{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:10:39Z","timestamp":1785751839561,"version":"3.56.0"},"reference-count":116,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960032, 32071279"],"award-info":[{"award-number":["31960032, 32071279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2018GXNSFAA138012, 2019JJD130040"],"award-info":[{"award-number":["2018GXNSFAA138012, 2019JJD130040"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Start-up Funding of Guangxi Academy of Sciences","award":["2017YJJ025"],"award-info":[{"award-number":["2017YJJ025"]}]},{"name":"Bagui Scholar Program Fund of Guangxi Zhuang Autonomous Region","award":["2016A24"],"award-info":[{"award-number":["2016A24"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>With the mortality rate of invasive aspergillosis caused by Aspergillus fumigatus reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of A. fumigatus to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against A. fumigatus when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against A. fumigatus. The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.<\/jats:p>","DOI":"10.3390\/antibiotics9110813","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T11:04:20Z","timestamp":1605524660000},"page":"813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects"],"prefix":"10.3390","volume":"9","author":[{"given":"Chukwuemeka Samson","family":"Ahamefule","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"},{"name":"College of Life Science and Technology, Guangxi University, Nanning 530005, Guangxi, China"},{"name":"Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing C.","family":"Ezeuduji","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Jos, Jos 930001, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Ogbonna","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anene N.","family":"Moneke","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-6141","authenticated-orcid":false,"given":"Anthony C.","family":"Ike","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-6290","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"},{"name":"State Key Laboratory of Non-food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-6374","authenticated-orcid":false,"given":"Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"},{"name":"College of Life Science and Technology, Guangxi University, Nanning 530005, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-2072","authenticated-orcid":false,"given":"Wenxia","family":"Fang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"},{"name":"State Key Laboratory of Non-food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e00140-18","DOI":"10.1128\/CMR.00140-18","article-title":"Aspergillus fumigatus and aspergillosis in 2019","volume":"33","author":"Chamilos","year":"2019","journal-title":"Clin. 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