany. J. Antimicrob. Chemother., 72, 2131\u20132133.","DOI":"10.1093\/jac\/dkx101"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Wang, W., Baloch, Z., Peng, Z., Hu, Y., Xu, J., Fanning, S., and Li, F. (2017). Genomic characterization of a large plasmid containing a bla NDM-1 gene carried on Salmonella enterica serovar Indiana C629 isolate from China. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2515-5"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e00573-19","DOI":"10.1128\/AAC.00573-19","article-title":"Rapid increase in Carbapenemase-producing Enterobacteriaceae in retail meat driven by the spread of the blaNDM-5-carrying IncX3 plasmid in China from 2016 to 2018","volume":"63","author":"Zhang","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2807\/1560-7917.ES.2017.22.43.17-00032","article-title":"VIM-1 Carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016","volume":"22","author":"Roschanski","year":"2017","journal-title":"Eurosurveillance"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.3201\/eid2209.160305","article-title":"Carbapenem-resistant Enterobacter spp. in retail seafood imported from Southeast Asia to Canada","volume":"22","author":"Janecko","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e02338-18","DOI":"10.1128\/AAC.02338-18","article-title":"Novel Carbapenemases FLC-1 and IMI-2 encoded by an Enterobacter cloacae complex isolated from food products","volume":"63","author":"Brouwer","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1099\/jmm.0.000620","article-title":"OXA-48 and CTX-M-15 extended-spectrum beta-lactamases in raw milk in Lebanon: Epidemic spread of dominant Klebsiella pneumoniae clones","volume":"66","author":"Diab","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jac\/dkx335","article-title":"Emergence of Escherichia coli co-producing NDM-1 and KPC-2 Carbapenemases from a retail vegetable, China","volume":"73","author":"Wang","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jgar.2017.02.006","article-title":"First detection of Klebsiella pneumoniae producing OXA-48 in fresh vegetables from B\u00e9ja\u00efa city, Algeria","volume":"9","author":"Touati","year":"2017","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-015-0080-5","article-title":"First detection of Klebsiella variicola producing OXA-181 Carbapenemase in fresh vegetable imported from Asia to Switzerland","volume":"4","author":"Zurfluh","year":"2015","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.00042-16","article-title":"Carbapenem-resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia","volume":"30","author":"Hsu","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1473-3099(11)70059-7","article-title":"Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: An environmental point prevalence study","volume":"11","author":"Walsh","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/JCM.01992-12","article-title":"Environmental contamination by Carbapenem-resistant Enterobacteriaceae","volume":"51","author":"Lerner","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/ofid\/ofz006","article-title":"Increased mortality among Carbapenemase-producing Carbapenem-resistant Enterobacteriaceae carriers who developed clinical isolates of another genotype","volume":"6","author":"Chen","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"02011","DOI":"10.1128\/mBio.02011-17","article-title":"Genomic analysis of hospital plumbing reveals diverse reservoir of bacterial plasmids conferring Carbapenem resistance","volume":"9","author":"Weingarten","year":"2018","journal-title":"mBio"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1099\/jmm.0.076026-0","article-title":"Detection of bla NDM-4 in Escherichia coli from hospital sewage","volume":"63","author":"Khan","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/AEM.00054-13","article-title":"Characteristics of extended-spectrum \u03b2-Lactamase-and Carbapenemase-producing Enterobacteriaceae isolates from rivers and lakes in Switzerland","volume":"79","author":"Zurfluh","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s10096-018-3365-9","article-title":"Related Carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden","volume":"37","author":"Khan","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Piedra-Carrasco, N., F\u00e0brega, A., Calero-C\u00e1ceres, W., Cornejo-S\u00e1nchez, T., Brown-Jaque, M., Mir-Cros, A., Muniesa, M., and Gonz\u00e1lez-L\u00f3pez, J.J. (2017). Carbapenemase-producing Enterobacteriaceae recovered from a Spanish river ecosystem. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175246"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2166\/wh.2019.165","article-title":"Survey of US wastewater for Carbapenem-resistant Enterobacteriaceae","volume":"17","author":"Hoelle","year":"2019","journal-title":"J. Water Health"},{"key":"ref_109","first-page":"61","article-title":"Carbapenemase-Producing Enterobacteriaceae Recovered from the Environment of a Swine Farrow-to-finish operation in the United States","volume":"61","author":"Mollenkopf","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1089\/fpd.2017.2406","article-title":"Functional blaKPC-2 sequences are present in U.S. beef cattle feces regardless of antibiotic use","volume":"15","author":"Vikram","year":"2018","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/mdr.2018.0087","article-title":"Carbapenem-resistant Acinetobacter baumannii recovered from swine manure","volume":"25","author":"Hrenovic","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Tang, B., Chang, J., Cao, L., Luo, Q.-X., Xu, H., Lyu, W., Qian, M., Ji, X., Zhang, Q., and Xia, X. (2019). Characterization of an NDM-5 Carbapenemase-producing Escherichia coli ST156 isolate from a poultry farm in Zhejiang, China. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1454-2"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13213-020-01579-4","article-title":"Critical threat associated with carbapenem-resistant gram-negative bacteria: Prioritizing water matrices in addressing total antibiotic resistance","volume":"70","author":"Adegoke","year":"2020","journal-title":"Ann. Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.scitotenv.2019.01.179","article-title":"Whole genome sequencing reveals resemblance between ESBL-producing and carbapenem resistant Klebsiella pneumoniae isolates from Austrian rivers and clinical isolates from hospitals","volume":"662","author":"Lepuschitz","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1038\/s41598-019-40420-0","article-title":"Multi-state study of Enterobacteriaceae harboring extended-spectrum beta-lactamase and Carbapenemase genes in U.S. drinking water","volume":"9","author":"Tanner","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-020-00736-3","article-title":"Emergence of \u03b2-lactamase-and Carbapenemase-producing Enterobacteriaceae at integrated fish farms","volume":"9","author":"Hamza","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/cid\/cix893","article-title":"Carbapenemase-producing organisms: A global scourge","volume":"66","author":"Bonomo","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.molmed.2012.03.003","article-title":"Carbapenem resistance in Enterobacteriaceae: Here is the storm!","volume":"18","author":"Nordmann","year":"2012","journal-title":"Trends Mol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/AAC.00774-09","article-title":"Characterization of a new Metallo-\u03b2-Lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India","volume":"53","author":"Yong","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1128\/CMR.00047-19","article-title":"Epidemiology of \u03b2-Lactamase-producing pathogens","volume":"33","author":"Bush","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1128\/AAC.46.12.4026-4028.2002","article-title":"Novel variant (blaVIM-4) of the Metallo-\u03b2-Lactamase gene blaVIM-1 in a clinical strain of Pseudomonas aeruginosa","volume":"46","author":"Pournaras","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e02729-16","DOI":"10.1128\/AAC.02729-16","article-title":"Global molecular epidemiology of IMP-producing Enterobacteriaceae","volume":"61","author":"Matsumura","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eclinm.2018.11.003","article-title":"Emerging carriage of NDM-5 and MCR-1 in Escherichia coli from healthy people in multiple regions in China: A cross sectional observational study","volume":"6","author":"Shen","year":"2018","journal-title":"EClinicalMedicine"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"107009","DOI":"10.1289\/EHP5251","article-title":"Inter-host transmission of Carbapenemase-producing Escherichia coli among humans and backyard animals","volume":"127","author":"Li","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"105715","DOI":"10.1016\/j.envint.2020.105715","article-title":"Contaminated in-house environment contributes to the persistence and transmission of NDM-producing bacteria in a Chinese poultry farm","volume":"139","author":"Zhai","year":"2020","journal-title":"Environ. Int."},{"key":"ref_126","unstructured":"ECDC (2019). European Centre for Disease Prevention and Control. Carbapenem-Resistant Enterobacteriaceae, second Update, ECDC."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cmi.2017.09.013","article-title":"Review of antimicrobial resistance surveillance programmes in livestock and meat in EU with focus on humans","volume":"24","author":"Schrijver","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_128","first-page":"7956","article-title":"Carbapenemase-producing bacteria in food-producing animals, wildlife and environment: A challenge for human health","volume":"8","author":"Bonardi","year":"2019","journal-title":"Ital. J. Food Saf."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1038\/nmicrobiol.2016.260","article-title":"Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production","volume":"2","author":"Wang","year":"2017","journal-title":"Nat. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2478\/jvetres-2019-0049","article-title":"Carbapenem-resistant Pseudomonas aeruginosa originating from farm animals and people in Egypt","volume":"63","author":"Elshafiee","year":"2019","journal-title":"J. Veter.-Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.3389\/fmicb.2019.01823","article-title":"Carbapenemases in Enterobacteriaceae: Detection and antimicrobial therapy","volume":"10","author":"Cui","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tim.2018.08.004","article-title":"From theory to practice: Translating whole-genome sequencing (WGS) into the clinic","volume":"26","author":"Balloux","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1128\/CMR.00001-16","article-title":"A Primer on infectious disease bacterial genomics","volume":"29","author":"Lynch","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1574-6976.2011.00277.x","article-title":"Analysis of antibiotic resistance regions in Gram-negative bacteria","volume":"35","author":"Partridge","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1574-6976.2011.00273.x","article-title":"Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens","volume":"35","author":"Stokes","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1574-6976.2011.00294.x","article-title":"Combinatorial events of insertion sequences and ICE in Gram-negative bacteria","volume":"35","author":"Toleman","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1128\/AAC.00014-16","article-title":"Horizontal transfer of Carbapenemase-encoding plasmids and comparison with hospital epidemiology data","volume":"60","author":"Hardiman","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fmicb.2019.00404","article-title":"Identification of diverse integron and plasmid structures carrying a novel Carbapenemase among Pseudomonas species","volume":"10","author":"Liapis","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Sugawara, Y., Akeda, Y., Sakamoto, N., Takeuchi, D., Motooka, D., Nakamura, S., Hagiya, H., Yamamoto, N., Nishi, I., and Yoshida, H. (2017). Genetic characterization of blaNDM-harboring plasmids in carbapenem-resistant Escherichia coli from Myanmar. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184720"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3201\/eid1207.051555","article-title":"Replicon typing of plasmids encoding resistance to newer \u03b2-Lactams","volume":"12","author":"Carattoli","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1128\/AAC.01707-08","article-title":"Resistance plasmid families in Enterobacteriaceae","volume":"53","author":"Carattoli","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3201\/eid1609.091389","article-title":"Worldwide diversity of Klebsiella pneumoniae that produce \u03b2-Lactamase blaKPC-2gene1","volume":"16","author":"Cuzon","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3201\/eid2506.181939","article-title":"New Delhi Metallo-\u03b2-Lactamase 5-producing Klebsiella pneumoniae sequence type 258, Southwest China, 2017","volume":"25","author":"Zhang","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1099\/jmm.0.044156-0","article-title":"Role of ISAba1 and ISAba125 in governing the expression of bla ADC in clinically relevant Acinetobacter baumannii strains resistant to cephalosporins","volume":"61","author":"Lopes","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1128\/AAC.01663-08","article-title":"In vivo selection of reduced susceptibility to Carbapenems in Acinetobacter baumannii related to ISAba1-mediated overexpression of the natural blaOXA-66 Oxacillinase gene","volume":"53","author":"Figueiredo","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"AAC.01755-16","DOI":"10.1128\/AAC.01755-16","article-title":"Transposition of Tn125encoding the NDM-1 Carbapenemase in Acinetobacter baumannii","volume":"60","author":"Bontron","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.meegid.2019.01.024","article-title":"Molecular characterization of NDM-1-producing Klebsiella pneumoniae ST29, ST347, ST1224, and ST2558 causing sepsis in neonates in a tertiary care hospital of North-East India","volume":"69","author":"Mukherjee","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1128\/AAC.02522-13","article-title":"Class D \u03b2-Lactamases: Are they all Carbapenemases?","volume":"58","author":"Antunes","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e00025-17","DOI":"10.1128\/AAC.00025-17","article-title":"Enhanced Klebsiella pneumoniae Carbapenemase expression from a novel Tn4401 deletion","volume":"61","author":"Cheruvanky","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMp1011715","article-title":"NDM-1-A cause for worldwide concern","volume":"363","author":"Moellering","year":"2010","journal-title":"New Engl. J. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/jac\/dkq520","article-title":"Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?","volume":"66","author":"Nordmann","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2147\/IDR.S175041","article-title":"Detection and characterization of a clinical Escherichia coli ST3204 strain coproducing NDM-16 and MCR-1","volume":"11","author":"Li","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e02642-17","DOI":"10.1128\/AAC.02642-17","article-title":"Heavy metal resistance genes are associated with blaNDM-1- and blaCTX-M-15-carrying Enterobacteriaceae","volume":"62","author":"Yang","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e00470-18","DOI":"10.1128\/mBio.00470-18","article-title":"Escherichia coli ST131-H22 as a foodborne uropathogen","volume":"9","author":"Liu","year":"2018","journal-title":"mBio"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e02040-18","DOI":"10.1128\/AAC.02040-18","article-title":"Diverse vectors and mechanisms spread New Delhi Metallo-\u03b2-Lactamases among Carbapenem-resistant Enterobacteriaceae in the Greater Boston area","volume":"63","author":"Pecora","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jhin.2010.02.005","article-title":"New Delhi metallo-\u03b2-lactamase: A cautionary tale","volume":"75","author":"Muir","year":"2010","journal-title":"J. Hosp. Infect."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e00115-18","DOI":"10.1128\/CMR.00115-18","article-title":"NDM Metallo-\u03b2-Lactamases and their bacterial producers in health care settings","volume":"32","author":"Wu","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/AAC.01312-09","article-title":"Spread of OXA-48-encoding plasmid in Turkey and beyond","volume":"54","author":"Poirel","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fmicb.2017.00133","article-title":"Coexistence of blaOXA-48 and truncated blaNDM-1 on different plasmids in a Klebsiella pneumoniae isolate in China","volume":"8","author":"Xie","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1128\/AAC.01451-07","article-title":"Genetic structures at the origin of acquisition of the \u03b2-Lactamase blaKPC gene","volume":"52","author":"Naas","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3389\/fmicb.2019.00572","article-title":"A phage-like plasmid carrying blaKPC-2 gene in Carbapenem-resistant Pseudomonas aeruginosa","volume":"10","author":"Galetti","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1128\/JCM.02038-07","article-title":"Detection of the Klebsiella pneumoniae Carbapenemase type 2 Carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid","volume":"46","author":"Rasheed","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fmicb.2019.00276","article-title":"Plasmid-mediated transmission of KPC-2 Carbapenemase in Enterobacteriaceae in critically ill patients","volume":"10","author":"Schweizer","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/AAC.01539-07","article-title":"Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated Carbapenem-hydrolyzing \u03b2-Lactamase KPC-2 in intensive care units of a Chinese hospital","volume":"52","author":"Cai","year":"2008","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/9\/10\/693\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:20:32Z","timestamp":1760178032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/9\/10\/693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":164,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["antibiotics9100693"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics9100693","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]}}}